Information for Users of

A treatment for acne vulgaris

Information for Users of

A treatment for acne vulgaris

Bepio® Gel 2.5%

Please read this before use.

Dr. Ichiro KurokawaDirector, Department of Dermatology, Meiwa Hospital

Supervising editor

Hair

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AAcne bacteria

How does acne (pimples) occur?

2 Follicles are obstruc 3 Acne Bacteria (proliferates in follicles.

There are three major factors for acne.

Normal skin

To avoid acne scars, it is important start

Sebum secretion is 1

The photo above shows comedo,red acne, and yellow acne.

Propio

2

P.acnesprolifenation

Inflammatory substances are induced.

ted and filled with old keratinous materials.) or other acne-related bacteria

Symptoms of acne

Inflammatory acne

early treatment.

Red acne Yellow acne with pus

P.acnes

Pore closure

Enhancedsebumsecretion

Sebaceous gland

Non-inflammatory acne

Comedo

enhanced by male hormones (androgen) or other factors.

P.acnes proliferationing in follicles induces inflammatory substances and result in inflammation.

The contents in comedo spread and aggravate the acne.

If inflammation spreads to the surrounding tissues, acne scars might be left behind on the skin.

This picture shows the condition in which no sebum is excreted from follicles because the follicles are obstructed, and appear white or black comedones. This condition is an ideal environment for the growth of P.acnes, which favors sebum and dislikes oxygen.

anibacterium acnes

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What is Bepio® Gel?

This drug improves follicular obstructionas one of acne pathogenesis. 【horny layer peeling effects (comedolysis)】

This drug inhibits the proliferation of P.acnesand other acne-related bacteria. 【antibacterial effects】

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Treatment(image)

You might have skin redness, dry skin, skin irritations, or other symptoms when you begin treatment. These symptoms usually become milder in the course of treatment. However, if the application site becomes swollen or red, stop using the gel and discuss it with your physician or pharmacist.

Acne is likely to repeatedly occur for various reasons. To keep your acne relieved, continue treatment with the gel following the instructions of your physician.

Small

Great

Number of acne

Treatment started 1 month 3 months 1 year（2 weeks）

Non-inflammatory acnesInflammatory acnes

At treatment start Period for confirmationof the treatment effect

Period for maintenance of the improved status

At treatmentstart

From the start oftreatment to

1 month after thestart of treatment

The number of acnes will be reduced gradually. You can see the effect of the gel if you compare your present condition with a photo of yourself taken when you started treatment.

Period forconfirmation of thetreatment effect2 weeks to

3 months after thestart of treatment

Period formaintenance of theimproved status3 months to1 year after thestart of treatment

～Possible changes in the number of acne (image)～

＊Therapeutic outcomes differ among patients.

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step2

＊If you have dry skin, you may use moisturizers.

How to use Bepio® Gel

●Apply an appropriate amount of the gel once a day after washing your face.

　Do not apply Bepio® Gel more than once a day.　Do not use more Bepio® Gel than prescribed.●The application site, dose, and period differ according to symptoms. Follow the instructions of your physician or pharmacist.

Wash your face to keep the affected area clean. With a foam facial wash, wash well and cover yourface with foam. Rinse your face well with lukewarm water up to your hairline carefully. Gently wipe off water using a soft towel.

Squeeze out an appropriate amount of Bepio® Gel onto your clean fingertip and spread the gel without rubbing, taking care not to apply the gel to your eyes, lips, mucosa, or wounds.

step1

DoseSqueeze out an amount onto your index finger, along the length between the tip and the first joint (approximately 0.5 g)ApplicationDab the gel from your fingertip to the right and left sides of your forehead, cheeks, nose, and chin, and spread the gel.

If you apply the gel to your whole face

＊ ＊If the gel gets in any of these areas, immediately rinse the area with water.

step3Wash your hands well after use.

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● Dander /desquamation (powdery or pealed skin)

● Skin irritations (stinging)

● Erythema (skin redness)

● Dry skin

Possible adverse reactions induced by Bepio® Gel

The skin symptoms below might occur during treatment with the gel. If you are concerned about symptoms, immediately discuss it with your physician or pharmacist.

I f rash, fever , or other general hypersensit ive react ions occu r o r i f the app l i ca t ion s i te and i t s surrounding areas become severely red, swollen, or overreacted, stop using the gel and immediately discuss it w i th your phys i c ian . Accord ing to the sever i t y o f symptoms, you might be asked to withdraw treatment with the gel and undergo treatment for symptoms.

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Name of medical institution

Distributor

2018年9月作成A0918EX-NJ5040605

Precautions for the use of Bepio® Gel

●Because the gel has a bleaching effect, take care not to get the gel on your hair or clothing.

●Avoid high, long-term ultraviolet (UV) exposure to the application site.

●Store the gel unfrozen in a cool room (≤25ºC).