hla antigen apc cell lfa-1 signaling t cell receptor lfa-1 ser 1140 intracellular signaling

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gen LFA-1 signaling T cell T cell receptor LFA-1 Ser 1140 intracellular signaling

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Page 1: HLA antigen APC cell LFA-1 signaling T cell receptor LFA-1 Ser 1140 intracellular signaling

LFA-1 signaling

T cell

T cell receptor

LFA-1

Ser 1140

intracellularsignaling

Page 2: HLA antigen APC cell LFA-1 signaling T cell receptor LFA-1 Ser 1140 intracellular signaling

HLA

antigen

APCcell

TalinCalpainPtdIns(4,5)P2

TalinHead

LFA-1 signaling

LFA-1

Ser 1140

T cell

intracellularsignaling

T cell receptor

Page 3: HLA antigen APC cell LFA-1 signaling T cell receptor LFA-1 Ser 1140 intracellular signaling

HLA

antigen

APCcell

LFA-1

increased affinity

for ICAM-1

PKC

LFA-1 signaling

Ser 1140

T cell

Thr 758

intracellularsignaling

T cell receptor

Page 4: HLA antigen APC cell LFA-1 signaling T cell receptor LFA-1 Ser 1140 intracellular signaling

HLA

antigen

APCcell

increased affinity

for ICAM-1

14-3-3 ? GEFactin reorganization

LFA-1 signaling

LFA-1

Ser 1140

T cell

Thr 758

Rac1GDP

GTP Rac1LFA-1

clustering

intracellularsignaling

T cell receptor

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