HypersensitivityArfiani Dwi Ika Endra Kusumawati

Kusumaningtyas

Definition (MSH)

Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.

Definition (CSP)

state of previously immunized body in which tissue damage results from the immune response to a further dose of antigen.

Definition (HL7V3.0)Hypersensitivity to an agent caused by an immunologic response to an initial exposure

Definition (NCI)

Hypersensitivity; a local or general reaction of an organism following contact with a specific allergen to which it has been previously exposed and to which it has become sensitized.

Definition (NCI)An exaggerated response by the immune system to a drug or other substance.

Definition (GO)

An inflammatory response to an exogenous environmental antigen or an endogenous antigen initiated by the adaptive immune system. [GOC:jal, ISBN:0781735149 "Fundamental Immunology"]

Hipersensitivitas ????

Gambar : Sistem imunitas yang non spesifik dan yang spesifik

Type I Type II

Type III Type IV

Classification

Type I anaphylactic hypersensitivity

HYPERSENSITIVITY TYPE I

Type II ADCC/CDC

Type II ADCC/CDC

Antibody-dependent cell-mediated cytotoxicity ADCC

Natural killer cell Macrophage

Cell

surface

antigen

Monoclonal

antibodyFc

receptor

Complement

pathway

Lymphoma cell

Type II ADCC/CDC

Type III immunecomplex

Tipe Ig/Ly Patogenesis Penyakit Hipersensitivitas

I Ig E IgE terikat pada sel Mast berikatan dengan Ag, menstimuli degranulasi Histamin. Relaksasi otot polos kapiler dan kontriksi otot polos saluran nafas

Urtikaria, Asma, Syok

Anafilaktik

II IgG, IgM

Antibodi bereaksi dengan Ag yang berada pada membran. Aktivasi Komplemen, dan menarik sel lekosit, lisis membran

Ketidak cocokan gol darah (transfusi)

Sitotoksik bergantung pada

Ab (ADCC)

III IgG, IgM

Antibodi berikatan dengan Ag partikel larut, membentuk kompleks yang beredar ikut sirkulasi, terperangkap, aktivasi komplemen, lisis membrane dan menarik lekosit

Penyakit serum,Glomerulonefritis akut. , SLE

Kompleks imun

IV Ly T Ag menstimuli Ly T-CD4, dihasilkan sitokin, mengaktifkan Ly T-CD8, makrofag. Timbul nekrosis, sebukan Ly dan Histiosit (epiteloid), sel Datia

Test Mantoux,Tuberkel (TBC)

Tipe lambat

HIPERSENSITIVITAS SISTEM IMUN HUMORAL DAN SELULER