Hepatitis D (Delta) VirusHepatitis D (Delta) VirusHBsAg

RNA

antigen

• Coinfection–severe acute disease– low risk of chronic infection

• Superinfection–usually develop chronic HDV infection–high risk of severe chronic liver disease

Hepatitis D - Clinical

FeaturesHepatitis D - Clinical

Features

•Percutanous exposures–injecting drug use

•Permucosal exposures–sex contact

Hepatitis D Virus

Modes of TransmissionHepatitis D Virus

Modes of Transmission

HBV - HDV CoinfectionHBV - HDV CoinfectionTypical Serologic CourseTypical Serologic Course

Time after ExposureTime after Exposure

Tit

er

Tit

er anti-

HBs

Symptoms

ALT Elevated

Total anti-HDV

IgM anti-HDV

HDV RNA

HBsAg

HBV - HDV SuperinfectionHBV - HDV SuperinfectionTypical Serologic CourseTypical Serologic Course

Time after ExposureTime after Exposure

Tit

erT

ite

rJaundice

Symptoms

ALTTotal anti-HDV

IgM anti-HDV

HDV RNA

HBsAg

Geographic Distribution of HDV InfectionGeographic Distribution of HDV Infection

HDV PrevalenceHigh

Intermediate

Low

Very Low

No Data

Taiwan

Pacific Islands

• HBV-HDV Coinfection

Pre or postexposure prophylaxis to prevent HBV infection

• HBV-HDV SuperinfectionEducation to reduce risk behaviors among persons with chronic HBV infection

Hepatitis D - PreventionHepatitis D - Prevention