honors biology chapter10 section 3 sc b-2.7: summarize how cell regulation controls &...
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REGULATING THE CELL CYCLE
Honors Biology Chapter10 Section 3SC B-2.7: Summarize how cell regulation controls & coordinates cell growth & division & allows cells to respond to the environment, and recognize the consequences of uncontrolled cell division
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Essential Question
How does cancer happen?
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Cell Cultures
Cells in a petri dish with appropriate nutrients will continue to grow until they come in contact with other cells: called
Contact Inhibition
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Contact Inhibition
similar controls in body occurs in wound healing
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Cell Cycle & Its Regulators
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Cell Cycle Regulators: Cyclins regulators are cell proteins
(cyclins) regulate timing of cell cycle in
eukaryotic cells dozens other proteins since
discovered1. Internal Regulators2. External Regulators
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Internal Regulators
proteins that respond to events inside the cell
allow cell cycle to proceed once certain processes have been completed inside cell
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External Regulators
proteins that respond to events outside cell
direct rate of cell division most important ones:
Growth Factors important in embryonic
development also used in wound healing
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Uncontrolled Cell Division Cancer
cancer: disorder in which some of an organisms cells have lost ability to control growth
Cancer cells do not respond to signals that regulate cell division
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Cancer Cells have Loss of Contact Inhibition
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Causes of Loss of Control??? appears to have many causes:
carcinogenssome affect internal regulators, some external regulators
defect in gene p53
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Carcinogens
Nicotine Viruses
Hepatitis Human Papilloma Virus (HPV) Bovine Papilloma Virus Tobacco Virus
Radiation
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Skin Cells
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Stomach Cells
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HeLa Cells
Henrietta Lacks died of cervical cancer in Johns Hopkins Hospital, Baltimore, MD in 1950’s
Biopsies of her cervix taken to researchers @Johns Hopkins where they were cultured &they are still growing!
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HeLa Cells
used in multiple medical areas: development of Polio Vaccine trip to the moon : What is the effect of
weightlessness on rate of cell growth/division ?
cell cloning gene mapping hybrid cell lines