how can cells precisely measure time-varying external signals? - giulia malaguti
TRANSCRIPT
Giulia Malaguti
Pieter Rein ten Wolde's groupAMOLF, Amsterdam
Quantitative Laws II, ComoJune 13th, 2016
How can cells precisely measuretime-varying external signals?
Cell sensing system is surprisingly accurate
ligand molecules
receptors
cell surface
readout molecules
ATP
ligand molecules
receptors
cell surface
readout molecules
Cell sensing system is surprisingly accurate
NOISE
NOISE
ATP
Cell sensing system is surprisingly accurate
ligand molecules
receptors
cell surface
readout moleculesNOISE
NOISE
What is the fundamental limit on the precision of concentration measurements?
ATP
Cell sensing system is surprisingly accurate
ligand molecules
receptors
cell surface
readout moleculesNOISE
NOISE
Berg and Purcell (1977).Bialek and Setayeshgar (2005).
Ueda and Shibata (2007).Wang et al. (2007).
Govern and ten Wolde (2012).Lang et al. (2014).
Kaizu et al. (2014).Govern and ten Wolde (2014).
Rappel et al. (2008).Endres and Wingreen (2009)
Mora and Wingreen (2010).Skoge et al (20112013).
What is the fundamental limit on the precision of concentration measurements?
ATP
Cell sensing system is surprisingly accurate
ligand molecules
receptors
cell surface
readout moleculesNOISE
NOISE
What is the fundamental limit on the precision of concentration measurements?
When measuring time-varying ligand concentrations!
Timevarying!
ATP
Cell resources fundamentally limitthe sensing precision
t
t
unboundbound
N samples
Cell resources fundamentally limitthe sensing precision
unboundbound
N samples
unboundbound
N samples
t
unboundbound
N samples
# receptors
Cell resources fundamentally limitthe sensing precision
t
unboundbound
N samples
ATP
# receptors
Cell resources fundamentally limitthe sensing precision
t
unboundbound
N samples
ATP
# receptors
# readout molecules
Cell resources fundamentally limitthe sensing precision
t
unboundbound
N samples
ATP
# receptors
# readout molecules
power
Cell resources fundamentally limitthe sensing precision
t
unboundbound
N samples
ATP
# receptors
# readout molecules
power
Cell resources fundamentally limitthe sensing precision
Optimal resource allocation
Thank you foryour attention!
AMOLFBiochemical Networks group
Yao Li AdithyaVijaykumar
Pieter Reinten Wolde
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