hyperbaric oxygenation therapy in infertility patients
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8/18/2019 Hyperbaric Oxygenation Therapy in Infertility Patients
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Critical Care Obstetrics and Gynecology2016
Vol. 2 No. 1:12
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Editorial
Ana Mitrovic Jovanovic
University hospital for Gy and OB,
Narodni front, School of Medicine,
Univerisity of Belgrade, Serbia
Corresponding author:
Ana Mitrovic Jovanovic
University hospital for Gy and OB, Narodnifront, School of Medicine, Univerisity of
Belgrade, Serbia
Modern era of inferlity treatment with the advent of the
reproducve technologies increased the success of inferlity
treatment but sll not enough. Aer idencaon of the riskfactor that may explain the inferlity usually we perform clear
steps in diagnosc and therapeuc procedures with dierent
successful rate.
Embryo quality, endometrial recepvity, repeated implantaon
failure, ovarian reserve and quality of the spermatozoa are the
most common factors which can cause inferlity.
Implantaon will usually only take place if a good blastocist exist
and if the endometrium has reach a certain stage of recepvity
with the adequate oxygenaon, vascularisaon, endometrial
grow with development and expression of dierent gens and
molecular factors -causing opmal endometrial recepvity.To improve all of this factors contribung to dierent individually
inferlity factors and events we use hyperbaric oxygenaon
therapy with dierent protocol regimes for more than 15 years.
The paents were treated in mulplaced chamber at pressure of
2.1 ATA to 2.3 ATA during 70 minutes, 7 -10 days consecuvely
beginning from the day 2nd - 5th of menstrual cycle.
The evaluaon of eects of hyperbaric oxygen therapy was carried
out and we noce improvement of endometrial oxygenaon
and vascularisaon, with beer eggs quality, beer respond to
ovarian smulaon, beer embryo quality and higher pregnancy
rate.
Folliculometry in the cycles when hyperbaric oxygen therapy
was applied indicated an excellent response of endometrial
(thickness of endometrium at the me of ovulaon was beer
and triple line endometrium). Desirable quality of endometrium
was signicantly beer in the cycle when HBO therapy had been
applied but also we noced prolongaon of the eects in the
next month as well. The power doppler and 3DPD of the uterine
arteries indicated that the uterine blood vessel resistance was
slightly higher than expected, but that was expected reacon
of the major blood vessels on hyperbaric therapy. Mapping of
subendometrial blood vessels in the cycles covered and followed
by hyperbaric oxygen therapy showed the intensive capillary
network of endometrium especially aer 4-6 weeks aer HBO
therapy. The oxygen used under higher pressure -- oxygen as a
drug, may have an extraordinary signicance for beer outcome
of pregnancy implantaon by improving endometrial recepvity.
If endometrial recepvity is condioned by adequate grow,vascularisaon and oxygenaon, and then hyperbaric oxygen
therapy is the treatment of choice.
From the other side we also treated paents with male factor
inferlity. Signicant increase in motor acvity was registered
as well as increased spermatogenesis aer two months aer
therapy. The biggest increased in vigilance of spermatozoids was
found in the samples during in vitro preparaon with good quality
sperm preparaon mediums. The obtained results suggest that
the acute exposure of the sperm samples to HBO has favorable
impact to funconal capacity of spermatozoids in view of their
beer molity. Prolongaon and postpone eects of hyperbaric
oxygen therapy were verify by control spermogram-semen
analysis aer 70 to 90 days aer therapy with the results of the
good inducon of the spermatogenesis, thanks to hyperbaric
oxygen and eliminaon of the reacve oxygen species and
avoiding infecon due to hyperoxia. There are also good eects
on the DNA integrity with less DNA fragmentaon in hyperoxya
condion.
There are many factors that ulmately impact on the male and
female ferlity and chances of conceiving, but our experience
show that hyperbaric oxygen therapy could have posive impact
on inferlity treatment and increase male and female ferlity.
Hyperbaric Oxygenation Therapy in
Infertility Patients
Received: February 06, 2016, Accepted: February 10, 2016, Published: February 15,
2016
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