hiv screening and testing san francisco area aids education and training center university of...
TRANSCRIPT
![Page 1: HIV Screening and Testing San Francisco Area AIDS Education and Training Center University of California, San Francisco at San Francisco General Hospital](https://reader035.vdocument.in/reader035/viewer/2022062404/5518c227550346b31f8b5606/html5/thumbnails/1.jpg)
HIV Screening and TestingHIV Screening and TestingSan Francisco Area
AIDS Education and Training Center
University of California, San Francisco
at San Francisco General Hospital
![Page 2: HIV Screening and Testing San Francisco Area AIDS Education and Training Center University of California, San Francisco at San Francisco General Hospital](https://reader035.vdocument.in/reader035/viewer/2022062404/5518c227550346b31f8b5606/html5/thumbnails/2.jpg)
2
About this PresentationAbout this PresentationThese slides were developed by the UCSF San Francisco Area AIDS Education and Center as a component of the SFAETC HIV Screening and Testing Training Curriculum Guide. The intended audience is experienced AETC trainers, clinical faculty, and training participants.
Users are cautioned that concepts of HIV management and clinical care continue to evolve rapidly, and this information may become outdated. The information contained herein is not intended to constitute or substitute for medical advice from a licensed health care professional.
![Page 3: HIV Screening and Testing San Francisco Area AIDS Education and Training Center University of California, San Francisco at San Francisco General Hospital](https://reader035.vdocument.in/reader035/viewer/2022062404/5518c227550346b31f8b5606/html5/thumbnails/3.jpg)
3
Welcome!Welcome!
Please sign in Please complete:
1. Participant Information Form & Pre-Test
(“bubble form”) NOW
2. Program Evaluation & Post-Test Later Please silence cell phones and pagers
![Page 4: HIV Screening and Testing San Francisco Area AIDS Education and Training Center University of California, San Francisco at San Francisco General Hospital](https://reader035.vdocument.in/reader035/viewer/2022062404/5518c227550346b31f8b5606/html5/thumbnails/4.jpg)
4
Learning ObjectivesLearning Objectives
At the end of this session you will be able to: Explain rationale for revised HIV screening
recommendations Clarify definitions of “HIV testing” Review CDC routine HIV testing recommendations Discuss HIV testing modalities Apply routine HIV screening recommendations in
clinical practice
![Page 5: HIV Screening and Testing San Francisco Area AIDS Education and Training Center University of California, San Francisco at San Francisco General Hospital](https://reader035.vdocument.in/reader035/viewer/2022062404/5518c227550346b31f8b5606/html5/thumbnails/5.jpg)
5
HIV Testing:HIV Testing:
James Curran, dean of public health at Emory University and director of the university's Center for AIDS Research,
was head of the Centers for Disease Control task force as the HIV epidemic unfolded in the early 1980s.
19851985
![Page 6: HIV Screening and Testing San Francisco Area AIDS Education and Training Center University of California, San Francisco at San Francisco General Hospital](https://reader035.vdocument.in/reader035/viewer/2022062404/5518c227550346b31f8b5606/html5/thumbnails/6.jpg)
6
HIV Testing: 2008HIV Testing: 2008
A 38 year-old man presents to urgent care with complaints of burning while urinating for the past 2 days. He denies fevers, flank pain, or penile discharge. He is sexually active with both men and women and uses condoms sporadically.
![Page 7: HIV Screening and Testing San Francisco Area AIDS Education and Training Center University of California, San Francisco at San Francisco General Hospital](https://reader035.vdocument.in/reader035/viewer/2022062404/5518c227550346b31f8b5606/html5/thumbnails/7.jpg)
7
Would you include an HIV test as Would you include an HIV test as part of his visit?part of his visit?
1. Yes
2. No
3. Maybe/Depends
4. I have no idea
![Page 8: HIV Screening and Testing San Francisco Area AIDS Education and Training Center University of California, San Francisco at San Francisco General Hospital](https://reader035.vdocument.in/reader035/viewer/2022062404/5518c227550346b31f8b5606/html5/thumbnails/8.jpg)
8
HIV Testing: 2008HIV Testing: 2008
A 38 year-old man presents to clinic to establish care. His only complaint is of a sore ankle for the past week after an injury while playing soccer. He states he is otherwise healthy.
![Page 9: HIV Screening and Testing San Francisco Area AIDS Education and Training Center University of California, San Francisco at San Francisco General Hospital](https://reader035.vdocument.in/reader035/viewer/2022062404/5518c227550346b31f8b5606/html5/thumbnails/9.jpg)
9
Would you include an HIV test as Would you include an HIV test as part of his visit?part of his visit?
1. Yes
2. No
3. Maybe/Depends
4. I have no idea
![Page 10: HIV Screening and Testing San Francisco Area AIDS Education and Training Center University of California, San Francisco at San Francisco General Hospital](https://reader035.vdocument.in/reader035/viewer/2022062404/5518c227550346b31f8b5606/html5/thumbnails/10.jpg)
10
Case DiscussionsCase Discussions
Answer for both case scenarios: YES!!YES!!
![Page 11: HIV Screening and Testing San Francisco Area AIDS Education and Training Center University of California, San Francisco at San Francisco General Hospital](https://reader035.vdocument.in/reader035/viewer/2022062404/5518c227550346b31f8b5606/html5/thumbnails/11.jpg)
11
According to the CDC, what According to the CDC, what percentage of people infected percentage of people infected with HIV in the U.S. do not know with HIV in the U.S. do not know they are infected?they are infected?
About 25%About 25%
![Page 12: HIV Screening and Testing San Francisco Area AIDS Education and Training Center University of California, San Francisco at San Francisco General Hospital](https://reader035.vdocument.in/reader035/viewer/2022062404/5518c227550346b31f8b5606/html5/thumbnails/12.jpg)
12
The CDC has estimated that The CDC has estimated that approximately how many approximately how many persons in the U.S. become persons in the U.S. become infected with HIV each year?infected with HIV each year?
Approximately 56,000 per yearApproximately 56,000 per year
![Page 13: HIV Screening and Testing San Francisco Area AIDS Education and Training Center University of California, San Francisco at San Francisco General Hospital](https://reader035.vdocument.in/reader035/viewer/2022062404/5518c227550346b31f8b5606/html5/thumbnails/13.jpg)
13
HIV Incidence in the U.S.HIV Incidence in the U.S.180
160
140
120
100
80
60
40
20
01978 1980 1986 1988 1990 1992 1994
180
160
140
120
100
80
40
20
01982 1984 1996 1998 2000 2002
Est
imat
ed N
um
ber
of
An
nu
al I
nfe
ctio
ns
(X 1
,000
)
![Page 14: HIV Screening and Testing San Francisco Area AIDS Education and Training Center University of California, San Francisco at San Francisco General Hospital](https://reader035.vdocument.in/reader035/viewer/2022062404/5518c227550346b31f8b5606/html5/thumbnails/14.jpg)
14
HIV Incidence in the U.S.HIV Incidence in the U.S.
Transmission is higher among people unaware of infection
Risk behavior is reduced with awareness of HIV+ status:
68% reduction in unprotected sex
![Page 15: HIV Screening and Testing San Francisco Area AIDS Education and Training Center University of California, San Francisco at San Francisco General Hospital](https://reader035.vdocument.in/reader035/viewer/2022062404/5518c227550346b31f8b5606/html5/thumbnails/15.jpg)
15
What we’ve learned so far . . . What we’ve learned so far . . .
Individuals remain untested Routine HIV testing reduces stigma Routine HIV screening is highly
effective: Perinatal transmission reduced from
25-30% to <2% w/ interventions
![Page 16: HIV Screening and Testing San Francisco Area AIDS Education and Training Center University of California, San Francisco at San Francisco General Hospital](https://reader035.vdocument.in/reader035/viewer/2022062404/5518c227550346b31f8b5606/html5/thumbnails/16.jpg)
16
CDC Recommendations: CDC Recommendations: ObjectivesObjectives
Increase HIV screening Detect disease earlier ID & counsel HIV+ patients Link patients to services Further reduce perinatal
transmission
![Page 17: HIV Screening and Testing San Francisco Area AIDS Education and Training Center University of California, San Francisco at San Francisco General Hospital](https://reader035.vdocument.in/reader035/viewer/2022062404/5518c227550346b31f8b5606/html5/thumbnails/17.jpg)
17
CDC Recommendations: CDC Recommendations: Routine Testing for HIVRoutine Testing for HIV
Routine, voluntary testing for all patients ages 13-64
“Opt-out” testing; no separate consent for HIV
Pretest counseling not required
Repeat testing at provider’s discretion
![Page 18: HIV Screening and Testing San Francisco Area AIDS Education and Training Center University of California, San Francisco at San Francisco General Hospital](https://reader035.vdocument.in/reader035/viewer/2022062404/5518c227550346b31f8b5606/html5/thumbnails/18.jpg)
18
DefinitionsDefinitionsThe “Old”
Opt-in screening: performing an HIV test after assessing patient’s risk, obtaining informed consent, and conducting pre-/post-test counseling
The “New”
Opt-out screening: performing an HIV test after notifying patient that the test will be done; consent is inferred unless patient declines
![Page 19: HIV Screening and Testing San Francisco Area AIDS Education and Training Center University of California, San Francisco at San Francisco General Hospital](https://reader035.vdocument.in/reader035/viewer/2022062404/5518c227550346b31f8b5606/html5/thumbnails/19.jpg)
19
DefinitionsDefinitions
Routine testing: performing an HIV test for all persons in a defined population
Diagnostic testing: performing an HIV test for persons with clinical signs or symptoms of HIV infection
Targeted testing: performing an HIV test for subpopulations of persons at higher risk based on behavioral, clinical or demographic characteristics
![Page 20: HIV Screening and Testing San Francisco Area AIDS Education and Training Center University of California, San Francisco at San Francisco General Hospital](https://reader035.vdocument.in/reader035/viewer/2022062404/5518c227550346b31f8b5606/html5/thumbnails/20.jpg)
20
So, Who Should Be Tested?So, Who Should Be Tested?
Everyone ages 13-64 in all healthcare settings
Everyone beginning treatment for TB Everyone seeking treatment for STDs All pregnant women For all: no separate consent or required
prevention counseling (“opt-out”)
![Page 21: HIV Screening and Testing San Francisco Area AIDS Education and Training Center University of California, San Francisco at San Francisco General Hospital](https://reader035.vdocument.in/reader035/viewer/2022062404/5518c227550346b31f8b5606/html5/thumbnails/21.jpg)
21
Who Needs Repeat Testing?Who Needs Repeat Testing?
High-risk patients: Who is included? How frequently?
Anyone engaging in a new relationship Occupational exposure to blood or bloody
fluid which can contain HIV Pregnant women in 3rd trimester in high HIV
prevalence areas
![Page 22: HIV Screening and Testing San Francisco Area AIDS Education and Training Center University of California, San Francisco at San Francisco General Hospital](https://reader035.vdocument.in/reader035/viewer/2022062404/5518c227550346b31f8b5606/html5/thumbnails/22.jpg)
22
Law??Law??
Recommendation??Recommendation??
State HIV Testing Laws Compendium
http://www.ucsf.edu/hivcntr
![Page 23: HIV Screening and Testing San Francisco Area AIDS Education and Training Center University of California, San Francisco at San Francisco General Hospital](https://reader035.vdocument.in/reader035/viewer/2022062404/5518c227550346b31f8b5606/html5/thumbnails/23.jpg)
23
CA HIV/AIDS Testing BillCA HIV/AIDS Testing Bill
AB 682: Effective January 1, 2008 Paves the way for HIV screening to be a
routine part of medical care Repeals written informed consent for HIV
testing Patient can decline test and if so, should be
noted in chart
![Page 24: HIV Screening and Testing San Francisco Area AIDS Education and Training Center University of California, San Francisco at San Francisco General Hospital](https://reader035.vdocument.in/reader035/viewer/2022062404/5518c227550346b31f8b5606/html5/thumbnails/24.jpg)
24
Necessary DocumentationNecessary Documentation
Accepts test:
(Nothing!)
Declines test:
“Patient declines HIV test”
![Page 25: HIV Screening and Testing San Francisco Area AIDS Education and Training Center University of California, San Francisco at San Francisco General Hospital](https://reader035.vdocument.in/reader035/viewer/2022062404/5518c227550346b31f8b5606/html5/thumbnails/25.jpg)
25
Group DiscussionGroup Discussion
1. “What SHOULD BE” Advantages and disadvantages of routine HIV testing
2. “What IS” Misconceptions about HIV testing Barriers to implementation
3. “What COULD BE” Changes needed to implement HIV testing as part of
routine medical care
![Page 26: HIV Screening and Testing San Francisco Area AIDS Education and Training Center University of California, San Francisco at San Francisco General Hospital](https://reader035.vdocument.in/reader035/viewer/2022062404/5518c227550346b31f8b5606/html5/thumbnails/26.jpg)
26
HIV Testing . . . ???HIV Testing . . . ???
Rapid?
ELISA?Western Blot?
Blood test?
Oral test?
UniGold?
OraQuick?
IFA?
Confirmatory?
False positive?
![Page 27: HIV Screening and Testing San Francisco Area AIDS Education and Training Center University of California, San Francisco at San Francisco General Hospital](https://reader035.vdocument.in/reader035/viewer/2022062404/5518c227550346b31f8b5606/html5/thumbnails/27.jpg)
27
How is HIV Diagnostic Testing How is HIV Diagnostic Testing Done?Done?“Gold Standard:”
ELISA followed by Western Blot confirmatory test or immunofluorescence assay (IFA)
Detects antibody to HIV virus Usually takes a few days for results May not be positive during window period Indeterminate result possible
![Page 28: HIV Screening and Testing San Francisco Area AIDS Education and Training Center University of California, San Francisco at San Francisco General Hospital](https://reader035.vdocument.in/reader035/viewer/2022062404/5518c227550346b31f8b5606/html5/thumbnails/28.jpg)
28
Window PeriodWindow Period
Virus in Blood
Antibodies Detected
Window PeriodWindow Period
Infection
![Page 29: HIV Screening and Testing San Francisco Area AIDS Education and Training Center University of California, San Francisco at San Francisco General Hospital](https://reader035.vdocument.in/reader035/viewer/2022062404/5518c227550346b31f8b5606/html5/thumbnails/29.jpg)
29
The Indeterminate TestThe Indeterminate TestWestern Blot: looks for antibodies to specific HIV proteins
and demonstrates presence by a change in color. Indeterminate Result: Some, but not all, bands are present. Causes: recent infection; advanced HIV; certain strains of HIV; cross reaction to other antibodies; HIV vaccine; lab error
Next Steps: Retest in >6 weeks. Risk counseling if
indicated.
![Page 30: HIV Screening and Testing San Francisco Area AIDS Education and Training Center University of California, San Francisco at San Francisco General Hospital](https://reader035.vdocument.in/reader035/viewer/2022062404/5518c227550346b31f8b5606/html5/thumbnails/30.jpg)
30
The Indeterminate TestThe Indeterminate Test
Column 1: Positive Control
Column 2: Negative Control
Column A: Negative Test
Column B: Indeterminate Test
Column C: Positive Test
![Page 31: HIV Screening and Testing San Francisco Area AIDS Education and Training Center University of California, San Francisco at San Francisco General Hospital](https://reader035.vdocument.in/reader035/viewer/2022062404/5518c227550346b31f8b5606/html5/thumbnails/31.jpg)
31
ELISA: ~25% do not return for test results of standard test
RAPID TESTS: Only ~2% leave before results of rapid HIV test
The ELISA HIV Test: The ELISA HIV Test: Perils of WaitingPerils of Waiting
![Page 32: HIV Screening and Testing San Francisco Area AIDS Education and Training Center University of California, San Francisco at San Francisco General Hospital](https://reader035.vdocument.in/reader035/viewer/2022062404/5518c227550346b31f8b5606/html5/thumbnails/32.jpg)
32
Rapid HIV TestsRapid HIV Tests
Uni-Gold Recombigen
Reveal G2
Multispot HIV-1/HIV-2
OraQuick Advance
Stat Pak
Complete
![Page 33: HIV Screening and Testing San Francisco Area AIDS Education and Training Center University of California, San Francisco at San Francisco General Hospital](https://reader035.vdocument.in/reader035/viewer/2022062404/5518c227550346b31f8b5606/html5/thumbnails/33.jpg)
33
A patient has a rapid HIV test performed A patient has a rapid HIV test performed and it is positive. What does this and it is positive. What does this mean?mean?
A. Patient has HIV.
B. Patient most likely has HIV: repeat rapid test now.
C. Patient most likely has HIV: order a Western Blot or IFA.
D. Unclear if the patient has HIV: do another rapid test after window period.
![Page 34: HIV Screening and Testing San Francisco Area AIDS Education and Training Center University of California, San Francisco at San Francisco General Hospital](https://reader035.vdocument.in/reader035/viewer/2022062404/5518c227550346b31f8b5606/html5/thumbnails/34.jpg)
34
Rapid HIV TestsRapid HIV Tests
Results available in < 1 hour Most easy to perform High specificity: negative means negative
except during window period! High sensitivity: positive means likely
positive BUT…
Important! Positive rapid test results must be confirmed for HIV diagnosis!
![Page 35: HIV Screening and Testing San Francisco Area AIDS Education and Training Center University of California, San Francisco at San Francisco General Hospital](https://reader035.vdocument.in/reader035/viewer/2022062404/5518c227550346b31f8b5606/html5/thumbnails/35.jpg)
35
Group DiscussionGroup Discussion
1. What are the advantages and disadvantages to using the rapid HIV test?
2. What changes would need to occur in your healthcare setting to implement use of the rapid HIV test?
3. What would you tell patients before and after running a rapid test?
![Page 36: HIV Screening and Testing San Francisco Area AIDS Education and Training Center University of California, San Francisco at San Francisco General Hospital](https://reader035.vdocument.in/reader035/viewer/2022062404/5518c227550346b31f8b5606/html5/thumbnails/36.jpg)
36
SummarySummary
All persons ages 13-64 should be screened for HIV
No need for written informed consent or counseling
High risk patients should be screened more frequently
![Page 37: HIV Screening and Testing San Francisco Area AIDS Education and Training Center University of California, San Francisco at San Francisco General Hospital](https://reader035.vdocument.in/reader035/viewer/2022062404/5518c227550346b31f8b5606/html5/thumbnails/37.jpg)
37
ResourcesResources http://www.hivtest.org/
![Page 38: HIV Screening and Testing San Francisco Area AIDS Education and Training Center University of California, San Francisco at San Francisco General Hospital](https://reader035.vdocument.in/reader035/viewer/2022062404/5518c227550346b31f8b5606/html5/thumbnails/38.jpg)
38
ResourcesResourcesAETC National Resource Centerhttp://www.aids-etc.org/
AIDSinfoDHHS Treatment Guidelineshttp://aidsinfo.nih.gov/
Centers for Disease Control & Prevention (CDC)http://www.cdc.gov/hiv/default.htm
HIV InSitehttp://hivinsite.ucsf.edu/InSite
National HIV/AIDS Clinicians’ Consultation CenterWarmline, PEPline, Perinatal HIV Hotlinehttp://www.ucsf.edu/hivcntr/
Pacific AETChttp://www.ucsf.edu/paetc