iei zue711i' am e euine encephalomyelitisi · volume 1 of [ \i'olumies a ddc bibliography...
TRANSCRIPT
UNCLASSIFIED AD- 732 950
IEI ZUE711I' AM
E EUINE ENCEPHALOMYELITISI
Volume 1 of [ \I'olumies
A DDC BIBLIOGRAPHY
1:C ) r I I- \' 1901 - January 1971 1
DDC-TAS-71-51-1
[Approved for public release;
distribution unlimited.
"Rlpýd.-d by
NATIONAL TECHNICALINFORMATION SERVICE
Spintll, . * 22151
NOVEMBER 1971 UNCLASSIFIED
D F lNSE l1!u1 ,A*tIO CENTERDEFENE S PP AGE, C1
U NCLA SS IFIEDSecurity Classiftcpelono
DOCUMENT CONTROL DAIA.- R & D(SIC"011y claeaijicafia of tiffbdy. of 8690 fAbe~u nd iidesed. miaefaron mwust be# *..f*d h... the ove"'11 V.X" - rf.ia ited.
I OXIGINA TWO AC TIVITVY (C4.pIWI. aSUONW.. SEU)t CL&65-FICA1'iON
FDEFFNSF fnlAIMFNTATTAN rENTEr ______________
VENEZUELAN EQUINE ENCEPHALOMYELITIS. Volume I
0,.1 UTPORISC (""uRome, udnf *RJII sel * alu .)
6. 011PORT DATE 786 TOTA6 NO. OP PARS. 7b. NO. OF Rep$Nove Mber 1971 ill11 74
k.CONTRACT on GRANT NO. I& ORIGINATORES REPORT NUMMEA(St
op. PaoJScr No. DDC-TAS-7l-51-I
C.61. OTHER REPORT NOIS) (A"p .A., him~b&S "ta ~y b. ... idn.d
d. AD-732 950M 10,OTRIBUTION STATEMENT
Approved for public release; distribution unlimited
If. SUPPLEMCNTARY NOTES 12. SPONSORING MILITARY AC TI VITY
I . ADSTRACT
This bibl iography is a compilation of unclassified citations[to reports on Venezuelan Equine Encephalomyelitis. The entrieswere selected from references processed into the AD data bankfrom January 1953 to August 1971.
Corporate Author-Monitoring Agency, Subject, and PersonalAuthor Indexes are provided.
DDFOVRM17 UNCLASSIFIEDSecurity Claosilication
UNCLASSIFIEDSecurity Class ication ,_,,_,_ ,
4. I LINK A LiNK 0 L 1mN. C
*Venezuelan Equine Encephalomyelitis Virui I-*BibliographiesVirus ulseasesInfectious DiseasesDisease VectorsImmunologyVaccinesTissue CultureViabilityPreparationImmune SerumsEncephal omyel i tis
Ii
UNCLASSI FIEDmciarity Cleasiflcatiot
UNCLASSIFIED
An-73q; 9OfAv
VENEZUELAN
EQUINE ENCEPHALOMYELITIS
Volume I of II Volumes
A DOC IMBLIMGRAPHY
February 1961 January 1971
oC.TAS.7I.SI
SApproved for public release;distribution unlimited.
November 1971
DEFENSE DOCUMENTATION CENTERCAMERON STATION
ALEXANORIA. VIRGINIA 22314
UNCLASSIFIED
FOREWORD
This bibliography is Volume I of a series of two
volumes and is compiled of unclassified citations to
reports on Venezuelan Equine Encephalomyetitis. The
entries, arranged in AD number sequence, were selected
from references processed into the AD data bank from
January 1953 to August 1971.
Corporate Author-Monitoring Agency, Subject, and
Personal Author Indexes are provided.
BY ORDER OF THE DIRECTOR. DEFENSE SUPPLY AGENCY
OFFICIAL
Admintstrator S A , JR.
Defense Documentatlon Center
iii
CONTENTS
Page
FOREWORD .................................................. i i
AD BIBLIOGRAPHIC REFERENCES ............................... 1
INDEXES
CORPORATE AUTHOR-MONITORING AGENCY .................... 0-1
SUBJECT ............................................... D-1
PERSONAL AUTHOR ....................................... P-1
HOW TO ORDER BIBLIOGRAPHIC REPORTS ......... (Inside back cover)
PARTIAL LIST OF SCHEDULED BIBS ..................... (Back Cover)
V
r!UNCLASSIFIED
DDC REPORT BIBLIOGAAPHY SEARCH CONTROL NO. /ZIM•|
AD-2AA 323ARMY 9h1uIRflhm!mvA' U-0P~E. "L AZNC C VUUý1 ARSENAL MD
SEROLOGICAL AND VIROLOGICAL STUDIES OF ARTHROPODBORNE
ENCEPHALII' IN THE CHESAPEAKE BAY REGION lU)
AUG 62 IV FAVORITFFRANK G4oFOWLERtHARLAND NoJRoIWHITEHEAV,"ONALD Rol
UNCLASSIFIED PEPORT
nESCRIPTORS: *BIOLOGYo *BLOOD SERUM, *r|)SEASES,*ENCEPHALITIS VIRUS, *EOUtNE ENCEPHALOMYELITIS VIRUS,*VIRUSEP, ANTIGENS * ANTIBODIES, ARTHROPOOS; BIRDS,BLOOD, COLLECTING METHOOSt CULICIDAE, EPIDEMIOLOGY,INSECTS, MAMMAL:, a:,.7SLiS, TICKS (u)
SU6JECTS0 PERFORMANCE ON TESTS OF IMMEDIATE ANDDELAYED RETENTION WAS MEASURED FOLLOWING INSTRUCTIONBY TWO VERSIONS OF AN AUTOINSTRUCTIONAL PROGRAM: ONEVERION EMPLOYED VANISHING (THE SUCCESSIVE REDUCTIONOF STIMULUS SUPPORT) AND THE OTHER DID NOT,CLASSES OF qTH-, OTH-, AND 6TMGRADE STUDENTS SERVEDAS SS, NO SIGNIFICANT DIFFERENCE BETWEEN THEPERFORMANCE OF SS WHO MD USED THE VANISHING AND THENONVANISHING VFRSIONS Of THE PROGRAM WAS FOUND ON THEIMMEDIATE TEST# ON THE TEST TAKEN TWO WEEKS AFTER
INIIAL TRAININGt HOWEVER, THE SS WHO MAD USED THEVANISHING VERSION OF THE PROGRAM WERE FOUND TO HAVERETAINED SIGNIFCANTLY MORE THAN tS WHO HAD USED THENONVANISMING VERSION* THE RESULTS ARE INTERPRETEDIN TERMS OF THE EFFECTS OF CONTEXT VARIBLES UPONRETENTION* (AUTHOR) (U)
U. /
1
UNCLASSIFIED /ZIMSI
UNCLASSI I CO
DOC REPURT rPrRLZO.RAPWY SEAPCI4 CONTROL No. /ZIMgj
ARMY atmne flto... am -
SIALIOGRAPHY ON FQUINE ENCEPHALOMYELITIS
I V
UNCLASSIPIED REPORT
DESCIPTRS; BIDIOGAPHI~t DISASCS #EUIN
ENCE HAL MYC ITIS VIR S. NIMA ~ s RTH ~ pOD O D AGN SIS
UNCLASSIFIEDI#5
UNCLASSIFIED
DOC REPORT BIBLIOGRAPHY SEARCH CONTROL NO, /ZI";j
ADw405 977GENERAL ELECTRIC CO MILWAUKEE *IS
STUDIES ON AR OViRUS iNFFCTIONS IN EQUINES* fUI
nESCRIPTIVE NOTEI ANNUAL PRnGRESS HEFT. I JU6Y 42.30JUNE 62,
JUN 6) 6P BYRNElROBERT JI
CONTRACT: DA MDq9 19) 62669
UNCLASSIFIED REPORT
IESCRIPTORS; *VlRfIS, EQUINES, IMMUNITY, BIRDS;TISSUE CULTURE, MItE, RABBITS, CHICKENS, AN!MALS, ANTIGENS AND ANTIBODIES, INFECTIONS, (U)
IDENTIFIERS: AR9OV!RUS. (U)
A SLRIES OF EXPERIMENTS WERE CONDUCTED IN WHICHBURROS WERE SUBJECTED TO MULTIPLE EXPOSURES TOGROUP A ARBOVIRUSES. PRODUCTION OF BROADLY REACTIVE CF ANTIBODIES WAS FOUND TO DEPEND ON THESEQUENCE OF DIFFERENT VIRUSES INJECTED. THEHIGHEST BROAD SPECTRUM CF REACTIONS APPEAREO INECE IMMUNE BURROS AFTER CHALLENGE WITH VIRULENTVEE VIRUS. PRIMARY INOCULATION WITH WEo,WEE, AND VEE GAVE GOOD SPECIFIC CF AND HAIANTIBODY RESPONSE. IN WEE IMMUNE BURROS,CHALLENGED WITH SINDC;S VIRUS, ANTIBODY RESPONSEWAS INSIGNIFf CANTb THE IMMUNE RESPONSE OfDOMESTIC CHICKENS OF VARIOUS AGES TO INOCULATION WITHEEC VIRUS IS IN PROGRESS. BLOOD VIRUS LEVELS INYOUNGER BIRDS WERE OF A HIGHER ORDER AND PERSISTLONGER THAN IN OLDER BIRDS INOCULATED WITH THE SAMEQUANTITY OF VIRUS* GUAROA VIRUS WAS CULTIVATED ONA DIFFER TITISSUE CULTURE LINES, THE VIRUS ISBEING CHARACTERITLD AND THE IMMUNOLOGIC RESPONSE ISBEING MEASURED IN MICE; RABBITS, AND CHICKENS.UNSUCCESSFUL ATTEMPTS WERE MADE TO PRODUCE AHEMAGGLUTININ TO CACHE VALLEY-LIKE VIRUS RECENTLY ISOLATED. OF 116 NON-VACCINATED PONIES,NEUTRALIZING ANTIBODIES TO EEC WERE DETECTED IN 40
WITH HA ANTIBODIES TO ECE DETECTABLE IN J9, ASEROLOGIC SURVEY INDICATES THAT A CACHE VALLEY-LIKE VIRUS IS RATHER WIDELY DISSEMINATED IN DOMESTICANIMALS IN THE TIDEWATER AREAS OF MARYLAND ANDVIRGINIA. (AUTHOR) (U)
3UNCLASSIFIED /ZlMo
UNCLASSIFIOE
DOC REPORT RIPLIOGRAPHY SEARCH COmTROL NO. /Z|mgAD-440 166
WALIER REED ARMY INST OF RESEARCH WASHINGTON 0 C
COMPLEMENT LrrVL• 1.4 EX•FR!MMENTAL ALLG:t.?CENCEPHALOMYELITIS, Eu,
44 2P TARRANT;CARL Jo |FIrE;EARLH.o
UNCLASSIFIED REPORTREPRINT FROM NATURE, 2021492qi, Ps $19 ONLY.23 MAY 64.4COPIES NOT SUPPLIED BY DOC)
SUPPLEMENTARY NOTE!
4ESCRIPTnRS: (.COMPLEMENT, PHYSIOLOGY;; LeANTIGEN-ANTIBODy REACTIONS)# PARALYSIS, ALLERGY, IMMUNOLOGY.BRAIN, CELLS !RIOLOGY)t NEUTRALTZATION; DISEASES,MEDICAL RESEARCH
fu)IOENTIFIERS: ENCEPHALOMYELIT|S (U,
If
4UNCLASSIFIED /ZtNsi
UNCLASSIFIED
DOC REPORT AIRLIOGRAPHY $EARCH CONTROL NO* /Z|IM9
AD-q49 927ARMY MEDICAL UVIT FREDERICK MD
ISOLATION Of VENEZUELAN EQUINE ENCEPHALOMYELITISVIRUS BY BONE MARROW CULTURE, fUl
DUN 64 OP SMITHTTOMAS J, |MCKINNEY,RORERT so ISAWYERWILLIAM D0 I
UNCLASSIFIED REPORTREPRINT FROM PROCEEDINGS or THE SOCIETYFOREXPERIMENTAL SIOLOGY AND MEDICINE, 117, PP0271o
27st 1964o fCoPIES NOT SUPPLIED BY DCC'SUPPLEMENTARY NOTE!
DESCRIPIORS: EeVENEZUELAN EQUINE ENCEPHALOMYELITISVIRUS, DIAGNOSIS), CULTURE MEDIA, DONE MARRO#, ANTIGENS+ ANTIBODIES, MONKEYS, FEASIBILITY STUDIES, TISSUECULTURE CELLS, SAMPLING, LYMPHATIC SYSTEM, RLOOO gUl
INFECTION IN HUMANS AND MONKEYS WITH THE TRINIDADSTRAIN OF VENEZUELAN EQUINE ENCEPHALOMYELYTIS(VEE) VIRUS IS TYPICALLY A FEBRILE DISEASE oF 2 TO
7 DAYS DURATION, VIRUS USUALLY APPEARS IN THEBLOOD DURING THE FIRST 24 HOURS OF INFECTION, OAPIDLYACHIEVES HIGHER TITER, AND SOON DISAPPEARS; RARELYBEING DEMONSTRABLE AFTER THE FOURTH OR FIFTH DAY,SHORTLY AFTER THE END OF THE VIREMIC PHASE;
HEMAGGLUTINATIONINHIBITING (HI! AND NEUTRALIZINGANTIBODIES APPEAR IN THE PERIPHERAL BLOOD, THERELATIVELY BRIEF PER:OD DURING WHICH VIRUS CIRCULATES
LIMITS THE ARILITY TO ISOLATE AND IDENTIFY THE AGENT,A DIFFICULTY COMMON TO MANY VIRAL INFECTIONS@ THEPRESENT STUDY WAS UNDERTAKEN IN AN EFFORT TO OVERCOMETHIS PROBLEM# VIRUS CONTENT OF BONE MARROW WASMEASURED DURING THE COURSE OF VEE INFFCTION ToDETERMINE IF VIRUS PERSISTED IN THIS TISSUE BEYONDTHE VIREMIC PERIOD AT A TIME WHEN ANTIBODY WASPRESENT, AND TO INVESTIGATE THE USEFULNESS OF IN
VITRO CULTURE OF BONE MARROW AS A SOURCE OF VIRUS ANDAS A SUSCEPTIBLE TISSUE FOR VIRUS PROPAGATION.(AUTHOR) (U)
5UNCLASSIFIED /ZIMSI
UNCLASSIfIED
DOC RrPORT AIRLTOGRAPHY SEARCH CONTROL NO* lZIM9|
AO-993 928ARMY MEDICAL UNIT FREOERICK Nb
SIMULTANEOUS AEROSOL IMMUNIZATION OF MONKEYS WITHLIVE TULAREMIA AND 4?VE VENEZUOLAN CQUtNEENCEPHALOMYELITIS VACCINES, ful
64 1P SANER;WILLIAM 0. IKUEHNE,RALPH W, IGOCHENOURWILLIAM So ,JR,.
UNCLASSIFIED REPORT
SUPPLEMENTARY NOTE: REPRINT FROM MILITARY MEDICINE,120:1,o PP. Ifl0O|Oi41 NOV 64* (COPIES SUPPLIED ByDOC)
MESCRIPTORS: feBACTERIAL AEROSOLS, IMMUNITY),(|IMIUNITY, BACTERIAL AEROSOLS), 46VACCINES;
ErFECTIVENESS), VENEZUELAN EQUINE ENCEPHALOMYELITISVIRUS, PASTEURELLA TULARENSIS; OOSAGE, RESPIRATION,SAMPLING, EXPOSIORE, MONKEYS, FEASIBILITY STUDIES,ANTIGENS * ANTIRODIES tU) liIDENTIFIERS: SEROLOGY (U)
THE PRESENT STUDY IN MONKEYS DEMONSTRATES THATEFFECTIVE PROTECTION AGAINST VFE AND TULAREMIA CANBE ACHIEVED WITHOUT ADVERSE REACTION BY EXPOSURE TOREADILY ACHIEVABLE QUANTITIES OF THC RESPECTIVE
LIVING VACCINES IN THE FORM OF A MIXED AEROSOL.(AUTHOR) (U)
6UNCLASSIFIED /IS
UNCLASSIFIED
DOC REPORT RIRLIOGRAPHY SEARCH CONTROL NO, /ZIM51
AD-612 P4iARMED FORCES INST OF PATHOLOGY wASHINGTON 0 C
El:ECTRON MICROSCOPIC STUDIUS OF THE VASCULARPERMEABILITY AND THE MECHANISM OF OEMYELINATION INEXPERIMENTAL ALLERGIC ENCEPHALOMYELITTSt fUl
6 fliP LAMPERTP, ICARPENTEAS, I
UNCLASSIFIED REPORT
SUPPLEMENTARY NOTE" PUB, IN. JOURNAL OF NEUROPATHOLOGYAND EXPERIMENTAL NEURflLOGY (U. Sol V24 NI P11-24 JAN1969 (COPIES NOT AVAILABLE TO DOC OR CLEARINGHOUSECUSTOMERS) PRESENTED IN PART AT THE ANNUAL MEETING or THEAMERICAN ASSOCIATION Of NEUROPATHOLOGISTSo 12 JUN
64t HELD AT ATLANTIC CITY, N, J,
nESCRiPTORS: (eSRAIN, DISEASESI; (#SPINAL CORD,DISEASESi' (*NERVE FIRERS, PATHOLOGY), ELECTRONMICROSCOPY, ALLERGY, TRACER STUDIES, PERMEABILITY, CELLS(BIOLOGYP, THORIUM COMPOUNDS, DIOXIDESt RATS (U)
IDENTIFIERS; MyFLIN, ENCEPHALOMYELITIS,THOROTRAST cU)
IN EARLY LESIONS Of EXPERIMENTAL ALLERGICENCEPHALOMYELITIS IN RATS THOROTRAST PASSES THROUGHVESSEL WALLS CONCOMITANT WITH INVADING MONONUCLEARCELLS. THE PARTICLES ARE FOUND BETWEEN THEENOOTHELIAL CELLS, WITHIN THE VACUOLATED BASEMENTMEMBRANE, AND IN THE EXTRACELLULAR SPACE BETWEENGLIAL PROCESSES. IN ADVANCED j.ESIONS, MARKEDLYWIDENED EXTRACELLULAR SPACES OFTEN CONTAIN THREADS OfFIBRIN ALONG WITH TmOROTRAST. OEMYELINATIONOCCURS IN THE PRESENCE OF MONONUCLEAR CELLS WHICHINVADE THE MYELIN SHEATH, PEELING OFF INDIVIDUALMYELIN LAMELLAF OR THE ENTIRE SHEATHe A SEPARATEALTERATION OF MYELIN CONSISTS OF A REGULAR WIDENINGOF THE INTERLAMELLAR SPACE BEGINNING WITH THE OUTERLAYERS. THE POSSIBILITY THAT THIS CHANGE PRECEDESTHE CELLULAR INVASION OF THE MYELIN SHEATH ISDISCUSSED* (AUTHOR) (U)
7UNCLASSIFIED /ZMWIM
UNCLASSIFIED
DOC REPORT BIBLIOGRAPHY SEARCH CONTROL NO* ,ZIMSl
AD-62U 4q4ARMY MEDICAL UNIT FREDERICK MO
FXPERIMENTAL INFECTION OF DOGS WITH TWO STRAINS OfVENEZUELAN EoUINE ENCEPHALOMYELMTJS VTRUS, IU)
60 P TABER;L. I- ;HOGGEA. L,JR*;MCKINNEYR* W* I
UNCLASSIFIED REPORT
SUPPLEMENTARY ROTE: PUS. IN AMERICAN JOURNAL OFTROPICAL MEDICINE AND HYGIENE VI1 N4 P'607SI ICOPIESNOT AVAILABLE TO DDC OR CLEARINGHOUSE CUSTOMERS'.
DESCRIPTORS: (,VENEZUELAN EQUINE ENCEPHALONYELITISVIRUJ50 MOGS), INFECTIONS, IMMUNITY, ANTIGENS *ANTIBODIES (U)
DOGS INFECTED WITH UNMODIFIED VEE DEVELOPEDFEVER, VIREMIA, AND LEUKOPENIA. SEVEN OF THE DOGSINFECTED FAILED TO MANIFEST FRANK CLINICAL SIGNS OFILLNESS. THE REMAINING THREE DOGS BECAME SOMEWHATAGGRESSIVE TOWARD THE OTHER DOGS AND LESS RECEPTIVETO HANDLINGI NO OTHER FRANK SIGNS OF ILLNESS WEREOBSERVED, THE INFECTION WAS FATAL FdR TWO OF THETHREE, MICROSCOPIC EXAMINATION OF THE BRAINS OFTHESE TWO ANIMALS FAILED TO REVEAL EVIMENCE OFENCEPHALITIS EVEN THOUGH VIRUS WAS RECOVERED. THEATTENUATED STRAIN CAUSED AN INAPPARENT INFECTIONDETECTABLE ONLY BY SEROLOGIC METHODS* THEINFECTION RESULTED IN IMMUNITY TO SUBSEQUENTCHALLENGE WITH UNMODIFIED VIRUS* (AUTHOR) (Ul
8UNCLASSIfIED ,ZlMWI
UNCLASSIFIED
ODC REPORT BIBLIOGRAPHY SEARCH CONTROL NO, /ZIM01
ARMY MEDICAL UNIT FREDERICK MO PHYSICAL SCIENCES DIV
ALTERATIONS OF PROTEIN SYNTHESIS IN ARFOVIRUS- jINFECTED L CELLS. lUi
NOV 60 7P LUST.GEORGE I
UNCLASSIFIED REPORT* AVAILABILITY: PUALISHED IN 4OURNAL OF BACTERIOLOGY
V91 N% P1612-7 APR 1964.SUPPLEMENTARY NOTEI
DESCRIPTORS; I.ARROVIRUSES, RIBONUCLElC ACIDS)#(ORIBONUCLEIC ACIDS# SYNTHESIS1, (*PROTEINS;BIOSYNTHESIS), VENEZUELAN EQUINE ENCEPNALONYELITISVIRUS, ENZYMCS, CYTOPLASM, NUCLEOSIDES,PHOSPHATES# MAGNESIUM, TISSUE CULTURE CU)
IDENTIFIERS: ACTINOMYCINS (U)
CELLULAR PROTEIN SYNTHESIS AND RIBONUCLEIC ACID(RNA) SYNTHESIS IN MOUSE L CELLS WERE MARKEDLY
DEPRESSED I HR AFTrR INFECTION WITH VENEZUELANEQUINE ENCEPHALO"YELITIS VIRUS. MOST RNA ANDPROTEIN SYNTHESIS WERE INHIBITED MORE RAPIDLY BY THE
VIRUS INFECTION THAN BY ACTINOMYCIN 0. ZN CELLSINFECTED 4 HR, A CYTOPLASMIC RNA POLYHERASE WASDEMONSTRATED WHICH WAS ABSENT IN UNINrECTED CELLSMAT THIS TIME, DEOXYRISONUCLCIC ACID.DIRECTEO RNASYNTHESIS CATALYZED BY THE NUCLEAR RNA POLYMERASEWAS INHIBITED IN NITRO IN ENZYME PREPARATIONS FROMNUCLEI OF VIRUS INFECTED CELLS. FOR OPTIMALACTIVITY, THE CYTOP4ASMA RNA POLYMERASt REQUIREDTHE FOUR NUCLEOSIDE TRIPHOSPHATES, MG4*O), ANDRNA* THE ENZYME WAS INSENSITIVE TO ACTINOMYCIN 0
AND DEOXYRIOONUCLEASE, INDICATING THAT IT CATALYZEDRNA-DIRECTED RNA SYNTHESIS. ATTEMPTS TO PURIFYTHE INDUCED POLYMERASE FURTHER WERE UNSUCCESSFUL.FRESH PREPARATIONS HAD TO BE USED BECAUSE THEENZYMATIC ACTIVITY WAS UNSTABLF. IAUTHOR) fUl
9UNCLASSIFIED /ZIMP1
UNCLASSIFIED
0DC REPORT RIALIOGRAPHY SEARCH CONTROL NO, !ZIMOI
Ar.6)q 223 6tl) 6/3ARMY MEDICAL UNIT FREDERICK MD
MOSWUITC TRANSMISSION OF VENCZIfELAN EQUINEENCEPHALOMYELITIS VIRUS FROM EXPERIMENTALLY INFECTED
DAVOMHHOOEA(U)
66 14P DAVIS s•, He IMO06E;A,Lo j JR, ilCORRISTAN rE* C, IF[RRELL$J. f, I
UNCLASSIFIED REPORTAVAILABILITY? PUBLISHED IN AMERICAN JOURNAL OfTROPICAL MEDICINE AND HYGIENE V19 N2 P227-30 1966#
qUPPLEMENTARY NOTE? PREPARED IN COOPERATION WITH ARMYBIOLOGICAL LARSS, FORT DETRtCK, MO.
MESCRIPTORS: goVENEZUELAN EQUINr ENCEPHALOMYELITISVINUb, DISEASE VECTORS), COGS, AIDES, ANTIGENS# ANTIBODIES, GUINEA PIGS, SERODIAGNOSIS,HISTOLOGY (U)IOENTIFIERS; HEMAGGLUTINATION.INHISITION TESTS iU)
DOGS EXPERIMENTALLY INFECTED WITH THE TRINIDADSTRAIN OF VENEZUELAN EQUINE ENCCPHALOMYCLITIS(VEE) VIRUS SERVED AS DONOR HOSTS FOR THE INFECTIONOF AEOES TRISERIATUS MOSQUITOES, 10 PERCENT OFWHICH THEN TRANSMITTED THE DISFASE TO GUINEA PIGS BYBITE 21 DAYS LATER, A. AEGYPTI WHICH FCDSIMULTANEOUSLY DID NOT BECOME INFECTED# THEINFECTION IN DOGS CAUSED A FRANK FEBRILE RESPONSE ANDHEMAGGLUTINATION-INHIBITION ANTIBODY FnRMATION.SIGNIFICANT VIRUS CONCENTRATIONS WERE DEMONSTRATEDIN THE BLOOD, BRAINP AND TESTICLE. ALTHOUGH DEATHOCCURRED IN 6 OF THE 10 CHALLENGED ANIMALS; OVERTSIGNS OF ILLNESS WERE MINIMAL, THE TWOUNINOCULATED DOGS WHICH WERE IN CONTACT WITH THECHALLENGED DOGS BECAME INFECTED, BUT tJEITHER DIED,MICROSCOPIC STUDY OF THE BRAINS DISCLOQED VARIOUSALTERATIONS, WHICH, ALTHOUGH NOT DIAGNOSTIC, ARECONSIDERED COMPATIBLE WITH VEE INFECTION.(AUTHOR I (U)
10UNCLASSIFIED lZipSt
UNCLASSIFIED
DOC REPORT BIRLIOGRAPHY SEARCH CONTROL NO. /ZIMoj
AD0626 90 6#/1) 6/,
ARMY BIOLOGICAL LASS FREDERICK MD
DIFFERENCES AMONG VIRUS POPULATIONS RECOVERED PROM
MICE VACCINATED WITH AN ATTENUATED STRAIN OFVINMELAN COU114C IMCEPHALfýMYLETIS VIRUS@ (U)
Fle 61 op HEARNHENRY Js # JR;
UNCLASSIFIED REPORT
AVAILAMILITY? PUBLISHED IN THE JOURNAL OF
IMMUNOLOGY VI? Ng P071-7 NOV 1961#SUPPLEMENTARY NOTEI
DESCRIPTORS: (*VENEZUELAN £QUINr ENCEPHALOMYELITISVIRUS, VACCINES), IMMUNITY, SPLEEN, LIVER.BRAIN, MICE, RECOVERY (Up
THE DIFFERENCES AMONG VIRUS POPULATIONS THAT WCRERECOVERED AFTER THE VACCINATION OF MICE WITH ANATTENUATED STRAIN OF VENEZUELAN EQUINEENCEPHALOMYELITIS VIRUS WERE INVESTIGATED. LARGEQUANTITIES Or VIRUS WERE RECOVERED FROM SPLEEN AND
LIVER TISSUES; SMALLER AiiOUNTS WERE ISOLATED PROM THEBRAIN, DURING THE FIRST 24 HR, VIRUS POPULATIONSRECOVERED PROM ALL THREE TISSUES CONTAINED A MAJORITYOf NONLETHAL, IMMNIZING PARTICLES WHICH GAVE HIGHERTITERS IN L CELLS THAN IN MICE, SUCH VIRUSPREPARATIONS RESEMBLED THE ATTENUATED VACCINE VIRUSSTRAIN WITH RESPECT TO THE DEGREE OF VIRULENCE FORMICE AND IN THE SMALL SIZE OP THE PLAGUES PRODUCED ONCHICK FIBROBLASTS. AT 72 HR, VIRUS PARTICLESLETHAL FOR MICf NY THE INTRAPERITONEAL I4eP1)
ROUTE APPEARED IN SPLEEN TISSUE AND A SMALLPERCENTAGE OF PLAQUES* LARGER IN SIZE THAN THOSEPRODUCED BY THE ATTENUATED STRAIN SERE FOUND. SUCHVIRUS POPULATIONS, THEREPORE; SHOWED PROPERTIESSIMILAR TO THOSE SHOWN BY THE VIRULENT PARENT VIRUSFROM-WHICH THE ATTENUATED STRAIN WAS DERIVED* INCONTRAST, LIVER AND BRAIN TISSUE TAKEN FROMVACCINATED MICE YIELOED ONLY VIRUS WHICH WASNONLETHAL WHEN TESTED I,P. AND WHICH PRODUCED ONLYSMALL PLAQUES, DESPITE THE PRESENCE Of VIRULENTVIRUS IN SPLEEN DEMONSTRABLE AFTER SUBINOCULATION, NOSIGNS OF CLINICAL ILLNESS WERE OBSERVED IN ANY OF THEVACCINATED MICEo (AUTHOR) (U)
11UNCLASSIFIED ,ZIMSI
UNCLASSIFIED
DDE REPORT RIBLIOGRAPHY SEARCH CONTROL NO* flIMfI
AD-617 74/IARMY BIOLOGICAL LASS FREDERICK ND
ESTIMATION OF TITER OF VENEZUELAN EQUINEtNiLPHALOMYCLITIS VIRUS PREPARATIONS FROM A SINGLE-DILUTION ASSAY@ U
JAN 6. sP RILEY OJEAN No IPATRICK,WILLIAM C.o i LI ICAMPBELL•WILLIAM Et 9 JRl
UNCLASSIFIED REPORTAVAILABILITY: PUBLISHED IN JOURNAL OF BACTERIOLOGYV89 N6 P1296-60 JUN 194P#
AESCRIPTORS! (oVENEZUELAN EQUINr ENCEPHALOMYELITIS
VIRUS, BIOLOGICAL ASSAY,, MORTALITY RATES, DOSAGE,TIME, VIABILITY# BRAIN, NICE (Ul
WHFN SUSPENSIONS OF VENEZUELAN EQUINEENCEPHALOHYELITIS (VCEi VIRUS WERE INJECTEDINTRACEREBRALLY INTO GROUPS OF MICEI A NEARLY LINEARRELATIONSHIP WAS OBSERVED PETNEEN THE CONCENTRATIONOF THE VIRUS INJECT90 AND THE MEN4 RECIPROCAL TIME-TO-DEATH OF THE MICE, A TOTAL OF 91 VEFPREPARATIONS NERF ASSAYED IN DUPLICATE, AND, BYPLOTTING THE RELATIONSHIP RETWEEN THE RECIPROCAL
TIME-TO-DEATH FOR MICE GIVEN THE .000001 DILUTION OFVIRUS AND THE MICLDPO (MOUSE INTRACERENRALCHALLENGE, LOO RESPONSE) VALUES FOR THE VIRUSPREPARATIONS, A REFERENCE CURVE WAS ESTABLISHED#USING THIS REFERENCE CURVE, IT WAS POSSIBLE TOESTIMATE DIRECTLY THE LDPO VALUES OF VIRUSSUSPENSIONS OF UNKNOWN CONCENTRATION FROM THE MEANRECIPROCAL TT1E-TO-DEATH OF A GROUP OF NICE INJECTEDWITH A SINGLE DILUTION. IN THIS WORK, THE NUMBEROF MICE USED WAS REDUCED BY 62*51, THE TITRATIONSWERL COMPLETE IN ) TO 5 DAYS COMPARED WITH THE USUAL I10 TO I4 DAYS, THREE TO FOUR TINES AS MANY ASSAYSCOULD BE OCNE IN A DAY, AND NO ASSAYS HAD TO BEREPEATED SINCE END POINTS WERE NOT MISSED. THEPRECISION OF THE SINGLE-DILUTION ASSAY COMPAREDFAVORABLY WITH THAT OF THE LD90 TITRATION.(AUTHOR) (U)
12UNCLASSIFIED J'ZINfI
UNCLASSIFIED
DOC REPORT RISLIOGRAPHY SEARCH CONTROL NO# /ZlM9I
AD-067 264 64s 4/13
ARMY BIOLOGICAL LASS FREDERICK MD
CROSS"PROTECTJON IN ANIrIALS INFECTED WITH GROUP AARBOVIRUSES. fUl
OCT 62 6P HEARNMENRY Jo , JR9 IRAINEYCULLEN To I
UNCLASSIFIED REPORT
AVAILABILITY? PUBLISHED TN JOURNAL OF IMMUNOLOGYV90 Ng P720-4 MAY 196).
SUPPLEMENTARY NOTEI
nESCRIPTORS; (*GROUP A ARSOVIRUSES, IMMUNITY;,VENEZUELAN EQUINE ENCEPHALOMYEL'TIS VIRUS, SEMLIKIVIRUS, AEROSOLSt INJECTIONtME.sCiNEI, DOSAGE,RESISTANCE(UIOLOGICAlI, GUINEA PIGS, MICE (Ul
EXPERIMENTS WERE CAARIED OUT TM INVESTIGATE THEPHENOMENON OF CROSS-PROTECTION AMONG VENEZUELANEQUINE ENCEPHALOMYELITIS (VEE), EASTERN EQUINEENCEPHALOMYELITIS (EEE) AND SEMLIKI FOREST(SF) VIRUSES I' A VARIETY Of LABORATORY ANIMALSAFTER IMMUNIZATON BY THE INTRAPERITONEAL,SUBCUTANEOUS OR RESPIRATORY ROUTESI THE LAST WASEFFECTED BY EXPOSING THE ANIMALS TO AEROSOLS OFVIRUS* ONE INJECTION Of AN ATTENUATED STRAIN Of
VEE VIRUS f9T) PROTECTED GUINEA PIGS AGAINST ALETHAL CHALLENGE DOSE OF EEC OR SF VIRUS INGUINEA PIGS AND MICE, RESPECTIVELY@ TWO INJECTIONSOF LIVE SF VIRUS PROTECTED GUINEA PIGS AGAINSTSMALL DOSES OF VEE OR EEE VIRUS, MICEVACCINATED WITH STRAIN 9Y RESPONDED BY DEMONSTRATINGRESISTANCE MECHANISMS THAT APPEARED TO OPERATE INSERIES. THIS CONSISTED Of, FIRST, AN EARLYNONSPECIFIC INTERFERENCE PHASE, FOLLOWED BY A SECOND;SPECIFIC PHASE, THE SECOND PHASE ALSO INCLUDED APARTIALLY SPECIFIC MECHANISM OF RESISTANCE OF UNKNOWNORIGIN AND OF RELATIVELY LONG DURATION MANIFESTED ASCROSS-PROTECTION IN THE GROUP A VIRUSES.(AUTHOR) (U)
13UNCLASSIFIED 0ZIM0I
_________
IUNCLASSIFIED
DOC REPORT RIRLIOGRAPHY SEARCH CONTROL NO. iZIM91
AO-627 267 6/!2ApfMw mini nfltrat 1AR4 Fo£Un aw~tw mf
EFFLCT OF ADJUVANTS ON ANTIBODY RESPONSE Of RABBITSINOCULATED WITH VENLZUELAN EQUINE ENCEPHALOMYELITISVIRUS* .Ul
DEC 62 7P SHEPELMICNAEL IKLUGERMAN,MAXWELL Re I
UNCLASSIFIED REPORTAVAILARILITY! PURI4SHED TN JOURNAL Of BACTERIOLOGYVB5 NO P1150-5 MAY 1963o
SUPPLEMENTARY NOTE:
DESCRIPTORS: (*VENEZUELAN EGUINE ENCEPHALOMY4LITISVIRUS, ANTIGENS + ANTIBODIES), SERODIAGNOSIS,MYCObACTERIUMt ELECTROPHORESISt IMMUNE SERUMS,GAMMA GLOBULIN# PROTEINS, GLOBULINS, SERUMALBUMIN, RABBITS (U)
IOENTIFIERS: HEMAGGLUTINATIMNaINHIBIT|ON TESTS$COMPLEMENT-FIXATION TESTS (U)
HEMAGGLUTINATION-INMIBITION, NEUTRALIZATION, ANDCOMPLEMENT-FIXATION TESTS WERE PERFORMED ON SERA OPRABBITS INOCULATED WITH VENLZUELAN EQUINEENCEPHALOMYELITIF (VgEi VIRUS IN COMBINATION WITHFREUNO'S ADJUVANTS AND IN HANKIS SALT SOLUTION#THIS STUDY INDICATED THAT THE COMPLETE ADJUVANTS(IoEo, WITH MYCORACTERTA) CONSIDERABLY lICREASEDTHE ANTIBODY RESPONSE TO VEE VIRUS9MYCOBACTERIUM BUTYRICUM (Mo SMEGMATIS) APPEAREDTO Of MORE EFFECTIVE THAN Me TUBERCULOSISH?27A, IN THE ABSENCE OF MYCOBACTERIA; THERESPONSE WAS MUCH LESS PRONOUNCED. PAPERELECTROPHORETIC STUODES OF THE ANTISERA DEMONSTRATEDA MARKED INCREASE IN GAMMA-GLOBULIN PRODUCTION; ANINCREASE IN THE AETA.GLORULIN, AND AN INCREASE INTOTAL PROTEIN AS THE RESULT OF ADDING VEE VIRUS TOTHE COMPLETE Af)JIJVANTS* A DECREASE IN THE ALBUMINFRACTION APPEARED TO BE CAUSED BY THE COMPLETEADJUVANTS RATHER THAN BY THE VEE VIRUS ITSELF*THE INCOMPLETE ADJUVANT (WITHOUT MYCOBACTERIA)PLUS VIRUS CnNTRIBUTED LITTLE, IF ANY; STIMULATIONTOWARD THE PRODUCTION OF GAMMA-GLOBULINV NOR DID ITAPPEAR TO AFFECT THE SERUM-ALBUMIN LEVELS.(AUTHOR) (U)
14UNCLASSIFIED /ZlMgl
UNCLASSIFIED
DOC REPORT RIBLIOGRAPHY SEARCH CONTROL NO. /ZIMJI
AD-427 406 /IARMY BIOLOGICAL LAI.S FREOERICK MO
DirrERENCES IN HAXIMUM AND MINIMUM PLAQUEwFORMINGTEMPERATURES AMONG SELECTED GROUP A ARBORVIRUSESv ful
JUL 6A lip BROWNtARTMUR I
UNCLASSIFIED REPORTAVAILABILITYI PUBLISHED IN VIROLOGY V21 N2 PP62-72NOV 196,.
SUPPLEMENTARY NOTE:
nESCRIPToRS: (*GROUP A ARSORVIRLISES, TEMPERATURE),GROWTH, VENEZUELAN EQUINE ENCEPHALOMYE61TIS VIRUS,EASTERN EQUINE ENCEPHALOMYELITIS VIRUS, THERMA1.STABILITY, CULTURE MEDIA, MUTATIONS (UI
VENEZUELAN EQUINE ENCEPHALITIS IV) AND EASTERNEQUINE ENCEPHALITIS (Es VIRUSES SHOW DtSTINCTPLAQUE FRONTS AT MAXIMUM TEMPERATURES (IF*MAX) Of46 DEGREES* TWO ATTENUATED VARIANTS OF V (T ANDA) SHOW A TF-MAX OF 47 DEGREES AND 40 DEGREES,RESPECTIVELY* ALL FOUR VIRUSES SHOWED INDISTINCTPLAQUE FRONTS AT A MINIMUM TEMPERATURE ITFoMINIOf 24*S DEGNEESI UP TO If OF THE INOCULUM FORMEDPLAQUES THAT WERE CISTRIPUTED BETWEEN THE TF-MIN AND20 DEGREES# FROM V INOCULATED PLATES, THEPROGENY DERIVED FROM ONE OF 71 PLAQUES SELECTED BELOWTHE TF.MIN WAS AVIRULENT AND RESEMBLED T. T MAD ASELECTIVE ADVANTAGE OVER V IN PASSAGE EXPERIMENTSIN LIQUID CULTURES AT LOW TEMPERATURES. VIRULENTMUTANTS OF T, RESEMBLING Vs WERE ISOLATED FROMPLAQUES BEYOND THE TF-MAE OF T ONLY AFTEROVERCOMING A REVERSIBLE INTERFERENCE EFFECT IN WHICHT INTERFERED WITH PLAQUE FORMATION OF V ABOVE THETF-MAX, THE POSSIBLE RELATION Of TF*MAX AND TF.MINTO VIRULENCE AMONG THESE VIRUSES IS DISCUSSED.(AUTHOR) fUl
U S5
UNCLASSIFIED
DOC REPORT |IBLIOGRAPHY SrARcH CnMTROI NA. ?71MN:
*-637 qlI 6/11ARMY SIOLOGICAL LAOS FREDERICK HO
INACTIVATION Of T7O ARBOViRUSES AND THEIR ASSOCIATEDINFECTIOUS NUCLEIC ACIDS. (U)
JUN 6; 9P MIKA#LEONARD A4 ;OFFICERoJULIUS Es ISROWNARTHUR I
UNCLASSIFIED REPORT
AVAILABILITY: PUBLISHED IN JOURNAL Of INFECTIOUS
DISEASES Vill P195-202 NOV-DEC 196,.SUPPLEMENTARY NOTE:
nESCRIPTORS: t*ARBOVIRUSES, *NUCLEIC ACIDS);teEASTERN EQUINE ENCEPHALOMYELITIS VIRUS.VIABILITY), (*VENEZUELAN EQUINE ENCEPHALOHYELITIS
VIRUS@ VIABILITY), THERMAL PROPFRTIES, NITRICACID, ULTRAVIOLET RADIATION* LIPOPROTEINS (U)
THE INACTIVATION OF 2 DISTINCT BUT RELATEDARROVIRUSES (EASTERN AND VENEZUELAN EQUINE
ENCEPHALITIS) BY HEAT (90 C); NITROUS ACID
tHN02), AND ULTRAVIOLET LIGHT WAS STUDIED IN IRELATION TO THE INFECTIOUS RISONUCLEIC ACID (RNA),THE 2 VIRUSES COULD BE DISTINGUISHED BY THEIR HEATINACTIVATION CURVES. ALTHOUGH THE CURVES FOR BOTHVIRUSES WERE APPROXIMATELY BIPHASICo THEIR PHASESWERE REVERSED. THE HEAT INACTIVATION RATES OF
RECOVERABLE RNA (FROM THE HEATED VIRUS PARTICLE)AND OF EATRACTED RNA (FROM UNHEATED VIRUS) WERELESS THAN THnSf FOR THE VIRUS# THE RESULTS
(LIPOPROTEIN) COMPONENT AND THEN ON THE NUCLEIC
ACID. THE KINETICS OF INACTIVATION OF THE 2VIRUSES AND THEIR RNAIS BY HNO2 SUGGESTED THATINACTIVATION OF BOTH SURFACE PROTEIN AND NECLEIC ACIDBEGAN SIMULTANEOUSLY BUT THAT THE LATTER INACTIVATIONWAS SLOWER. THE RESPECTIVE VIRUSES AND THEIRRECOVERAOLL RNA COULD BE DISTINGUISNEO BY THEIR
RATES OF INACTIVATION. THE RESULTS WITHUJLTRAVIOLET IRRADIATION AGREED *ITH THE CONCEPT OF
PRIMARY DAMAGE TO THE NUCLEIC ACID# (U)
UNCLASSIFIED /!IMII
_________________________ ______________ _________________________________________________________
UNCLASSIrIED
DOC REPnRT mlmLfnAhp.... CAM.' C• TtL hEv iimpi,
AD-628 42Pt1
ARMY BIOLOGICAL LAOFREDERICK MD
ABILITY OF A FISH CELL LINE TO SUPPORT THE GROWTH OFMAMNALIAN VIRUSES* .ul
JAN 64 oP OFFICERJULIUS E, I
UNCLASSIFIED REPORTAVAILABILITY: PUBLISHED IN PROCEEDINGS Of THESOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE V1I6P190-q 1964,
SUPPLEMENTARY NOTE:
MESCRIPTORS: (*TISSUE CULTURE CELLS, FISNES),(*EQUINE ENCEPHALOMYELITIS VIRUS, TISSUF CULTURE),VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS* EASTERNEQUINE ENCEPHALOMYELITIS VIRUS; SEX G.ANDS,GROWTH (U)
A FISH CELL LINE DERIVED FROM RAINBOW TROUT GMNAOS(RTG) HAS BEEN SHOWN TO SUPPORT THE PROLIFERATIONOF 2 ARBOVIRUSES, VENEZUELAN EQUINE ENCEPHALITIS(VEE) VIRUS AND EASTERN EQUINE ENCEPHALITISIEEE) VIRUS$ AT 22C@ EEE VIRUS WAS MORECYTOPATHOGENIC FOR RTG CULTURES THAN VEE VIRUSITHUS MAKING IT FEASIBLE TO DISTINGUISH BETWEEN THETWO. A PERSISTENT INFECTION WAS OBTAINED WITH VfE
VIRUS FOR AS LONG AS CULTURES WERE CARRIED, BUT NOTWITH EEE VIRUS, BOTH VIRUSES MULTIPLIED IN CHICKFIeROBLAST. (Cr) CELLS AT 22C TO SLIGHTLY HIGHERTITERS THAN IN tHE FISH CELL LINE AND BOTHE VIRUSESCAUSED A CYTOPATHOGENIC EFFECT IN CF CELLS, LCELLS FAILED TO SUPPORT THE GROWTH OF EITHER VIRUSAT 22C, IAUTHOR) (U)
17UNCLASSIFIED /ZMSI
UNCLASSIFIED
DOC REPORT SBILIOGRAPHY SEARCH CONTROL NO* eZIMPI
ARMY BIOLOGICAL LARS FREDERICK NO
DEFINEO MAINTENANCE NEDIUM FnR SUPPORTING CHICK
FIBkOBLAST MONOLAYERS AND FOR PLAQUE FORMATION BY
VENEZUELAN AND EASTERN EQUINE ENCEPNALITIS VIRUSES. (U)
AUG 64 &P ZEBOVITZlEUGENE I
UNCLASSIFIED REPORTAVAILABILITY: PUBLISHEO IN JOURNAL OF INFECTIOUSDISEASES V1I9 P77-82 FEB 19699
qUPPLEMENTARY NOTE:
nESCRIPTORS: (*VENEZUELAN EQUINE ENCEPHALOMYELITISVIRUS, GROWTH), 46EASTERN EQUINE ENCEPHALONYELITISVIRUS, GROWTH), 40CULTURE MEDIA* EQUINEENCEPHALOMYELtTtS VIRUSI, TISSUE CULTUIEtVIABILITY (Ul
A DEFINED MAINTENANCE MEDIUM THAT SUPPORTS CHICKFIBROBLAST (CF) CLLL MONOLAYERS IN A VIA6LE STATEFOR AT LEAST 10 DAYS AND PERMITS THE FORMA AON OFPLA4UES BY VENEZUELAN YVEE) AND EASTERN (rEE)EQUINE ENCEPHALITIS VIRUSES IS DESCRIBED, THEMEDIUM CONSISTS OF A BALANCED SALTS SOLUTION,GLUCOSE, 2 AMINO ACIDS fLaCYSTINE AND L-MI$VIDINEHCI), SODIUM BICARRONATEp AND AGAR* PLAQifCOUNTS BY VEE AND IEE VIRUSES ON CF MONOLAYERSOVERLAID WITH THIS MEDIUM COMPARED FAVORABLY WITH
THOSE OBTAINED ON A COMPLEX OVERLAY MEDIUM,(AUTHOR) IU)
18UNCLASSIFIED nIlMll
_________________________,_
I
UNCLASSIFIED
DDC REPORT BIBLIOGRAPHY SEARCH CONTROL NO. /ZiMO3
ARMY BIOLOGICAL LABS FREDERICK MD
SUSCEPT181LITY OF WHITE CARNEAU PIGEONS TO
RESPIRATORY INFECTION BY VENEZUELAN EQUINEENCEPHALITIS VIRUS, oUi
APR 69 6P MILLERWILLIAM So I
UNCLASSIrEDO REPORTAVAILABILITY: PUBLISHED IN AMERICAN JOURNAL OFEPIDEMIOLOGY VB8 NI Pq4-02 1969o
SUPPLEMENTARY NOTEl
MESCRIPTORS; (#VENEZUELAN EQUINE ENCEPHALOMYELITISVIRUS., *PIGEONS), RrSPIRATORY DISEASES; DOSAGE,IMMUNITY, ANTIGENS * ANTIBODIES; SERODIAGNOSIS,AEROSOLS (U)
WHITE CARNEAU PIGEONS WERE FOUND TO BESUSCEPTIBLE TO RESPIRATORY INFECTION BY VENEZUELANEQUINE ENCEPHALITIS VIRUS, WITH DOSES AS LOW AS l7qHOUSE INTRACEREBRAL LDVO UNITS INHALED, 7 OF eBIRDS EXHIBITED VIREMIAS THAT APPROACHEDIO 100000MICLDPO UNITS PER ML Of BLOOD. VIREMIASGENERALLY PERSISTED THROUGH THE THIRD DAY AFTEREXPOSURE. BIRDS WERE NOT OBSIOUSLY ILL AND SHOWEDSEROLOGIC EVIDENCE OF IMMUNIZING INFECTIONS9(AUTHOR) IUl
19UNCLASSIFIED /ZIMPI
UNCLASSIFIED
DOC REPORT RIBLI8GR&PHY SEARCH CONTROL NO# /ZIMPi
Ao-441 9)7 All)ARMY Rin nevl -A LAISA l f t * :*, n"
HEMAGGLUTINATION'INHIBITION METHOD ANDIHMuNOFLUURESCENCL STA~hING WITH VENEZUELAN EQUINE
ENCEOHALOMYELITIS VIRUSt
OCT 6 IFP SHEPELMICHAEL I
UNCLASSIFIED REPORTAVAILABILITYI PUBLISHED IN APPLIED MICROBIOLOGYVI4 N3 P34'6-2 MAY 1966o
tESCRIPTORS: I*SERODIAGNOSIS, *VENEZUELAN EQUINEENCEPHALOMYELITIS VIRUSl,.FLUORESCENT ANTIBODYTECHNIQUES, EFFECTIVENESSo TEST METHODS, IMMUNESERUMS ful
IDENTIFIERS: HEMAGGLUTINATION-IIHIIBITION TESTS IUl
HEMAGGLUTINATION AND FLUORESCENT ANTIBODY (FA)ARE COMPARED FOR THE DIRECT DETECTION OF VIRUS DEVOIDOF HOST CELLS, A DETERMINATION WAS MAOE OF THEMINIMAL NUMBER OF TISSUE PLAOUr.FORMING UNITS OFVENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS THATCOULD BE DETECTED BY THE HEMAGGLUTINATION TECHNIQUE.SIMILAR CONCENTRATIONS OF THE VIRUS IN BOVINEALBUMIN BORATE SALINE, BRAIN HEART INFUSIONBROTH (DIFCO)t AND DEMINERALIZED WATER WERETESTED BY THE rA TECHNIQUE, SOEWHAT HIGHERCONCENTRATIONS Of THE VIRUS IN BOVINE ALBUMIN BORATESALINE WERE USED IN THE HEMAGGLUTINATION-INHIBITIONTEST* THE QUANTITATIVE HEMAGGLUTINATION PROCEDUREEMPLOYED FOR THESE STUDIES WAS CARRIED OUT At 77 CFOR 75 MIN WITH VARIATIONS IN CONCENTRATION OF GOOSERED CELLS. AS A RESULT OF LOWERING THE RED CELLCONCENTRATION, SMALLER CONCENTRATIONS OF VIRUS WEREDETECTED# THE DIRECT IA STAINING PROCEDUREAPPLIED TO SLIDE PREPARATIONS CONTAINING KNOWNNUMB!RS OF TISSUE CULTURE PLAQUE*FORMING UNITS OFVIRUS WAS NEGATIVE. ADSORBED VIRAL ANTIGEN ONAGGLUTINATED GOOSE ERYTHROCYTES WAS VISUALIZED BYDIRECT AND INDIRECT FA TECHNIQUES, (AUTHOR) fU)
: 20UNCLASSIFIED 4ZIMpI
j*. ."."'
IUNCLASSIFIED
DOC REPORT RIRLIOGRAPNy SEARCH CONTROL NO. /ZIMPIAD-tq! 9•1 6~11
ARMy BIOLOGICAL LABS PRbCRiKC MIO
"MODIFIED ORAD|FNT PLATE Pon USE RN THf VIRUS PLAQUETECHNIQUE, P UE
DEC 69 2P SOPERWILLIAM 1, 5
tUNCLASSIFIED REPORTAVAILABILITY: PUSLISHE4 IN APPLIED HICROBIOLOGYV14 N3 PqOw! MAY 19&46
nesCRIPTORSI (*VENEZUCLAN EQUINE ENCEPHALOMYELITISVIRUS* GROWTH), CULTURE MEDIAA LABORATORYEQUIPNENT, IMMUNE SERUMSt BACTERIA,RESISTANCE(DIOLOGICALI, ANTIBIOTICS
(U)THE REPORT DESCRIBES THE PRELIMINARY RESULTSOBTAINED IN AN APPLICATION Or T1r GRADIENT PLATECONCEPT TO THE VIRUS PLAQUE TECNNIQUts* IN THiSTEST SYSTEM IMMUNE SERUM WAS USED AS AN INHIS|TO* OFPLAQUE FORMATION BY VENEZUELAN EQUINEENCEPHALONYELITIS IVEE) VIRUS* (AUTHOR,
2UUNCLASSIp|[
/Z HS
UNCLASSIFIED
DOC REPORT BIBLIOGRAPHY SEARCH CONTROL NO* tZIMPj
AO*G'41 9111 6/I,ARMY BIOLOGICAL LABS FREDERICK NO
HOST INFLUENCE ON 741 CHARACT['!STICS OF VENEZUELANEQUINE ENCOPHALOMYELITIS VIRUS; tU)
JAN 66 7P HEYORICKFRED Ps IWACHTERsRALPH Fq ;HEARA1eHENRY J. i
UNCLASSIFIED REPORTAVAILABILITY! PUBLISHED IN JOURNAL Of BACTERIOLOGYV91 N6 P23'3-e JUN 1946,
DESCRIPTORS: (*VENEZUELAN EQUINE ENCEPHALOMYELITISVIRUS, TISSUE CULTURE), VIABILITY, LIPIDS,TISSUE CULTURE CELLS (U)
ALTERATIONS IN PLAQUE SIZE, VIRULENCE; AND LIPIDCONTENT OF VENEZUELAN EQUINE ENCEPHALOMYELITTS(VEE) VIRUS WERE EXAMINED FOR POSSIBLE:NTERRELATIONSHIPS AMONG THESE PROPERTIES DURING 10SERIAL PASSAGES IN EMBRYONATED EGGS, SUCKLING NICE,CHICK EMBRYO FIBROBLASTS, AND L CELLS. THE CHICKEMPRYO HOST MAINTAINED THE SAME LARGE-PLAQUE ANDVIRULENCE PROPERTIES OF THE VIRUS THROUGH 10 PASSAGESAS SEEN IN THE ORIGINAL SEED, PASSAGE OF VIRUS INEITHER L CELLS OR CHICK FIBROBLASTS RAPIDLYPRODUCED POPULATIONS THAT WERE; IN THE MAIN,INTERMEDIATE WITH RESPECT TO PLAGUE SIZE ANDVIRULENCE. PASSAGE Of VIRUS IN SUCKLING MOUSEARAIN YIELDEn POPULATIONS THAT WERE INTERMEDIATE WITHRESPECT TO PLAQUE SIZE ONLY. THE NATURE OF THELIPID OF THE VIRUSt IN TERMS Of THE RATIO OFPETROLEUM ETHEReSOLUSLE TO-INSOLUBLE LIPID; CHANGEDAFTER ONLY ONE PASSAGE IN ALL SYSTEMS EXCEPT IN CHICKEMBRYOS, NINE ADDITIONAL SERIAL PASSAGES FAILED TOENHANCE THESE CHANGES IN VIRAL LIPID, SUGGESTING THATTHE DECREASE IN THE LARGE-PLAQUE AND VIRULENCEPROPFRTIES *AS NUT DIRECTLY ASSOCIATED WITH CHANGESIN LIPID C3NTENT, (AUTHOR) (U)
22UNCLASSIFIED /ZIMOI
UNCLASSIFIED
DOC REPORT 4IWLIOGRAPIY SEARCH CONTROL NO. 0#ZINMo
AOe44I 992 A/I)
ARMY BIOLOGICAL CENTER FREDERICK HO
EFFLCT OF SODIUM BICARBONATE ON PLAQUE FORMATION BYT0O STmAINS Or VENEZUELAN EQUINE ENCEPwALONYELITISVIRUS9 fU)
JAN 66 qP SOPER;NILLIAN Y40HAS I
UNCLASSIFIED REPORT
AVAILABILITY: PUBLISHED IN CANADIAN JOURNAL OFMICROBIOLOGY V12 P8?7-) tY66&
nESCRIPTORS$ t*VENEZUELAN EQUINE ENCEPHALOMyCLITISVIRUS, INHIBITIONI, SODIUM COMPOUNDS,
BICARBONATESt lROWTH, CULTURE MEDIA fUt
RESULTS SUPPORT THE CONCLUSION OF COLON ET AL.THAT AN AGAR INH!ITOR IS RESPONSIBLE FOR THE 9TSTRAIN PLAQUE SIZ-1 INHIBITION OCCURS OVER A WIDERANGE OF 8ICARRONAT& CONCENTRATION* HOWEVER$ ITWAS FOUND THAT PES STRAIN PLAQUES ARE ALSO REDUCEDIF A LOW BICARRONATE CONCENTRATION 15 USED IN THEOVERLAY, PRESUMABLY, THE AGAR INHIBITOR IS ACTIVEAGAINST THE PES STRAIN ONLY IF THE BICARBONATELEVEL IN THE OVERLAY Is LOW. THIS FINDING SUPPORTSTHOSE OF AGOL AND CHUMAKOVA, AND LIEOHAOER ANDTAKEMOTO, DEMoNSTRATING THAT AGAR INHIBITION CAN BEABSENT WHEN BICARBONATE CONCENTRATION IS RELATIVELYHIGH. LIEBHABER AND TAKEMOTO SUGGESTED THATSULFATED POLYSACCHARIDES MIGHT PREVENT PLAQUEFORMATION BY VTRUStS THAT ARE NORMALLY CYTOPATHIC INLIOUID CULTURES* IN THIS SENSE; IT 15 NOTEWORTHYTHAT THE 9T STRAIN IS MORE CYTOPAT41C IN L.CELL ORCHICK FIBROBLAST FLUID CULTURES THAN IS THE P1SSTRAIN, THE OBSERVATIONS REPORTED HERE EMPHASIZETHE IMPORTANCE OF BICARBONATE (PH AND IONICSTRENGTH) IN ASSAYING FOR INHIBITION BY AGAR-ASSOCIATED FACTORS AND FOR ACCURATELY ASSESSINGPLAQUE SIZE AS A GENETIC PROPERTY RATHER THAN APHENOTYPIC CHARACTER, tAUTHOR) (Ul
23UNCLASSIFIED #ZIMPI
UNCLASSIFIED
DOC REPORT BIBLIOGRAPHY SEARCH CONTROL NO* "ZINM9
AD-642 077 6/1)ARMY BIOLOGICAL LARS FREDERICK NO
DYNAMICS OF MULTIPLICATION Or vNr vr! V!*aJ !qu ?!5S J
CULTURE CELLS, (Ul jSEP 6A Wo CRSHOVtF, E9 IVAGZHANOVAiV. A.
||VANOVSKAGOvDo It o9EPT. NO, TRANS-I179MONITOR: NCH 2U9 769
UNCLASSIFIED REPORT
SUPPLLMENTARY NOTE! TRANS. OF VOPROSY VIRUSOLOGII(USSR) VIO N2 Pt?6p$O 190,s
nESCRIPTORS: (oVENEZUELAN EQUINr INCEPHALOMYELITISVIRUS, TISSUE CULTURE CELLS), GROWTH,.TISSUECULTURE; EMBRYOS# MORPHOLOGY4BI5OLOGV-o IMMUNESERUMS, AGGLUTININS, ERYTHROCYTES* DIAGNOSIS,ANTIGENS * ANTYIODIES, SCROOIASNOSIS& CYTOLOGY,USSR fU).IDENTF IERS; HEMAGGLUTINATIONaINHIBITION TESTS*COMPLEMENT-FIXATION TESTS (Ul
THE VIRUS OF VENEZUELAN EQUINE ENCEPHALOMYELITI'.IS CAPABLE Or AGGLUTINATING GOOSE CRYT4ROCYTES Al APH OF go$a-6,0o THE 'THRESMOLD OF INFECTIVITYOWHICH IS NECESSARY FOR THE EXPOSURE-Of VEEHEMAGGLUTININS COMPRISES 4o6*6S,? LG TCOOO 1;200,OOCV--2,00oOOO PLAQUE FORMING UNITS)* THE REACTIONOF HEMADSORPTION MAKES IT POSSIBLE TO EXPOSE THEMULTIPLICATION Or VEE IN 6-o9 HOURS FOLLOWINGINFECTION OF A SENSITIVE CULTURE* THE RGA ANDTHE REACTION Or HEMAOSORPTION MAY BE USED FORDETERMINING THE DYNAMICS OF MULTIPLICATION OP VEEAND THE EARLY OIAGNOSIS OF THIS VIPIJS APROLONGED LIBERATION OF VIRUS PARTICLES INTO THESURkOUNOING MEOIUM IS CHARACTERISTIC rFR VEEt(AUTHOR) (tU
24 'UNCLASSIFIED 41MW)
i.i
DOC REPORT RIOLIOGRAPHY SEARCH CONTROL NO. lZIM51
ARMY BIOLOGICAL CENTER FREDERICK MO
INFECTION Of pIGEONS BY AIRBORNE VENEZUELAN EQUINEENCEPHALITIS VIRUS, (U)
SEP 66 SP MILLER;WILLIAM S9 1
UNCLASSIFIED REPORTAVAILABILITY? PUSLISHED IN BACTERIOLOCTCAL REVIEWSV3O N) Ppa9-9g SEP 1966,
OESCRIPTORS3 I*PIGEONI, *VENEZUELAN EQUINEENCEPNALOMYELITIS VIRUS•, VIRUS DISEASES, AEROSOLS,RESPIRATION, !NJECTION(MEOICINE), DRUGS,EFFECTIVENESS, DOSAGE, EPIDEMIOLOGY,ANTIBIOTICS, OXYTETRACYCLINE lUl
CONTENT3; COMPARATIVE SUSCEPTIBILITY OF FOWL TOAEROSOLS Of VEE VIRUSI COMPARISON OF RESPONSESAFTER INHALATION AND INJECTION OF VEE VIRUSIBIRO-TO-BIRD TRANSMISSION OF VIRUSI EFFECT OFEXPOSURE TIPE ON VESPONSC TO INFVCTIONI EFFECT OFANTIMICROBIAL DRUGS ON SUSCEPTIBILITY; CONCLUSIONSAND DISCUSSION. (U)
25UNCLASSIFIED /'ZIMq1
UNCLASSIFIED
DOC REPORT SIFLIOGRAPHY SEARCH CONTROL NO. /ZIMfl
AO-6q 2 476 6//I) 1 6/ARMY BIOLOGICAL LARS FREDERICK NO
STUDIES OF THE RESPONSE OF WHITE CARNEAU PIGEONS TORESPIRATORY AND SUBCUTANEOUS DOSES Of VENEZUELANEWUINE ENCEPHALITIS VIRUS, fUl
FEB 66 12P MILLERtOlLLIAM So I
UNCLASSIFIED REPORTAVAILABILITY! PUBLISHED IN AMERICAN JOURNAL OFEPIDEMIOLOGY VB4 N2 PItI-92 1966.
MESCRIPT-ORS; i#PIGEONSt *VENEZUELAN EQUINEENCEPHALOMYELITIS VIRUS)o ANTIGENS 4 ANTIBODIES,IMMUNITY, RESPIRATION, DOSAGE, AEROSOLS IUD
THF ABILITY OF VENEZUELAN EQUINE ENCEPHALITIS(VEE) VIRUS To INDUCE FORMATION OF PROTECTIVE SERUMNEUTRALIZING (SN) ANTIBODIES WAS STUDIED IN WHITECARNEAU PIGEANS, AMONG BIRDS RECEIVING VIRUS BYTHE RESPIRATORY ROUTE, AN INHALED DOSE OF ),7I9
MICLO90 UNITS PRESENTED IN ONE MINUTE RESULTED INBOTH VIREMIC AM'D SEROLOGIC RESPONSE IN 60 TO 8O PERCENT OF THE •IRDS TESTED@ THE BIRDS DID NOTRESPOND TO A sUBSLOUENT CHALLENGE OF 3#279 MICLOJOINHALED, INDICATING A DEGREE OF IMMUNITY TO VEEVIRUS INFECTION. BIRDS RECEIVING VIRUS BESUBCUTANEOUS INJECTION RESPONDED SIMILARLY TO THERESPIRATORY GROUP IN TERMS OF LEVEL AND DURATION OFVIREHIA AND SERUM NEUTRALIZING ANTIBODIES. SNTITERS WERE FOLLOWED FOR 112 DAYS AFTER EXPOSURE TO
OR INJECTION Op VIRUS, THE TIME OF THE FIRSTAPPEARANCE OF ANTIBOOIES AND THE SUBSEQUENT INCREASEIN TITERS WERE ALMOST IDENTICAL FOR THE TWO ROUTES.
FURTHER, BIRDS SHOWING VIREMIAS AFTER INFECTION BYBOTH ROUTES HAD VIRUS IN THE ORAL CAVITY. BECAUSEOF THIS LATTER FACTORp COUPLED WITH SUSCEPTIBILITY TOAEROSOLSo IT WAS POSSIBLE THAT GENERAL BIRD-TO-BIROTRANSMISSION OF VEE VIRUS INFECTION COULD BEDEMONSTRATED. THAT OBJECTIVE; HOWEVER, WAS NOTMET. SUBSEQUENT EXPERIMENTS WERE CONDUCTED TODETERMINE WHETHER OR NOT DOSAGF RATE WAS CRITICAL TOINFECTION. THE RESULTS INDICATED THAT VIREMIC ANDSEROLOGIC RESPONSES COULD NOT RE PRODUCFD UNLESS THEDOSAGE RATE EQUALEn THE MINIMUM INFECTIVE DOSE PERMINUTE, REGARDLESS Of THE TOTAL DOSE INHALED,iAUTHOR) IUD
26
UNCLASSIFIED /ZlMJl
UNCLASSIFIED
DOC REPORT BIBLIOGRAPNY SEARCH CONTROL NO /ZIM9I
AD-648 126 6/I 6/tiFiRF ULTRSCI' FRLULRICK MO
EFFECTS OF METHYLATED ALBUMIN ON INFECTIOkS INA!
REVERSIBLE INFECTIVITY LOSS AND RESISTANCE TONUCLEASE DIGESTION, EUl
JAN 47 OP NORRELL;STEPHEN At ICOSTLOW,
RICHARD D0 I
UNCLASSIFIED REPORTAVAILABILITY: PUBLISHED IN BIOCHEMICAL ANDBIOPHYSICAL RESEARCH COMMUNICATIONS V26 N4 P481*9I9&7,
DESCRIPTORS: (ImIBONUCLEIC ACIDS, *INFECTIOUSDISEASES), VENEZUELAN EQUINE ENCEPHALOMYCLIT;SVIRUS, ENZYMES, INFECTIONS, BIOLOGICAL ASSAY,TISSUE CULTURE, SERUM ALBUMIN, BOVINES (U)
THE DOCUMENT IS A REPORT OF SOME INVESTIGATIONS ONTHE EFFECT OF NETHYLATED BOVINE SERUM ALBUMIN(MBSA) ON THE INFECTIVITY AND ENZYMATIC DIGESTIONOF INFECTIOUS PIBONUCLEIC ACID (-IRNA) FROM THETRINIDAD STRAIN OF VENEZUELAN EQUINE ENCEPHALITIS(VEE) VIRUS, IAUThOR) (U)
27UNCLASSIFIED izItmp
UNCLASSIFIED
DOC 'EPoRT BIBLIOGRAPHY SEARCH CONTROL NO. IZIM91
AD-600 167FORT DETRICK FRLERICK ND
TE[*PERATUREmSENSITIVE STEPS IN THE BIOSYNTHESIS OfVENEUrLAN QUPNE ENCEPHALITIS VIRUS, gUt
NOV 66 iP ZEBOVIT?;EU4EN[ IBROWNqARTHUR I
UNCLASSIFIED REPORTAVAILABILITY1 PUBLISHED IN JOURNA6 OF VIROLOGYV| NI PI2S-2 FEB 196?.
nESCRIPTORS; (*VENEZUELAN EQUINE ENCIPHALONYELITISVIRUS, BIOSYNTHESIS), TEMPERATURE, EMBRYONATEDEGG TECHNIQUE, RIBONUCLEIC ACIDS* ANTIGENS .ANTIBODIES, FLUORESCENT ANTIBODY TECHNIQUES;INHIBITION, MUTATIONS, SENSITIVITY Jul
IN CONTRAST TO EASTERN EQUINE ENCEPHALITIS VIRUS;THE REPLICATION O" VENEZUELAN EQUINE ENCEPHALITMS(VEEI VIRUS WAS STRONGLY INHIBITED AT 44C INCHICK EMBRYO cFLLS* THE INHiBITED STEPS WEREANALYZED BY SHIFTING THE INCUBATING TEMPERATURES UPOR DOWN, AND BY DETERMINING DURING THE SHIFTS THERATE AND EXTENT Of INFECTIOUS RIBONUCLEIC ACID IRNA)SYNTHESIS, INTACT VIRUS SYNTHESIS, AND FORMATION OFCOMPLEMENTeFIXING ANTIGEN OR OF ANTIGEN DETECTABLE BYA DIRECT FLUORESCENT*ANTIGOOY TECHNIQUE, THEINHIBITION APPEARED TO BE DUE To TWg TEMPERATURE-SLNSITIVE STEPS INVOLVED IN THE SYNTHESIS OP VEEVIRUS IN CHICK EMBRYO CELLS. THE FIRSY STEP OfINH;8ITION AT qqC OCCURRED EARLY IN VIRUSREPLICATION AND COULD BE COMPLETELY REVERSED SIMPLYBY TRANSFERRING CULTURES TO 27C9 THE IMHIBITIONAPPEARD TO TAKE PLACE AT SOME POINT BETWEEN THE TIMEWHEN THE VIRUS ENTERED THE CELL AND WAS UNCOATED ANDTHE BEGINNING Of VIRAL RNA SYNTHESIS. THE SECONDTEMPERATURE-SENSITIVE STEP IN VEE VIRUS SYNTHESISWAS IRREVERSIBLE; IT OCCURRED AT A POINT AFTER THESYNTHESIS OF VIRAL RNA; ANO BEFORE THE FORMATION OFVIRUS PROTEIN MEASURED AS COMPLEMENTPFIXING ANTIGENOR AS ANTIGEN THAT COULD BE STAINED SITy FLUORESCENTANTIBODY, (AUTHOR) JU)
28UNCLASSIFIED /ZIMJI
UNCLASSIFIED
ODC REPORT RILIOGRAPHY SEARCH CONTROL NO. /ZImo
AD-649 673 6/I)
EARLY DETECTION OF ARBOVIRUSES IN TISSUE CULTURES BYHEMAGGLUTINATION, fUl
JUl bh 5P GAIDAMOVICHS, YA IFAGZHANOVA*Vp A. IREPT. NO. TRANSwI8I9MONITOR: TT 67-62049
UNCLASSIFIED REPORT
SUPPLEMENTARY NOTE: TRANS. OF VOPROSY VIRUSOLOGII(USSR) v9 N6 Pýl2.( 1941qo
MESCRIPTORS; fsARBOVIRUSES, TISSUE CULTURE);AGGLUTININSr SERODIAGNOSIS, VENEZUELAN EQUINEENCEPHALOMYELITTS VIRUSI WESTERN EQUINEENCEPHALOMYELITIS VIRUSt EMBRyONATED EGG TECHNIQUE;CYTOLOGY, PH, USSR fUl
THE HEMAGGLUTINATION REACTION WITH THE VIRUS OF
VENEZUELAN ENCEPHALOMYE6.TIS AND THE WESTERN
VARIANT OF AMERICAN EQUINE ENCEPHALOMYELITIS;INCUBATED IN TISSUE CULTURES OF CHICK FIBROBLASTS#TAOES PLACE AT 4C IN A PH ZONE OF 95.--4*66OPTIMUM PH $,ao-6*0, DURING INFECTION OF THE
CULTURES WITH LARGE DOSES JF VIRUS WITHIN THE LIMITSOF 10 TO THE 7TH POWER TO 10 rf THE 9TH POWER CPD9OTHE HEMAGGLUTININS APPEAR IN THE CULTURAL FLUID IN 0.06 HOURS FOLLOWING INrECTION; AND THE CYTOPATHICEFFECT 15 DETECTED AFTER 24 HOURS. THEHEHMGGLUTINATION PHENOMENON MAY BE USED FOR THE EARLYDETECTION OF A VIRUS IN CULTURES. (AUTHOR) (U)
29'NCLASSIFIED /ZIMPI
UNCLASSIFIED
DOC REPORT RIBLIOGRAPHY SEARCH CONTROL NO. /ZIM9 1
AD-665 170 6/I3FOQf DETRICK FREDERICK MD
PROPERTIES Of VENEZUELAN EQUINE ENCEPHALOMYELITISVIRUS ACCOMPANYING ATTENUATION IN VITRO, sU)
DEC 66 SP HEARNHENRY Js . JR9;SOPERwILLIAM To I
UNCLASSIFIED REPORTAVAILABILITY: PUBLISHED IN JOURNAL OF VIROLOGYVI N1 Pq53-.9 jUN 19647
nESCR!PTORS; (*VENEZUELAN EQUINE ENCEPHALOMYELITISVIRUS, IN VITRO ANALYSIS,, VIABILITY, GROWTH,HICE, ATTENUATION, DISEASES, IDENTIFICATION;TISSUE CULTURE (U)
VIRUS OBTAINED DURING SERIAL PLAQUE PASSAGE Of THEVIRULENT PARENT EGG SEED (PES) Of THE TRINIDADSTRAIN OF VENEZUELAN EQUINE ENCEPHALOMYELITISEVEL) VIRUS PRODUCED ONLY LARGE PLAQUES DURINGFITHER 3 SERIAL PLAQUE PASSAGES IN CHICK FIBROBLASTSOR 10 PLAQUE PASSAGES IN L CELLS, AND WAS LETHALFOR MICE BY THE INTRAPERITONEAL ROUTE, VIRUSSHOWING THESE CHARACTERISTICS WAS DESIGNATED THESTABLE LARGE-PLAQUE tLS) TYPE. IN CONTRAST,VIRUS OBTAINED DURING SERIAL PLAQUE PASSAGE OF THEATTENUATED 9T STRAIN IN CHICK FIBROBLASTS FORMED ONLYVERY SMALL PLAQUES AND WAS NOT LETHAL FOR MICE BY THEINTRAPERITONEAL ROUTE. VIRUS SHOWING THESEPROPERTIES WAS DESIGNATED THE STABLE SMALL.PLAQUECSSI TYPE. UNDER OTHER PASSAGE CONDITIONS,HOWEVER, LARGE-PLAQUE VIRUS THAT YIELDED ABOUT 901LARGE AND 10s SMALL PLAQUES WAS ORTAINE0I THISV!RUS WAS DESIGNATED THE UNSTABLE LARGE OR LU TYPEBECAUSE IT DIFFERED FROM THE LS TYPE, WHICH YIELDEDONLY LARGE PLAQUES, THE LU TYPE Cký.TINtUED TOYIELD THE SAME RATIO Of LARGE TO SHALL PLAQUES FORSEVERAL Pi.AQUE-TO-PLAQUE PASSAGES* IN ADDITION,SMALL-PLAQUE VIRUS THAT YIELDED BOTH LARGE AND SHALLPLAGUES AND THAT SHOWED A REDUCED CAPABILITY TOINFECT MICE WAS ALSO RECOVERED, THIS VIRUS WASDESIGNATED THE UNSTARLE SMALL OR SU TYPE BECAUSE ITDIFFERED FROM THE SS TYPE IN ITS HIGHER LEVEL OFVIRULENCE AND IN ITS PLAeUE-FORMING PROPERTIES*THUS, BASED UPON THE PROPERTIES OF VIRULENCE FORMICE AND PLAQUE SIZE, FOUR VIRAL TYPES COULD BEDISCERNED. THE EVIdENCE SUGGESTS THAT SERIALPASSAGE IN CELL CULTURE IMPOSED ENVIRONMENTALPRESSURES THAT SEQUENTIALLY SELECTED THE FOLLOWINGVIRAL TYPES: LSt LU, SUs AND SS (U)
30UNCLASSIFIED IZImBl
UNCL ASS IFIED
DOC REPORT RISLIOGRAPHY SEARCH CONTROL NO. IZIN91
FORT9 DETIC FREDERICK
PROPCRTIES OF VENEZUELAN EOVINI ENCEPHALOMYEVITIS UVIRUS GROWN IN vivol *
DEC 66 7P SOPERsILLIAN 7, IMEARN9HENRY J9 j JRI
UNCLASSIrIED REPORTAVAILABILITY1 PUBLISHED IN JOURNAL OF VIROLOGYvi N2 P46-00 JUN 1987.
DESCRIPTORS: toVENEZUELAN EQUINE ENCEPmALONVELIVISVIRUS, 0NVV ANALYSISj, GROWTH, TISSUECULTURE, MVICIE, VIAOILITYo $MAIN; SPLEEN.DISEASES fUl
ONE INTRACERESRAL PASSAGE OF EIThER T~4[ PARENT-EGGSEED iPESI OR AN ATTENUATED VARIANT itOT orTHE TRINIOAD SRIOFVENFZuELAN EQUINECENCEPHALOMYELITIS (VEEt VIRUS IN YOUNG ADULT MICEPRODUCED PROGENY THAT WERE NO LONGER DIFFERENT'IATEDUNEQIUIVOCALLY ON THE BASIS Of PLAQUE SIZE. PLAQUESAVERAGING ABOUT 2 MH IN DIAMETER, WHICH WAS SOMEWHATSMALLER THAN THOSE FORMED 9Y ?HE PES VIRUS ANDLARGER THAN THOSE OP THE lOT STRAIN, WERE FORMED BYBOTH STRAINS. SEVEN SERIAL PASSAGES OF THE PC$VIRUS IN MOUSE BRAIN FAILED TO ALTER ITS VIRULENCEAPPRECIABLY. IN CONTRAST. PASSAGE IN MOUSE BRAINPROGRESSIVELY CHANGED THE PROPERTIES of THEATTENUATED 10T STRAIN* A SUSSTRAIN WAS ISOLATEDTHAT POSSESSED VIRULENCE SIMILAR TO THAT OF THE PESVIRUS AND FORMED SMALL PLAQUES SIMILAR TO THOSE OFTHE lOT STRAIN. THESE FINDINGS SHOWED A UNIQUEDISSOCIATION BETWEEN THE PLAQUE SIZE AND VIRULENCE OFTHE lOT STRAIN. THE NEW SUSSvRAIN DIFFERED FROMTHE PES VIRUS AND THE JOT STRAIN IN ITS CAPACITYFOR GROWTH IN HOUSE TISSUES AFTER INTRAPCRJTONEALINOCULATION. THE SUBSTRAIN MULTIPLIED POORLY INSPLENIC TISSUE, WHICH SUPPORTS GROWTH OF THE PISAND 10T STRAINS, BUT GREW TO HIGH TITERS IN THEBRAIN, WHICH DOES NOT SUPPnRT APPRECIABLE GROWTH OFTHE JOT STRAIN. (AUTHOR) U
31
UNCL.ASSITIED /ZImgI
UNCLASSIFIED
DOC REPORT BIBLIOGRAPHY SEARCH CONTROL NO. /ZIMPI
£O-690 696 6/11FORT DETRICK FWEOERICK MO
PRIMARY vIRUS.CELL INTERACTIONS IN THEIMMUNOFLUORESCENCE ASSAY OF VENEZUELAN EQUINEENCEPHALOMYELITIS VIRUS, (U)
JAN 67 lOP HAHON,NICHOLAS ICOOKE,KENNETH O I
UNCLASSIFIED REPORTAVAILABILITY: PUBLISHED IN JOURNAL OF VIROLOGYVI N2 PIY7-26 APR 1967.
NESCRIPTORS: (*VENEZUELAN EQUINE ENCEPHALOMYELITISVIRUSt COUNTING METHOOS,, FLUORESCENCE; PH,TEMPLRATURE# BIOLOGICAL ASSAY, IMMUNE SERUMS,PENETRATION$ FLUORESCENT ANTIBODY TECHNIQUES (UL
THE CONDITIONS UNDER WHICH VENEZUELAN EQUINEENCEPHALOMYELITIS (VEE) VIRUS ATTACHED TO HOSTCELLS MARKEDLY INFLUENCED THE ASSAY OF VIRUS BY THEFLUORESCENT CELL-COUNTING TECHNIQUE, WHEN VIRUSINOCULUM WAS CENTRIFUGED ONTO MCCOY CELLMONOLAYERS, APPROXIMATELY 974 MF VIRUS WAS ATTACHEDTO CELLS WITHIN 10 MIN; IN CONTRAST TO 34S AFTERSTATIONARY INCUBATION AT 35 C FOR 2 MR* MAXIMALBINDING OF VIRUS OCCURRED ONLY IN THE PRESENCE OF 01TO O.IS M NACL. THIS SALT REQUIREMENT; ADDEDTO EVIDENCE OF PH DEPENDENCE AND TEMPERATUREINDEPENDENCE OF VEF VIRUS ATTACHMENT TO CELLS,INnICATED THAT THE INITIAL UNION INVOLVEDELECTROSTATIC FORCES. VIRUS PENETRATION, MEASUREDMY THE INSENSITIVITY OF VIRUS-CELL COMPLEXES TO VIRALANTISERUM, WAS COMPLETE IN 20 MIN AT 39 C. THEPROCESS WAS TEMPERATURE.DEPENDENT AND UNAFFECTED BYTHE IONIC CONTENT OF MEDIUM. FOR ASSAY OF VEEVIRUS sY THE FLUORESCENT CELL-COUNTING TECHNIQUE#INFECTED CELLS MAY BE ENUMERATED AS EARLY AS 12 HRAFTER INFECTION OF CELL MONULAYERS, THERELATIONSHIP BrTWEEN VIRUS CONCENTRATION AND CELL-INFECTING UNITS WAS LINEAR; THE DISTRIBUTION OFFLUORESCENT CELLS WAS RAHOOM. THE VIRUS ASSAY WASEQUIVALENT IN SENSITIVITY BUT MORE PRECISE AND RAPIDTHAN THAT OF INTRACEREBRAL INOCULATION OF MICE.(AUTHOR) (U)
32UNCLASSIFIED /Z1M19
UNCLASSIFIED
DDC REPORT RIBLIOGRAPHY SEARCH CONTROL NO* IZIMO!
AD-697 50O 6/I 4/11ARMY MEDICAL UNIT F4EDERICK NO
MOSQUITO-INDUCED INFECTION WITH EQUINEENCEPHALONVELITIS VIRUS IN DOGS, (U)
67 qP *IVIN,0. So IBARRYtC, IHOGGE9A, Lo , JR*;CQRRISTANsE C. I
UNCLASSIFIED REPORTAVAILABILITY1 PUALISMED IN AMERICAN JOURNAL OFTROPICAL MEDICINE AND HYGIENE V16 N* P544-7 1967o
MESCRIPTORS; (*VENEZUELAN EQUINE ENCEPHALOMYELITISVIRUS, oISEASES)o AEGESt INFECTIONSe COGS,ANTIGENS * ANTIBODIES* SERO.DIAGNOSIS fU)
DOGS INFECTEO WITH VENEZUELAN EQUINEgNCEPHALOHYELITIS VIRUS VIA THE SITE OF INFECTEDAEDES TRISERIATUS RESPONOEO WITH FEVER ANDHEMAGGLUTINATION-INHIBITING ANTIBODIES* EVENTHOUGH HIGH TEMPERATURES OER'ELICITED IN 14 OF THEANIMALS, IN ONLY SEVEN DID VIREHIA DEVELOP ABOVE 1OTO THE 2.1 POWER MOUSE INTRAPERITONEAL MEDIAN LETHALDOSE 00 PER ML. SUFFICIENT QUANTITIES OFMOSQUITOES WERE INFECTED FROM THE DOGS TO PERMITPASSAGE OF THE VIRUS ON to GUINEA PIGS, THERE WERENO OTHER CLINICAL SIGNS OF ILLNESS OBSERVED IN THEANIMALS# (AUTHOR) (U)
33UNCLASSIFIED lZiHSi
UNCLASSIFIED
DOC REPORT BIBLIOGRAPHY SEARCH CONTROL NO. lZIM91
AD-697 689 6#/ 4/) 4/s1FORT OETRICK FREDERICK MO
EFFECT OF APHOLATE AND METEPA ON AIDES AEGYPTIINFECTED WITH VENEZUELAN EQUINE ENCEPWALOMYELITISVIRUS. U)I
67 6P KAPPUS;KARL D# |CORRISTANoEDWIN c. I
UNCLASSIFIED REPORTAVAILABILITY? PUBLISHED IN AMERICAN JOURNAL OFTROPICAL MEDICINE AND HYGIENE V16 14 PP;9o*2 1967.
MESCRIPTORS? (,AEOES, sINSECT CONTROL), VIRUSDISEASESt DISEASE VECTORS, VENEZUELAN EQUINEENCEPHALOMYELITIS VIRUS: REPRODUCTIONIPHYSIOLOGY),INHIBITION, ENTOMOLOGY, VIABILITY, EGGS fUl
IDENTIFIERS: CHEMOSTERILANTS cUl
GROUPS OF AEDES AEGYPTI FEMALE MOSQUITOES WEREFED 0,25 AND 0029$ CONCENTRATIONS OF APHOLATE ANDMETEPA, FOUR DAYS LATER THEY WERE rED A SOLUTIONCONTAINING VEE VIRUS AND SWEETENED BLOOD. MALEMOSIUITOES WERE INTRODUCED ALSO AT THIS TIME,TREATMENT WITH THE O025S CONCENTRATIONS OF EITHERSTERILIZING AGENT COMPLETELY INHIBITED OVIPOSITION,BOTH THE TOTAL NUMBER OF EGGS AND THE PERCENTAGE OFVIAbLE EGGS IN THE GROUPS TREATED WITH 0.0299CONCENTRATIONS WERE A FRACTION OF THOSE DEPOSITED SYTHE UNTREATEn GROUPS* MORTALITY IN THE TREATEDVECTORS, ESPFCIALLY THOSE GIVEN THE 0.25SCONCENTRATIONS, WAS HIGHER THAN THAT IN THE UNTREATEDMOSQUITOES. THE LOWER CONCENTRATIONS OP
STERILIZING AGENTS HAD NO DEMONSTRABLE EFFECTS ON THESUSCPPTIBILITy OF THE VECTORS TO VEE VIRUS OR ONSUBSE011ENT TRANSMISSION OF THE VIRUS.SUSCEPTIBILITY TO VIRUS INFECTION AND THE ABILITYTO TRANSMIT THF DISEASE WERE SIGNIFICANTLY INFLUENCED8Y THE HIGWER CONCENTRATIONS OF BOTH COMPOUNDS.THE RESULTS SUGGEST THAT OTHER MOSQUITO VECTOR.ARqOVIRUS COMBINATIONS COULD DEMONSTRATE SIMILAR ORINCREASED POTENTIALS* (AUTHOR) (U)
34UNCLASSIFIED /ZIMPl
UNCLASSIFIED
DOC REPORT BIBLIOGRAPHY SEARCH CONTROL NO* /ZIMPI
AD-464 203 6/1; 4/18PORT DETRICK FREDERICK NO
IiIINACTIVATION Of VENEZUELAN EQUINE ENCEPHALOMYCLIT|S
VIRUS BY GAMMAwRADIATION,
JUL 47 %P REITMAN;MORTON |TRIBBLEeHENRY Re 9 JR;
UNCLASSIPIED REPORTAVAILABILITY: PUBLISHED IN APPLIED MICROBIOLO0YV19 N& P14P9- 9 NOV 1967.
flESCRIPTORS; (*VENEZUELAN EQUINE ENCEPHALOMYELITISVIRUS, *RADIATION E9FECTS), VIABILITY, TISSUECULTURE# GAMMA RAYS, RADOILOGICAL DOSAGE, LETHALDOSAGE, ANTIGENS * ANTIBODIES (U)
EXPOSURE Of VENEZUELAN EQUINE FNCEPHALOMYELITIS(VEE) VIRUS (AT -7MC) TO 6,000,000 R GAMMA-RADIATION C60CO) RESULTED !N LOSS Of LETHALITYFOR YOUNG ADULT MICE AND GUINEA PIGS, AND LOSS OfCAPACITY To PRODUCE PLAQUES OR CYTOPA741C EFFECTS INTISSUE CULTURE. THE SUCKLING MOUSE WAS MORESENSITIVE FOR DETECTING LIVE VIRUS IN RADIATEDSUSPENSIONS THAN WAS THE ADULT MOUSE OR GUINEA PIG.LIVE VIRUS WAS DEMONSTRABLE IN PREPARATIONS EXPOSEDTO 4,000,000 R BUT NOT IN SUSPENSIONS EXPOSED TO of000,000 R AND MORE. THE RATE OF INACTIVATION OPVEE VIRUS BY GAMMAoRADIATION WAS AN EXPONENTIALFUNCTION OF THE DOSAGE. (AUTHORi (U)
35
UNCLASSIFIED /ZIMPI
IUNCLASSIFIED
DOC RFPORT RIBLIOGRAPHY SEARCH CONTROL NO, JZIMI
AO-664 223 601V 6/9
A•t ~MEVI.AL UNIT iNLOERTCK MO
LIVE, ATTENUATED VENEZUELAN CQUINE INCEPHALOQYFLITISVIRUS VACCINE, It* WHOLC-HLOOD AMINO-ACID ANDFLUORESCENT-ANTIBOOY STUDIES FOLLOWING IMMUNIZATION;
67 lOp FEIGNRALPH Do IJAEGER,ROBERT F. IMCKINNEYpRONERT We IALEVIZATOS,ARISTIDES C. o
UNCLASSIFIED REPORTAVAILABILITY: PUBLISHED IN AMERICAN JOURNAL OfTROPICAL MEDICINE AND HYGIENE V14 N6 P76917? 1967.
MESCRIPTnRS; (*VENEZU'LAN EQUINE ENCEPHALOMYELITISVIRUS, *VACCINES), AMiNO ACIPS, FLUORESCENTANTIBODY TECHNIQUES, IMMUNITY; ATTENUATION,SCRODIAGNOSIS, DIURNAL VARIATIONSe STATISTICALANALYSIS (U)
REPRINT: LIVE, ATTENUATED VENEZUELAN EQUINE
ENCEPHALOMYELITIS VIRUS VACCINE, Ile WHOLE-BLOODAMINO-ACID AND rLUORESCENT.ANTISODY STUDIES FOLLOWINGIMMUNIZATION,
36
UNCLASSIFIED IMP1
I
UNCLASSIFIED
DOC REPORT RIBLIO4RAPHY SEARCH CONTROL NO. IZIMSg
ADo466 862 6l, 6/14ARMY MEDICAL UNIT FREDERICK MD
EARLY ALTERATIONS |4 THYROID HORMONE PHYSiOLOGYDURING ACUTE INFECTION IN MAN. (U)
fESCRIPTIVE NOTES REVISED EO.,
AUG 67 7P SHAMIAUGHOGEORGE to , 1I1lSEISEL;,ILLIAM R- I
UNCLASSIFIED REPORTAVAILABILITY? PUBLISHED IN JOURNAL OP CLINICALENDOCRINOLOGY AND METABOLISM V77 NI2 P1667972 DCC1967.
SUPPLEMENTARY NOTEI REVISION Of MANUSCRIPT RECEIVED 12APR 67.
MESCRIPTORSI (THYROID HORMONES; *INFECTIOUSDISEASES)* PASTEURELLA TULARENSIS, VENEZUELANEQUINE ENCEPHALOMYELITIS VIRUS, THYROXINE, DISEASES,FEVERS; BLOOD pROTEINS, DEGRADATION, RESPONSES,VACCINES (U)
IDENTIFIERS: PROTEINOBOUNO IODINE tU)
CERTAIN ASPECTS OF PERIPHERAL THYROID HORMONEPHYSIOLOGY WERE MCASURED SEQUENTIALLY !N SUBJECTSEXPOSED TO PASTEURELLA TULARENSIS OR VACCINATEDWITH A LIVING ATTENUATED STRAIN OF VENEZUELANEQUINE ENCEPHALOMYELITIS (VEE) VIRUS. IN BOTH
GROUPS A SIGNIFICANT RISE IN THE PER CENT OF UNBOUNDTHYROXINE (P(O#00I WAS OBSERVED WITHIN 24 HRFOLLOWING EXPOSURE TO THE INFECTING AGENT. ANINTERPRETATION Of THESE OBSERVATICNS WAS ADVANCED
THROUGH A HYPOTHESIS WHICH INCLUDED 4 DISTINCTSEQUENTIAL CHANGES: (I) A OECRFASE IN THYROXINEBINDING BY SERUM PROTEINS AND AN ASSOCIATED INCREASEIN THYROID HORMONE UTILIZATION OR DEGRADATIONI(2) A DELAY IN THYROID GLAND RESPONSE TO THESEEARLY CHANGES IN PERIPHERAL THYROID HORMONES FOLLOWEDBY (7) A LATE RISE IN THE POT FOLLOWINC THE
INSTITUTION OF THERAPY AND ONSET OF RECOVERYI AND
(4) A FINAL RETURN OF THE P8I AND BINDINGALTERATIONS TO A NORMAL EQUILIBRI14M MATE SIMILAR TO
THE PREINFECTION CONTROL, ALTHOUGH THESE CHANGESAPPEARED TO PE NONSPECIFIC FOR UFECTION PER SE, ACONCEPT OF DYNAM!C ALTERATIONS IN PERIPHERAL THYROIDHORMONE PHYSIOLOGY DURING INFECTION MIGHT SERVE TO
CONSOLIDATE PREVIOUS CONCEPTS DERIVED FROMNONSEQUENTIAL OBSERVATtONS, (&UTHORI (U)
37UNCLASSIFIED /71M,3i
UNCLASSIFIED
DOC REPORT BIBLIOGRAPHY SEARCH CONTROL NU. /ZiMI4!
AD-669 2)6 6/q 6/12ARMY MEDICAL UNIT FREDERICK MO
LIVE, ATTENUATED VENEZUELAN EQUImE ENCEPMALUMYtLITISVIRUS VACCINE* to CLINICAL EFFECTS IN MAN, (U)
67 ap ALEVIZATOSARISTIOES CsMCKINNEYROBERT We ;FEIGINRALPH Do I
UNCLASSIFIED REPORTAVAILABILITY: PUBLISHED IN AeERICAN JOURNAL OFTROPICAL MEDICINE AND HYGIENE, V16 N6 P762-I 1967,
DESCRIPTORS: (*VENE7UELAN EQUINE ENCEPHALOMYELITISVIRUS, *VACCINES), ATTENUATION, VIABILITY,It':'ITYt SERODAA6NMSIS, ANIGEN-ANTIRODYREACTIONS, ELECTROCARDIOGRAPHYtELECTROENCEPHALOGRAPHY, BLOOD DISEASES, RESPONSES (U)
FORTY YOUNG MEN WEPE tNOCULATED WITH LIVE,ATTENUATED VEE VIRi)S VACCINE, ANDj AS EVIDENCED BYA SIGNIFICANT INCREASE IN HEMAGGLUTINATION-INHIBITIN6AtfTlBOrý TITERS, ALL WERE INFECTED@ HOWEVER,VIREMIA WAS DEMONSTRATED IN ONLY Pe. THE LEVEL OFVIREMIA WAS LOW, VARIED WITH TIME, ANO OCCURRED
BETWEEN 60 HOURS AP'D 12 DAYS AFTER VACCINATION*ALL SUBJECTS WERE FVAUATED CLOSELY FROM CLINICAL,LASORATORY, VIROLOAIC, AND SEROLOGIC STANDPOINTS,SOME DEGREE OF REACTION WAS SEEN IN 377#0 OFTHESE PERSONS. IOS OF THEM HAVING A 1+ REACTION,OF A POSSIBLE 4*4 VIREMIA WAS DEMONSTRATED IN32gst. TRANSIENT ELECTROCARDIOGRAPHICABNORMALITIES WERE NOTED IN 47*,02 AN '405 HADTRANSIENT LEUKOPENIA, EIGHT MEN FOLLOWrD NITHDAILY ELECTROENCEPNALoGRAPHIC TRACINGS DEMONSTRATEDNO SIGNIFICANT CHANIGE SUBSEQGIENT TO VACCINATION*THERE WAS NO CONSISTENT POSITIVE OR NEGATIVECORRELATION BETWEEN ANY OF THESE RESPONSES ORCOMBINATION OF RESPONSES, (AUTHOR) (U)
38UNCLASSIFIED /ZIM5t
UNCLA5SIFIED
DOC REPORT BIBLIOGRAPHY SEARCH CONTROL NO, /ZIM51
AO-672 469 6/13 6/5CALIFORNIA UNIV OAKLAND NAVAL BInLOGICAL ,AH
THE PATHOGENICITY IN MICE OF AEROSOLS OFENCEPHALONVOCARDITIS GROUP VIRUSS OR TH~iRINFECTIOUS NUCLEIC ACIDS, (U)
48 aP AKERSpTo Go IMADINpS. He;SCRAFPERe,7 Lo I
UNCLASSIFIED REPORTAVAILABILITY: PUB. IN JNLs OF IMMUNOLOGY, VIO0 NIP120-127 1966o
DESCRIPTORS: (OENTEPOV|RUSES9 AEROSOLS)lIMMUNITY, RIBONUCLEIC ACIDS, BIOLOGICAL ASSAY,HISTOLOGY, PATHOLOGY, MICE (U)
IOENTIFIERS!: EN(EPMALOMYOCAROITIS VIRUSES, MENGOVIRUS (U)
WHEN MICE WORE EXPOSED To AEROSOLS OF nIFFERENTSTRAINS OF THE ENCEPHALOMYOCAROITIS VIRUS GROUP ORMENGO RNA, THE OBSERVED DIrFERENCES INPATHOGENICITY WERE CORRELATED WITH PLAGUE SIZE, STATEOF THE VIRUS 4INTACT OR RNA) AND THE PRESENCE ORABSENCE OF CIRCULATING ANTIBODIES@ NITH AERUSOLSOF HENGO-.7A, A SMALL PLAOUEwFORMING IMMUNOGENICSTRAIN, VIRUS WAS RECOVERED FROM THE LIUNGS,INTESTINESt SPLEEN, LIVER AND BLOOD. PATHOLOGICCHANGES OCCURRED IN THE LUNGS AND HEART, NICEEXPOSED TO LETHAL AEROSOLS OF MENGO MR COL-SK(LARGE PLAQUE-FORMING STRAINS) YIELDED VIRUS FROMEVERY ORGAN* HOWEVER, WITH LETHAL MENGn RNAAEROSOLS THERE WAS A DELAYED APPEARANCE OF VIRUS INTHE INTESTINAL TRACT* MICE EXPOSED TO LETHALMENGO RNA, COL-SK AND MENGO VIRUS AEROSOLSEXHIBITED SIMILAR PATHOLOGIC CHANGES, WHICH OCCURREoONLY IN BRAIN AND LIVER TISSUES. CHALLENGE WITHLETHAL COLuSK OR MrNGO AEROSOLS RESULTFD IN NODEATHS OF MENGO-37A IMMUNIZED MICE. HOWLVER,CHALLENGE VIRUS WAS RECOVERED FROM THE LUNGS,INTESTINAL 'RACT, SPLEEN, LIVER AND BLOOD,PATHOLOGIC CHANGES WERE ALSO OBSERVED IN LUNG ANDLIVER TISSUES. RNA AEROSOL EXPOSURE OF MICEIMMUNIZED WITH MENGO-77A RESULTED IN VIRUS BEINGISOLATED FROM LUNG TISSUE ONLY. (AUTHOR) (U)
39UNCLASSIFIED /ZIM5!
UNCLASSIFIED
DDC REPORT BIBLIOGRApHY SEARCH CONTROL NO, /Z!Mo3
AD-671 207 6/sARMY BIOLOGICAL LAPS rREOERICK fmr
THE CLINIC OF VENEZUELAN EQUINE ENCEPHALOMYELITIS IN
JUL 68 12P ALEKSEEVAIAo A* ;LEBEDEVA,N. V. iOUBNYAKOVAtlo, Me ;
REPT. NO. TRANSeq22
UNCLASSIFIED REPORT
SUPPLEMENTARY NOTE: TRANS. OF ZHURNAL NFVROPATOLOGII IPSIKHIATRI? (USSRi V%9 N; P)1--)2o 1959,
DE!CRIPTORS: (oVENEZUELAN EQUINE ENCEPHALOMYELITISVIRUS, VIRUS DISEASFSIK EPIDEMIOLOGY# DIAGNOSIS,HEMATOLOGY, BLOOD COUNTS, ANTIBIOTICS*CHEMOTHERAPY, USSR fU)
IDENTIFIERS: CLINICAL SYMPTOMS, TRANSLATIONS lU)
TWENTYvTWO VENEZUELAN EQUINE ENCEPHALOMYELITISPATIENTS (TWENTY FEMALES AND TWO MALES) WEREEXAMINED. OF THESE, TWENTY WERE SITUATED IN THECLINIC OF THE VIROLOGY INSTITUTE, AND TWO WEREEXAMINED AMBULATORILY. THE PATIENTS WERE OBSERVEDBOTH IN THE ACUTE PERIOD OF THE oISEASF AND IN THEPERIOD OF CONVALESCENCE. FROM THE FIRST DAYS OFTHE SICKNESS THE CLINICAL PICTURE CORRESPONDED TOTHAT OF AN ACUTE NEUROINFECTION. SUBSEQUENTLY THEEPIDEMIOLOGICAL AND PARTICULARLY LABORATORY DATACONFIRMED THE DIAGNJOS I S; THE TYPE OF CAUSATIVE AGENT*AS ESTABLISHED. IN THE VIROLOG!CAL INVESTIGATIONSTHE VENrZUELAN ENCFPHALOMYELITIS VIRUS WAS ISOLATEDFROM THE NASOPHARYFx WASHINGS OF FIVE eF THEPATIENTS; IN TWO IT WAS ISOLATED FROM THE BLOOD; ANDIN ONE IT WAS ISOLATED FROM THE BLOOD AND FROM THEWASHING SIMULTANEOt'SLY. (AUTHOR) cu)
40
LUNCLASSIFIED /ZlIM5
UNCLASSIFIED
DOC REPORT BIBLIOqRApHY SEARCH CONTROL NO. /ZIM5J
A0-677 210 6/131A!!M Z:QLC ;CAL L~ii rRLvEMLtK moTHE UTILIZATION OF TISSUE CULTURES FOR PRODUC•TIO OF
VACCINES AGAINST VENEZUELAN AND AMERICAN WESTERN
EQUINE ENCEPmALOMYELITtS VIRUSES, (U)
JUL 68 I1fP KAVERINtNN V. IREPT* NO* TRANSm04o
UNCLASSIFIED REPORT
SUPPLEMENTARY NOTE: TRANS, OF VOFROSY VTRUSOLOGII(USSRp V6 N2 PI56-IAO 1961, BY ELDON Es EWING.
DESCRIPTORS: (*EQUINE ENCEPHALOMYELITIS VIRUS,VACCINES), TISSUE ClILTURE, ANTIGENS +ANTIBODIES, WESTERN EQUINE ENCEPHALOMYELITIS VIRUS,VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS, USSR (U)IDENTIFIERS: TRANSLATIONS IU)
THE AMERICAN WESTEqN AND VENEZUELAN EQUINEENCEPHALOMYELITIS VIRUSES ACCUMULATE IN CULTURALFLUID IN HIGH TITERS1 WITH THE USE Or A PROTEIN-rREEMEDIUM, HOWEVER, THE VIRAL TITER SOON CROPS SHARPLY,IT FOLLOWS, THEREFORE: TO USE A CULTURAL FLUID THATHAS BEEN COLLECTED WITHIN 24 HOURS AFTFR INOCULATIONFOR THE PRODUCTION OF VACCINE* THE CULTURALFORMALINIZED VACCItNES AGAINST THE AMERICAN WESTERNAND VENEZUELAN EQUtNE ENCEPHALOMYELITIS VIRUSESCAUSE THE APPEARANCE OF VIRUS-NEUTRALIZING ANTIBODIESIN THE SERA OF VACCINATED ANIMALS AND PROTECT MICEFROM THE DISEASE WHEN THEY ARE GIVEN ANINTRAPERITONEAL INJECTION OF UP TO IOD0OOO LDSOOF THE VIRUS, THUS PROVING THEMSELVES TO BE HIGHLYIMMUNOGENIC PREPARATIONS. (AUTHOR) (U)
41UNCLASSIFIED /ZIM5I
UNCLASSIFIED
DOC REPORT BIBLIOGRApHY SEARCH CONTROL NO. /Z1Mo5
AD-672 203 61o)
ARMY BIOLOGICIkL LAPS FREDERICK MD IVIROLOICAL 51'UOY 'r LABORATORY INFECTIONS •TTHVENEZUELAN EQUINE ENCEPHALGMYCLITIS, (U)
JUL 6B 9P SHUBLADZEA. K. IGAIDANOVICHSb YA. ;GAVRILOVoV* 1, .
REPTo NO. TRANS-4Oq
UNCLASSIFIED REPORT
SUPPLEMENTARY NOTE: TRANS. OF VOPROSY VIRUSOLOGII4USSR) V4 N3 P20-w)io 19.90
DESCRIPTORS: (*VENEZUELAN EQUINE ENCEPHALOMYELITISVIRUS, INFECTIONS , SERODIAGNOSIS, TISSUECULTURE, IMMUNE S6RUNS, ANTIGENS * ANTIsODIES,
MEDICAL TECHNICIANS, USSR (U)IDENTIFIERS: TRANSLATIONS (U)
VIROLOGICAL AND SEROLOGICAL EXAMINATIONS WERE
CONDUCTED ON 62 PEnPLEt THE PATIENTS WITHVENEZUELAN EQUINE ENCEPHALOMYELITIS, THE PERSONSWHO HAD BEEN IN COtfTACT WITH THE PATIENTS, AND THOSE
HAVING WORKED WITH THE INDICATED VIRUS* THIRTY-SIXPERSONS WERE EXAMINED BY SEROLOGICAL AND VIROLOGICALMETHODS, AND 27 WEQE EXAMINED BY SEROLOGICAL METHODSALONE, ISOLATION OF THE vIRUS WAS CONDUCTED ONWHITE MICE AND CHICK EMBRYOS. FROM THE 36 PERSONSa7 DIFFERENT SAMPLES OF BLOOD, MOUTH WASHING%, URINEAND FECES WERE EXAMINED FOR THE VIRUS. THE VIRUSWAS DETECTED IN EIGHT PATIENTS ON THE 2"6TH DAY OFTHE DISEASE. THREE STRAINS WERE ISOLATED FROM THEBLOOD, AND SIX STRAINS FROM THE MOUTH WASHINGS. INTHE NEUTRALIZATION TEST 99 BLOOD SERA, TAKEN FROM 63PERSONS, WERE EXAMINED. THE RLOOD SERA FROM THECONVALESCENTS WERE INVESTIGATED DYNAMICALLY 2-3TIMES. ANTISODIES TO THE VENFZUELAN EQUINEENCEPHALOMYELITIS VIRUS WERE OBSERVED IN TWENTYPERSONS, WITH WHICH ALL OF THEM ENDURED THE OISEASE.
THERE WERE NO CASES OBSERVED OF AN ASYmPTOMATICCOURSE OF THE INFECTION IN THOSE PERSONS HAVING HAD
CONTACT WITH THE PATIENTS# OR IN THOSE HAVING WORKEDWITH THE VIRUS. ANTIBODIES WERE DETECTFU IN THECONVALESCENTS IN A SUFFICIENTLY HIGH TITER BY THE IU-12TH DAY OF THE ILLNESS, AS A RESULT OF COMPLEXVIROLOGICAL AND SEPOLOGICAL INVESTIGATIONS ADIAGNOSIS OF VENEZUELAN ENCEPHALITIS WAS CONFIRMEDIN TOENTY PERSONS. (AUTHOR) fUl
42UNCLASSIFIlED /! 11451
UNCLASSIFIED
DOC REPORT BIBLIOnRApHY SEARCH CONTROL NO. /ZIMSI
ARMY BIOLOGICAL LAOS FREDERICK MO
EPIOEMIOLOGICAL STUDY OF A LABORATORY INFECTION *ITHTHE VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS, (U)
JUL 6S 7P SLEPUSHKINA, N. I
REPT* NO* TRANS-o?07
UNCLASSIFIEO REPORT
SUPPLEMENTARY NOTE: TRANS. OF VOPROSY VIRUSOLOGII(USSR) Vq N2 Pl-lmlq 1959,
DESCRIPTORS: fEVCNEzU[LAN EQUINE ENCEPHALONYELITISVIRUS, INFECTIONS), EPIOHEIOLOGY, MEDICALTECHNICIANS, VIRUS DISgASESt ACCIDENTS, bIOLOGICALLABORATORIES, USSR (U)
IOENTIFIERS: TRANSLATIONS (U)
THE RESULTS OF AN ACCIDENT WIiCH CAUSED THESICKNESS OF MORE THAN TWENTY LABORATORY WORKERS VASINVESTIGATED. AS A RESULT OF THE CARELESSNESS OF ALABORATORY WORKER, NINE AMPOULES CONTAINING Do$MILLILITER EACH OF A FIVE*PER CENT BRAIN SUSPENSIONFROM MICE INFECTED WITH THE VENEZUELAN EQUINFENCEPHALOMYELITIS VIRUS WERE BROKEN. (U)
43UNCLASSIFIED lZIMSI
UNCLASSIFIED
DOC REPORT BIBLIOeRApHY SEARCm CONTROL NO. /ZIM51
FORT DETRICK FREDERICK ND
ANTIBODY RESPONSES IN RHESUS MONKEYS EXPOSED TO
WHOLE-BODY X.IRRADTATiONb (U)
0EC 67 7P REYNOLDSsSCOTT Le ;CRAIG,CHARLES Po iWHITFOPDHOWARD We IAIRHARTJIM ISTAABEDWARO V. ;
UNCLASSIFIED REPORTAVAILABILITY: PUB. IN RADIATION RESEARCH, VIS N2Pq4l9o57 AUG 680
DESCRIPTORS: ioANTIGENS * ANTIBODIES, RADIATIONEFFECTS), MONKEYS, AGGLUTININS, INHIBITION,RADIOLOGICAL DOSAGE, VACCINES, IMMUNITY, WHOLEBODY IRRADIATION, VENEZUELAN EQUINE ENCEPHALOMYELITIS
VIRUS, BLOOD SERUM (U)
NEUTRALIZING AND HI ANTIBODIES WERE MEASURED IN
CONTROL AND SHORT-TERM NEAR-LETHALLY IRRADIAT•ORHESUS MONKEYS VACCINATED WITH ATTENUATED VEE VIRUSVACCINE. SIGNIFICANTLy LOWER Ht ANTIRODY TITERS
IN IRRADIATED ANIMALS WERE OBSERVED 14 AND 21 DAySAFTER VACCINATION, AS COMPARED TO THOSE IN THE
NONIRRADIATEO CONTOOLSo NEUTRALIZING ANTIBODYTITERS WERE LOWER 4T I1 DAYS BUT BY DAY 28 HAGATTAINED LEVELS COMPARABLE TO CONTROL VALUES. NODIFFERENCE WAS MEASURED IN HI ANTIBODY TITERSBETWEEN IRRADIATED AND NONINRADIATED CnNTROLS BY DAY42. 4AUTHOR) (U)
44tUNCLASSIrIED /71mol
UNCLASSIFIED
CDC REPORT BIBLIOnRAPHY SEARCH CONTROL NO. /ZIMq5j
IIARMy BIOLOGICAL LARS FREDERICK MD
NEUTRALIZATION REACTION OF THE VENJEZUELANENCEPHALOMYELITIS VIRUS BASED ON THE HFMAGGLUTINATIONPHENOMENON,
UDEC 66 Bp GIAOIHs ~
VAGZMANOVAV. A, I GIAOI~S A
REPT. NO. TRANS-22~~ 4
UNCLASSIFIED REPORT
SUPPLEMENTARY NOTE: TRANS. OF VOPROSy VIRUSOLOGIItUSSR) VI N3 P271-274 1996, By CHARLES To OSTFRTAG#
DESCRIPTORS: (0 VENE7UELAN EQUINE ENCEPHALOMYELITz%VIRUS, ANTIGEN-ANTIP06Y REACTIONS),NEUTRALIZATION, IMMU1NE SERUMS, TISSUE CULTURE,SERODIAGNOSIS, USSRjIDENTtIFERS: TRANSLATIONS
(U)THE NEUTRALIZATION REACTION OF THE VENEZUELANEQUINE ENCEPHALOMYFLITIS VIRUS IN~ TISSujE CULTURES,BASED ON THE PHENOMENON OF HEMAGr.LUTINATION@ MAKES ITPOSSIBLE TO OBTAIN RESULTS IN 18 HOURS INSTEAD OF THF72 HOURS REQUIREO rOR AN EVALUATION BASED ON THECYTOPATMOLOGICAL EFFECT* WHEN INYIESTIGATING THESERA OF CONVALESCEpirs IN THE NEUTRALIZATION REACTIONIN TISSUE CULTURES,' PRACTICALLY THE SAME RESULTS AREOBTAINED DURING EVALUATION BY BOTH METHODS. THEIMMUNE SERA Of RA81ITS GAVE SIGNIFICANTLY HIGHERNEUTRALIZATION INDICES WHEN EVALUATED ACCORDING TOHEMAGGLUTINATION, COMPLEMENTwFIXING ANTIBODIES INTITERS OF 1-Ii WERE STILL DETECTE!, IN THESERA OF CONVALESCENTS S YEARS FOLLOWING ILLNESS.(AUTHOR)
(U)
UNCLASSIFIED /ZIH9I
UNCLASSIFIED
DOC REPORT BIBLIOGRAPHY SEARCH CONTROL NO, /ZIM51
AD.&a2 sa. 114ARMY BIOLOGICAL LARS FREDERICK MD
iNFE•|OUS ENCEPmALOMYELITISt (U)
JUL 48 447P LEKAREVAV. Me IREPT. NO* TRANS-421
UNCLASSIFIED REPORT
SUPPLEMENTARY NOTE: EXTRACT TRANS. OF MONO, INFECTIOUSAND INVA1IVE DISEASES OF HORSES, MOSCOW, 199' P269-290.
DESCRIPTORS: (*ARBOVIRuSES, DISEASES),46OISEASESt EQUINES?, INFECTIONS, CENTRALNERVOUS SYSTEMt ETInLOGY, PATHOLOGYtCELLSBIOLOGY), CELL STRUCTURE, HISTOLO(Y,EPIDEMIOLOGY, MORTALITY RATES, THERAPY,VACCINES, USSR (U)
IDENTIFIERS: ENCEPHALOMYELITIS1 TRANSLATIONS (U)
INFECTIOUS-ENCEPHALOMYELITIS (IEM) OF t4ORSES ISAN ACUTE INFECTIoUI DISEASE. IT IS CAUSED BY ANEUROTROPIC FILTERABLE VIRUS AND IS ACCOMPANIED BY ADISRUPTION OF THE ACTIVITY OF THE NERVOUS SYSTEM,JAUNDICE OF THE MUCOUS MEMBRANES AND WITH ADISTINCTLY EXPRESSED PARESIS OF THE GASTRO-INTESTINALTRACT# THIS ILLNESS IS OBSERVED AS AN ENZOOTIC OFSPORADIC CASES AND VERY SELDOM AS AN EPIZOOTIC.iAUTHOR) fU)
46UNCLASSIFIED /ZIM51
UNCLASSIFIEO
DOC REPORT BIBLIOGRAPHY SEARCH CONTROL NO* /Z!M51
AUOUbi '66 6f . 6f
ARMY BIOLOGICAL LABS FREDERICK MD
THE EFFECT OF INTERFERON ON THE INHIRITION OFSYNTHESIS OF PROTEINS IN A CULTURE OF CHICK EMBRYOFIBROBLASTS INOCULATED WITH ARBOR VIRUSs (U)
FEB 69 7P KAVERINN, Ve IREPT. N0. TRANS0239P
UNCLASSIFIED REPORT
SUPPLEMENTARY NOTE: TRANS* OF ANTIBIOTIKI (USSR) VIiNI P28w;I 1946.
DESCRIPTORS: (*ARBOVIRUSESs ANTIMLTABOLITES)oINHIBITIONt BIOSYNTHESISo PROTEINS,CELLSIBIOLOGY), INFECTIONS, VENEZUELAN FQUINEENCEPHALOMYELITIS VIRUS, USSR lU)
IDENTIFIERS? oINTERFERON, TRANSLATIONS (u)
IN CHICK EMBRYO FIRROBLASTS INFECTED WITH THE VIRUSOF VENEZUELAN EQUISIE ENCEPHALITIS THE RATE OFPROTEIN SYNTHESIS FELL TO 20020s OF THE INITIALLEVEL WITHIN 2 HR AFTER INFECTION, IN CULTURESTREATED WITH HIGH CONCENTRATIONS OF INTERFERON ASUGSEQUENT INFECTIMN FAILED TO CAUSE A DECLINE OFPROTEIN SYNTHESIS NOT ONLY 3a4 BUT ALSO 24 HR AFTERINFECTION. THE CYTOPATHIC EFFECT EITHER DID NOTAPPEAR OR ELSE (AT AN INFECTION DENSITY OF 900 PFUPER CELL) DEVELOPEr ONLY TO A MINOR DEGREE.LOWER CONCENTRATIONS OF INTERFERON 112-|O UNITSPER ML) INHIBITED MULTIPLICATION OF THE VIRUS BUTDID NOT PREVENT THE DECLINE OF PROTEIN SYNTHESIS ANDTHE DEVELOPMENT OF THE CYTOPATHIC EFFECT.(AUTHOR) (U)
47
UNCLASSIFIED /ZtMg1
UNCLASSIFIED
DOC REPORT BIBLIOARApHY SEARCH CONTROL NO. /ZIMSI
AD-689 389 6/13ARMY BIOLOGICAL LAPS FREDERICK MO
PRODUCTION OF INTERFERON IV SOME ARBOR VIRUSES OFGROUP A,
FEB 69 lip KRSHOVF, It ITAZULKHOVA,E, B. ;KRMOLEVAoZ* V. I
REPT, NO* TRANS-2299
UNCLASSIFIED REPORT
SUPPLEMENTARY NOTE: TRANS. OF ANTIBIOTIVI (USSR) VIINI P132-g 1966.
DESCRIPTORS: (*GROUP A ARBOVIRUSLS, IMMUNITY),VENEZUELAN EQUINE ENCEPHALOMYCLITIS VIRUS, EASTERNEQUINE ENCEPHALOMYELITIS VIRUS, SEMIIKI VIRUS,INFECTIONS# VOLUMETPIC ANALYSIS, PROTEINS,CELLSBIOLOGYo ANTIBIOTICSo EMBRYONATED EGGTECHNIQUE, USSR (U)
IDENTIFIERS: *INTERFERON, TRANSLATIONS (U)
THE KEE# VEE AND SF VIRUSES RAPIDLY PRODUCEDINTERFERON IN CHICK EMRRYO FIBROULASTS. MAXIMALTITERS OF INTERFERON IN THE CULTURE FLUID WEREOBTAINED BY USING THE METHOD OF DOUBLE INFECTION OFTHE CELLS WITH THE PARTIALLY INACTIVATED FOLLOWED BYTHE INTACT VIRUS. (AUTHOR) (U)
48UNCLASSIFIED /ZIZmI
I
UNCLASSIFIED
DOC REPORT BIBLIOGRAPHY SEARCH CONTROL NO. /ZIM91
*D.G$• '901 6/11
ARMY BIOLOGICAL LARS FREDERICK Mo
REPRODUCTION OF VENEZUELAN EQUINE ENCEPHALOMYELITISVIRUS IN CHICK EMBPYO FIBROBLAST SUSPENISIONS, fu)
69 lip NOVOKHATSKIIA, So ;MISHIN#Lo No I
RtPT. NO. TRANS"2412
UNCLASSIFIED REPORT
SUPPLEMENTARY NOTE: TRANS. OF VOPROSY VIRUSOLOGIIIUSSRI VI; NO P966-914 19686
DESCRIPTORSI (OVENEZUELAN EQUINE ENCEPHALOMYELITISVIRUS, EMBRYONATED rGG TECHNIQUE),REPRODUCTION(PHYSIOLOGY), EFFECTIVENESS,INFECTIONS, CCLLSIBIOLOGY),CONCENTRATION(CHEMISTRylI TRYPSINt DESIGN,MORPHOLOGY(SIOLOGY), USSR (U)
IDENTIFIERS: TRANSLATIoNS (U)
THE UNIT FOR DEEP CULTIVATION CAN BE USEDSUCCESSFULLY FOR THE MULTIPLICATION OF VIRUSFS IN ASUSPENSION OF TRYPsINIZEO CELLS. IT WASDEMONSTRATED THAT THE EFFECTIVENESS OF REPRODUCTIONOF VIRUS IS DETERMINED BY THE MULTIPLICITY OFINFECTION, CONCENTRATION OF CELLS IN THE SUSPENSION,AND THE REGIMEN OF AERATION, OPTIMUM TECHNOLOGICALCONDITIONS HAVE BErN DEVELOPED FOR THE ACCELERATEDOBTAINING OF LARGE QUANTITIES OF A REPRESENTATIVE OFGROUP A ARBOVIRUSE5 - THE VEE VIRUS.
(AUTHOR) (U)
49UNCLASSIFIED Z1M91
UNCLASSIFIED
ODC REPORT BIBLIOCRApHy SEARCm CONTROL NO* /ZIM5|
FORT DETRICK FREDERICK MD
o-AZACYTIOINE AS A NUTAGEN FOR ARSOVIRUSES, (U)
JUN 68 3P HALLESIONEY I
UNCLASSIFIED REPORTAVAILABILITYt PUB. IN JNL9 OF VIROLOGY$ V2 NJVP1220-1229 OCT 68.
OESCRIPTORS: (*ARBOvIRUSES# *MUTATIONS),40TRIAZINES, MUTATIoNS), FURANSo VENEZUFLANEQUINE ENCEPHALOMYELITIS VIRUS, ESCHERICHIA COLIPNUCLEOSIDES
(u)IDENTIFIERSI MUTAGENIC AGENTS* *CyTIDINE/5,AZA (U
THIS REPORT DISCUSSES THE MUTAGEuIC EFFECT OF 5-AZACYTIDINE ON ARS8VIRUSES ESPECIALLY VENEZUELANEQUINE ENCEPHALOMY-LITSs
(Up
50UNCLASSIFIED
/ZIM5I
IUNCLASSIFIED D
DOC REPORT 8iBLIORApHY SEARCH CONIOL NO. /ZIMOI
AO4O06 4&0FORT DETRICK FREDERICK MO
THE KINETICS OF NLI]TRALIZATION OF VENEZUELAN EQUINEENCEPHALOMYELITIS VIRUS BY ANTISERUM AND THEREVERSIBILITY OF THE RFACTIONo (U)
JUL 6B 12P HAHONNo
UNCLASSIFIED REpORTAVAILABILITY: PUB* IN Js GENe VIROLt V4 P77-8I969,
DESCRIPTORS: (OVENEZUELAN EQUINE ENCEPHALOMYELITISVIRUS, NEUTRALIZATION); ImMUNE SERUMS, ANTIGENS* ANTIBODIES, TEMPEPATURE, DYNAMICS, PH,DISSOCIATION, CONCENTRATION(CHEMISTRY),CELLS(BIOLOGY) (U)
THE NEUTRALIZATION nF VENEZUELAN EQUINFENCEPHALOMYELITIS VIRUS FOLLOWED FIRST-ORDERKINETICSf WITH 1HE REACTION RATE DEPENDENT ON THEANTIBODY CONCENTRATION AND THE REACTION TEMPERATUREBUT INDEPENDENT OF PH AND VIRUS CONCENTRATIONWITHIN THE PRESCRIMED LIMITS, THE LINEARRELATIONSHIP OBTAINED BETWEEN THE NEUTRALIZATIONREACTION RATE CONSTANT (K) AND ANTISCRUM UIL'PTIOqSHOWE0 THAT K INCREASED FIVEFOLD FOR EACH TENFOLDDILUTION OF ANTISERUM, THE ENERGY OF ACTIVATION,CALCULATED FROM AN ARRHENIUS PLOT OF THE DATA, WASAPPROXIMATELY 9000 CAL-,MOLE OF VIRUS. EACH O0DEG, CHANGE IN TEMPERATURE 0QIO) ALTERED THE KVALUE BY A FACTOR OF 1,7# IN THE PRESENCE OFEXCESS ANTIBODY, A SMALL FRACTION OF VIRUS NESISTEDNEUTRALIZATION# NEIJTRALIZED VIRUS COULD NOT REAPPRECIABLY REACTIVATED BY SIMPLE DILUTION UNDERPHYSIOLOGICAL CONDITIONS BUT WAS DISSOCIATEO ATEITHER ACID OR ALKALINE PH VALUES. RE-NEUTRALIZATION OF VIRUS OCCURRED WHEN THEENVIRONMENTAL MEDIUM WAS ADJUSTLD TO NEUTRALITY,INDICATING THAT REACTIVATION WAS THE RFSULT OF
DISSOCIATION AND NOT DENATURATION@ NEUTRALIZEDVIRUS COULD RE ATTACHED TO CELL MONOLAYERS ANDREACTIVATED TO AN INFECTIOUS STATE BY TREATMENT ATACID PH, (AUTHOR) (U)
51
UNCLASSIFIED /ZIMSI
tiN A S Ir i;.
DOC RELPORT BRLIOrApHY SEARC , CNT P O.OL NO, / 17s)
AD-6b7 361 6/1FORT DETRICK FREDEPICK MO
GROArTH OF VENEZUELAN, AND EASTERN, EQUINE
E•4CE&ALOCYEL!T!S "I-uSES ;s T;35uE CvLTvfEci oFMINCED AEDES AEGYPTI LARVAEj (U)
6b 12P JOHNSON,JAMES W,
UNCLASSIFIED REPORTAVAILABILITY: PUbs IN AMERICAN JNL, OF TROPICAL
MEDICINE AND HYGIEnE $ VIS NJ P1O0-I1 4 JAN 69.
DESCRIPTORS: (*VENEZUELAN EQUINE ENCE ,,ALOMYELITISVIRUS, TISSUE CULTURE), (*EASTERN EQUINrENCEPHALOMYELITIS VIRUS, TISSUE CULTURE), GROUPA ARBOVIRUSES, GROWTH, AEDES, LARVAE,TEMPERATURE, PH# MORPHoLOGY(BIOLOGY)tVIABILITY. ADSORPTInN, CULTURE MEDIA (U)
A METHOD FOR THE GERM.FREE CULTIVATION OF THEMOSQUITOES AEDES AFGYpTI AND AEDES TRISERIATUS*AS DEVELOPED, AND PPIMARY TISSUE CULTURES *EREPREPARED FROM MINCFO LARVAE OF BOTH INSECT SPECIES,THE TRINIDAD AND THE 9T STRAINS OF VENEZUELANEQUINE ENCEPHALOMYELITIS (VE!) VIRUS AND THELOUISIANA STRAIN OF EASTER1! EQUINEENCEPHALOMYELITIS IEEE) VIRUS WERE GROWN IN LARVALTISSUE CULTURE OF A. AEGYPTI. THE TRINIDADSTRAIN OF VE! VIRUS WERE ALSO GROWN IN A,TRISERIATUS LARVAL TISSUE CULTURES. THE GROWTH OFVEE VIRUS IN A. AE6YPTI LARVAL TISSUE CULTURE WASINFLUENCED BY THE LENGTH OF TIME, THE TEMPERATURE,AND THE VIRUS CONCeNTRATION USED FOR THE ADSORPTIONPROCESS, AND THE TEMPERATURE, PH, AND AGITATION OF
CULTURES DURING GRPNTHO IN THESE CULTURES, THE
TRINIDAD STRAIN GRFW SOMEWHAT BETTER THAN THF 9TSTRAIN; ITS LATENT PERIOD WAS SHORTER, ITS (RoWTw
RATE WAS FASTER, ANJD IT REACHED HIGHFR MAXIMUM TITERS
OF VIRUS. HOWEVLR, EEE VIRUS WAS SUPERIOR TO THE
TRINIDAD STRAZN IN EACH OF THESE CHARACTERISTICS OFGROWTH. SOME EVIDE*jCE SUGGESTED THAT A VIRUS-INACTIVATI'G MATERIAL WAS PRESENT IN LARVAL TISSUE
CULTURES OF BOTH SPECIES OF MOSQUITO. TEN SERIALPASSAGES OF THE TRINIDAD STRAIN OR FIVr SERIALPASSAGES OF THE 9T STRAIN IN At AEGYPTI LARVAL
TISSUE CULTURES CA10SED NO DETECTABLE CHANGES INEITHLR THE VIRULENrE FOR MICE OR THE DISTRIBUTIOm OFPLAQUE SIZE OF THERE VIRUS STRAINS- (AUTHOR) (U)
52UNCLASSIFIED /ZIMfl
UNCLASSIFrIED)
DOC REPORT SIBLIOefRAPHy SEARCm CONTROL NO. /ZlM5I
AD.609 891 6/i1ARMY MEDICAL UNIT FroE[RICK ND
ALTERAT!ONS !N :XMUNE RESPONSES Of ATTENUATED
VENEZUELAN EQUINE ENCEPHALITIS VACCINC, to
ADJUVANT EFFECT OF VEE VIRUS INFECTION IN GUINEAPIGS, (U)
NOV 68 9P CRAIGCHARLES Po IREYNOLDS,SCOTT Le $AIRHARTJIM W, ISTAABEDWARD V. I
UNCLASqIFIED REpORTAVAILABILITY: PUB@ IN JNL. OF IMMUNOLOGY, V102 N5P1220*1227 1969.
SUPPLEMENTARY NOTE: SEE ALSO AD-489 892o
DESCRIPTORSI 4*VENEUELAN EQUINE ENCEPHALOMYELITISVIRUS, VACCINES)t INFECTIONS, RESPONSES, GAMMA
GLOBULIN, ANTIGENS + ANTIBODIES, IMMUNITY,ATTENUATION, VOLUMETRIC ANALYSISo GUINEA PIGS lU)
ATTENUATED VENEZUELAN EQUINE ENCEPHALITIS VIRUS
VACCINE INFECTION ENHANCED TWE IMMUNE RESPONSE IkiHARTLEY STRAIN GUINEA PIGS. ACCELERATED IMMUNECLEARANCE OF I OR 20 MG 12fl-BOVINE GAMMA GLOBULININJECTED 24 OR 48 HP BEFORE OR 2q HR AFTER VEEVACCINE WAS DEMONSTRATED. ELEVATED
NEMAGGLUTINATING TITERS TO BGG *ERE OBTAINED ONDAYS B, 129 21, 28 AND 39 WHEN THE VEE VACCINEPRECEDED OGG BY 24 MR AND ON DAYS A ANr 12 WHENVEE FOLLOWED BGG BY 2q OR q6 MR. INCREASEDTITERS WERE DEMONSTRATED ONLY AT 8 DAYS IN GUINEAPIGS INFECTEn 9 TO 10 MIN OR 48 HR BEFnRE BGGALL THE HA ANTIBODY ACTIVITY IN THE SERACOLLECTED ON THE HAH AAY DAS 2-MERCAPTOITHANIL (2-*¶E ) REr'u%. f8i 7o '5 -. , &Cl&'T PORT 1^:i (QF "" HAANitouuY AT 6 AND 12 DAYS WAS 2-ME RESISTANT.NONINFECTIVE FORMALIN.KILLED ATTENUATED VEE VIRUSDID NOT PRODUCF AN INCREASE IN THE HA TITERS,lAUTHOR) (U)
53UNCLASSIFIED /ZtHSI
AD-.a# qqz .|
FORT ODTRICK rQEOEýICK MO
ALTERATIONS IN IMMIuNE RrSPONSES BY ATTENUATEDL.^ LV Lui ME FNCEPHALITIS vACCINE. II.PATHOLOGY AND SOLUPLE ANTIGEN LOCALIZATION IN GUINEA
'U,
NOw 68 8P AIPHAPTJIM Wo iTREVINO,ILBERTO S. ;CRAIGoCHARLES P. I
UNCLASSIFIED REPORTAVAILABILITY: PUI. IN JNLf OF ItMUNOLOGY, VI02 NOP1228-12114 1969.
SUPPLEMENTARY NOTE: SEE ALSO AD-689 891.
DESCRIPTORS: (eVENE7UELAN EQUINE ENCEPHALOmYELITISVIRUS, VACCINES)# ATTENUATION, INFECTIONS,VISUAL INSPECTION, rLUORESCENT ANTIBODY TECHNIWUES,LIVER, SPLEEN, KIDNFYS; LYMPHATIC SYSTEM,GAMMA GLOBULIN, LEUVOCYTES, PATHOLOGY (U)
THE PATHOLOGY OF INFECTION WITH ATTENUATEOVENEZUELAN EQUINE rNCEPHALITIS VACCINE, 83RD TISSUECULTURE PASSAGE, 1,, GUINEA PIGS AAS STUDIED RYROUTINE MICROSCOpY- EXAMINATION OF TISSUES ANDFLUORESCENT ANTIBODy STAINING FOR VIRAL ANTIGEN,TRANSIENT CENTRILORULAR HEPATIC DEGENERATION,ARTERIOLAR ENDOTHELIAL SWELLING, AND SPLENIC ANDLYMPH NODE GERMINAL CENTER PROLIFERATION, CHIEFLy OFRETICULOENDOTHELIAI ELEMENTS BUT ALSO CF IMMATURELYMPHOBLASTS, WERE DEMONSTRATED, CIRCULATINGLYMPHOPENIA AND LEItKOpENIA, FOLLOWED BYLYMPHOCYTOSISo ALSn OCCURRED, T*O PEAKS OF VIRALANTIGEN CONCENTRATIONS WERE FOUND IN LIVER, SPLEEN,LYMPH NODES AND KIDNEY, THE FIRST IMMEDIATELY AFTERINFECTION, THE SECOND BETWEEN DAyS 7 AM'D [$. NODIFFERENCES WERE FOUND IN ORGAN LOCALI7ATION ORPERSISTENCE OF FLUnRESCENT BOVINE GAMMA GLOBU1LINGIVEN 24 HR AFTER VLE. THE SIGNIFICANCE ANDIMPLICATIONS OF THE FyNDjNGS TO THE ADJUVANT EFFFCTOF VEE VIRUS INFECTION WERE DISCUSSED.(AUTHOR)
N 4UNCLASSIFIED /ZtMf!
DOC REPORT BI9LlO+ 4*pwv " co* mc¢ i+, (
AO-493 9qq6 6%i)
FORT OETRICK FREOEPICK ma
... .. . . .n..r•ALu yLLITlSHENA44LUTININ PREP R O rROM TISSUE CULTVRES My GAmMARADIATION,
MAY 69 3P REITMAN,MOHTON 1
UNCLASSIFIED REPORTAVAILABILITY: PUB. IN APPLIE( MICROBIOLUGY, vJi N2P278*279 AUG 69.
DESCRIPTORS? (*VENEZUELAN EQUINE ENCEPHALOMYELITISVIRUS, AGGLUTININS)l (*AGGLUTININ$,PREPARATION), TISSUF CULTURE, EXPOSURE, GAMMARAYS, SERODIAGNOSISo RADIATION EFFECTS (u)
HEMAGGLUTININS OF VEPNEUELAN EQUINEENCEPHALOMYELITIS VIRUS WERE PRODUCED IN TISSUECULTURES, AND THE INFECTIVE VIRUS WAS RENDEREDNONVIABLE BY EXPOSURE TO GAMMA RADIATION.(AUTHOR)
(U)
55UNCLASSIFIED
/zIM51
•jCLASSIP I[O
00( WePORT I$iLIOGRAp"Y SCARCm CONTPOL NO. ,ZIM9I
AW-691 260 6/'I)FORT DETRICK FREOEICK No
FACTORS INFLUENCING VIRULENCE AND PLAQUE PROPERTIES
OF ATTENUATEO VENCIUELAN EQUINE ENCEPHALONYELITISY ! P 41 P0.P*JL AT ta 0N$, (u I
JUL 69 31p HEARNNENRY Jo lSELIOKAS (
ZENONAS V. IANDERSENtARTMUR A. s
UNCLASSIFIED REPORT
AVAILABILITY: PUB* IN JN.* Of VIROLOGY, V* N4
P049-5q6 OCT 69#
DESCRIPTORS: (OVENEIELAN EQUINE ENCEPHALOMYELITIS
VIRUS, ATTENUATION), (*VIABILI T Y# VENEZUELAN
EQUINE ENCEPHALOMYELITIS VIRUS)# STORAGE,
STABILITY, IMMUNITY (U)
IDENTIFIERS: *PLAQUrS(mICROBIOLOGY) ful
A MINORITY OF STABLE LARGEoPLAQUE VIRUS INCREASED
PROPORTIONALLY IN STORED UNSTABLE ATTENUATED 49T)
VENEZUELAN EQUINE FNCEPHALOMYELITIS VIRUS
POPULATIONS* L-CELL-GROWN PROGENY (9T2) OF
STORED 9T SHOWED LARGE AMOUNTS Of LARGE-PLAQUE VIRUS
AND INCREASED VIRULENCE. SMALL-PLAGUE VIRUS
INHIBITED LARGE-PL49UE VIRUS BUT NOT THE REVERSE.
SERIAL PASSAGE OF SMALL-PLAQUE VIRUS FROM 9T2
YIELDED A STRAIN i2OT) THAT WAS MORE ATTENUATED
THAN 9T. (AUTHOR) (U)
56
UNCLASSIFIED 'ZIM5I
UNCLASSIrID [
DOC REPORT hIBLIOnAApHYv SEARCo CONTROL NO. /ZIM01
A*0701 ! •'"
FORT DETRICK FREOrICK MD
GRO*ft aF VEhEZUELAN EQUINE ENCEPHALOMYLLITIS VIRUSIN HUMAN DIPLOID CrLL STRAIN o!(8)
OCT 69 "P REITHANIMORTON ;GREENLEONARD I
UNCLASSIFIED REPORTAVAILASILITY: PUS* IN APPLIED MICROBTOLOGY, VI9NI P196*198 JAN 70.
DESCRIPTORS% I*VENE7U[LAN EQUINE ENCE7HALOMYELITISVIRUS, *TISSUE CULTURE CELLS), GROWTH,ARSOVIRUSES, CULTURE MEDIA* VACCINES IU)
IDENTIFIERS1 HUMAN DIPLOID CELL STRAIN *128 (U)
IT WAS DEMONSTRATEt% THAT VENEZUELAN EQUINEENCEPHALONYELITIS IVEE) VIRUS REPLICATFO IN AND
ADAPTED RAPIDLY TO HUMAN DIPLOID CELL STRAIN wI-•.PEAK TITERS OF APPuoXIMATELY 10 TO THE 9.8TH POWERMOUSE INTRACERESRAL 0o0 LETHAL DOSES NFRE OBTAINEDAT LOW PASSAGE LEVFLS IN EAGLES BASAL MEDIUMSUPPLEMENTED WITH CALF SERUM. VEE VIRUS REPLICATEDPOORLY IN SERUMoFRFE MEDIUM* PROPAGATInH OF VEEVIRUS WAS ACCOMPANIED By THE PRODUCTION OFHEMAGGLUTININ AND CYToPATHOGENIC EFFECTS.(AUTHOR) (U)
57UNCLASSIFIED /ztMpI
I.I
UNCLASSIFIED
DOC REPORT BIBLIOGRApMH SEARC¢ CONTROL NO* iZIM5l
AD-705 7)9 6/13
FORT DETRICK FREDERICK MD
NEUTRALIZATION OF OESIDUAL INFECTIVITY OF VENEZUrLAN
EQUINR ENCEPVALOMYFLITIS VIRUS By ANTI-(PAMMAU N )GLOBULIN,
OCT 69 12P HAHONsN e
UNCLASSIFIED REPORTAVAILABILITY: PUB@ IN JNL, OIM GENERALVIROLOGY# V4 P361-172 1970,
DESCRIPTORS: (*VENEZUELAN EQUINE ENCEPHALOMYELITIS
VIRUS, NEUTRAL|ZATIrN)o (*GAMMA GLOIULIN9*ANTIGENS # ANTIBODIES) t ARGOVIRUSES# VIRUSES,
ANTIGEN-ANTIBODY REACTIONS# IMMUNOLOGY* IMMUNE
SERUMS (U)
RESIDUAL INFECTIVITY DETECTEO AFTER THE INTERACTIONOF VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS %ITH
SPECIFIC ANTISERuM *AS CAUSED MAINLY BY THE FORMATIOvOF INFECTIVE VIRUS + ANTIBODY COMPLEXES(SENSITIZED VIRUS) THAT COULD BE NEUTRALIZED dY
SERUM CONTAINING ANTIGAMMA GLOBULIN 4IG6)9 THEQUANTITIES OF VIRUS SENSITIZED BY ANTISERUM To
VENEZUELAN EQUINE FNCEPHALOMYELITIS AND NEUTRALIZEDBY ANTI-.GG SERUM nEPENDED ON THE ANTIBODYCONCENTRATIONS OF THESE SERA. IN CONTRAST TO THEMARKED TEMPERATURE AND TIMEeDEPENDENCE OF
VENEZUELAN EQUINE FNCEPMALOMYELITIS VIRUSNEUTRALIZATION BY PNTISERUM, NEUTRALIZATION OF
SENSITIZED VIRUS BY ANTI-IGG SERUM WAS MORERAPID, BEING ALMOST COMPLETE PITMIN I MIN, AT •
DEGREES, AND LESS SENSITIVE TO TEMPERATURE, VIRUSSENSITIZATION PRECFDED NEUTRALIZATION AND INDICATED
THAT INFECTIVE VIRUS * ANTIBODY COMPLEXES WEREFORMED BEFORE VIRUS NEUTRALIZATION BEGAN, THE
NEUTRALIZATION OF qNZITIZEfn VvUS BY ANTIwiGr
SERUM WAS GENERALLY SPECIES SPECIFIC# DIFFERENCESIN THE ABILITY OF ANTI-IGG, ANTI-IGA, AND
ANTI-IGN SERA TO NrUTRALIZE SENSITIZED VIRUSINDICATED THAT THE REACTION WAS ALSO INFLUENCED BY
THE CLASS SPECIFICITY OF THE ANTI-IMMUNOGLOBULIN*SENSITIZED VIRUS WAS pARTIALLY NEUTRALIZED BY GOAT
ANTISERUM TO MONOVALENT FAB FRAGMENTS OF HUMANIGG AND, TO A LESSFR DFGREEg BY THE FC
FRAGMENT@ SENSTIIZFD VIRUS *AS NEUTRALIZED OY AN IN
VITRO MIXTURE OF THESE FRAGMENTS TO ALMOST THE SAME
DEGREE AS BY GOAT ANTISERUM TO INTACT HUMAN I1G6
THE FC FRAGMENT MAY, THEREFORE, BE INVOLVED INVIRUS NEUTRALIZATION* (AUTHOR) (U)
58UNCLASSIFIED /ZIM11
UNCLASSIFIEO LDOC REPORT B|ILIORApHY SEARCH CONTOOL NO* /ZIMqj
AD*O.0 766 5/0i_f:--C 7I;5CwIC NO I
NEUTRALIZATICN ANTI.Ieq TEST FOR ANTISrRA TOVENEZUELAN EQUINE rNCEPHALOMYELITIS, (U)
OCT 69 7P HAHONN9 I
UNCLASSIFIED REPORTAVAILABILITY: PUB@ IN JNL* Of GENERALVIROLOGY, V6 P26S'291 1970#
SUPPLEMENTARY NOTEI REVISION OF REPORT WATED 14 JUL
DESCRIPTORS? (*VENEZUELAN EQUINE ENCEPHALOMYELJI7SVIRUS, *ANTIGENS * ANTIBODIES), (*SERODIAGNOSIS,ANTIGENS * ANTIBODIES); NEUTRALIZATION,ANTIGEN-ANTIBODY REACTIONS, IMMUNE SERUMSt GAMMAGLOBULIN, ARBOVIRUSrS, VIRUSES (Ul
A PRECISE, REPRODUCIBLE, AND SENSITIVE SERUMNEUTRALIZATION TEST WAS DEVELOPED TO ESTIMATEVENEZUELAN EQUINE FNCEPHALOMYELITIS NEUTRALIZINGANTIBODY ACTIVITY VITHIN 2'1 HR. THE TEST DEPENDS ONTHE INTERACTIONS OF VIRUS WITH ANTIVIRAL GLOAULINSAND OF THE RESULTANT COMPLEXES WITH ANTI-GAMMA
GLOBULIN (1GG) ANTIBODIES* THE gOt SERUMNEUTRALIZING DILUTIONS WERE CALCULATED FROM THEREDUCTION OF FLUORESCENT CELLS IN MCCOY CELL
MONOLAYERS RESULTING FROM THE NEUTRALIATION OFINFECTIVE VIRUS BY ANTIBODY* IN COMPARATIVEESTIMATES OF THE NEUTRALIZING ACTIVITY OF HUMAN ANDMONKEY ANTISERA, THE SENSITIVITY OF THF SERUMNEUTRALIZATION ANTI-IGG TEST WAS SEVERALHUNDREDFOLD GREATEP THAN THAT OF THE CONVENTIONALSERUM NEUTRALIZATION TEST IN MICF, (AUTHOR) IU)
59UNCLASSIFIED !Z41MW
L ______
UNCLASSIFIlO
DDC REPORT BIBLIOGRAPHY $EARCm CONTROL NO. /ZIM91
AD-706 $53 6/12fAB? t•rymiwfr• AVOIv Mft
COMPARATIVE STUDY OF THE HAEMAGGLUTINATINGAR60VIRUS ANTIGENS PHEPARED FROM TISSUE CULTURES
AND MOUSE BRAIN (SRAVNITELNOE IZUCHENIE
GEMAGGLYUTINIRUYUSHCHIKH ARBOVIRUSNYKH
ANTIGENOV, PRIGOTOVLENNYKH IZ TKANEVYKH
KULTUR I IZ MOZGA MYSHrI)o fU|
APR 70 lIP GAIDAMOVICHS, YA. ICASALS,
REPT. NO* TRANS02701
UNCLASSIFIED REPORT
SUPPLEMENTARY NOTE# TRANS, OF VOPROSY VIRUSOLOGI|
(USSR) VI) N2 P2)5-242 1968.
DESCRIPTORS: (oARBOVIRuSESs AGGLUTININS,,
(*AGGLUTININS, PREPARATION)s ANTIGENS +
ANTIBODIES, SERODIAGNOSIS,'INFECTIONS, IMMUNITY$VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS, WESTERN
EQUINE ENCEPHALOMYELITIS VIRUS# CHIKUNGLINYA VIRUS,TISSUE CULTUREt MICr, BRAIN, USSR (U)
IDENTIFIERS: TRANSLATIONS fU)
THE LABORATORY DIAGNOSIS OF THE ARBOVIRUSINFECTIONS AND THE INVESTIGATION OF THF IMMUNITY
STRUCTURE OF THE PnPULATION ARE RESTRICTED TO A LARGE
EXTENT BY THE LACK OF A SUFFICIENT SET OF NON.
INFECTIOUS ANTIGENS FOR THE HAI AND HA TESTS.
UP TO NOW THE M0ST WIDELY USED METHOD OF PRODUCING
THE ARBOVIRUS ANTIGENS IS THAT FROM MOUSE BRAIN BY
THE METHOD OF THE AQUEOUS-SALINE OR SUCROSE-ACETONE
EXTRACTIONs WITH T14E DEVELOPMENT OF THE METHOD OF
GROWING ARBOVIRUSES IN TISSUE CULTURES IT BECAME
POSSIBLE TO OBTAIN FROM THIS MATERIAL THE ANTIGENS
FOR HAl AND HA TESTS. THE PURPOSE OF THE
RESEARCH IS THE INVESTIGATION OF THE SPECIFICITY AND
OF THE ACTIVITY SPECTRUM AT VARIOUS PH AND
TEMPERATURE VALUES OF THE NON-INFECTIOUS ANTIGENS FOR
THE VIRUSES OF THE VENEZUELAN (VEL), AND
WESTERN (ZEL) EQUI'.JE ENCEPHALOMYELITIS AND OF
CHIKUNGUNYA IN THE HAI TEST. (AUTHOR) (U)
60UNCLASSIFIED /ZIM5l
UNCLASSIFIEO
O0" REPORT BIBLIOGRApHY SEARCm CONTROL. N0. /ZI1m5
AD-7O0 9qZ 6/;I1 6/IFORT DETRICK FREDEPICK MD
VIRUS-SPffIFIC POLySOMES IN CELLS INFECTED *ITHTHE VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS, fUw
JUL 7T 9P ERSMOVsFo I# IZIDANOVoV*M, ;URYVAEVL9 V. I
REPT. NO. TRANS02721
UNCLASSIFIED REPORT
SUPPLEMENTARY NOTE: TRAK , OF UNIDENTIFIED RUSSIANLANGUAGE ARTICLE,
DESCRIPTORS! (OVENETUELAN EQUINE ENCEP14ALOMYELITISVIRUS, *R|OSOMES), (.TISSUE CULTURE CELLS,RIBOSOMES,, GROWTH, INFECTIONS, RIBONUCLEICACIDS, ARSOVIRUSES, VIRUSES, NUCLEIC ACIDS,BIOSYNTHESIS, REPROPUCTION(PHYSIOLOGY), USSR,MOLECULAR STRUCTURE (Ul
IDENTIFIERS! TRANSLATIONS (U)
THE USE OF A DOUBLE ISOTOPIC TAG IS A CONVENIENTMETHODOLOGICAL TECHNIQUE WHICH PERMITS SIMULTANEOUSDETERMINATION OF THE STRUCTURAL STATE AND THEFUNCTIONAL ACTIVITY OF THE POLYSOMES, STUDY OF THEDYNAMICS OF POLYSOME FORMATION IN TOE CASE OFARBOVIRUS INFECTION TESTIFIES TO THE FACT THAT THISPROCESS IS CLOSELY CORRELATED WITH THE VIRUSREPRODUCTION CYCLE, IN THE CASE OF INFECTION bY THEVEE VIRUS, THE MAXIMUM OF THE FORMATION OF ACTIVELYFUNCTIONING VIRUS-SPECIFIC POLYSOMES IS NOTED BETWEENTHE 3-RD AND THE 4-TH HOUR AFTER INFECTION, It,•, ATTHE HEIGHT OF THE INFECTIONo OF THE 2 TYPES OFVIRUS-SPECIFIC POLYSOMES THE GREATEST INTEREST ISAFFORDED BY 'HEAVY' POLYSOMESt WHICH HAVE ASEDIMENTATION CONSTANT OF 2*0 S AND HIGHER. THEYARE, APPARENTLYt THE MAIN STRUCTURE ON THE BASIS OFWHICH THE SYNTHESIS OF VIRUS PROTEINS IS EFFFCTED,A SPECIAL COMMUNICATION WILL BE DEVOTED TO ADETAILED ANALYSIS OF THE STATE AND FUNCTIONING OFVIRUS-SPECIFIC POLYSOMES OF THIS TYPE. THEPRESENCE, ON THE POLYSOMES, OF AN RNA WHICH IN ITSPROPERTIES IS ANALOGOUS TO THAT OF THE VIRI,APPARENTLY TESTIFIES TO ITS INFORMATION FUNCTIONS.(AUTHOR) (U)
61
UNCLASSIFIED /ZIMSI
IUNCLAS-I FICO
DOC REPORT BIBLIOGRApHY SEARCH CfNTROL. NO* /ZIM9I
AD-711 680 6/16
ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASESFREDERIC% MO
ThT EFFECT OF LIVE ATTENUATED VENEZUELAN EQUINEi
ENCEPHALOMYELITIS VIRUS VACCINE ON SERUM IRON,
ZINC, AND COPPER CONCENTRATIONS IN MAN* (U)
OCT 69 lip PEKAREK#ROOERT S. ISURGHEN,
GEORGE A* ISARTELL'NI•PETER Js |CALIA.FRANKMe iSOSTIAN*KAREN A, I
UNCLASSIFIED REpORTAVAILABILITY' PUB. IN THE JNL9 Of LABORATORYAND CLINICAL MEDICINE' ST. LOUIS, V76 N2 P291-30OAUG 7Co
DESCRIPTORS: 10INFECTIoUS DISEASES, *METABOLISM),(eMETALS, METABOLISmi, (*VACCINES, 9VFNFZUELANEQUINE ENCEPHALOMYELITIS VIRUS)# BLOOD SERUM,RESPONSES, MICROORG4NISMS9 COPPER, ZINC, IRON,FEVERS (U)
SERUM IRON AND ZINC CONCENTRATIONS FrLL EARLY AFTEREXPOSURE OF VOLUNTEERS TO LIVE ATTENUATEDVENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS VACCINE,
WITH A RISE IN SEROM COPPER CONCENTRATTONS*ALTERATIONS IN THESE SERUM METAL CONCENTRATIONS
WERE SIGNIFICANTLY DIFFERENT FROM CHANAES EXPECTED ONTHE BASIS OF DAY-TO-DAY VARIABILITY DIFFERENCES AMONGINDIVIDUALS. THE PROSPECTIVE NATURE Of THIS STUDY
AND THE RAPID DEVELOPMENT OF ALTERED SERUM METALMETABOLISM, EVEN Im* EXPOSED SUBJECTS WHO REMAINED
ASYMPTOMATIC, SUGGEST THAT TNE CAANGFS IN THESEMETALS IN THE PRODROMAL PERIOD REPRESENT AN EARLY
HOST RESPONSE TO THE pRESENCE OF INVADINGMICROORGANISMS. ;N TMOSE SUBJECTS WHO DEVELOPED
FEBRILE ILLNESS, THE RESPONSES BECAME EXAGGERATE[ ANDAPPEARED To BE RELATED IN TIMING AND MAGNITUDE TO THEONSiT AND SEVERITY OF THE FEBRILE REACTION. THESE
CHANGES MAY HAVE SIGNIFICANCE IN PROVIDING NERAPPROACHES TO DTAGý*OSIS AND TO AN IMPROVEDIUNDERSTANDING OF HOST METABOLIC RESPONSES DURING
INFECTIOUS ILLNESS, (AUTHOR) (U)
62UNCLASSIFIED /Zl1MW
UNCLASSIFIED
DOC REPORT BIBLIOGRApHY SEARCH CONTROL NO, /ZINgsAD-7I1 201 4/11 I
FORT DETRICK FREDERICK MO
MULTIPLE ASSESSMENT AID SERUM NEUTRALIZATIONOr ARBOVIRUS MIXTURES, (U)
AUG 70 xP MAHONNtCHOLAS IMAYHEW,CHARLES ji I
UNCLkSSIFIED REPORTAVAILABILITY: PUB, IN APPLIED MICROBIOLOGY, V20Nq P62-64q OCT 70.
DESCRIPToRSI WOARBOVIRUSES, FLUORESCENT ANTIBODYTECHNIQUESIt 1SERODIAGNOSIS, ARBOVIRUSFS)oTEST METHODS, *UANTTTATtVE ANALYSIS, VIRUSES,ANTIGENS * ANTIBODIES, VENEZUELAN CQUINFtNCEPHALOMYELITIS VIRUS, RIFT VALLEY FEVER VIRUS,CHIKUNGUNYA VIRUS (U)
MIXTURES OF VENEZUELAN EQUINE ENCEPHALOMYELITIS,
RIFT VALLEY FEVER, AND CH!KUNGUNYA VIRUSES MA- BEASSAYED BY SELECTIVE IHMUNOFLUORESCENCE STAIN! JG OFINFECTED CELL HONOLAYERSO A MULTIPLE SFRUMNEUTRALIZATION TEST IS OESCHIBED FOR QIOANTIFYINGREACTIONS OF THESE VIRUSES WITH MIXTURES Of SERUMANTIBODIES. (AUTHOR) (U)
63UNCLASSIFIEU /ZIM9I
iUNCLASSIFIEO
DOC REPORT BIBLIOGRApHY SCARCm CONTROL NOD. #ZNSg
40-717 414 6/13FORT DETRICK FREDERICK MDCELL SURFACE ANTIGEN INDUCED By VENEZUELAN
EQUINE ENCCPNAL004Y!LITI'3 VIRUS, U
AUG 70 sP HAHONtNICHOLAS I
;• UNCLASSIFIED REPORT
AVAILABILITYl PUBo IN INFECTION AND IMMUNITY, V2N& P11-?7if DEC 70,
DESCRIPTORS! ($VENEZUELAN EQUINE ENCEPHALONYCLITISVIRUS, *ANTIGENS 0 ANTIBODIES)oCELLSIBIOLOGY) BSIOSYNyHESIS, FLUORESCENTANTIBODY TECHNIQUES (U)
BY IMMUNOFLUORESCENCE STAINING, A SPECIFIC SURFACEANTIGEN INDUCED BY VENEZUELAN EQUINEENCEPHALOMVELITIS VIRUS WAS DETECTED 06, L-929CELLS, FORMATION OF THE ANTI4EN WAS INDEPENDENT OFVIRAL RIBONUCLEIC ACID SYNTHESIS# (AUTHORt (U)
N 4UNCLASSIFIED lZlN5I
IUNCLASSIFIED
DOC REPORT 8!bLIOCRApMY SEARCH CONTROL NO* /ZimpjAD-?19 946 6/1;
ARMY FOREIGN SCIENCE AND TECHNOLOGY CrNTVD ruNA01-co.,o-oi
VA
REPLICATION Of YELP vINUS IFENLIKATI[ioloKONPL[KS VIRUJA V[+:[SuZLYSKOGOZITSCFALOMIELITA LOSNADEOilt fUl
OCT 70 9P ZHOANOVoV Me |ERSHOVsFoIt *URYVAAEVOL Vs ;
RIPT? NO, FSTC.HT-2w.•9•47O
UNCLASSIFIED REPORT
SUPPLEMENTARY NOTE; TRANS* OF AKAOEMIYA NAUK SSSR,DOKLAOY, V189 N6 Ply$2.1,14 1969,
OCSCRIPTORSI 10VENEZUELAN EQUINE ENCEPHALOMYELITISVIRUS, GROWTH), EMBRYONATED EGG TECHNIQUIE,RIBONUCLEIC ACIDS, PROTEINS, SYNTHESISt USSR (U)
IDENTIFIERSI TRANSLATIONS, VIRUS SPECIFICPROTEINS, REPLICATING IU)
A REPORT IS GIVEN OF THE RESULTS OF TEST WHICH ToDEMONSTRATE THAT IN CELLS INFECTED WITH VENEZUELANEQUINE ENCEPHALITIS VIRUS THE REPLICATTV[NTERHEDIARy FORM OF THIS VIRUS FUNCTIONS IN WHAT ISCALLED A REPLICATIVC-CONPLEX FORM, OHICH ENSURESSIMULTANEOUSLY BOTw REPLICATION AND THF SYNTHESIS OFVIRUS-SP[CIFIC PROTEINS, (AUTHOR) EU)
65UNCLASSIFIED /ZIMI
UNCLASSIFIED
DOC REPORT BISLIOARApHY SEARCH CONTROL NO* /ZIMP!
AD-723 2?7 6/I3ARMY BIOLOGICAL DEFENSE RESEARCH CENTER FREDERICK 00
[ REPLICATION 07 VENEZUrLAN E&UINSENCEPHALOMYELITIS VIRUS IN VITRO. If*VIRAL GROWTH RESPONSE TO SELECTEDNUTRITIONAL ADDITIVES IN SUSPENSION CULTURES,
IU)
OCT 70 PP HEARNHo J# ITRIMBLEHsRe s JR*|NAGLESo C, , JReo&OWERSOXO, C.* JRI
UNCLASSIFIED R.PORTAVAILABILITYI PU8o IN APPLIED MICROBIOLOGY, V2IN2 P4q2?.qt 713 71,
DESCRIPTORS: (*VENEZUELAN EQUINE ENCEPHALOMYELITISVIRUS, GROWTH1, 10CULTURE MEDIA, VENEZUfLANEQUINE ENCEPHALOMYELITIS VIRUSI, IN VITRO ANALYSIS,
ARBOVIRUSESt VIRUSES, CHOLINES. AMINO ACIDS,NUTRITION tUl
IDENTIFIERS$ SERINE; PROLINES (U)
AN ATTEMPT RAS MAOF TO IDENTIFY NUTRITIONALADDITIVES THAT INFLUENCE THE REPLICATION OfVENEZUELAN EQUINE FNCCPHALONYELITIS VIRUS INSUSPENSION CULTURES GROWN IN A DEFINED SERUM-FREE"MEDIUf, PROLINE, SrRINE, AND CHOLINE ENHANCEDTITERS Of THE VIRULENT PES STRAINI THE PROGENYPOPULATION, HOWEVEro pOSSESSED A VIRULrNCE CHARACTERTHAT WAS SOMEWHAT oIFFERENT FROM THAT OF THE PESINOCULA, THESE NUTRITIONAL SUPPLEMENTS DIn NOTAPPRECIABLY INFLUENCE THE TITERS Or THy ATTENUATED 9TAND 20T VIRAL STRAINS, *MEN BOTH THE PES AND 20TSTRAINS WERE EMPLOYED AS A MIXED INOCULUUN INCULTUREt THE PRESEFICE Of THE LATTER STRAIN APPEAREDTO INTERFERE WITH THE GROWTH OF THE PES STRAIN ANDREDUCED ITS RESPONSE TO THE MEDIUM SUPPLEMENTS.
(AUTHOR) (U)
66UNCLASSIFIED /ZIMgI
UNCLASSIFIED
DOC REPORT RIULIOGRApNY SEARCH CONTROL NO. /ZINmt
AD-722 267 6/11FORT DETRICK FREDERICK NO
... 0. -, a*b-,vimm I S.*fl nRuAI url AP4vSODIUM FLUOREICEIN ON THE RECOVERY OrVENEZUELAN EQUINE ENCEPHALOMY[LITIS VIRUS
FROH AEROSOLS, oU)
OCT 70 SP BERENDTtRICHARD Fe IDORSEvYEMERSON Le I
UNCLASSIFIED REPORTAVAILABILITY:_PUS. IN APPLIED MICROSIOLOGY, V2IN2 Pq4qT-o MAR 71,
DESCRIPTORS: (oVENEZUELAN EQUINE ENCEPHALONYELITIsVIRUS, AEROSOLS), ARBOVIRUSES, VIABILITY,TOXICITY, AEROSIOLOGY, SOLAR RADIATION, 0-HETEROCYCLIC COMPOUNDS (U)IOENTIFIERSI *PLUORESCEIN, VIRAL AEROSOLS (U)
ALMOST 901 OF THE TRINIDAD STRAIN OFVEN9ZUELAN EQUINE ENCEPHALOMYELITIS (VFE) VIRUSSURVIVED FOR I HR AFTER AEROSOLIZATION INTO A DARKENVIRONMENT AT 205 RELATIVE HUMIDITY (PH)# AND781 SURVIVED FOR I HR AT 601 RH, AFTEREXPOSURE TO SIMULATED SOLAR RADIATION (P0I MCAL PERCM SQ PER MIN) O0O02 OF THE AEROSOLIZED VIRUSSURVIVED FOR I IR AT 20 RH AND O.O65 SURVIVEDFOR I HR AT 601 RH, WHEN 19o MG OF SODIUMFLUORESCEIN PER ML WAS ADDED TO SUSPENSIONS PRIOR TOAEROSOL DISSEMINATION (TO DETERMINE PHYSICAL LOSSO AEROSOL)# NO VIPus WAS DETECTED AFTER 30 MIN ATEITHER RH UPON IRRADIATION* SODIUM FLUORESCEINALSO EXHIBITED SOME TOXICITY I4is SURVIVAL AT 60MIN) FOR NONIRRADIATED AEROSOLS OF VEE VIRUS AT401 RHi NO EFFECT *AS NOTED AT )CtoIAUTMOR)
(U)
67UNCLASSIFIED /ZIMl5
I.
UNCLASSIFIED
DOC REPORT BIBLIOGRAPHY SEARCH CONTROL NO, 4ZiMI|
AV*723 272 445 4/11
IMMUNOGENICITY OF PURIFIED VENEZUELAN FQUI1ESENCEPHALITIS VIRUS INACTIVATED By IONIZINGRADIATION,
fUl
OCT 70 7P GRUNERJACK I
UNCLASSIFIED REPORTAVAILABILITYi PUb, IN INFECTION AND IMMUNITY. V3N4 P574S•?9 APR 71.
DESCRIPTORS: (*VENEZUELAN EQUINE ENCEPHALONVELITISVIRUS, *IMMUNOLOIY); (,VACCINES, VENEZUELANEQUINE ENCEPHALOMYELITIS VIRUS), ARBOVIRUSES,VIRUSES, ATTENUATION,# NUCLEAR *ADIATION,PURIFICATION, ANTIGFNS + ANrIBODIES, DOSAGEIGUINEA PIGS
(U)
PURIFIED AND CONCENJTRATED VENEZUELAN EQUINFENCEPHALITIS 'VEl VIRUS DERIVED FROM TISSUECULTURES, RENDERED NONINFECTIOUS BY IONIZINGRADIATION WITN RETENTION IN VITRO SEROLOGICALACTIVITY, ALSO RETAINED A HIGH LEVEL OFIMMUNOGENICITY, IN MICE, FLUID VACCINES AFFORDEDEXCELLENT PROTECTION AGAINST LETHAL CHALLENGE WITHHOMOLOGOUS TAINIOAn STRAIN Vft VIRUS* A DIRECTRELATIONSHIP WAS ORSERVEO BETWEEN CONCENTRATION OFVACCINE OR NIPMfER OF INJECTIONS AND SURVIVAL. ONEINTRAPERITONEAL INMCULATION Or UNDILUTED VACCINEPROTECTED ESSENTIALLY ALL NICE CHALLENGED 21 DAYSLATER WITH 1ooO00 MOUSE INTRAPERITONEAL LO50 OFVIRUS* SIMILARLY, MICE RECEIVING THREE INJECTIONSOF VACCINES DILUTED 1:100 WERE COMPLETFLYPROTECTED. NONINFECTIOUS ViE VIRUS PREPARATIONSCOMBINED WITH ADJUVANT 69, A NONTOXIC METAbOLIZABLEVEHICLE, WERE LIKEY'ISE VfRY EFFECTIVE IN PROTECTINGMICE IMMUNIZED INTRAPERITONEALLY OR SUsCUTANEOUSLYAGAINST LETHAL CHALLENGE. GUINEA PIGS IMMUNIZEDSUBCUTANEOUSLY WITH ADJUVANT-COMBINED VACCINESURVIVED LETHAL CHALLENGE OF 1,000,000 GUINEA PI6SINTRAPERITONEAL LO50, (AUTHOR) (U)
68UNCLASSIFIEU tZIMol
I
UNCLASSIFIED
DOC REPORT SISLIOGRApHY SEARCh CONTROL NO* /ZINWI
AD£723 497 £1!FORT DETRICK FR[EDRICK MO
REPLICATION OF VENrZUeLAN EQUINECNCEPMALOMYELITIS VIRUS IN SUSPENSION CELLCULTURES GROWN IN SERUMaFREE AND DEFINEDMEDIA, Atf)
OCT 70 6P TRI|SLEH, f, N JR,1NEARN,HM J, INAGLES Co. ,jR;
UNCLASSIFIED REPORTAVAILABILITY: PUS* IN JNL* OF GENERALVIROLOGY, VlO P221-224 1971.
DESCRIPTORSI (*VENEZUELAN EQUINE ENCEPHALOMYELITISVIRUS, TISSUE CULTURE SELLSI, I*CULTURE MEOIA,*TISSUE CULTURE CELLS), GRO*TH, ARSOVIRUSES,VIRUSES, ILOOD SERUM, ALSUMINS lUl
VARIOUS MAMMALIAN CELLS PROPAGATED IN %ERUM-FREEAND CHEMICALLY DEFINED MEDIA YIELD NIGH TITRFS OFVENEZUELAN EQUINE FNCEPHALOMYVLITIS VIRUS, SOMEDIFFERENCE IN MAXIMUM TITRES WAS NOTED, DEPENDINGUPON THE MEDIUM EMPLOYED, OF THE TWO SERUM-FREEMEDIA TESTED, LACTALBUMIN HYDROLYSTATE MEDIUM WASMORE EFFECTIVE THAN THE CHEMICALLY DEFINED MEDIUM INSUPPORTING VIRUS GROWTH# THE ADDITION OF SERUM ToSERUM.FREE CULTURES AT THE TIME OF VIRUS INOCULATIONHAD A PRONOUNCED EFFECT CHARACTERIZED PY A DELAYFOLLOWED BY A BURST OF VIRUS REPLICATIMN TO VERY HIGHTITRES. THUS, THE PEGREE OF REPLICATION OFVENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS APPEARED
TO SE INFLUENCED BY A VARIETY OF UNKNOWN NUTRITIONALFACTORS. IAUTHOR) IU)
69UNCLASSIFIED IZIM51
UNCLASSIFIED
ODC REPORT BIBLIOGRAPHY SEARCH CONTROL NO. iZimsi
AD-724 874 61IJ 4/1
FORT DETRICK FREBERirv Nn
IMMUNITY TO AEROSOL CHALLENGE IN GUINEA PIGS
IMMUNIZED WITH GAMHA-IRRADIATED VENEZUELAN
EQUINE ENCEPHALITIS VACCINES, (U)
JAN 71 6P REITMANtMORTON ITONIKELLIS
Jo
UNCLASSIFIED REPORTAVAILABILITY: PUB* IN APPLIED MICROBIOLOGY9 V21N* P 6 88 -6 q 2 APR 71,
DESCRIPTORS: (OVENEZUELAN EQUINE ENCEPHALOMYELITISVIRUS, IMMUNITY), (OVACCINES, VENEZUELAN EQUINE
ENCEPPALOMYELITIS VIRUS), GAMMA RAYS, APBOVIRUSESt
VIRUSESo AEROSOLS, EFFECTIVENESS, SEROOIAGNOSIS,GUINEA PIGS IU)
IDENTIFIERSt IRRADIATED VACCINES (U)
IN A PREVIOUS REPORT, IT WAS SHOON THAT NONVIABLEVENEZUELAN EQUINE FNCEPHALITIS (VEE) VACCINESPREPARED BY EXPOSURE OF VIRUS SUSPENSI.ONS PRODUCED IN
WI-18 CELLS TO IONIZING RADIATIONS WERF HIGHLYEFFECTIVE IN PROTECTING GUINEA PIGS SUBJECTED TO
INTRAPERITONEAL 4Ipi CHALLENGE *ITH VEF VIRUS#TO CHARACTERIZE FURTHER THE EFFICACY OF IRRADIATEDVACCINES, GUINEA PIGS WERE IMMUNIZED WITH THREE LOTSOF VACCINE AND THEmI WERE CHALLENGED VIA THERESPIRATORY ROUTE rITH AEROSOLS OF VEE VIRUS*ANIMALS THAT RECEIVED A SERIES OF THREF IP
INOCUATIONS OF VACCINE AT IoWEEK INTERVALS SHOWED
HIGH LEVELS OF RESISTANCE TO AEROSOL CHALLENGE. THE%0$ EFFECTIVE DOSE VALUES OF VACCINES RANGED FROM
40.0016 TO 0,0091 ML FOR RESPIRATORY CHALLENGE ANDFROM 4OO0074 TO 0.0011 ML FOR INTRAPERITONEAL
CHALLENGE. SEROLOGICAL STUDIES SHOWED THATANTIGENICITY OF THE IRRADIATED VACCINES WASEXCELLENT. MOOCRATF TO HIGH LEVELS OF SERUM-
NEUTRALIZING AND "rMAGGLUTINATION-INHIIITINGANTIBODIES WERE DEMONSTRATED IN THE MAJORITY OFANIMALS VACCINATED JIMH UNDILUTED OR 0o. DILUTIONS OFTHE VACCINES. HOWEVER, SERUM-NEUTRALIZING AND
HEMAGGLUTINATIONaI•tHIBITING ANTIBUDY LrVELS WERE NOT
ALWAYS INDICATIVE OF THE LEVEL OF IMMUNITY, BECAUSE
SOME ANIMALS IN WHICH SIGNIFICANT ANTIBODY COULD NOTBE DEMONSTRATED WERE ABLE TO SURVIVE CHALLENGE WITH.VEE VIRUS. (AUTHtRI (U)
70UNCLASSIFIED "Z!MI
UNCLASSIFIED
DOC REPORT BIBLIOGRApHY SEARCH CONTROL NO, /Z[MUJ
AD-726 ItO 4/I) 6/IA.... ,BVbLwUCAL U0CFPhSi RiSIARCG CENTER FREDERICK MD
EFFECTS OF POLYoL.LYSINE ON INFECTIOUSVIRAL NUCLEIC OCIDl)
JAN 71 gp IOOINEJANE Be I*ACHTER9RALPH Fe IC6:tLOWswICHARO Do I
UNCLASSIFIED REPORTAVAILABILITY: PUto IN JNLo Of VIROLOGY, V7 NOPf9S.6C2 MAY ?Is
DESCRIPTORSI t*VENEZUEhAN EQUINE ENCEPHALOMYELITISVIRUS, *NUCLEIC ACIDS), (oAMINO ACIDS, NUCLEICACIDS), VIRUSES, ARROVIRUSES, INFECTIONS,IMMUNOLOGY* INHIBITION, MOLECULAR PROPERTIES (U)ID[NTIFIERSI GLYSINE, MOLECULAR BIOLOGY fU)INFECTIOUS RIBONUCLEIC ACIDS (IRNA) OFVENEZUELAN EQUINE ENCEPHALITIS AND EASTERN EQUINEENCEPHALITIS VIRUSES WERE OBSERVED TO FORMNONINFECTIOUS COMPLEXES WITH A BASIC POLYAMINO ACID,POLY-L-LYSINE, ORIGINAL INFECTIVITY WASRECOVERED FROM THE COMPLEXES BY DIGESTION OF THEPOLYLYSINE WITH.PRONASE, AND PARTIAL RECOVERY WASEFFECTED BY TREATMENT WITH SODIUM oODErYL SULFATEDINFECTIVITY COULD NOT BE RECOVERED FROM THECOMPLEXES CONTAINING POLYLYSINE OF 100,000 MOLECULARWEIGHT BY CHANGES IN IONIC STRENGTH, PH, OR BYTREATMENT WITH PHENOL, DEOXYCHOLATE, OR DIGITONIN,MASKING OF INFECTIVITy BY POLYLYSINE WASDEMONSTRATED IN VIVO AS WELL AS BY PLA4UE ASSAY INTISSUE CULTURE* POLYOL-LYSINE PREPARATIONS OFHIGH MOLECULAR WEIGHT (qq4o9o TO 1OOoOnOP WEREMORE EFFECTIVE THAN LOW MOLECULAR WEIGHT (3.OOO)MATERIALS IN MASKING INFECTIVITY OF IRNAo WHENCOMPLEXES, IN WHICH INFECTIVITY HAD REEN MASKED BYLOW MOLECULAR WEIGMT POLYLYSINEo WERE SUSPENDED IN IN NACLI SO1E INFECTIVITY WAS RECOVERED*COMPLEXES OF POLYLYSINE-IRNA DIFFERED FROMCONTROL IRNA ALONE IN (I) RESISTANCE TOINACTIVATION BY RIPONuCLEASEt fit) SEDIMENTATIONPATTERNS IN SUCROSE GRADIENT CENTRIFUGATION* AND(Ill) STABILITY OF RECOVERABLE INFECTIVITY DURINGoIFFtEaNT PHYSICAL TREATMENTS* (AUTHOR) (U)
71UNCLASSIFIED tZIMS1
UNCLASSIFIED
ODC REPORT BIBLIOGRAPHY SEARCH CONTROL NO. ,ZiM5i
AD-726 lot 6/11 6tiARMY BIOLOGICAL DEFENSE RESEARCH CENTER FREDERICK MO
PMOSPHOLIPID COMPOSITION OF VENEZUELAN EQUINEENCEPHALITIS VIRUS, (U)
JAN 71 diP HEYDRICKFRED P. iCOMERiJOANN Fe IWACHTERPALPH Fp I
UNCLASSIFIED REPORTAVAILABILITY? PUB* IN JNL, OF VIROLOGY; V7 NO
P642w6..' MAY 71.
DESCRIPTORS: (OVENEZUELAN EQUINE ENCCPHALOMYELITIS.VIRUS, *PNOSPHOLIPIDSI, ARSOVIRUSES, CHEMICALANALYSIS, TISSUE CULTURE CELLS, GROWTH, THERMALSTABILITY (U)
IDENTIFIERS: L TISSUE CULTURE, CHICK FIPROBLASTSTISSUE CULTURE 1U)
PHOSPHOLIPID ANALYSES OF VENEZUELAN EQuINEENCEPHALITIS VIRUS SHOWED THAT VIRUS PROPAGATED INL-CELL MONOLAYERS HAD A HIGHER SPHINGOMYELINCONTENT AND A LOWER PHOSPHATIDYLCHOLINE CONTENT THANVIRUS GROWIJ IN CHICK FIBROBLAST MONOLAYERS, VIRUSOF L-CELL ORIGIN ALSO WAS FOUND TO POSSESS GREATERTHERMAL STABILITY THAN VIRUS DERIVED FROM THE CHICKFIBROBLAST CELL. (AUTHORo (LI)
72
UNCLASSIFIED #ZIMfI
IUNCLASSIFIED
DOC REPORT BIDLIOGRIApHY SVARCm CONTROL NO. /ZIPI5
AD-Oo 069 6.01 j41DUGWAY PROVIKG GROUND UTAH BIOLOGICAL DIV
EXPERIMENTAL INFECTION Of COYOTE PUPS WITHVENEZUELAN EQUINE ENCEPHALITIS VIRUS* lu)
DESCRIPTIVE NOTES TECHNICAL REPT.,NOV 66 I'Ip LUNDGRENtDAVIO Le [TERRY,
DAVID Re ISMARTKEITH Lo IPROJ; OA-ILOIMOOIAgtA, USATECOM-g-*-900t-OOMONITOR: OPG T67-10
UNCLASSIFIED REPORT
DESCRIPTORS: (OVENE2UELAN EQUINE CNCLPAALOMYELITIS
VIRUS, EPIOEMIOLOGY1, (ODOGS, DISEASE VFCTORS),
VIRUS DISEASES, RESISTANCEIBIOLOGICAL),INFECTIOUS DISEASES; I"MUNITY, SENODIAGNOSIS,ANTIGENS * ANTIBODIES, MICE (U)
IDENTIFIERS: COYOTES (U)
AN INVESTIGATION WAS UNDERTAKEN TO DETERMINE THEDISPOSITION OF COYITEs TO INFECTION BY THE VIRUS OFVENEZUELAN EQUINE ENCEPHALOMYEIiTIS, AND ALSO TODETERMINE ONSET, HEIGHT AND DURATION OFHAEHAGGLUTINATION INHIBITING, COMPLEMENT-FIXING ANDVIRUSwNEUTRALIZING ANTIBODY, IN THIS INITIALREPORT, 1i IS SHOWN THAT YOUNG COYOTES WERE HIGHLY
.SUSCEPTIBLE TO THE EPIDEMIC STRAIN OF VEE VIRUSUSED, AND THAT THEY DEVELOPED A DOSE-INDEPENDENT
VIREMIA LASTING FOR AN AVERAGE OF 2o6 DAYS IN I TO k
MONTHS-OLD PUPS, AND 2,6 DAYS IN 6 TO 7 MONTHS-OLDPUPS. LESS THAN ONE MOUSE INTRA CEREBRAL MEDIALDOSE (NICLDOO) MAY INITIATE INFECTION WITHIN 24HOURS* INFECTION WITH STRAIN OF VEE V'RUS LED TOA CHARACTERISTIC SYMPTOMATOLOGY, BUT WASCHARACTERIZED BY A LOO INCIDENCE Of LETHALITY EVEN INVERY YOUNG ANIMALS. THESE RESULTS INDICATE THATTHE COYOTE MAY SERVE AS A SHORT TERM SOURCE 4F VEEVIRUS IN THE NATURAL INFECTION CHAIN. ALTHOUGH TWECOYOTE DOES OCCUR OVER A WIDE GEOGRAPHIC RANGEINCLUDING ENDEHIC AREAS, ITS ROLE AS A LINK IN THEDISSEMINATION CHAIN, LEADING TO HUMAN CmHMUNITIES HAYNEVERTHELESS BE MINIMAL BECAUSE OF ITS LOW POPULATIONDENSITY. (AUTHOR) (U)
73UNCLASSIFIED /ZIMI
UNC0.ASSIFIEDI DOC REPORT 81LIOGRApMY SCARCm CONTROL NO, IZIM5I
AD-$)$ 7ot 6*13L18RARy O CONGRESS WASHINGTON 0 C AEROSPACE TECWNOLOGYDIV
SOVIET? VIROLOGY* fU)
ODSCRIPTIVE NOTE: SURVEYS OF FOREIGN SCIENTIFIC ANDTECHNICAL LITERATUCE,
JUN 60 lOop PERKINSLEE INRU&IAKIASYL IREPT. NO# ATD*.7*6S
UNCLASSIFIED REPORT
DESCRIPTORS: (*VIRUS DISEASCS, REPORTS),ARSOVIRUSES, DISEASE VECTORS, TICKS,EPIDEMIOLOGY, TISSUF CULTURE, MUTATIONS,DIAGNOSIS, VACCINES, JAPANESE S ENCEPHALITISVIRUS, OMSK VIRUS, FOOT * MOUTH DISEASE VIRUS,RABIES VIRUS, VENEZUELAN EQUINE ENCEPHALOMYELITISVIRUS, POX VIRUSES, INFECTIONS, SYMPOSIA,MEDICAL RESEARCH, BIBLIOGRAPHIES, USSR (U)
IDENTIFIERS: SWINE PLAGUE tU)
'ONTCNTS: (HE TICKSORNE ENCEPHALITIS COMPLEX--EPIOEMIOLOGICAL DATA, BEHAVIOR OF TSE VIRUS IH CELLAND TISCUE CULTURE, INDUCED MUTATION OF TIEVIRUSES, DIAGNOSTIC METHODS FOR TBE9 TPE THLRAPY,JAPANESE 8 ENCEPHALITISt OMSK FEVER ANn RELATEDDISEASES; HOOF-AND-MOUYH DISEAS|I RASIFS;SWINE PLAGUE1 VENEZUELAN EQUINEENCEPHALOMYELITISI MISCELLANEOUS DISEASES; POX-VIRUS INFECTIONSI SUPPLEMENTARY BI5LIOGRAPHYICONFERENCES ON VIRAL DISEASES; SOME SOVIETVIROLOGICAL RESEARCH INSTITUTES AND THEIRPERSONNEL# (U)
74
UNCLASSIFIED /ZIM1L
CURfORA?( AUTHOR *MONITORING A4ENCI
OAIN FANC% CAMBRIDGE 11659RCM LABS k 4 61LIOGRAPHY 0% MSINEHANSCOM ft9LD MASS ;"CEPMALOSIL6I?as
THin-FiLft amon@R ojoc,- aIFFERENcES A"ONG VIRUSA99477 ylq POPULATIONS mtco0go rOm FRO ICE
VACCINATED *IIM AN AITENgATE0
T HE VASCULAR PgRtEA$IjLIYY AND THE ESTIMATION OF TlgTR OrMECC ANISM OF DEH'EKLINATION IN VCNCIUCLAN EQUINE CNjClPALa~yf6ITISEXPERIMENTAL ALLERbIC VIRUS PRCPANAtIONS FR~OM A SINGLE-ENCEPMALMyf.ELITIS, DILUTION ASSAY,
A001264 A00637 343
e9ARN? BIOLOGICAL CENTER fRID(RzK NO CRtOSSwPftOTECjION IN ANIMALSINFECTED OITh GROUP A ANSOVIOUSE5.
EFFECT 07 SODIUN BICARBONATE Oh ADw£37 3649PLAQUE FORMATION BY Tito iTNAINS OF**.VENEZUELAN EQUINE EN4CEPNALDOYE61TIS EfFECT OF hD6tJVANTS ON ANiTIBODYVIRUS* RCSPONSE Of RABBITS INOCULA?&11 *ITI-(AP.41I 9S2 VENEZUCLAN E4UINCE NCEPHALOMELITus
INFECTION or PIGEON$ Iy AD"637 367AIRBORNE VELNEZUELAN EQUINE 0ENCEPHALITIS VIRUJS& DIFFERENCES; MNAXIMUM AND
* AD*682 il ..7IMINIMUM PLAQU(IIFONMnI% IFNPERATUREi.AMONG SELECTED GROUP A
* *SRRT BIOLOGICAL DEFENS9 RESEARCH ANBORVIRUSE2.Cebit* PKEDERhCK 0D 'AD0637 q06
REPLJCATlON OF VENEZUELAN INACTIVATIO14 OF TOO A#BOVIRUSESMQINE ENCEPNALQI¶YCLITIS YIRUS IN AND THE'IR ASSOCIATto INFECTIOUS
VITRO. Ils VIRAL GROoTN RESPONSE NUCLEIC ACIDS.TO 5ELECTC3 NUTRITIONAL ADDITIVES A09637 %11IN SUSPENSICN CULTURES,
AD0723 liT ABIL.ITY Of A FISH4 CELL LINE TO** *SUPPORT THE GRO11TH Of MAMMALIAN
EFFECTS Of POLYOL*LTSINE ON *VIRUSCS'..INFLCious VIRAL NUCLEIC ACD*, A006442. ilA09726 ISO EIE E)U O
f* EIE MAINTENANCE MDU O
PHOSPHOLIPID COMPOSITION Of SUPPORTING CHICK flINOSLASTVENEZUELAN EQUINE ENCEPHALITIS MONOL-AYERS ANO FOR PLAQUE FOftMTIOti.VIRUS* BY VENEZUELANi AND EASTERN E4UINEA00726 151 ENCEPNALLTIS VlR~oSfSs
.eARN? BIOLOGICAL LASS FREDERICK No AD*896 * *000 SUSCEPTIBILITY OF ONITE CARN.EAU
UNCLA'SSIh s9a
VNCLASS IfI ED
PIGEONS 14 OF90ft"ATORV INFECTION by CULTURES rOR PRODUCTION OF Wa~CtluEVENEZUELAN EQUINE ENCEPMALITIS AGA1INST VENEZUELAN AND0 AMERICANVIRS lfvtgSTIAtN EQUINE ENC~ePHAI.ONYLITh5
A00640 3S2 VRSS* * A0473 Ito
METHOD AND IMMUNOfLUO"9SCENCC RNINSTAINING PITH VEN~iU9LA%- EUZNE DYNA14ICS OF- FlU671PLgCATION OF9NCEOhALOMYKLITI5 vIRUS, - TooE VEE VIRUlI)N T'SSUE CUO.URE
AD-aNI 937 CiELLS9
MODlFl9ih GRADIENT PLATE FORl USE Ao-&is 07Y.INTHE VIRUS PLAIUEC TLCNNlwUto..
ADTRANSISIIEARLY DETECTION Or A1BOVIRUSES.
MOST. INFLUENCE ON THE IN TIS1SUE CULTUR~ES ATCAA CTERISTIC OF VEEUCA.HAGOLIJTINATIO:,EQUINE NOALhEII RUS 707b49iI
ADW64I 673
STUDIES OF THE RESPONSE OF TRANS-2234*MITE CARNEAU PIGEONS TO NCUTRALItATtON REACTION i0, Th~eRESPIRATOAY AND SUBCUTANEOWS DOSES VENEZUELAN 9NC9PhAOMLOPIITIZ VIRUSOr VENEZUELAN EQUINE ENCEPHALITIS IIASED ON THE HEMAGG&.UTINATIOi4'
VIRUS$ PNENQAENONOAp6 4$2 476 AD'&671 3 I
VIROLOGICAL STUDY Of LABORATORY THE EFF9CT OF INTERFERON ON THE:INFECTIONS 41TH VENEZUELAN EQUINE INNIBiTION OrFsTNinEsZs Of P.ROTEINS.9NC1PmdALOMYlLTIS;. I I A CULTURE OF 'CHICF. ENSlAYA00673 303 .FIDROOLASTS ANOCULAtED 0I7M ARBOR
TRANS-407 40466 304-EPIDEMIOLOGICAL. STUDY Or A . .. * *
FLASORATONY INFLCTION WITH INC TRANS02311VENEZUCLAN E(iUINE ENCEUIMALQNYELITI-S PRODUVtION OF INTERFERONd 51
* VIRUS, SOME ARBOR VIRUSES Of GROUP AsAO.473 301 AO~ 38,
TRANS-421 TRANS-2qI2INFECTIOVS ENCEPHALONYELITZS, REPRODUCTION Or WVENEZUELAN
A*0.482 $44 EQUINE ENCEPMALOMYE.LIVIS VIRUS IN
TRANS-1422 SUSPENSION$$THE CLI41C OF vENEZUELAAI EQUINE hom&B1 qc3
ENCEPHALOMYELITIS IN MAN@ NIOMNA YINA00673 207 *ARHY NT OMNA-Y~~ AGENCY
* . . 049E000 ARSENAL NO
IR* NS-SO4 0THE UJTIL.IZATIONi Of TISSUE, SEROLOGICAL AND VIROLO61CAL
UNCL.AtSIPIeD
stypits of 4RTHRC&P(CDORt4E '' D-6f? soRM~tNCEPMALITIS IN TMb CH[SAP9A9E SAY A*5 OREGION LIVE. ATT9NUATED VENE110ELAN
*0.251 ~ CUgINENCCPIIALO$IYELlTIS VIRUSVACCINE, Il. vtM@LC-SLO 0 A~NO.
SANNY FOREIGN UCIENig AND 19CMNOLOGY ACID Aho FLUORESCE~..NT-Aft oogCaNTafR CNAR&OIC@TEVILLE, VA_ -StUDs f@LL-OSINI. I"MiuILAv~lDho
RENOICAIYION'07 VEE VIRUS EARLY ALTERAT IONS I.WTiYROID(PCNLIEATIVIIOI MOPPLEAS VIRUSA 0MORMONE PRYSIOLOGY DU.RING ACUTEVCNES91LYSKQGO tIsEVA6OmI9LITA INFECTION IN MAN*
LIVE. ATTENUATED VENEZUELAN-SAAMY MEDICAL RESEARCM INS? 0f CEQUINE ENCEPI4ALOMYCLITIS VIRUS*INFECTIOUS DISEASES FREDERICK NO VACCINE. Is CLINICAL EFFECTS IN
THE tErECc OF LIVE ATTENUATED 40in666 236VENEZUELAN EQUItkE ENCEPI4ALOMYELITIS. *VIRUS VACCINE, ON SERUM IkON, ZINC, ALTERATIONS IN IM4MUNE RESPONtýESANO.COPPER CONCE.vTRATIONS IN MAN# SY ATTENUATED VEC.EZUELAN EQUINE
A001.3I 040 ENCEPHALITIS VACCIue. I$ ADqJUVANT-* EfFECT OF VEE VIRUS INFECTION IN
*ARINY MEDICAL UNIT FiCDERICK MO GUINEA PIG1169 . 0 * AD',4S9 191
*ISOLATION 07 VENEZUELAN EQUINEENCtPb4ALOMYCLITIS VIRUS NY SOME *ARMY MEDICAL UNIT fREDERnICK noMA*IRO*.CULTURE, PHYSICAL. SCIENCES aIV
*** * ALTERATIONS Of PROTEI-NSINULTANLOUS AEROSOL . SYNTMESIS I.N ARBOVIRUS-INFECYCO L
IMMUNIZATION Of M~ONKEYS *IIM LIVE 'CELLS.
TULAREMIA ANDb LIVE VENEZUELAN ADv&33 S31EQUINE E4CEPNALOMYELITIS VACCINES,
AD.413 920 $ CALIFORNIA UNIV OAKCLAND NAVAL
WITH TOO STRAINS OF VENEZUELAN -THE PATHOGENICITY IN "ICE orEQUINE ENCEPHALOMYELITIS VIRUS. .AEROSOLS OF ENCEPH&LONVOCAeROZTIS
A~m4.20 'd446 GROUP VIRUSES OR Tb.LIR INFECTIOUS& 6 . UCLEI$ ACIDS,
MOSQU ITO TRANSMISSIokOF 07 Aow&2 #40VENE2UELAN EQUINE INCEPMALOMYELIYIS
*VIRUS FROM EXPER IMENTALLY INVECTED *DVGWVAY PROVING-4GROUND UTAHDO~eso 1IOLOGIcAl. DI
A09634, 223 2."OSQUTO-NOVCO IFECTON ITMINFECTION or CoyOT.E PUPS OITM
EQUIE ICEPgLOVLLIIS IRU INVENEZUELAN EwUtMC ENCEPHALITISDVOGU@
00
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MNK~EYS EXPOSED TQ.01HOLEF-GODT A* NEUTRLIZATiON ANTI.IGG TESTIRNAGIATION. FOR ANTISERA TO VENEZUELAN E4UItiEA0067s 07 49 ENCEPNALOMTELITI5,
SeAZACYTIDINE AS A MUTAQEN FOR 0AROOVIRUSESa NULTIeLE ASSESSMENT AN SERUMAD9644 3S NEUTRALIZATJOtj*Qp ARSOVINUS
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A0072a 247
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ACRO@PACE 0E4NL~YDVNELICATIcOya OF VENLZUKLAN - 0Mt 0 0EQUINE ENCEPMALO,1YaLITIS VIRUSM IN 4** e1waSUSPENSM4~ CELL CUL.TURES GkOWiN IN STOVIE 7.6s q'vSCRUM.TREC AND DEFINED MLDSA, .AD-436 366
*0.723 4, C * CALIEN .RgO ARMY IMST Or RESEARCHIMMUNITY TO AEI4OS04 CHAI.LENG9 .RAS5ldETQN a CIN GUINEA PEGS IMMUNIZCO WITH (*ANI4A9 eIRRADIATED VENEZUELAN CQUINI9 CON1PL.EgNT LEVEL.S INENCEPHALITIS VACCINES, gft'*#IMCNTAL ALLERGIC
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SUBJECT INDEX
*AEM( AD-71? 414INSECT CONTROL
REPRINT: EFFECT Of APHOLATE AND "ANTI[N.ANTIBOOY *!"nI.-u;--'& -- " ;v I• NFECTE COMPLEMENT LEVELS INSWITH VCIdZUILAN wEU.NE EXPERIMENTAL ALLERGICEIJ.IPHALOMYELITIS VIRUS. ENCEPNALOMYELITIS.*AD-07 689 AD*445 166
*AG4LUTININS #ARUOViRUSESPREPARATION AGSLUTININSRE"IZNTI NONVIABLE VENEZUELAN C OMPARATIVE STUDY OF THE[
CVUINE ENCEPHALOMYELITIS HAEMAGOLUTINATING ARBOVIRUSH.MAOOLUTININ PREPARED FROM TISSUE ANTIGENS PREPARED FROM TISSUECULTURES BY GAMMA RADITON, _CULTURES AND MOUSE BRAIN--
AD-693 96 .TRANSLATIONeCOMPARATIVE STUDY OF THE AD"?06 553
HAENASOLUTINATING ARBOVIRUS '70 5"ANTIGENS PREPARED FROM TISSUE ANTIMETABOLITESCULTURES AND MOUSE BRAIN•- THE ElrFECT OF INTERFERON ON THETRANSLATION. INHIBITION OF SYNTHESIS OF PROTEINS
AO-706 553 IN A CULTURE OF CHICK EMBRYOFIBR6BLASTS INOCULATED WITH ARBOR
*AMINO ACIDS VIRUS-TRANSLATION.NUCLEIC ACIDS * AD-685 388* REPRINT: EFFECTS OF POLY-L-LYSINE ON INFECTIOUS VIRAL NUCLEIC DISEASESACID* INFECTIOUS ENCEPHALOMYLITIS
.A-?*6 150 TRA"NMLATION*ADO.66 568
*ANTIGENS + ANTIBODIES.GAM*MA OLOBULIN FLUORESCENT ATIBODY T1ECHNIOUES
REPRINTS NEUTRALIZATION OF REPR:NTt MULTIPLE ASSESSMENT'RESIDUAL INFECTIVITY OF VENEZUELAN AND SERUM NILJTRALIZATION OFESUINE ENCCPHALOMYELZTIS VIRUS BY . ., ARBOVIRUS MIXTURES.ANTI-GAMMA GLOBULIN. * A0-715 801
* AD-7OS 739' MUTATIONS
RADIATION EFFECTS REPRINT: 5-AZACYTIDINE AS A'REPRINTI ANTIBODY RESPONSES IN MUTAGEN FOR ARBOVIRUSES*
RHESUS MONKEYS EXPOSED TO WHOLE-, AD-6B6 35ABODY X-IRRADIATION,
". AD-675 074 NUCLEIC ACIDSREPRINT: INACTIVATIOm OF TWO
VENEZUELAN EQUINE ENCEPIqALOWIELzTIS V ARBOVIRUSES AND THEIR ASSOCIATEDREPRINT: NEUTRALIZATION ANTI- INFECTIOUS NUCLEIC ACIDS.
1106 TEST FOR ANTISERA TO VENEZUELAN AD-637 411EQUINE ENCEPHALONYELITIS.
AD-7O0 768 -'RIBONUCLEIC ACIDSREPRINT: CELL SURFACE ANTIGEN REPRINTI ALTERATIONS OF PROTEIN
INDUCED BY VENEZUELAN EGUINE SYNTHESIS IN ARBOVIRUSINFECTED L
ENCEPHALOMYELITIS VIRUS, CELLS.
D-1UNCLASSIFIED
I
UNCLASSIFIEDIIAC-DIS
AD-633 531
TIS MT IID COT "6MENT LEVELS INTRANSLATIOA OF RUSSIAN RESEARCH: tx~tAIMENTAL ALLERGIC
EARLY DETECTION OF ARUBOVIRUSES IN NEAOMLTS.0TISSUE CULTURES BY AD-445 s66HEMAGGLtJTINATION,AD-652 673
*BACTERIAL AEROSOLSlwMUNT~y
SIMULTANEOUS AEROSOLIMMUNIZATION OF MONKEYS WITH LIVE *"ULURE MEDIA-TULAPEMIA AND LIVE VEE VACCINES* EQUINE ENCEPHALOMYEPLITIS VIRUS
AD-4453 928 REPRINT: DEFINED MAINTENANCE*SIBLOGRAPIES 14901DUM FOR'SUPPORTING CHICK0$18LOGRAMIESFIBROBLAST MONOLAYERS AND FOR
A COMPREHENSIVE BIBLIOGRAPHY ON -PLAGUE FORMATION BY.VE4EZUELAN ANDEQUINE ENCEPHALOMYELIT:S. EASTERN EQUINE ENCEPHALITISAD-291 081 VIRUSES.,
*BIOLOGY.A-3 6SURVEILLANCE OF PROBABLE HOSTS TISSUE CULTURE CELLS
AND VECTORS OF EASTERN AtRPRINT? REPLICATION OFENCEPHALITIS VIRUS INCLUDING THE VENEZUELAN 1EQUINE ENCEPHALOMYELITISSCREENINGOF SPECIMENS IN 3-WEEK- VIRUS IN SUSPENSION CELL CULTURESOLD MICE FOR INDICATIONS OF GROWN IN SERUM-FREE AND DEFINEDVIREMIA AND HOLDING 0F ARTHROPOD MEM*SPECIMENS AND SERUM FRACTIONS FOR .AD-723 497CONFIRMATORY STUDIES
.AD-285 323 VENEZUELAN EWUINE ENCEPHALOMIYELITIS VREPRINT: REPLICATION OF
*BLOOD SERUM VENEZUELAN EQUINE ENCEPHALOMYELITISSURVEILLANCE OF PROBABLE HOSTS VIRUS IN VITRO. II. VIRAL GROWTH
AND VECTORS OF EASTERN RESPONSE To SELECTED NUTRITIONALENCEPHALITIS VIRUS INCLUDING THE' ADDITIVES IN SUSPENSION CULTURES.OLD NICE FO SNDICTIOENS IN3WEOFA-2 5OLCMIENFNOR SPEICAIOENS IN3WEOFA-2 5
* VIREMIA AND HOLDING OF ARTHROPOD* SPECIMENS AND SERUM FRACTIONS FOR -
CONFIRMATORY STUDIES.AD-285 3235
MBRAIN 'DISEASES.DISEASES SURVEILLANCE OF PROBABLE HOSTS
*REPRINT: ELECTRON MICROSCOPIC AND VECTORS OF EASTERNSTUDIES ON THE VASCULAR ENCEPHALITIS VIRUS INCLUDING THE'PERMEABILITY AND"THE MECHANISM OF SCREENINOOF SPECIMENS IN 3oWEEK-DEMYELItdATION IN EXPERIMENTAL OLD MICE FOR INDICATIONS OFALLERGIC ENCEPHALOMYELZTIS, VIREMIA AND VILDING OF ARTHROPOD
AD-612 $5'. SPECIMENS AND SERUM FRACTIONS FOR
D-2UN~CLASSIFIED
UNCLASSIFIED000-GRO
CONFIRMATORY STUDIESe. AD-285 323AD-285 323
A COMPREHENSIVE BIBLIOGRAPHY ON *ENTEROVIRUSESEQUINE ENCEPMALOMfELITIS, AEROSOLS
AO-491 081 REPRINTS THE PATHOGF&,TeTTY tINMICE OF AEROSOLS OF
QUINES . ENCtPHALOMYOCARDITIS GROUP VIRUSESINFECTIOUS ENCEPHALOMYELiTIS-- OR THEIR INFECTIOUS NUCLEIC ACTOS.TRANSLATION. AD-672 469
AD-662 58S4EQUINE ENCEPHALOMYELITIS VIRUS.,co SURVEILLANCE OF PRO0ABLE HOSTSDISEASE VECTORS AND VECTORS OF EASTFRNINFECTION OF COYOTE PUPS WITH ENCEPHALITIS VIRUS INCLUDING THEVENEZUELAN EQUINE ENCEPHALITI. SCREENINGOF SPECIMENS IN 3-WEEK-
VIRUSA0 -OLD MICE-FOR INDICATIONS OFAD-804 069 "VIREMIA AND HOLDING OF ARTHROPOD
SPECIMENS AND SERUM FRACTIONS FOR$9ASTERN EQUINE ENCEPHALOHyrLITIS VIRUS CONFIRMATORY STUDIES.GROWTH AD-285 383
RFPRINTS DEFINED MAINTE AN C"' A COMPREHENSIVE BIBLIoGRAPHY ONMEDIUM FOR SUPPORTING CHIP CKUINE ENCEPHALOMYELITIS.FIBROBLAST MONOLAYERS AND FOR AD-291 081PLAGUE FORMATION BY VENEZUELAN AND 4EASTERN EQUINE ENCEPHALITIS TISSUE CULTUREVIRUSES. REPRINT: ABILITY OF A FISH CELLAD-638 563 LINE TO SUPPORT THE GROWTH OF
"MAMMALIAN VIRUSES.TISSUE CULTURE AD-638 425
REPRINT: ekOWTH.OF VENEZUELAN#AND EASTERN# EQUINE VACCINESENCEPHALOMYELITIS VIRUSES IN TISSUE THE UTILIZATION OF TISSUECULTURES OF MINCED AEDES AEGYPTI CULTURES FOR PRODUCTION OF VACCINESLARVAE g AGAINST VENEtUELAN AND AMERICAN
AID-687 363 WESTERN EQUINE ENCEPHALOMYFl:TISVIRUSES--TRANSLATION.VIABILITY AD-6?3 210REPRINT: INACTIVATION OF TWO
ARBOVIRUSES AND THEIR ASSOCIATED *GAMMA GLOBULININFECTIOUS NUCLEIC ACIDS* ANTIGENS * ANTIBODIES
AD-637 411 REPRINTS NEUTRALIZATION OFRESIDUAL INFECTIVITY OF VENEZUELAN*ENCEPHALITIS VIRUS EQUINE ENCEPHALOMYELITIS VIRUS BYSURVEILLANCE OF PROBBLE HOSTS ANTI-GAMMA GLOBULIN.
AND VECTORS OF EASTERN AO-705 739ENCEPHALITIS VIRUS INCLUDING THESCREENINGOF SPECIMENS IN 3-WEEK- *GROUP A ARBORVIRUSESOLD MICE FOR INDLCATIONS OF TEMPERATUREVIREMIA AND HOLDING OF ARTHROPOD REPRINT: DIFFERENCES IN MAXIMUMSPECIMENS AND SERUM FRACTIONS FOR AND MINIMUM PLAQUE-FORMINGCONFIRMATORY STUDIES. TEMPERATURES AMONG SELECTED GROUP A
0-3UNCLASSIFIED
- - - -- --- - - -
~1
I jS... .. L~~~~N•CLA•S•tF . .. .. . . .. .. .. .
* oINSECT CONTROLSAD-637 406 AbKS, I
REPRINT: EFFECT oF APHOLATE AND*GROUP A ARBOVIRUSES .METUPA ON AEDES AECYPTI INFECTED
ZMMJJNITY WITH VENEZUELAN EQUINEREPRINT: CROSI;-PROTECTION IN ENCEPHALOMYELITIS VIRUS*
ANIMALS INFECTED WITH GROUP A AD-657 689ARBOVIRUSES.
AD-637 36 *METABOLISMPRODUCTION OF INTERFERON BY SOME. INFECTIOUS DISEASES
* .ARSON "VARUSES "FSROUP Ain "REPRINTl THE EFFECT OF LIVETRANSLATION, ATTENUATED VENEZUELAN EQUINE
AD'685 389 ENCEPHALOMYELITIS VIRUS VACCINE ONSERUM IRON# ZINCP AND COPPER
*IMMUNITY CONCENTRATIONS IN MAN.BACTERIAL AEROSOLS .!'AD-713 680
SIMULTANEOUS AEROSOLIMMUNIZATION OF MONKEYS WITH LIVE SMETALSTULAREMIA AND LIVE VEE VACCINES. . METABOLISM
AO-•53 926 REPRINTS THE EFFECT OF LIVEMN Y . ATTENUATED VENEZUELAN EQUINE
VEMMUNOULOGY ENCEPHALOMYELITIS VIRUS VACCINEONVENEZUELAN EQUINE ENCEPHALOMYELI|TIS V ,SERUM IRONP ZINCP AND COPPER
REPRINT: IMMUNOGENICITY OF 'CONCENTRATIONS IN MAN.PURIFIED VENEZUELAN EQUINE AD-713 680ENCAPHALITIS VIRUS INACTIVATED BYIO/NZINS RADIATION. *MUTATIONSAD793 272 •ARSOVIRUSES
. REPRINTS 5-AZACYTIOINE AS A*INFECTIOUS DISEASES MUTAGEN FOR ARBOVIRUSES,
.METABOLISM AD-686 351REPRINT: THE EFFECT OF LIVE
ATTENUATED VENEZUELAN EQUINE *NERVE FIBERSENCEPHALOMYELITIS VIRUS VACCINE ON1' PATHOLOGYSERUM IRON# ZINC. AND COPPER REPRINTS ELECTRON MICROSCOPICCONCENTRATIONS IN MAN. STUDIES ON THE VASCULAR %
AD-713 680 PERMEABILITY AND THE MECHANISM OF, DEMYELINATION IN EXPERIMENTAL
RIGONUCLEIC ACIDS ALLERGIC ENCEPHALOMYELITISoREPRINT: EFFECTS OF METHYLATED AD-612 545
ALBUMIN ON INFECTIOUS ANA:REVERSIBLE INFECTIVITY LOSS AND *NUCLEIC ACIDSRESISTANCE TO NUCLEASE.DIGESTION. ARBOVIRUSES
AD-648 826 REPRINT: INACTIVATION OF TWOARBOVIRUSES AND THEIR ASSOCIATED
THYROID HORMONES INFECTIOUS NUCLEIC ACIDS.REPRINT: EARLY ALTERATIONS IN AD-637 41.1
THYROID HORMONE PHYSIOLOGY. DURINGACUTE INFECTION IN MANt VENEZUELAN EQUINE ENCEPHALOMYELITIS V
AD.66 862 REPRINTS EFFECTS OF POLY-L
LYSINE ON INFECTIOUS VIRAL NUCLEIC
UNCLASSIFIED
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ACID. arm!NN ALTURAiioNs OF PROTEIN•AD-ýii ISO SYNTHESIS IN ARBOVIRUSINFECTEO L
* CELLSv9*$,4Ol,,I,,PI " AO,33 531
VENEZUELAN EQUINE ENCEPHALOMYELITIS VREPRINTI PHOSPHOLIPID *RIIOSOMES
COMPOSITION OF VENEZUELAN EQUINE VENEZUELAN EQUINE ENCEPHALOMYELITIS VENCEPHALITIS VIRUS# VIRUS-SPECIrIC POLYSOMES IN
AD-786 151 CELLS INFECTED WITH THE VENEZUELANEQUINE ENCEPHALOMYELITIS VIRUS--
"4P4.EONS TRANSLATION1VENEZUELAN EQUINE [NCPHALOMYELPITISIV AD-709 949.-
REPRINT: SUSCEPTIBILITY OFWHITE CARNEAU PIGEONS TO *SIRODIAGNOSISRESPIRATORY INFECTION BY VENEZUELAN ANTIGENS 4 ANTIBODIESEQUINE ENCEPHALITIS V.IRUS. REPRINTS NEUTRALIZATION ANTI-
AD-640 352 106 TEST FOR ANTISERA TO VENEZUELANREPRINT$ INFECTION OF PIGEONS .EQUINE ENCEPHALOMYELITIS,
BY AIRBORNE VENEZUELAN EQUINE AD,705'768ENCEPHALITIS VIRUS.
AD-6 4 2 4?71 ARBOVIRUSESREPRINT$ .STUDIES OF THE' . REPRINTS MULTIPLE ASSESSMENT
RESPONSE OF WHITE CARNEAU PIGEONS AND SERUM NEUTRALIZATION OFTO RESPIRATORY AND SUBCUTANEOUS *.ARBOVIRUS MIXTURES*DOSES OF VENEZUELAN EQUINE AD-?7S 201ENCEPHALITIS VIRUS,ADE I2I •76 I VENEZUELAN EQUINE 'ENCEPHALOMYELITIS V
• .. ' 447 1"2NTI HEMAGBULTINATION-
OPROTEINS * INHIBITION METHOD ANDBIOSYNTHESIS IMMUNOFLUORESCENCE STAINING WITH
REPRINT: ALTERATIONS OF PROTEIN VENE;UELAN EQUINE ENCEOHALOMYELIT1SSYNTHESIS IN ARBOVIRUSZNF£CTED L VIRUS.CELLS, AD-64l 937 "
A0-33 531*SPINAL CORD
*RADIATION EFFECTS DISEASES.VENEZUELAN EQUINE 9NCEPHALOMYELITIS V , REPRINTS ELECTRON MICROSCOPIC
.REPRINT: INACTIVATION OF STUDIES ON THE VASCULARVENEZUELAN EQUINE ENCEPHALOMYELITIS PERMEABILITY AND THE MECHANISM OF
* .VIRUS BY GAMMA-RADIATIONt DEMYELINATION IN EXPERIMENTAL- AD-6"* 203 ALLERGIC ENCEPHALOMYELITIS,
,AD-61 5145*RIBONUCLEIC ACIDS 4
INFECTIOUS DISEASES *THYROID HORMONESREPRINT: EFFECTS OF METHYLATED INFECTIOUS DISEASES
ALBUMIN ON INFECTIOUS RNA: REPRINTS EARLY ALTERATIONS INREVERSIBLE INFECTIVITY LOSS AND THYROID HORMONE PHYSIOLOGY DURINGRESISTANCE TO NUCLEASE DIGESTION. ACUTE INFECTION IN MAN,
AD-644 826 AD-664 862
SYNTHESIS *TISSUE CULTURE CELLS
0-5UNCLASSIFIED
_19
UNCLASSTF7EDTRI"•V.:N
CULTURE MEDIA AD-665 236REPRINT: REPLICATION OF REPRINT: THE EFFECT OF LIVE
VENEZUELAN EQUINE ENCEPHALOMYELITIS ATTENUATED VENEZUELAN EOQINE• . .IlUN .ELL CULTURES ENCEPHALOMYELITIS VIRUS VACCINE ON
GROWN IN SERUM-FFErE AND DEFINED SERUM IRONt ZINC. AND COPPERMED'IA* CONCENTRATIONS IN MAN.AD-72Z 497. AO-713 680
REPRINT: IMMUNOGENICITY OFFISHL5 PURIFILD VENEZUELAN EQUINE
REPRINT: ABILITY OF A FISH CELL F-CAPHALITIS VIRUS INACT!VATEO BYLINE TO LUPPORT THE GROWTH-OF IONIZIN4 RADIATIONj.MAMMALIAN VIRUSES. AD-723 272
AD-638 425 REPRINT: IMMUNITY TO AEROSOLCHALLENGE IN GUINEA PIGS 1MMUNIZED
RIBOSOMES WITH GAMMA-IRRADIATED VENEZUELANVIRUS-SPECIFIC POLYSOMES IN EQUINE ENCEPHALITIS VACCINES.
CELLS INFECTED WITH THE VENEZUELAN AD-724 874EQUINE ENCEPHALOMYELITIS VIRUS--TRANSLATION, *VENEZUELAN EQUINE ENCEPHiALOMYELITIS VI
AD-709 942 AEROSOLSREPRINT: EFFECT OF SIMULATED
VENEZUELAN EQUINE ENCEFHALOMYELITIS V SOLAR RADIATION AND SODIUMREPRINT: GROWTH OF VENEZUELAN FLUORESCEIN ON THE RECOVERY OF
EQUINE ENCEPHALOMYELITIS VIRUS IN * VENEZUELAN EQUINE ENCEPHALOMYELITISHUMAN DIPLOID CELL STRAIN WI-38 VIRUS FROM AEROSOLS.
A0-701 251 AD-723 267
rTRIAZINES AeGLVrTININSMUTATIONS REPRINT: NONVIABLE VENEZUELAN
REPRINT: 5-AZACYTIDINE AS A EQUINE ENCEPHALOMYELITISMUTAGEN FOR ARBOVIRUSES. HEMAGGLUTININ PREPARED FROM TISSUE
AD-686 351 CULTURES BY GAMMA RADIATION,
*VACCINES AD-693 946 '.
EFFECTIVENESS ANTIGONS + ANTIBODIESSIMULTANEOUS AEROSOL REPRINT: EFFECT OF ADJUVANTS ON-
IMMUNIZATION OF MONKEYS WITH LIVE ANTIBODY RESPONSE OF RABBITSTULAREMIA AND LIVE VEE VACCINES, INOCULATED WITH VENEZUELAN EQUINE
AD-453 928 ENCEPHALOMYELITIS VIRUS.AD-637 367VENEZUELAN EQUINE !NCEPHALOMYELITIS V REPRINT: NEUTRALIZATION ANTI-
REPRINT: LIVEt ATTENUATED IGG TEST FOR ANTISERA TO VENEZUELANVENEZUELAN EQUINE ENCEPHALOMYELITIS EQUINE ENCEPHALOMYELITIS.VIRUS VACCINE, Ilo WHOLE-BLOOD AD-705 768
AMINO-ACID AND FLUORESCENT-ANTIBODY REPRINT: CELL SURFACE ANTIGEN,STUDIES FOLLOWING IMMUNIZATION* INDUCED BY VENEZUELAN EQUINEAD-664 223 ENCEPHALOMYELITIS VIRUS.
REPRINT: LIVEo ATTENUATED AD-717 414VENEZUELAN EQUINE ENCEPHALOMYELITISVIRUS VACCINE. I. CLINICAL ANTIGEN-ANTIBODY. REACTIONSEFFECTS IN MAN, NEUTRALIZATION REA;TION OF THE
D-6UNCLASSIFIED
UNCLASSIFIEDTRI-VEN
VENEZUELAN ENCEPHALO0YELITIS VIRUS .An-657 508BASED ON THE HEMAGGLUTINATIONPHENOMENON--TRANSLATIONo Dees
, 1_ 3 REq'rr,•1Ni; c.reLIMLNIAL INFECTION'OF DOGS WITH TWO STRAINS OF
ATTENUATION VENEZUELAN EQUINE ENCEPHALOMYELITISRERH:FACTORS 'a FLU-ENC 1NG VIRUS6
VIRULENCE AND PLAQUL PROPERTIES OF AD-620 445ATTENUATED VENEZUELAN EQUINEENCEPHALOMYELITIS VIRUS EMBRYONATED EGG TECHNIQUEPOPULATIONS& .EPRODUC'TION OF VENEZUELAN
A 260UINE ENCEPHALOMYELITIS VIRUS INCHICK EMBRYO FIBROBLAST SUSPENSIONS-
BIOLOGICAL ASSAY -TRANSLATION#REPRINT: ESTI4ATION OF TITER OF AD-585 -03
VENEZUELAN EQUINE ENCEPHALOMYELITISVIRUS PREPARATIONS FROM A SINGLE- -EPIDEMIOLOGYDILUTION ASSAV* INFECTION OF COYOTE PUPS WITH
AD-637 343 VENEZUELAN EQUINE ENCEPHALITISVIRUS.
BIOSYNTHESIS AD-804 069REPRINT: TSMPERATURE-SENSIT/VE
STEPS IN THE.BIOGYNTHESIS OF GROWTHVENEZUELAN EQUINE ENCEPHALITIS n REPRINT: DEFINED MAINTENANCEVIRILIS MEDIUM FOR SUPPORTING CHICK
AD650 187 FIBROBLAST MONOLAYERS AND FORPLAQUE FORMATION BY VENEZUELAN AND
COUNTING METHODS EASTERN EQUINE ENCEPHALITISREPRINT: PRIMARY VIRUS-CELL VIRUSES*
INTERACTIONS IN THE 'AD-638 563IMMUNOFLUCRESCENCE ASSAY OF REPRINT: MODIFIED GRADIENTVENEZUELAN EQUINE ENCEPHALOMYELITIS PLATE FOR USE IN THE VIRUS PLAQUEVIRUS* TECHNIQUE.
AD-655 696 ** AD-641 938REPLICATION OF VEE VIRUS--
DIAGNOSIS TRANSLATION,ISOLATION OF VEE VIRUS BY BONE AD-719 548
MARROW CULTURE* • REPRINT: REPLICATION OFAO-453 927 VENEZUELAN EQUINE .ENCEPHALOMYELITIS
VIRUS IN VITRO* I. VIRAL GROWTH
DISEASE VECTORS RESPONSE TO SELECTED NUTRITIONALREPRINT! MOSQUITO TRANSMISSION ADDITIVES IN SUSPENSION CULTURES.
OF VENEZUELAN EQUINE AD-723 257ENCEPHALOMYELITIS VIRUS FROFEXPERIMENTALLY INFECTED DOGS* IMMUNITY
AD-634 222 REPRINT: IMMUNITY TO AEROSOLCHALLENGE IN GUINEA PIGS IMMUNIZED
DISEASES WITH GAMMA-IRRADIATED VENEZUELANREPRINT: MOSQUITO-INDUCED EQUINE ENCEPHALITIS VACCINES.
INFECTI1N WITH EQUINE AD-724 B74ENCEPHALOMVELITIS VIRUS IN DOGS,
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BLANK PAGE 1--
I
- - -. 4
NOTICE
This bibliography references primarily those technical
reports that evolve from research and development sponsored
by the Department of Defense (DoD). No effort is made to
include citations from either the open literature or the
technical reports of non-DoD agencies.
For specific information regarding prices of documents
(hard copy or microform), call 703-321-8560 or write to
National Technical Information Service (NTIS), 5258 Port
Royal Road, Springfield, Virginia 22151.
For Information Concerning Technical Content
of this BIBLIOGRAPHY call
DDC-TAS 202 OX 4.7206
Always order Technical Reports by AD-Numbertl i i i I
~ AMPHIBIOUS OPERATIONS\ ARC WELDINGBIBLIOGRAPHY ON INFORMATION SCIENCES
CAPACITOR TECHNOLOGY
CARGO SHIPSCOLOR PHOTOGRAPHY
COMPUTERS IN INFORMATION SCIENCESCOST EFFECTIVENESS ANALYSIS
ELECTRODEPOSITIONFARADAY ROTATION
GAS DETECTORSFIRE EXTINGUISHERS
GROUND EFFECT MACHINESHOLOGRAPHY
IGNEOUS ROCKSINFRARED PHOTOGRAPHY
KRYPTONLASER COMMUNICATION SYSTEMS (11)
LIFE SUPPORT IN SPACE TRAVEL -,LIQUID CRYSTALMANAGEMENT ENGINEERING
MANAGEMENT INFORMATION SYSTEMSMERCURY LAMPS
THE MOONNONEQUILIBRIUM FLOW U
NUCLEAR MAGNETIC RESONANCEOCEANOGRAPHY
ON-LINE COMPUTER SYSTEMSPACKAGED CIRCUITS
PHOSPHATE COATINGSPITOT TUBES
THE PLANET MARSRADAR ANTENNAS
SEALSSOLAR WIND
TANKERSTECHNIQUES IN PLATING
USE OF COMPUTERS IN EDUCATIONWEATHER SATELLITES
WHITE PHOSPHORUSXENON LAMPS
rNOTICE
This bibliography references primarily those technic.1
reports that evolve from research and development sponsored
by the Department of Defense (DoD). No effort is made to
include citations from either the open literature or thettchnical reports of non-DoD agencies.
For specific information regarding prices of documents
(hard copy or microform), call 703-321-8560 or write to
National Technical Information Service (NTIS), 5258 Port
Royal Road, Springfield, Virginia 22151.
For Information Concerning Technical Content
of this BIBLIOGRAPHY call
DDC-TAS202.274-7206
f Always order Technical Reports by AD-Number
I
IIF~\ AMPHIBIOUS OPERATIONS
A Or WCI Ml kit'
BIBLIOGRAPHY ON INFORMATION SCIENCES 4
CAPACITOR TECHNOLOGYCARGO SHIPS
COLOR PHOTOGRAPHYCOMPUTERS IN INFORMATION SCIENCES
COST EFFECTIVENESS ANALYSISELECTRODEPOSITION
FARADAY ROTATIONGAS DETECTORS
FIRE E"TINGUISHERS
GROUND EFFECT MACHINESHOLOGRAPHY
IGNEOUS ROCKS!NFRARED PHOTOGRAPHY
KRYPTONLASER COMMUNICATION SYSTEMS (11) i
LIFE SUPPORT IN SPACE TRAVELLIQUID CRYSTALMANAGEMENT ENGINEERING
MANAGEMENT INFORMATION SYSTEMSMERCURY LAMPS
THE MOONNONEQUILIBRIUM FLOW
NUCLEAR MAGNETIC RESONANCE
OCEANOGRAPHYON.LINE C7OMPUTER SYSTEMSPACKAGED CIRCUITS
PHOSPHATE COATINGSPITOT TUBES
THE PLANET MARSRADAR ANTENNAS
SEALSSOLAR WIND
TANKERSTECHNIQUES IN PLATING
USE OF COMPUTERS IN EDUCATIONWEATHER SATELLITES
WHITE PHOSPHORUSXENON LAMPS