PowerPoint Presentation

Influenza virus research and funding opportunitiesGCEID Workshop-linking ideas to opportunities

A/Prof. John StambasSchool of Medicine4th july 2014 Deakin University CRICOS Provider Code: 00113BStrengths, capabilities and expertiseAnimal models of influenza virus infection (CSIRO AAHL/Deakin University)FerretChickenDuckMousePigsClinical/Translational (Barwon Health)Clinical trial experienceAccess to human clinical samplesWildlife Ecology/Surveillance (Deakin/CSIRO AAHL)Bird migration and disease ecologyPathogenesis, Immunity and therapeutics (CSIRO AAHL/Deakin)Virology/HistologyInnate and adaptive immunity

Deakin University CRICOS Provider Code: 00113BInfrastructurePC3 animal facilitiesPC3 laboratoriesPC3 ARC LIEF/NCRIS funded Immunology/flow facility laboratoryPC2 laboratoriesCollaborationsFederal and State Governments WHOFAONHMRC Influenza Program Grant Anne Kelso NIH/NIAID Centers of Excellence for Influenza Research and Surveillance (CEIRS)Emory/University of Georgia and St Jude Childrens Research HospitalDeakin University CRICOS Provider Code: 00113BEach NIAID Center of Excellence for Influenza Research and Surveillance has a focus on one or both of the following research areas:

Research Area 1: Animal Influenza Surveillance Conduct prospective international and/or domestic animal influenza surveillance for the rapid detection and characterization of influenza viruses with pandemic potential.

Research Area 2: Pathogenesis and Host Response Research Conduct research to enhance understanding of the molecular, ecological, and/or environmental factors that influence pathogenesis, transmission, and evolution of influenza viruses; and characterize the protective immune response.

http://www.niaid.nih.gov/labsandresources/resources/ceirs/Pages/introduction.aspxDeakin University CRICOS Provider Code: 00113BWhere to from here?

Realistically a 3-5 year processDeakin University CRICOS Provider Code: 00113BCo-supervise PhD/Honours students (Deakin/CSIRO AAHL)Develop fundable ideas and generate preliminary dataImprove our track recordsApply from small grants i.e university grants Apply for Nationally Competitive grant schemes i.e NHMRC, ARCApply for International grantsHow do we get there?Deakin University CRICOS Provider Code: 00113BGeneration of transgenic/knockout animals to study infection in host species using genome editing e.g ZFNs, TALENS, CRISPR MiRNAs (virus/host expressed; delivery)Therapeutics e.g IFN-lCharacterisation and modulation of overactive host immune responsesReagent developmentDeep sequencing/BioinformaticsEnhanced vaccine cell linesAreas of developing research and Innovation?Deakin University CRICOS Provider Code: 00113BNHMRCNHMRC Project grantsNHMRC Targeted and Urgent Calls: One off grant schemes; H5N1 and H1N1 NHMRC Development Awards: Industry partners requiredNHMRC Program GrantsNHMRC Centres for Research ExcellenceNHMRC FellowshipsARCARC DECRA: Early Career fellowshipARC Discovery ProjectsARC Linkage grants: Industry partners requiredARC LIEFARC Future Fellowships

Funding Opportunities-DomesticDeakin University CRICOS Provider Code: 00113BNIH - Development of Novel Therapeutics for Select Pathogens October 21, 2014 (LOI Sept 19)

Basic to translational research focused on development of novel therapeutics against select antibiotic-resistant gram-negative bacteria or influenza

Identification and validation of: new viral or host targets for drug discovery small molecule inhibitors directed at viral or host targets host-directed compounds that modulate immune response library screening in vitro or in vivo models preclinical characterization of candidate therapeutics

Funding Opportunities-InternationalSlide courtesy of J. Lowenthal, CSIRO AAHLDeakin University CRICOS Provider Code: 00113BNIAID:Targeting Therapeutics Development to Relieve Bottlenecks- August 13, 2014

Broad spectrum anti-viralHost-directed broad spectrum therapeutic Therapeutic with activity against more than one of the NIAID Category A, B and C viral threat agent AND including activity against at least one of the following viral pathogens:

Ebola virus, Marburg virus, Dengue virus, Chikungunya virus and Human influenza virus.

Funding Opportunities-InternationalSlide courtesy of J. Lowenthal, CSIRO AAHLDeakin University CRICOS Provider Code: 00113B