i. multiple mechanisms of accommodation a. variable axial ...schorlab.berkeley.edu/passpro/lecture 1...
TRANSCRIPT
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Mechanics, Aging and Neurological Control of accommodation:
I. Multiple Mechanisms of Accommodation
A. Variable axial length
B. Corneal Power
C. Lenticular power
D. Pupil size
E. Lenticular refractive index gradient (isoindical surfaces)
II. Anatomy
A. Lens
B. Capsule
C. Zonules
D. Ciliary Body
E. Index gradient
III. Autonomic innervation
IV. Amplitude of accommodation and age
A. Functional presbyopia
B. Absolute presbyopia
C. Treatment
Bifocals
Monovision
Surgically implanted prosthesis
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Course title- (VS217)
Oculomotor functions and neurology
Instructor - Clifton Schor
GSI:
James O’Shea, Michael Oliver & Aleks Polosukhina
Schedule of lectures, exams and laboratories:
Lecture hours 10-11:30 Tu Th; 5 min break at 11:00
Labs Friday the first 3 weeks
Examination Schedule:
Quizes: January 29; February 28
Midterm: February 14: Final March 13
Power point lecture slides are available on a CD
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Resources:
text books, reader, website, handouts
Class Website:
Reader. Website http://schorlab.berkeley.edu
Click courses
117 class page
name VS117
password Hering,1
First Week: read chapters 16-18
See lecture outline in syllabus
Labs begin this Friday, January 25
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Course GoalsNear Response-
Current developments in optometry
Myopia control –
environmental, surgical, pharmaceutical and genetic
Presbyopia treatment – amelioration and prosthetic treatment
Developmental disorders (amblyopia and strabismus)
Reading disorders
Ergonomics- computers and sports vision
Virtual reality and personal computer eye-ware
Neurology screening- Primary care gate keeper
neurology, systemic, endocrines,
metabolic, muscular skeletal systems.
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Mechanics, Aging and Neurological Control of accommodation:
I. Five Mechanisms of Accommodation
A. Variable axial length
B. Corneal Power and astigmatism
C. Lenticular power
D. Pupil size & Aberrations
E. Lenticular refractive index gradient (isoindical surfaces)
II. Anatomy & Mechanics
A. Lens
B. Capsule
C. Zonules
D. Ciliary Body
E. Index gradient
III. Autonomic innervation
IV. Amplitude of accommodation and age
A. Functional presbyopia
B. Absolute presbyopia
C. Treatment
Reduced pupil size
Bifocals
Monovision
Surgically implanted prosthesis
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Disaccommodated eye
Accommodated eye
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Conjugate Points
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Definitions:
1) Accommodation = the ability to focus images of objects at
various distances in space onto the retina.
2) Accommodation = the ability to make objects at various
distances in space conjugate to the retina.
3) Conjugacy = mathematical term that describes pairing of points
or interchangeable points in a function.
This principle is the basis of ophthalmoscopy (viewing the retina)
and retinoscopy
Objects and images, described for an optical system by the
Gaussian equation, are conjugate (i.e. objects and images are
interchangeable). 1/O + 1/I = 1/f
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Conjugacy described by the Gaussian equation
O = Object distance in space to the cornea
I = Axial length of the eye, or image plane (screen) distance from cornea
F = Optical power of the eye (lens + cornea) referred to cornea location
object
image
focallength
Power
O
I
f
P = 1/f = 1/O+ 1/I
1/O = P – 1/I
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Changes that could focus the retinal image:
O = Object distance in space from the cornea
I = Axial length of the eye, or image plane (retinal screen) distance
from the cornea
F = Optical power of the eye (lens + cornea) referred to the cornea (60D)
i.e. 1/ focal length
Accommodation can work by changing any one of these 3 parameters.
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Mechanisms of Accommodation
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Axial length24 mm adult, 17 mm neonate
Cornea is more powerful in neonate and reduces as the axial length
increases because the radius of curvature expands with eye growth.
1mm axial change of axial length = 5 D
Myopes have long eyes.
Emmetropization A process that keeps optics matched to axial length.
Ocular growth is stimulated by blur during the first two decades of life.
Eel’s have accordion eyes that change axial length by ocular
compression
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Corneal PowerEel and Owls flatten the cornea to see far away.
If we are myopes, we squint (narrow our palpebral aperture) to see far
away.
Corneas of infant eyes flatten with eye growth and elongation of the eye
during emmetropization.
Corneal astigmatism has a range of focal distances between the two
major meridians.
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Lenticular Accommodation
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Compression of lens by iris
can change power by over 40D
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LensCiliary
BodyChoroid
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1) Lens thickness increases by 0.5 mm during accommodation
2) Lens nucleus changes thickness more than the cortex.
During accommodation
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Lens translation is used by cats, and by humans
with prosthetic accommodating intraocular lenses.
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Refractive index gradient reduces spherical aberration
and increases refractive power with internal refraction
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Refractive index gradient increases refractive power
with internal refraction & reduces spherical aberration
Two outer surface
Refractions
Multiple internal
surface refractions
Lens and internal
isoindical surfaces
Lens
Incoming ray
1.406
1.386
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Isoindical surfaces & internal refraction
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Lens Paradox: Index compensation for lens growth
The effective index of refraction is reduced by
redistributing the refractive index gradient.
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Reduced pupil size component of
the near response reduces the spherical
aberration component of blur but adds
diffraction blur. 2mm is optimal.
This occurs automatically with age
starting in the second decade of life.
Disadvantage is reduced light
level, diffraction blur and reduced field
of view.
Aberrations increase the DOF.
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Anatomy and Biomechnics of Accommodation
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Gullstrand, Helmholtz Relaxation theory of
Accommodation.
LensCiliary
BodyChoroid
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Gullstrand, Helmholtz Relaxation theory of
Accommodation. Relax a stretching force on the
lens capsule to allow the lens matrix to round up.
Push-pull relationship between the passive
agonist lens complex and the passive antagonist
(choroid & lens bag, interconnected by zonules).
Balance of force between passive components is
changed by active force of the ciliary muscle.
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Lenticular & Extra-Lenticular
Components of Accommodation
Agonist (lens capsule
& matrix)
Antagonist (zonules,
ciliary muscle & choroid)
Choroid
Ciliary Muscle fibers:
Longitudinal
Radial and Circular
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Lens
Muscle
Choroid
Zonule
Gullstrand biomechanics model of Accommodation
CILIARY RING
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Extra-lenticular components of accommodation:
Suspensory zonules, Ciliary Muscle & Choroid
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Lens Capsule elasticity molds (shapes) the lens matrix
Passive agonist that shapes the lens
during ciliary muscle contraction:
Internal (viscous) and external (elastic) factors
Anterior ROC= 12- 5.0 mm
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Changes in the lens curvature during accommodation
How to measure accommodation objectively
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Purkinje Images
Catoptric images are reflected from optical surfaces
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Relaxed Accommodated
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Scheiner double pupil
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Two branches of the autonomic NS
Sympathetic and Parasympathetic pathways
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5 minute break
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Presbyopia: the reduction of accommodation
amplitude with age.
Compensation:
Adjust viewing distance
Constrict pupil and increase aberrations
increase the Depth Of Focus
Optical aids- bifocals, monovision,
& simultaneous vision (increase aberrations)
Accommodating intraocular lens implant (AIOL)
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Adjust the Object (viewing) Distance
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Absolute Presbyopia: Age 52
The near point equals the far point.
Amplitude of accommodation equals zero.
Functional Presbyopia:
The near point recedes out beyond the near
working distance.
The near working distance requires more
than the full amplitude of accommodation.
The Problem: PRESBYOPIA
After age 52 the eye no longer accommodates
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Time course of Presbyopia
Hofstetter’s rule:
Amplitude = 18.5 - age / 3
“Rule of 4’s”
Amplitude = 4 * 4 - Age / 4
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Amp = 18.5 – (Age/3)
rearrange
Age = 3 x (18.5 - Amp)
Age for amplitude of 2.5D
Age = 3 x (18.5 – 2.5) = 3 x (16) = 48 years
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What Causes Presbyopia.
It’s a combination of the way we
accommodate and the way the lens grows.
Presbyopia is accelerated by the same
factors that cause cataract. UV radiation &
diet have an influence. People living near
the equator have earlier onset of presbyopia.
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Ocular changes that contribute to Presbyopia:
Statics:
-Lens rounds with age & increases minimum curve
-Cortex of the lens becomes less malleable-
More layers cause pressure bandage friction effect
-Capsule is stiffer (less compliance)
-Choroid is stiffer (less compliant)Consequence:
Reduced amplitude of accommodation from rounding, and
greater elastic opposition force applied by the stiffer choroid.
Dynamics:
-Lens becomes more viscous- More sluggish
Consequence: Static & dynamic changes require more force
from the ciliary muscle to change accommodation quickly.
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A letter E as seen with out any correction (top line),
and with the addition of negative spherical aberration
(bottom line). G. Yoon, University of Rochester
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Treatment options:
Optical aids
Reduce pupil size (occurs naturally)
Bifocal spectacles
fixed and progressive
Contact lens bifocals
Simultaneous vision contact lenses
Monovision contact lenses
Surgical Correction
Accommodating IOL
IOL (intraocular lens implant)
Malleable and Preformed
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Bifocals
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Which of these aspects of presbyopia
can be changed to restore accommodation?
Lens position- translate toward the cornea
Lens matrix viscosity and compliance
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Lens matrix implants for treatment of
Presbyopia:
http://www.refractivesource.com/patients/
emerging/procedures_for_presbyopia.htm
http://schorlab.berkeley.edu/
click A-IOL model
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Accommodating Intraocular Lenses
Inserted into the Lens Bag (Capsule)
Malleable Polymer- Catarex
A problem is that it becomes opaque
Preformed Polymer- C&C Vision (AT-45)
Human Optics AG
Visiogen (Galelian Telescope)
B&L Safarazi technique
Limited amplitude of accommodation (1-2D)
Role of increased aberrations due to lens tilt is unclear.
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Accommodating IOL (+ 30D Galilean telescope)
1.5 mm produces up to 3D accommodation
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Haptics support Visiogen translating “Synchrony”
+ 30D IOL Galilean telescope
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Visiogen
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Haptics support Visiogen translating IOL telescope
http://www.crstoday.com/02_current/18.html
http://eyeworld.org/jan04/0104p12.html
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Lunch Time