ii-sdv 2013 challenges in visualizing pharmaceutical business information
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BizInt Smart Charts 2013
Challenges in Visualizing
Pharmaceutical Business Information
April 2013
II-SDV, Nice, FranceDiane Webb, President, BizInt Solutions Inc.
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BizInt Smart Charts 2013
The Problem:
Visualizations developed for
scientific and patent data
do not do a good job of “telling the story”
when applied to drug pipeline data
and often need significant changes.
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Examples of technical visualizations
Source: Erdi et al., Yang
et al, Search Technology
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Examples of pharma pipeline visualizations
Source: Roche, Ligand,
AmgenOncology websites
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The Drug Development “Pipeline”
At each stage of the pipeline, companies need information on drugs
in development to make both business and research decisions.
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Clinical Trials – Phases in the Pipeline
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Information on drug pipelines --
� Comes from a variety of sources – company
sources, published literature, conferences,
industry news, etc.
� Drug Pipelines Databases – constructed by
teams of editors at several companies, reviewing
public and proprietary sources.
� Sold to the pharmaceutical industry for
competitive intelligence on drug pipelines.
� Examples: Pharmaprojects, Integrity, R&D Focus
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BizInt Smart Charts 2013
An example of a company pipeline graph
Created in Excel from
BizInt Smart Charts
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There are lots of problems…
Vocabulary needs
to be normalized.
Created in Excel from
BizInt Smart Charts
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Challenges in multi-database reports
1. Multiple
Records for the
Same Drug
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BizInt Smart Charts 2013
Challenges in multi-database reports
2. Conflicting
Data for the
Same Drug
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Challenges in multi-database reports
3. Terminology
Variation
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After cleanup and de-duplication…
Created in Excel from BizInt Smart
Charts Reference Rows.
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But the phases are not ordered by time.
Marketed is the
final phase.
Research comes first.
Preclinical precedes
clinical phases.
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We need to order the phases chronologically
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Now we have a meaningful pie graph…
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BizInt Smart Charts 2013
Or we could create a pipeline bar graph…
Created in Excel from BizInt Smart
Charts Reference Rows.
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But the colors aren’t consistent by phase.
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BizInt Smart Charts 2013
So we apply color palette for phases.
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But pipeline bar charts often look like this…
Source: Novartis website
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Each bar/phase is made up of boxes…
Which represent a
drug in that phase.
With a color coding
scheme for another
aspect of the drug.
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BizInt Smart Charts 2013
If there are too many drugs in a phase…
The boxes are
stacked in multiple
columns.
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Many dimensions are overlaid…
Source: Anthony et al.
Malaria Journal
Boxes are color
coded for drug
“features”.
What do the dashed
lines mean?
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These are not standard bar charts!
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BizInt Smart Charts 2013
Here’s a “bulls-eye” pipeline visualization…
A Koul et al. Nature 469, 483-490 (2011) doi:10.1038/nature09657
A bull’s-eye representation of the current clinical pipeline for TB.
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Features of a pipeline “bulls-eye”
Each ring is a phase.
The circle is divided into
segments representing
mechanisms (MOA).
Each drug is
placed by phase
and MOA.
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BizInt Smart Charts 2013
This is not a standard visualization!
A bull’s-eye representation of the current clinical pipeline for TB.
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It has features of a polar scatter chart.
Sample from Chart Director
chart library.
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BizInt Smart Charts 2013
The radial values are related to time.
Rings represent progress
from Phase 1 to approval.
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BizInt Smart Charts 2013
But the segments are like a pie graph…
Each segment is
a different MOA.
And there is no
meaning to the
order of the
segments.
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Except the segments are the same size…
Even though
there is 1 drug
for this MOA.
And 3 for this
MOA.
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In this bulls-eye, segment sizes vary…
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BizInt Smart Charts 2013
Some issues creating pipeline bulls-eyes…
Artistic mockup created with data from
BizInt Smart Charts Reference Rows.
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Some issues creating pipeline bulls-eyes…
Where do you plot the
drugs in the segment?
Drug names
can be very
long.
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Some issues creating pipeline bulls-eyes…
We’d like different
symbols to represent
other drug features.
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And we want to use our phase color palette
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The “phase” in a drug pipeline database…
� Represents the furthest progress of clinical trials
for one or more indications in one or more
markets.
� There may be multiple clinical trials in progress.
� We want to show a timeline of clinical trials for
a particular drug.
� Sources: ClinicalTrials.gov; Citeline Trialtrove;
Adis Clinical Trials Insight
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Applying a standard GANTT visualization
Start/Completion
years not shown in
a familiar format
Cannot see the
trial phase
Created in VantagePoint – BizInt
Smart Charts Edition.
Significant manual
data cleanup
required
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A better trial timeline
Bars now show
duration of trials
Missing data is
clearly displayed
Created in VantagePoint – BizInt
Smart Charts Edition.
Bars color coded
by phase
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Consistent use of color
Use the phase
color palette
Legend explains
symbols
Created in VantagePoint –
BizInt Smart Charts Edition.
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Why use multiple sources?
� Indexing differences may return different results.
Additional trials
returned
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Why use multiple sources?
� Take advantage of content variation
More additional
trials returned
Missing end date
provided by Adis
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To summarize, pipeline visualizations…
� Require multiple sources for completeness and
accuracy.
� Rely on data cleanup and deduplication tools.
� Generally cannot be created with standard
visualization libraries.
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And pipeline visualizations…
� Often show discrete rather than aggregate values.
� Often show categorical rather than numeric
coordinate values.
� Need consistent use of order and color coding.
Do these visualizations operate at the exploratory or
explanatory levels?
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Come to
our table
to learn
more!
Slides at:
bizcharts.com/slides
Thank you!