induced electric field on subthalmic neurons
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An Outline of Evaluating the impact of the deep brain stimulation induced electric field on Subthalmic neurons: A computational modeling studyTRANSCRIPT
Evaluating the impact of the deep brain stimulation induced electric field on Subthalmic neurons: A computational modeling studyYousif N, et al.Journal of Neuroscience Methods 2010
Samuel JamesPurposeThe purpose of this study is to determine whether implementing the properties of the entire neuron may help theorize the parameters for DBSMethodsPassive Cable Model A. The distribution of extracellur stimulation was determine through the Laplace equation. B. The passive cable model looked at the Electrode Brain Interface.a. This includes the geometry of the electrod and the surrounding tissueC. However the Passive Cable Model does not look at the Peri electrode space. The Peri electrode space was not the subject of this study. Bu this is important to consider for the past studies have shown that the peri electrode space can affect the electrical frequency. D. The properties of the neurons were determined from prior studies. Grey matter had a conductivity of 25 S/m The axons were constrained within a ten by ten millimeter area.Axon modelA. The Axon model was models based off the conventional cable theory, including the passive cable model and Hodgkin and Huxley Model. The Mylelin sheath and Axolemma were the main aspects that were modeled. 100 Axons that were 5.7 micrometers in length were modeled.B. Gate channels included a fast and persistent sodium channels and a slow potassium channel.
Neuron ModelA. Nuerons all vary in relation to the area of the brain. The neurons modeled in this study were those of the subthalamic region. These neurons were based of the neural morphology in rats. B. The Dendrites and Soma were modeled as passive components. C. Two important irons that were included in this model were the Kv31 ion and the NaP ion. These were used to control the pulse width and the frequency and amplitude.
Volume of Tissue Activated (VTA) and Volume of Tissue Stimulated (VTS)A. VTA is what is generally looked at studies to determine how neurons are activates as a result of the extracelluar stimulation. However VTA holds limitations.