human experimentation - report iv med 50 of agent 233-7 (1969)

8/6/2019 Human Experimentation - Report IV MED 50 of Agent 233-7 (1969)

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).~eciic::ll .csearcI1 LcooratortesDil'~c~arrttc of I . . : : I bora tortesZdg.::woad Arsenal, :'~aryland 21010

DAAA 15-68-C-0627

:vy ~c.::SC:1 rch Lc born tories I Inc.n. :J.? Duhrtrur Laoornrortes36th and spruce sts.


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This r port d scr-ibes results of studies to determine thedo s for the minimal centra I or orthostatic hypotensive effect ofA g- nt 233-7. The : \ . 'P riments w r performed with humanvolunteers and followed he general procedure prescribed by theMedica 1 Research Laboratories .

.Ag nt 233-7 was administer d intramuscularly adult maleprisoner "oIunta r5. Dosage star cd at one microgram p r kilogram-(ug/kg) and was raised by increm n s according to protocol until theIn, xirnum sp cified dose of 10. 0 ug/kg was reached. There was nosi rrifica nt centra 1 or periphera I effect at any dosage. Physiologica 1measur s and toxicity studies also disclosed no significant effects,

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Vitol snms , NF performance and general behavior afterinjection were measured hourly for the first 8 hours. at 2-hourinte rva Is for the next -i hours, a nd then at 4-hour interva Is for thed~l 1'0 tiOI1 of the 24-hou r exper-iment. Time estimation W::IS mea suredat L 5, G.5, 7.5, .5 nnd24 hr. Irs after injection. Central effectwas measured by .:[0' perforrnnnce. The criterion specified forrn iriim a1 centre 1 effect wa s a . reduction. compa red to controlperformance, of more than 25% in the lowest average obta inable byselecting the lowest :3 of any 5 consecutive scores at the test intervals.The criterion specified for minimal orthostatic hypotensive effect wasa r educcion in th e 5- minute standing mea n arteria 1blood pressure(diastolic plus 1/3 pulse pressure) of 10 mm, Hg compared to tbesupine pressure.

RESULTS1. Effects

There was no Significant central or periphera Ieffectat any dosage. Table I lists the name and dosage forall subjects tested.

TABLE Io

Name and Dosage of Subjects Tested with Intramuscular 233-7D053,ge

1.0L O1.41 .42.02.02.2 .3.83.85.45 .. 47.fJ7.510. .010. C

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Toxicn.otrica l studies were performed :1 t ~'I a nd at 4hou r 5, :J t a pproximn tc ly 7 clays a nd 4 weeks :: I ftel'injection. These studies consisted of red and whitecell mc csures, u rina l sis, DUN. transaminase,a Ikn line phosphata se and bilirubin Iracttons. Therewe re no abnormalities suggesting any toxic effect of:lzent 3:3-7. Occa siona 1 slight changes were within theranee of technical variation or were due to conditionsother than the arrent, particularly chronic serum hepatitisappa rently related to previous intra venous use of na rcoticsand 0 her drugs.

2, Toxici v

The larger doses produced mild local discom ort at theinjection site lasting about 2 to hours, This waspr-obably the result of the volume of the injected fluid.

1. Agent 233-7 administered intramuscularly in dosages upto 10. 0 ug/ka produced no significa nt central or periphe ra Ie feet.

2. There were no toxic effects.

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~CY:~Herbert W. Copelan, :VLD .

. . . . . . . . ." ' . . . . & :.,-!if.iin....

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opie distributed as allows:Ori ina1 and or en ( 5) copies

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r. Frederick R. Sidell,Edgewood Arsena IIvy Resea r ch Laboratories


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TFTED, DOCUMENT CONTROL DATA R!.D" (5"'url,)' cl ... tllc.rlon 01 nu, body 01 .I . . 'MC' ond /"11 /1\11. no 11. .. mu. ' b "' . .. . d ...h.." ..... 0...,,.,, "pOri I. clAl 'fI1)~ I. OqIOIH" TIH G "CTIVI!Y (Corpor.' .... ,hor) 1 . I'IE"OPtT 'I:ClJII.'TY C ...... ,I",C ... f lON: Ivy Resca rch L bo rator ies , Inc.

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1 - ED 500 Agent 233-7I 4 OESCRIPTIVE HOTES (Typoo of "pOrt ..,,01/"clu.lv. d.' ), F'ina I Report; S. AU TH 0 R(S) (L. ... n ..... ( I , . . , n .., 'n/".r;,, .Ii Copelan, Herbert W . M.D., 6. REPO RT CA TE 7a. 1'OT"''' NO. Oil' ,. ...Oll. [7&. NO. Oil' 1I.1lil"1: ; ]\[a rch 1969 R -, 8 . CONT"'.CT 01'1 Q"..NT NO. ea. O .. 'GI'N .. TO .. "EPO"'T NU ... IEft(S)

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pproval of CO, Edgewood Arsenal, ATTN: SMUEA - TSTI-T. Edgewood Arsenal,~ _lla_r_vland aimnj 11. su PPI. I!ME'" TAIIIY HOTI:S U. SPONSORING WIL.ITA"Y ACTIVITY, Medical Research Laboratories~ Edgewood Arsenal, Edzewood Arsena I Ma rvland 21010.13. ABSTRACTThis report describes results of studies to determine the dose for the minimal

central or orthostatic hypotensive effect of Agent 233-7. The experiments wereperformed wtth human volunteers and followed the general procedure prescribed bythe Medical Research Laboratories.

Agent 233-7 wa5 administered intramuscularly to adult male prisoner volunteers.

I Dosage started at one microgram per kilogram (ug/kg) and was raised by incrementsa cco rdtns to protocol until the maximum specified dose of 10. 0 ug/kg was reached.I

There was no Significant central or peripheral effect at any dosage. Physio logica 1measures and toxicity studies a lso disclosed no significant effects.

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/UNeLASSIFIED

ADE 'i7~oJ 7Report Number VI

Pinal Report

By

Herbert W. Copelan, M. D.July 1969

Medical Research LaboratoriesDirec torateof LaboratoriesEdgewood Arsenal, 1aryland 21010

DAAA lS-68-C-0627

Ivy Research Laboratories . Inc.H. U. P. Duhring Laboratories36th and Spruce Sts.Phila., Pa.. 19104

UNe LASSIFIED TECHNICAL UeRA~ '1: .......-'":~BUILDING 3330EDGEW OO D ARSENAL', M D. 21010.


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Summary

This report describes l'esults of studies to determinethe intravenous dose of A ent 926 necessary to produce nauseaand vomiting inman. The experiments followed the methoprescribed by the Medical Research Laboratories.

The agent was administered to adult male inmate volunteersat Holmesburg Prison, Philadelphia. Dosage started at 0.05microgram per kilogram (ug/kg) and was raised by 40% incrementsto a dose of 1.0 ug/kg. Nausea occurred at a dose of 0.74 ug/kgand emesis at 1. 0 ug/kg. These were the dominant symptoms.Mild sedation also occurred. There was no significant peripheraleffect or toxicity.

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Minimal Effcc ive Dose Determination for Agent 926

INTRODUCTION

Agent 926 was tested at Ho1mesburg Prison. "Philadel~determine the dose that would produce naqsea and vomiting. The_e>..-perimems started 5 fay 1969 and ended 23 Jul 1969. The study-was can uc e according to he general protocol draft 0(9 July 1964prepared by the Medical Research Laboratories (!v!RL) as modifiedoy :vIRL Research Plan 17,109 of 27 February 1969.

METHOD

Subjects were adult male inmate volunteers, 21to 34 years ofage. All subjects had at least 8 years of formal education, the abilityto perform at least 20 simple addition problems in 3 minutes, noevidence of psychosis or Significant neurosis according to the MinnesotaMultiphasic Personality Inventory (University of Minnesota, 1943), nohistory of arrest for violent acts and good health by clinical and laboratoryexamination. Twenty subjects were used for the 22 trials in the study.An interval longer than the prescribed 30-day minimum separated thetrials for the two subjects who partrcipated twice. SUbjects entered thetesting area the afternoon preceding the test day and remained thereuntil the fnllowing morning. Subjects were tested in individual rooms.Before the agent was administered, series of control measures wereobtained for pupil size; vital signs, including blood pressure and pulsesupine and after standing; and performance on the Numerical FacilityTest (NF) of the Hogg Foundation for Mental Health, 1956.

The agent was injected in ravenously on the morning of the testday in a concentration of 5, 10or 20 mg. per milliliter. Doses startedat O . 05 microgram per kilogram (ug/kg) and were raised by 40%increments, according 0 the protocol, up to doses of 1 . 0 ug/kg.Inaccord ...ith safety precautions specified by MRL, no morefuan twosubjects were tested initially at each dose level. Increments were madeonly after laboratory studies at specified intervals indicated absence oftoxicity.

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TABLE I

A: L E . DOSE A:-ID RESULTS FOR INTRAVENOUS A:ENT 926

Tame Dose Nausea Vomiting0.050.050.070.07 . . . . .~.0.10

",-.49 "'~r0.10! __ w i -

0.14 _,' C \:0.14 . , . - . . . . . . .i0.19 ..*~~-0.19 -...00.27 . . . . . . . . . . .."0.27

(+ ) * ~" .. .0.380.38 .. . . , . .. . .:-0.53

0.530.74 +0.74 +1.0 +1.0 + +1.0 +1.0 + +

(+) ' " Result prob: bly affected by unrelated gastrointestinal discomfort. (see te:- 6 -


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The time relationships for nausea and vomiting are presentedinTnble II. This table also indicates the subjects I. activity, which mayhave influenced the results.

- TABLE n-

Name Dose Nausea Activity.~~_"'o!'.ij.0.3 2.5- 30 Recumbent

0.54 -...J)~.

Recumbent- - - - - - -~ ~." ~0.54 - - - - - - - - - Recumbent. .~~.0.1. 2.5- 14 -.::...l:!rj~ Recumbent. .. . ..0.74 2.5- 20 -~.~ Recumbent1.0 4.5 - 30 ~Jl"':sM'n(';' r Recumbent1.0 2. 7 - 12 ~~ Recumbent

'~S:i.I~ {Stood at 7 min,1.0 3 - 9.5 4.3 - 6.5 Sitting & Stand..:""","lil1'llC)fl

1.0 1.7 - 10 2.7- 5.5 Sitting & Stand. .~. . . . . ~'~-"r:~,ii

Treated with Tigan (200 mg. i,m.) at . 7 ~~s) l "" ' F ~ . " .I

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Naus a was first reported between two and three minutes afteriljccnon for most of the affected subjects, and one"subject, after 1. 0 ug/kg,.~~ote -:8 ..,ymptom as early as one minute forty-five seconds. In thissmall series, however , the average onset time did not occur earlier forthe 1 lgher dos ge level. The period of nausea for subjects who did notvom"t ended bout 20 minutes after injection. Among the three suchsubjects the symptom persisted longer for the one man at 1. 0 ug/kg thanfor the two at O . ug/kg. Thus, the duration of nausea, at least whenpresent wi ho t vomiting, may be greater with incr eastng dosage.Vorni "ng se led to relieve the nausea and in such subjects the symptomended earlier, at approximately 10 minutes after injection.

"\ 1e vomiting occurred. i usually began promptly after the.onset 0 na sea. There was a delay of 5 minutes after the start of naus!i!a'for t}c first subject who vomited. He had originally been kept recumbent,but he clid vomit almost immediately after standing. Theoth.er two subjects,wl 0were not recumbent, vomited about one minute after reporting nausea.Sta ing alw ys aggravated nausea or precipitated vomiting. The onesubject who id not vomit after 1. 0 ug/kg had been allowed to remainrecumbent throughou the experiment. Vomiting or wretching usuallylasted two or three minutes.

effective antidote, :lIlditdid pl"oduce some drowsiness. the prompt i~rove-~ ~ment of nausea o1ter vomi 'ng among untreated subjects makes it difficult toassess the effect of Tigan in this xperiment.

Sedation was the other consistent effect, but it was mild and muchless Significant than the nausea and vomiting. This symptom was notedearlier when subjects were recumbent and, in these instances, occurredt approxim tely the same time as the nausea. The two subjects who werenot recumbent did not report sedation until after they had vomited and nauseawas deer-cast g. It is probable that these strong and unpleasant symptomsobscured the milder sedative effect.

The speech of most of the affected s bjects was softened in_intenstty but remamed clear. This may have resulted from a combinati.onof seda 'on and disinterest m speaking during unpleasant symptoms.orne subjec s appeared mildly unsteady on Walking, and this also may havebe n a mani estation of sedation or marked nausea. A few subjectsEepolted a sensation of !!highness,. If as if they were mildly intoxicated orad received a narcotic. One subJect mentioned this atter fifteen seconds:'.:..:.:he val"d"ty or his repor is questionable. Generally this symptomace 'red C oser in time to the sedation.

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LtCol. James R. KetchumEdgewood ArsenalIvy Research Laboratories


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~. , ,_hJRT TITLEI )'IED 50 c Agent 926~..;. ';::"::11,10.-;" .v: I,OTES (T,ypu o. r_;xil' and incJu.~v. ddt ):-':::.~- Rcpcrt13. AU,HO,,(S) (1."., n.:mo. 11. . , n .m Inlll .1)j Copelan, Herbert W. NI.D.O. ~"l~P:) R"i :;,:., T a- 7 1 1 1 . 'I'O,. ...L NO. 0'" PAc;E. 1 7 1 > . NO. 0 ... "E"'.July 1969 10J~. ':~NT~""'::':' C "1'1,0" T O. g., O"IOIN.TO"'. "EPO"T "UIo(.ER(S)DAA...1_15-0 -C-0627b. PRO~EC T NO. VIt c. lb. OTHE'" "'SPO"T .. 0($) (Any olhorn_bo,. t h . , . . . . , b.... 1",_~ 1 1 '1 1 . . po,i d, N/A10. AVA II.. "'91L.ITY/L.IMITATION NOTICESThis document may be further distributed by any bolder only with specific priorappro of CO, Edgewood Arsenal, ATTN: SMUEA - TSTI-T, Edgewood Arsenal,Marvland 9:1010

I 1. SUPPL EM':," TARY HOTES 12. SPONSORING "'1L.ITA-IilY ACTIVITYI Medical Researcb Laboratories

I . . Edgewood ArsenalIEdl!'ewoodArsenal Marvland 'UOlO~ 13. ABSTRACT ~~j This report describes results of studies to determine the intravenous dose ofAgent 926 necessary to produce nausea and vomiting inman. The experiments followedthe method prescribed. by the Medical Research Laboratories.I The agent was administered to adult male inmate volunteers at Holmesburg~i Prison, Philadelphia. Dosage started at 0.05 microgram per kilogram (ugj'kg) and wasraised by 40% increments to a dose of 1.0 ug/kg. Nausea occurred at a dose of 0.74

1 ug/\g a d emesis at 1.0 ug/l


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II , SU?PL .!AI.! TAr lY NO zs

13, ASSTRACTT h i s r e p o r t d e s c r i b e s t' e results o f s t'..:d a s t o d e t e r - m r a e d:a i!:!:l"o:.,:,c!:Ol;. S

dos e of Agen 926 necessary to produce an tncanaci tat ing e ff ct : : 1 man. The ex-periments followed the met: od prescribed by me .. edical Research Laboratortes,The experiments were te rminated premature ly ceca se or syncope vaicb occurredin the fourth subject studied.

The agent V3.S adraini ste red :;0 adult :-,: :1' a inmate volunteer's at :'io::nGsb 'gPrison, Phfladelphia. Dos ge at 1. 2 micrcg: am ~')er kilog::,'am (ug/ ..g) pro ucedeither s dation or ause and wretchi .g wi '1 C!:3 type of reaction 0.. ; :b . . . o -~e:'clearly dominant. There was no signi .cant per ip ieral ef eet or toxicity.

Indian wrestling performance was tested and s emed a reliableand va id measure 01 cenrr c::ec~.

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were tea ted with. 16 d.1fferent ch.e.@,~aJ_lle. t 8copola:o.1ne "ld various c::!: :! 1m.enta.l

ate agents.SiD "! glyc.olil tes b..ave aot; been previously des cr+b ed Ln taie report, abrief desCription isprovide.d at this point. "~a.e glycolates causeincapacitar:::ion b:t iDterfC!r!-.n'" with. tmlScarinic fU!lctions (i.e. I activa- E !?d of SlrDotb._~cl~ .and-22~r;:!tory glaLl(f3j -.iiid. th-e- ~t=al ne rvousSYBte.II!:unctio=.s of acetylc.oline; tfiey depress or-i~ibit nervous,~tivir:::y, ~addid.on to dclirl.l!!Il t~2re is J!yi_c;_2.l 1IlcOordia.1tion,'blurred vi_sion. inhibition of ~ating and salivation. rapid heart rat~televc:tcd blood -pressure. Ulcteesed Iror.!y te=qeLElrU7:~, and.__.at h . : t & h . d::_se~,vomit.i.Dg;, p.!ost=u.~io!!, and a tupor or coca, The oCllet tiI:e 1:Jj.7 be ill..!~~or - hours J de?ending au the st~cture of the c ?l 1! ?o un d ,_ aud the duration ..?ou~Q..r dan...... Ihe_ e;fe.cJ:s may be rava raad al..=::J.st co;:rplet.ely by t::~l!t-ment v:ir.:l Pb.1So::"Cj_~:J.e or other c.e~trally active cholinest2rU13e1:lh.1bfEors such as VX.1113The LUbes c doll~r value cont:::-ac.c CD,\, lB-OJ5-A!"!C-126 (A) ) of the sj ....awa.rded to t~e Uoiversi t' of Pean..sy l vE!!1ia J.:~ dif:e.re..:!t than any c,f t!"le~rev ous co~t=~Ct5 vich the.. othe.r \!:J..i'le['!j~t:'~s. Q act J t e r~~and repor::s iodic at e.d th" t thr.!'e \lett? thr~e ~.:..j or d!fi:::=:::!:Jce!!!. ~,it VllS the firJc k::1C".;n cone:-;!!.:: tha~ ths :.;;~:ic:tl P,.!.SE.'.arc.'1L~o:-.:to-;:-: e;e..:J.tered ineo i:::lvol'r'~;; pt"isa::l. i!l=~ce!l. Scc.::::ldly, 1.t \ . 1 < 1 . 9 the first i:-c!.ic.5c.icn found ch at tile contract i:l 'J.:!:::!:-' ~.Jt.:'r!l = - : : . . . y not h.:lv~ bE:~-F in .2 ....... .:', c ae L~Ccrcs of C h 2 ?":~!}C''';c:!o:: .:;: :h ',!: conc r ac t inc.ic.:ited L : - . : . : . . :ooe ot the U~os2.!3 of. t..'1e cc::.tr:.:.c::: ~;;.;..s to .::':,a;: cll!:ta:;l d:>.tlTCTI.'"-, Jlve.!Jc'::'gnco::s to cccdt.:ct e :: Jc :: :: .. :! .OC O i l '. .s in S ::: -:'5 :0 0. i~!Elt2.s c.~,=i::- s;J;,-je.:ts.. Indic.:c:"'o;:s c: t~... cr.-:-2::l21.'::O::~2= o~ b=. c,,;:::::a,.: ...ot'5 t.~c[;..!.. i llVe_c" 'ig : . to : : -s tias reiected i!l a 5 :;o '. ' : ::::~C!= :'%4 r~'Jo::-to a \"-:'::1:': 07th.; Cb.e:ili.cal CO:"7s Med:"c:al Coct:-ac:: P:-ojec: ~::=icc=: Ed:::':"::lOdf.~~> (0the concr2cto~sl f-c~1~-~"9 That re oor t h . . . ~ 5~t ".l.'lr:JU'::'~''''''- t....~-...__~~ ,. ._ .. . ., lo - _ . .. __ ~ __ .. __ ,_"", .. .. .. .. . ~ Vi"""... -,,,",,C!l ti=C! ih : r ; : : : . : ! . . : : to e 511::ce~s:~, t:.e::e ..~s to C~ ----pd.:;.::ce. c:::J.dsupc_l"~si.on of tL2 testin.3 b:: c= cOO:::;)C::O_[l, Th:!.51!3e..sp"'ci;.:117 bc""-.:mt i=. t:l:l~- ear lv s ca as 0- -]'" 1)-O--z.::l -or~c-:'l.~nl.""'" 0::.._- ~ ..... -.... _.:t ~., "-6- .. -"'- .. I.. u" ... L~.... -",~ ~the uur sinc pt:!""sca..~e.L - , . . , . . . 1 ""--,.."lisl..';..,~ ----:--d ooe--cl_-::-orocc'. .._,,- Il_:ht:!_ ~.... ~~";J ~"" "",_;.; .. __ .Ir._ 2 ,:).......__,.".. L ~ ..i_ - " '" ' ;_ j , - - . . . . .~ .Bot!1.:!r r ao o r t o f e ".....iC '0" tIl'" ;-~'-:,"""o' .I-, r-l P'C;- ,~ "c": 0' l-:!'i-- ..t: t~.," - T J . . . - _ . , . . . . . . . . ~_J,..J 0 \,.Jr.; i, .J.... "",I.. '~i::!olt:".C!:;1-:u;:,g?':'!jcr: ir! ~!.::-ch lScc J hc1d d:.:t: ~


23/30

t: _"j,tJ. - ,volunteer expe.riments. l::Io-.;oever a fire within the risond:Image facil1t :e.s and eguipmeilt 10c3ced On the prison grounds loIhich__belonged t o t !" lep ri so n I Ivy RC!:iea:cch Laboratories and th!1 A:-!IlY. Be.caua eo f the ~ire and of crt tidsm of Ivy Research by the Prison Board. thecout r ac.t .....s t:e:-:-.inated in Fcbrua 1 73. No .,ork 00 volunteers hadbeen one since ie brya T7 1 97 1.- - = - -One of the contracts ~as ~arded to ~rican Institute for R~~earch.Silver Sp r iag , Xi) in 1964. The objective of the con trc c t was 1:0 developa compreher.$ive te9C battery to ~3ure the effects o f i nc ep ~c it 2t in s4g1lD.ts cn the abilities b as i,c to pet'fOri::lWlCe of militarily re.Levan ttasks. Revie'W' of seven r epor ts availab Le regarding the cont rac t i..,d1-cated that the AP.!!ric:!.I::. Ins ti cute. Lavas ciga tors CODCUC ted paychoac ttvec h e . m . 1 c a l c o t a p o u n d e..":?eriments on milit=.ry v o I u a t . e e r s . It ..s noc c I e a zfrom the r e p o r t s if the voLunr.e srs came fro:n Edge....o d A r s e n a l o r else-loIhere o r if th e e::q>er::iClentJ we re conducted at Edgewood Ars eua.L. He rccve r ,the on Ly agent ment.Loue d 1n the r apcr ta ~a.s 'f.A 3)80 I a !;lycolote. Orh e rst. dies cc cdu c r ad under the t2~S of th e ccut rnc c ~p?e.n!'!!d to focus or;acade:llc t:rp~ te s r I ng to d2.Ct!:-:::.l.r:eth!: vll_i.cii~7 of the !lc=~e!lil!g . : : . ~ c isele!:tioo process us ed to d e ce ..=in~ vh Lch Clilit ...ry voLucte e rs wcr_e l . ig ib l e t o receive psychoc..~e::::lical drugs.In 1955 an Ari:O!'! grant (D.!.l8-l0BC':::!.-5596) \i.3..5 prodded (.0 Tulane t.r!~1.."'::=:';:'C::"Dcpart!Dea.t of Paych ia c ry aad ~1euro10ZYt for ras e ar ch in abno rca.I b r ai nf..:nc::ioni;-:; as r eLa ce d to ce nt a i.!. acs s . T!:c fE!':1 P.r=y recorda av.:.il-able re6ardiug t~e ez pc ricents conduced under the terns of the An)'gr ca t revcal~c that cc n ta.l par t cnrs , ac rcs l vo lua ce e.rs and ncurolc;1icdpa tLcn cs ',"ere ue ed by the Tu l cne t::.eriic3.1 Lnvcs t ;a!:o;:3. The. ...c tuc ltC::-::::!.9 of the gT2..0t w'~rE! not fouad a..d the rafo re DO dec e= -t in 2t ioD ~-:iS

r e ! : d e CO c r n d n g t ~ e gr a c t e es I c c c p l . L e n G ! w"'ith D J p a r : : ~ o t of th e L-..:.ypol1c::'cs 0.;:1- CD:.l_ ';'jY jl.!cb=e,:: be c.at!e as to tL~ q..:.::._i~:t of co s en ;r eoc e red by the pc:;.t:'ents. One pa:::-ticu12r e~:?~rl;::e:lt in"c_vad giv-i.!1S LSDand ce s e a ':'ne to r;:'::iJ a p.:ltieats vho prev ious Iy h ad ' , , - : i . . ! . ' ( _ ; e_ectLOc!~:.'iimplanted io the:'r bra' s . Rapo r r s in icur ed that the. r e s ea r ch g r ouu

" ~ l ! ~ ' ei h"c " b a s i b c c h e n i a acno r a a I cy v a s r e s p cns L b L e f o r t:::!b iz a r r e b : : : h . : .v i o r d e m o n s t r a te d by a : ~ o y p u y c h o cd c p a :: i e o < : s j 2:1d t e c C' Jvt r e e.l cc trac.es se rved a t"".;o':-o_dpur pcs e : to record e_ecc~.:al a!:loo,-O!:1ice ~ ':J. e.l -~e ...- - I b t- ins "D' to s t';~l' ..,- > ~.., c~e'" t~b rc ; n ~ ~_ '-.~-...." '- - .1 \.. .::I. '-'" _ J U fJ _ ~ ...... C '!.. f..: r (,.r. _ .. j _ .. _ _ ..l _ __ "'. ~of curing or a oe lio!"a ing t;e ? ~ e i e r . c s ' pr~ble =. The re ~or:s 6 u 8 ~ e 5 t ~ dthat: the i- ?l~c~:-'iJn 0: elec;::-oces ...as f~nanced. ur.cie r a g r sa t f r on t::e.COeDO '-E.-1;:h r X ! 1 c a c i ' J end nor the A . . ! ! . y gr au c . F~:u!.2.1y, ic . . .: J . . S ;1!"J::cle a r ,.;ha: th~ Che::!c 1 C0=75 L1c2::estS it! tn e e:Qc:::'=::!:J:'s I,e;:::! at tilet lme , Cilt;'ou6r.. it ....s s,!~::'se~ thole t~ei;:- i~tc':es::: di z.ot go b.J)'o:-.';ga he r tcg :'.r1G enC 2 0: ::hc e::cc':s 0= LSD


24/30

",-- __.---.:.- -

Three contracts were ~arded Bavlor UniversitY for experi.mencs ~ithphys Lca I Lncap ac f tating ag e., t!l 1 0 hw::ao. subje~c3. The five. reportncouce rn Lng the ccc tr'a c ts es tab Lshed that the volunteers were e cr e ened ,selected end ~dic3 1y ~c~oed in accordance with Arcy policydirectives, The e:p2riI:entr. lo.-rolved the use of adult volu:ltcers ofboth sexes 'With tha r ap aut Lc drugs such as decerol, m.:;)rphin~ and e co+pol~ne.One of the. con tr ac cs iD'iOlvi!l!j p.hysicc.1 iOC3;:-s.citar.iD:; age::lt.s w c . ue:w ard ;;:d to th l! I 0:;1titu te for Ec ...i-t< IV 1.or.:ll R :lc rcarcn to s tt:dy "Drug et 2 e :: :;and co=plcy. bohsvicral r~?e~to=ies ~1er cc~ci1tions of full ~::l~rc~at~cca cro L v " E..""{jJc-:i!::.2.uts t;!::~~r ths t cont.r act p~i::l.arili involved a::;:lk~1::;aad bBboOU9. B.a


25/30

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26/30

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27/30

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28/30

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29/30

( .~_"

FOOnlOTESC l I A . P T E R . X

1. Con tract, DA 18-108-c:n.-632, University of Uaryland. 18 Hay 1950.2. Report of Hedical CO:".!nittce, Che::lical Corps Advisory Counsel. heldon )0 Se p terab e r and 1 October 1954.3. Chezri c.a I Corps !,:edical Laboratories I Special Rcpo r t C ISLR No. 71)First Psychoche~cJl Conference, held on 12 May 1954.4. Chenical Corps ~~cdical Laboratories, Letter, subject: US2 ofVolunteers in Research, dated 24 July 1953. . .S. Secretary of the Am.y ~e:"lorar:duc, subject: Use of Vol cn tee r s inResearch, da te d 5 ~ove=ber 1953. ,6. Bah nerrann ~1edica College and Hospital, P~i ad e Iph iz , PA, Conr r ac t,DA 18-l08-C"~-7723(A), da ced 26 June 1961.7. State",:!:!.,t by Cha r Les D. AbLa rd , Amy Ocne r a l Coun s e L, b e fo r eIrrve s tIg ar to ns Su~cC':"\!"itce-=. House A:-=eci S~".i::2S. da te d 8 Se;:t{::::~! 1?75.8. !'!':=or.1ndLO fo r ASA (~&D). suo jec r : Se~ute Se Le c CC:-.7Li:teeDiscussion - lnforoaticn ~~l:::Jorandu:J, Fr ota rIG.9. C RDL 1: - t 22-13 R zp o r t of Febroilry 2957.10. Edge' ..ood Ar s e na ?ep r t of 10 Noe~be!" 19.s!" sub j e c t: Repor t en

, ~ Tr ip to P . . ' ; I ;(!slurg C:ty Frison on 5 o'.'e:r.ber 1964 to beg In Pr a c tice; - . Drug Tasc'ng on ?risoner Vo ~nteers.i \~ct-;P_~~ll. ~:cd.i.c.J Re~e3["ch .L.Jbor~ rcr y ~!e::1orandUt.l1 s ubjc.et:' Rcpo r t of Vi~itI ..- / to !-!olnes.:'l::'': Pr is cn . r.v':::.eso'.Jrg, ?A, dated 24 ~~arch 1966. Repor t or

Treat::ent, d a ted 28 ~larch 1966 attached.12. ~cdic2Con tr ac t, D;.~Iay 19e6, 20

Re s e a r c I Labo r a or:' Report, s ub jec t : Visit to Ccnt ra c c o r ,lS-0J.5-"\?:C-l26 (.4.), L:niversicyoE Pe:-:nsy!v.:;n:"3., da te d 10" 1~'6 .... '\ 106- 110'" 1.... d?"O' le'". 3:: ;>0 > .:iy _ 0, c_:::Ooct' .on. an _? c tooer.l}c.

13. fd~e,;.:o.)ud Ar s e na Tec.hnica Rc?orc,. EATR 4210, The Search for '0:.:10::Checica As~ ~t s, Sov?~her 1969, pagp- 139.14. !:cigc\:ooc Ar sr na I Couns e I Oi5;)05':":'on Fo ru , !:t.:uject: Ccn crac r, DAH:'u{,,:'~('-]o(_\), da t ce _l'ictobe!:" -'966, attached He.:Jot


30/30

.~.( .. /"15. t '.-:d1c..:! keSIJ8I ch.o Chc.oical Compounds Fact $heet 62, Ant)r-J:.Sn

Re.gearch and Other Chemical Classes, dated 21.July 1975.I,1. (I

. _16. t~~t-act, Df~ 15-70-C-0324, to Ivy Research ~aboracories. Inc.,for Th r eaho l d Dce s e s in Bu:c.ans Annex 1: L1still8 of Toxic Chemicc.lAgents 17. EdgC".lood Azs ena I Letter to Directcr' of Procure:::enc. subj ec t:Iv y Research Labo r a.tor tes , Inc , Concract., DAAA 15-70-C-0324. d.ated9 February 1973.18. Deparc[;lent of the Ar:;;.y. Office of The Surgeon General Memot'.:.ndlO,sub je c c : Rev!e'1:." of Repc r ts on Deparo:e!lt: of the I-.ITfJYGrant, DA 18-108-CiL 5596. Co the De9art=.2nt of Psyc~iatry and Neurology. TulaneUniversity, 1955-59 - Illfo~atioo Memoranduo, dated 22 August 1975.19. Edgevocd At'senal Special Pub Id ca td.cn E.ASP 1800-2, ChemicalAgent9 in DOD Contracts, dated February 1972.

lGe

-:

human experimentation - report iv med 50 of agent 233-7 (1969)

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