hepatocellular carcinoma (hcc) - sirtex · 2017-05-23 · hepatocellular carcinoma (hcc) the most...

Hepatocellular Carcinoma (HCC) The most common form of primary liver cancer in the world Primary liver cancer is the SIXTH most common cancer in the world and the SECOND leading cause of cancer- related death. 1 Global burden of the disease is predicted to increase. 1 In Myanmar, the number of deaths is forecast to rise from 4,187 in 2012 to 5,485 by 2020 2 – a 31% increase. References 1 Ferlay J et al . Globocan 2012. v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer; 2013. Available from: http://globocan.iarc.fr, accessed on 13/March/2017. 2 Extrapolated from Ferlay J et al . Globocan 2012. v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer; 2013. Available from: http://globocan.iarc.fr, accessed on 13/March/2017. 3 Davis GL et al. Proc (Bayl Univ Med Cent) 2008; 21: 266–80. 4 EASL–EORTC Clinical Practice Guidelines: Management of hepatocellular carcinoma. J Hepatol 2012; 56: 908–943. 5 Di Bisceglie AM. Hepatology 2009; 49 (Suppl 5): S56–60. 6 Llovet JM et al. Nat Rev Dis Primers 2016; 2: 16018. doi: 10.1038/nrdp.2016.18. 2012 2014 2016 2018 2020 In the developed Western world, chronic Hepatitis C viral infection is the major risk factor for cirrhosis. 3 Other risk factors include Hepatitis B virus and alcohol misuse. 4 HCC occurs mainly in the liver of patients affected by cirrhosis. 3 In Africa and East Asia, the most common risk factor for HCC (60% of cases) is Hepatitis B virus. 5 NASH (non-alcoholic steatohepatitis) related HCC, often caused by obesity, is also on the rise worldwide. Hepatocellular carcinoma (HCC), which represents about 90% of primary liver cancer, results in more than 670,000 deaths globally per annum 2 – up to 1,837 people every day or 76 people every hour. There are around 4,200 deaths each year in Myanmar. 2 Global burden What causes HCC? Over the past 10 years no new first-line treatments have become available or proven effective against HCC. 6 As a result, HCC treatment lags behind other cancers. Myanmar More than 670,000 deaths That is one every 47 seconds 513-EUA-0317

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Hepatocellular Carcinoma (HCC)The most common form of primary liver cancer in the world

Primary liver cancer is the SIXTH most common cancer in the world and the SECOND leading cause of cancer-related death.1

Global burden of the disease is predicted to increase.1

In Myanmar, the number of deaths is forecast to rise from 4,187 in 2012 to 5,485 by 2020 2 – a 31% increase.

References1 Ferlay J et al. Globocan 2012. v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer; 2013. Available from: http://globocan.iarc.fr, accessed on 13/March/2017.2 Extrapolated from Ferlay J et al. Globocan 2012. v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer; 2013. Available from: http://globocan.iarc.fr, accessed on

13/March/2017.3 Davis GL et al. Proc (Bayl Univ Med Cent) 2008; 21: 266–80.4 EASL–EORTC Clinical Practice Guidelines: Management of hepatocellular carcinoma. J Hepatol 2012; 56: 908–943.5 Di Bisceglie AM. Hepatology 2009; 49 (Suppl 5): S56–60.6 Llovet JM et al. Nat Rev Dis Primers 2016; 2: 16018. doi: 10.1038/nrdp.2016.18.

2012 2014 2016 2018 2020

In the developed Western world, chronic Hepatitis C viral infection is the major risk factor for cirrhosis.3 Other risk factors include Hepatitis B virus and alcohol misuse.4

HCC occurs mainly in the liver of patients a� ected by cirrhosis.3

In Africa and East Asia, the most common risk factor for HCC (60% of cases) is Hepatitis B virus. 5

NASH (non-alcoholic steatohepatitis) related HCC, often caused by obesity, is also on the rise worldwide.

Hepatocellular carcinoma (HCC), which represents about 90% of primary liver cancer, results in more than 670,000 deaths globally per annum2 – up to 1,837 people every day or 76 people every hour.

There are around 4,200 deaths each year in Myanmar.2

Global burden

What causes HCC?

Over the past 10 years no new � rst-line treatments have become available or proven e� ective against HCC.6

As a result, HCC treatment lags behind other cancers.

Myanmar

More than 670,000 deathsThat is one every 47 seconds

513-EUA-0317

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