ins and outs of nih career development awards

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Ins and Outs of NIH Ins and Outs of NIH Career Career Development Awards Development Awards Slides adapted from: Slides adapted from: - Drs. Alan Willard, Henry Khachaturian, Milton - Drs. Alan Willard, Henry Khachaturian, Milton Hernandez, Marcia Hahn and NIH Web pages Hernandez, Marcia Hahn and NIH Web pages Research Career Program Awards - K Research Career Program Awards - K Series Series Grant Submission and Peer Review Grant Submission and Peer Review Strategy for Success Strategy for Success Gregory D. Sempowski, PhD Gregory D. Sempowski, PhD [email protected] [email protected] Duke Human Vaccine Institute Duke Human Vaccine Institute Member NIAID/NIH AITRC Committee Member NIAID/NIH AITRC Committee

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Ins and Outs of NIH Career Development Awards. Research Career Program Awards - K Series Grant Submission and Peer Review Strategy for Success. Gregory D. Sempowski, PhD [email protected] Duke Human Vaccine Institute Member NIAID/NIH AITRC Committee. - PowerPoint PPT Presentation

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Page 1: Ins and Outs of NIH Career  Development Awards

Ins and Outs of NIH Career Ins and Outs of NIH Career Development AwardsDevelopment Awards

Slides adapted from:Slides adapted from: - Drs. Alan Willard, Henry - Drs. Alan Willard, Henry Khachaturian, Milton Hernandez, Marcia Hahn and NIH Web Khachaturian, Milton Hernandez, Marcia Hahn and NIH Web pagespages

Research Career Program Awards - K SeriesResearch Career Program Awards - K Series

Grant Submission and Peer ReviewGrant Submission and Peer Review

Strategy for SuccessStrategy for Success

Gregory D. Sempowski, PhDGregory D. Sempowski, [email protected]@duke.edu

Duke Human Vaccine InstituteDuke Human Vaccine InstituteMember NIAID/NIH AITRC CommitteeMember NIAID/NIH AITRC Committee

Page 2: Ins and Outs of NIH Career  Development Awards

Research Training and Career DevelopmentResearch Training and Career Development

Predoctoral Individual NRSA (F31)Predoctoral Individual MD/PhD NRSA

(F30)Postdoctoral Institutional Training (T32)Postdoctoral Individual NRSA (F32)

Small Grant (R03) Research Project Grant (R01)

Independent Scientist (K02)

Senior Scientist (K05)

Career Stage‘Formal’ Training/Career Awards

GRADUATE/MEDICALSTUDENT

POSTDOCTORAL

EARLY

MIDDLE

SENIOR

CA

REER

Predoctoral Institutional Training Grant (T32)

NIH Pathway to Independence (PI) (K99/R00)Mentored Research Scientist Development (K01)Mentored Clinical Scientist Development (K08)Mentored Patient-Oriented RCDA (K23)Mentored Quantitative RCDA (K25)Research Scholar (K22)

Midcareer Investigator in Patient-Oriented Research (K24) Exploratory/Development Grant (R21)

Pre-Bac Pre-Bac Institutional Training Grant (T34)

‘Informal’ Training

and CareerDevelopment

Research Awards

Page 3: Ins and Outs of NIH Career  Development Awards

Research Career Program Awards - K SeriesResearch Career Program Awards - K Series

K-series awards:K-series awards: granted to research and academic institutions granted to research and academic institutions on behalf of scientists with on behalf of scientists with clear scientific potentialclear scientific potential

– part of integrated NIH Institute/Center Programs part of integrated NIH Institute/Center Programs – designed to foster development of outstanding scientists designed to foster development of outstanding scientists – enable scientists to expand their potential and make important scientific enable scientists to expand their potential and make important scientific

contributionscontributions

K Kiosk:K Kiosk: Information about NIH Career Awards Information about NIH Career Awards– http://grants1.nih.gov/training/careerdevelopmentawards.htmhttp://grants1.nih.gov/training/careerdevelopmentawards.htm

Career Award Wizard:Career Award Wizard: Helps you select the right career award Helps you select the right career award– http://grants1.nih.gov/training/kwizard/index.htmhttp://grants1.nih.gov/training/kwizard/index.htm

Page 4: Ins and Outs of NIH Career  Development Awards

Research Career Program Awards - K SeriesResearch Career Program Awards - K Series

New Parent FOA:New Parent FOA: NOT-OD-14-036; 12/18/13 NOT-OD-14-036; 12/18/13

– PA-14-042: NIH Pathway to Independence Award (K99/R00) PA-14-042: NIH Pathway to Independence Award (K99/R00) – PA-14-044: Mentored Research Scientist Development Award (K01) PA-14-044: Mentored Research Scientist Development Award (K01) – PA-14-045: Independent Scientist Award (K02) PA-14-045: Independent Scientist Award (K02) – PA-14-046: Mentored Clinical Scientist Research Career Development Award (K08) PA-14-046: Mentored Clinical Scientist Research Career Development Award (K08) – PA-14-043: Mentored Patient-Oriented Research Career Development Award (K23) PA-14-043: Mentored Patient-Oriented Research Career Development Award (K23) – PA-14-047: Midcareer Investigator Award in Patient-Oriented Research (K24) PA-14-047: Midcareer Investigator Award in Patient-Oriented Research (K24) – PA-14-048: Mentored Quantitative Research Development Award (K25) PA-14-048: Mentored Quantitative Research Development Award (K25)

Overall objectives of the programs, Overall objectives of the programs, except for the K99/R00except for the K99/R00, are not , are not changed in the reissued FOAschanged in the reissued FOAs

Page 5: Ins and Outs of NIH Career  Development Awards

K08 Mentored Clinical Scientist AwardK08 Mentored Clinical Scientist AwardK23 Mentored Patient-Oriented AwardK23 Mentored Patient-Oriented AwardOverview:Overview:

K08: K08: Supports individuals with a Supports individuals with a clinical doctoral degreeclinical doctoral degree for career for career development in biomedical, development in biomedical, behavioral research and behavioral research and translational research. translational research.

K23:K23: Supports career development Supports career development of investigators who have made a of investigators who have made a commitment to commitment to patient-oriented patient-oriented researchresearch. .

Majority of awardees are MDs and Majority of awardees are MDs and MD/PhDs.MD/PhDs.

Program Features:

Duration: 3 to 5 years

Salary Support: Up to legislative cap (varies by Institute/Center)

Research Support: up to $50,000/year (varies by Institute/Center)

Institute and Center contacts and policies: See Funding Opportunity Announcement

Page 6: Ins and Outs of NIH Career  Development Awards

K22 Research Scholar AwardK22 Research Scholar Award

Overview:Overview:

Facilitates the transition of Facilitates the transition of investigators from mentored to investigators from mentored to independent stage of career.independent stage of career.

Typically, transition award for Typically, transition award for Postdocs moving to Assistant Postdocs moving to Assistant Professor.Professor.

Two Phases:Two Phases:

Phase 1: May or may not be Phase 1: May or may not be affiliated with an institution. Some affiliated with an institution. Some IC’s require NIH Intramural IC’s require NIH Intramural experienceexperience

Phase 2: Assistant Professor with Phase 2: Assistant Professor with own lab and little to no teaching or own lab and little to no teaching or administrative responsibilities.administrative responsibilities.

Program Features:

Duration: 2 years mentored (Intramural), followed by 3 years independent

NIAID 2 years ONLY - independent

Salary Support: Up to legislative cap (varies by Institute/Center)

None during Intramural phase

Research Support: up to $50,000/year (varies by Institute/Center)

None during Intramural phase

Institute and Center contacts and policies: See Funding Opportunity Announcement

Page 7: Ins and Outs of NIH Career  Development Awards

K99/R00 Pathway to Independence AwardK99/R00 Pathway to Independence Award

Overview:Overview:

No citizenship/green card requirementNo citizenship/green card requirement

Transition award for postdocs Transition award for postdocs moving to Assistant Professor moving to Assistant Professor (tenure track or equivalent)(tenure track or equivalent)

NEW FOA:NEW FOA:

NO MORE THAN 4 years NO MORE THAN 4 years postdoctoral Experiencepostdoctoral Experience

Must propose up to 2 years Must propose up to 2 years mentored training in planmentored training in plan

R00 phase must be at least 1 yearR00 phase must be at least 1 year

If an applicant achieves independence prior If an applicant achieves independence prior to initiating the K99 phase, neither the K99 to initiating the K99 phase, neither the K99 nor R00 will be awardednor R00 will be awarded

Program Features:

K99 Phase Mentored Phase: Up to 2

years Research Support: Up to

$90,000/year (most Institutes & Centers provide more funds)

R00 Phase Independent Phase: Up to 3

years; 75% effort Research Support:

$249,000/year

Institute and Center contacts and policies: See Funding Opportunity Announcement

Page 8: Ins and Outs of NIH Career  Development Awards

Administrative Issues:Administrative Issues:

Read the Read the

Funding Opportunity Announcements (FOAs)!Funding Opportunity Announcements (FOAs)!

Research Career Program Awards - K SeriesResearch Career Program Awards - K Series

Page 9: Ins and Outs of NIH Career  Development Awards

Common Features: EligibilityCommon Features: Eligibility

Who can Apply?Who can Apply?

– Doctoral DegreeDoctoral DegreeK08, K23, K24 require clinical degreeK08, K23, K24 require clinical degree

– US Citizen, Non-Citizen National, Permanent Resident US Citizen, Non-Citizen National, Permanent Resident (except (except K99/R00K99/R00))

Duration?Duration?– Typically two, three, four, or five yearsTypically two, three, four, or five years– Entry level (Mentored) awards Entry level (Mentored) awards requirerequire a mentor a mentor– K99 phase of the K99/R00 generally 2 yearsK99 phase of the K99/R00 generally 2 years

Page 10: Ins and Outs of NIH Career  Development Awards

Common Features: Appointment & EffortCommon Features: Appointment & Effort

Appointment?Appointment?– Must have a full-time appointment at applicant Must have a full-time appointment at applicant

organizationorganization– Any minimum effort requirement must be covered by Any minimum effort requirement must be covered by

that appointment that appointment

Level of Effort?Level of Effort?

– Full-time research effort required Full-time research effort required (9 person months, 75% effort)(9 person months, 75% effort)

Page 11: Ins and Outs of NIH Career  Development Awards

Common Features: CostsCommon Features: CostsSalary/fringe benefits?Salary/fringe benefits?

– Salaries capped between $75,000 and legislatively Salaries capped between $75,000 and legislatively mandated cap (currently $179,700) mandated cap (currently $179,700)

– Fringe benefits are over & above any salary capFringe benefits are over & above any salary cap– Salary supplementation OK, but must be with non-Federal Salary supplementation OK, but must be with non-Federal

funds and not require extra duties that would interfere with funds and not require extra duties that would interfere with K activitiesK activities

– NOT ALLOWED: salary for admin/secretarial or mentorNOT ALLOWED: salary for admin/secretarial or mentor

Research/development costs (supplies/other)?Research/development costs (supplies/other)?– Generally $25,000 to $50,000Generally $25,000 to $50,000

F&A Costs (Indirects – Duke Cut)? F&A Costs (Indirects – Duke Cut)? Only 8%Only 8%

Page 12: Ins and Outs of NIH Career  Development Awards

Ins and Outs of NIH Career Ins and Outs of NIH Career Development AwardsDevelopment Awards

Research Career Program Awards - K SeriesResearch Career Program Awards - K Series

Grant Submission and Peer Review:Grant Submission and Peer Review:– ProcessProcess– ScoringScoring– CriteriaCriteria

Strategy for SuccessStrategy for Success

Slides adapted from:Slides adapted from: - Drs. Alan Willard, Henry - Drs. Alan Willard, Henry Khachaturian, Milton Hernandez, Marcia Hahn and NIH Web Khachaturian, Milton Hernandez, Marcia Hahn and NIH Web pagespages

Page 13: Ins and Outs of NIH Career  Development Awards

NIH Grant ProcessNIH Grant Process

1. Great Idea

2. Consult With Others

3. Write an Organized Proposal

4. Understand

Review

Page 14: Ins and Outs of NIH Career  Development Awards

My Applicati

onxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx

$$$$$$

Center for Scientific Review

Assigns IRG (CSR or IC)

Scientific Review Group

Evaluates Scientific Merit

Institute or Center

Evaluates Relevance

Advisory Council

Recommends Action

IC Director

Allocates Funds

PI / Institution Submits application

Conduct Research

Revision / Resubmission

DetailsDetails of the NIH Review Processof the NIH Review Process

Page 15: Ins and Outs of NIH Career  Development Awards

• ~12-24 members~12-24 members

• 3 meetings each year3 meetings each year

• Review ~10 – 100 Review ~10 – 100 applications per meetingapplications per meeting

• 3-4 Members read, write 3-4 Members read, write review and assign review and assign preliminary preliminary scorescore

• Full panel streamlines Full panel streamlines

• Apps are presented by Apps are presented by the assigned readersthe assigned readers

• Full Panel ScoresFull Panel Scores

Scientific Review Groups or Study SectionScientific Review Groups or Study Section

Page 16: Ins and Outs of NIH Career  Development Awards

NIH-Peer Review: Revised Scoring SystemNIH-Peer Review: Revised Scoring System

9-Point Rating Scale9-Point Rating Scale

Page 17: Ins and Outs of NIH Career  Development Awards

Shortened page limitsShortened page limits

Revised Biosketch with personal Statement and Revised Biosketch with personal Statement and publication limits (include PMCIDs)publication limits (include PMCIDs)

Modified Research Plan structureModified Research Plan structure

Note: Follow FOA page limit requirementsNote: Follow FOA page limit requirements

Full table of page limits available at:Full table of page limits available at: http://grants.nih.gov/grants/forms_page_limits.htmhttp://grants.nih.gov/grants/forms_page_limits.htm

Background and SignificanceBackground and Significance

Preliminary Studies/Progress Report Preliminary Studies/Progress Report

Research Design and MethodsResearch Design and Methods

Research Research StrategyStrategy

Recent Changes to ApplicationsRecent Changes to Applications

Page 18: Ins and Outs of NIH Career  Development Awards

What Has Not Changed!What Has Not Changed!

Need to have a good idea to answer an important Need to have a good idea to answer an important question that will question that will SIGNIFANTLY IMPACT SIGNIFANTLY IMPACT understanding/treatment of health and diseaseunderstanding/treatment of health and disease

Reviewers need to be able to understand:Reviewers need to be able to understand:– What you want to do?What you want to do?– Why it is important?Why it is important?– Can you do it?Can you do it?

Need to align YOUR goals with funding agency goalsNeed to align YOUR goals with funding agency goals– Contact the NIH Program Officer listed on the FOAContact the NIH Program Officer listed on the FOA

Page 19: Ins and Outs of NIH Career  Development Awards

Criteria for K Series Award ReviewCriteria for K Series Award Review GOAL: provide a quantitative assessment of the GOAL: provide a quantitative assessment of the

likelihood for the likelihood for the candidatecandidate to maintain a strong to maintain a strong research program in the future.research program in the future.

Five scored subcomponents:Five scored subcomponents:– CandidateCandidate

– Career Development Plan/Goals & Objectives/ Mentoring PlanCareer Development Plan/Goals & Objectives/ Mentoring Plan

– Research PlanResearch Plan

– Mentor(s), Consultant(s), Collaborator(s)Mentor(s), Consultant(s), Collaborator(s)

– Environment and Institutional Commitment to the CandidateEnvironment and Institutional Commitment to the Candidate

Overall IMPACT is up to the individual reviewerOverall IMPACT is up to the individual reviewer

Page 20: Ins and Outs of NIH Career  Development Awards

Criteria for K Series Award ReviewCriteria for K Series Award Review

Additional Review Criteria - Additional Review Criteria - Part of Impact ScorePart of Impact Score– Protection of Human SubjectsProtection of Human Subjects

– Inclusion of Women, Minorities and ChildrenInclusion of Women, Minorities and Children

– Vertebrate AnimalsVertebrate Animals

– BiohazardsBiohazards

Additional Review Considerations (no score)Additional Review Considerations (no score)– Training in the Responsible Conduct of ResearchTraining in the Responsible Conduct of Research– Select Agent ResearchSelect Agent Research– Resource Sharing PlansResource Sharing Plans– Budget and Period of SupportBudget and Period of Support

Page 21: Ins and Outs of NIH Career  Development Awards

Research Career Program Awards - K SeriesResearch Career Program Awards - K Series

Enhancing Peer ReviewEnhancing Peer Review

Strategy for SuccessStrategy for Success

Slides adapted from:Slides adapted from: - Drs. Alan Willard, Henry - Drs. Alan Willard, Henry Khachaturian, Milton Hernandez, Marcia Hahn and NIH Web Khachaturian, Milton Hernandez, Marcia Hahn and NIH Web pagespages

Ins and Outs of NIH Career Ins and Outs of NIH Career Development AwardsDevelopment Awards

Page 22: Ins and Outs of NIH Career  Development Awards

Remember that a K application is a collaboration Remember that a K application is a collaboration between you and your mentorbetween you and your mentor

Put together a mentoring committeePut together a mentoring committee

Draft specific aims and discuss with your mentor and Draft specific aims and discuss with your mentor and committeecommittee

Discuss your Career Development Plan with your Discuss your Career Development Plan with your mentor and committeementor and committee

Request STRONG Letters of ReferenceRequest STRONG Letters of Reference

Be sure to have your committee review the application Be sure to have your committee review the application before submitting (2-4 weeks prior)before submitting (2-4 weeks prior)

Before You Start Writing (6 Before You Start Writing (6 months)months)

Page 23: Ins and Outs of NIH Career  Development Awards

Biographical Sketch:Biographical Sketch: Personal Statement: Personal Statement: Your research experience and other Your research experience and other

qualifications for this K award.qualifications for this K award.

Research Support:Research Support: Your/colleagues accomplishments Your/colleagues accomplishments attesting to qualifications of the research team. Do not attesting to qualifications of the research team. Do not confuse this with “Other Support”confuse this with “Other Support”

Candidate’s Background:Candidate’s Background: Who are you as an investigator?Who are you as an investigator?

Coordinate with information on your BiosketchCoordinate with information on your Biosketch

e.g., research and/or clinical training and experience that e.g., research and/or clinical training and experience that has prepared you for the Khas prepared you for the K

Emphasize publications Emphasize publications

Candidate’s QualificationsCandidate’s Qualifications

Page 24: Ins and Outs of NIH Career  Development Awards

CandidateCandidate:: WHO ARE YOU AS A SCIENTIST?WHO ARE YOU AS A SCIENTIST?

Quality of research, academic and/or clinical recordQuality of research, academic and/or clinical record

Potential to develop as an independent and Potential to develop as an independent and productive researcherproductive researcher

Commitment to a research careerCommitment to a research career

Quality of the letters of referenceQuality of the letters of reference

Review CriteriaReview Criteria

Page 25: Ins and Outs of NIH Career  Development Awards

Career Goals and Objectives: Career Goals and Objectives: WHERE DO YOU WANT TO BE IN 5-10 YEARS AS A WHERE DO YOU WANT TO BE IN 5-10 YEARS AS A

SCIENTIST?SCIENTIST?

Have a focused goal or target and lead the reviewer to Have a focused goal or target and lead the reviewer to that goal with specific steps (objectives)that goal with specific steps (objectives)

You should always provide a career development You should always provide a career development timeline, including plans to apply for subsequent grant timeline, including plans to apply for subsequent grant support (use tables/charts)support (use tables/charts)

Review CriteriaReview Criteria

Page 26: Ins and Outs of NIH Career  Development Awards

Career Development/Training During Award: Career Development/Training During Award: WHAT NEW SKILLS DO YOU NEED?WHAT NEW SKILLS DO YOU NEED?

Fully explain any new or enhanced research skills you Fully explain any new or enhanced research skills you will gain as a result of the Kwill gain as a result of the K

Stress activities that will enhance your research career, Stress activities that will enhance your research career, e.g., courses, techniques e.g., courses, techniques

Likelihood that plan will contribute substantially to the Likelihood that plan will contribute substantially to the scientific development of candidate – Added Valuescientific development of candidate – Added Value

Content, scope, phasing, and duration of the plan in the Content, scope, phasing, and duration of the plan in the context of prior experience and stated career objectivescontext of prior experience and stated career objectives

Review CriteriaReview Criteria

Page 27: Ins and Outs of NIH Career  Development Awards

Statements by Mentor(s), Consultant(s):Statements by Mentor(s), Consultant(s): Each mentor must explain how he/she will contribute to the development Each mentor must explain how he/she will contribute to the development

of the candidate's research career and qualifications to be of the candidate's research career and qualifications to be mentor/collaboratormentor/collaborator

Mentor(s) must provide details for any previous experience as a mentor, Mentor(s) must provide details for any previous experience as a mentor, types (e.g., graduate students, Postdocs), numbers, and career outcomestypes (e.g., graduate students, Postdocs), numbers, and career outcomes

Document sources / amounts of support for the candidate’s researchDocument sources / amounts of support for the candidate’s research

Provide details on the candidate's anticipated teaching load, clinical Provide details on the candidate's anticipated teaching load, clinical responsibilities, etc.responsibilities, etc.

Discuss plans for transitioning the candidate to the independent Discuss plans for transitioning the candidate to the independent investigator stage by the end of the K award periodinvestigator stage by the end of the K award period

Review CriteriaReview Criteria

Page 28: Ins and Outs of NIH Career  Development Awards

Description of Institutional Environment: Description of Institutional Environment: Sponsoring institution must document a strong, well-established research Sponsoring institution must document a strong, well-established research

program related to the candidate's areas of interest.program related to the candidate's areas of interest.

Statement should include:Statement should include: Names of the mentor(s) and other relevant facultyNames of the mentor(s) and other relevant faculty Details of facilities and resources available for the candidateDetails of facilities and resources available for the candidate Opportunities for intellectual interactions, e.g., journal clubs, seminars, and Opportunities for intellectual interactions, e.g., journal clubs, seminars, and

presentations?presentations?

Review CriteriaReview Criteria

Page 29: Ins and Outs of NIH Career  Development Awards

Institutional Commitment to the Candidate:Institutional Commitment to the Candidate: The institution must document its commitment to the The institution must document its commitment to the

candidate’s career development candidate’s career development independent of the K independent of the K award!award!

The institution must agree to provide adequate time The institution must agree to provide adequate time and support to the candidate and mentor for the period and support to the candidate and mentor for the period of K awardof K award

The institution must provide office and laboratory The institution must provide office and laboratory space, equipment, and other resources and facilities to space, equipment, and other resources and facilities to carry out the proposed researchcarry out the proposed research

Review CriteriaReview Criteria

Page 30: Ins and Outs of NIH Career  Development Awards

Environment and Institutional Commitment:Environment and Institutional Commitment: Commitment of institution to ensure that the candidate's Commitment of institution to ensure that the candidate's

effort will be devoted to research (Minimum 75%)effort will be devoted to research (Minimum 75%)

Adequacy of research facilities and training opportunities, Adequacy of research facilities and training opportunities, including capable facultyincluding capable faculty

Assurance that institution intends for the candidate to be an Assurance that institution intends for the candidate to be an integral part of its research programintegral part of its research program

Review CriteriaReview Criteria

Page 31: Ins and Outs of NIH Career  Development Awards

Training in Responsible Conduct of Research: Training in Responsible Conduct of Research:

Discuss the five components outlined in the NIH Policy: Discuss the five components outlined in the NIH Policy: Format, Subject Matter, Faculty Participation, Duration, Format, Subject Matter, Faculty Participation, Duration, and Frequency.and Frequency.

Is the plan appropriate for your career stage, and will it Is the plan appropriate for your career stage, and will it enhance your understanding of ethical issues related to enhance your understanding of ethical issues related to research?research?

Responsible Conduct of ResearchResponsible Conduct of Research

Page 32: Ins and Outs of NIH Career  Development Awards

Significance:Significance: Importance of the problemImportance of the problem How will your project improve scientific knowledge, How will your project improve scientific knowledge,

technical capability, or clinical practice?technical capability, or clinical practice? How will the field be impacted if the proposed aims are How will the field be impacted if the proposed aims are

achieved?achieved?

Innovation:Innovation: How will your proposed research may challenge current How will your proposed research may challenge current

paradigms?paradigms? Present any novel theoretical concepts, approaches, Present any novel theoretical concepts, approaches,

methodologies, or interventionsmethodologies, or interventions Describe advantage over existing approachesDescribe advantage over existing approaches

Research StrategyResearch Strategy

Page 33: Ins and Outs of NIH Career  Development Awards

Approach:Approach: Describe and discuss the overall strategy, methodology, Describe and discuss the overall strategy, methodology,

and analyses to be used to accomplish the specific aims and analyses to be used to accomplish the specific aims of the projectof the project

Discuss potential problems, alternative strategies, and Discuss potential problems, alternative strategies, and benchmarks for success anticipated to achieve the aimsbenchmarks for success anticipated to achieve the aims

Discuss predicted outcomes based on your hypothesis Discuss predicted outcomes based on your hypothesis and preliminary workand preliminary work

Research StrategyResearch Strategy

Page 34: Ins and Outs of NIH Career  Development Awards

Research Plan:Research Plan:

Scientific and technical merit of the research question, Scientific and technical merit of the research question, design and methodologydesign and methodology

Relevance of the proposed research to the candidate‘s Relevance of the proposed research to the candidate‘s career objectivescareer objectives

Appropriateness of the research plan to the stage of Appropriateness of the research plan to the stage of research development and as a vehicle for developing the research development and as a vehicle for developing the research skills described in the career development planresearch skills described in the career development plan

Research Strategy: Review Research Strategy: Review CriteriaCriteria

Page 35: Ins and Outs of NIH Career  Development Awards

Make Life Easy for Reviewers:Make Life Easy for Reviewers: Write clearly and conciselyWrite clearly and concisely Less is More!Less is More! Use graphics as much as possibleUse graphics as much as possible Label all materials clearlyLabel all materials clearly Edit and proofreadEdit and proofread

Know These Review Problems and Solutions:Know These Review Problems and Solutions: Write a compelling argument for why your career will be enhanced by Write a compelling argument for why your career will be enhanced by

receiving a K awardreceiving a K award Write to the non-expert in the fieldWrite to the non-expert in the field Experiments support your aims, and aims support your hypothesis Experiments support your aims, and aims support your hypothesis

A Few TipsA Few Tips

Page 36: Ins and Outs of NIH Career  Development Awards

Ins and Outs of NIH Career Ins and Outs of NIH Career Development AwardsDevelopment Awards

Gregory D. Sempowski, PhDGregory D. Sempowski, [email protected]@duke.edu

Duke Human Vaccine InstituteDuke Human Vaccine InstituteMember NIAID/NIH AITRC CommitteeMember NIAID/NIH AITRC Committee

Questions?Questions?

Page 37: Ins and Outs of NIH Career  Development Awards
Page 38: Ins and Outs of NIH Career  Development Awards

K01 Mentored Research Scientist AwardK01 Mentored Research Scientist Award

Overview:Overview:

Supports an intensive, supervised Supports an intensive, supervised career development experience in career development experience in the biomedical, behavioral, or the biomedical, behavioral, or clinical sciences leading to research clinical sciences leading to research independence. independence.

Some ICs use the K01 for Some ICs use the K01 for individuals who propose to train in a individuals who propose to train in a new field or those who have had a new field or those who have had a hiatus in their research career.hiatus in their research career.

Some ICs utilize the K01 award to Some ICs utilize the K01 award to increase research workforce increase research workforce diversity.diversity.

Primarily for PhDs or equivalent Primarily for PhDs or equivalent research doctoral degrees.research doctoral degrees.

Program Features:

Duration: 3 to 5 years

Salary Support: Up to legislative cap (varies by Institute/Center) – Most common salary cap is $75,000

Research Support: Up to $50,000/year (varies by Institute/Center)

Institute and Center contacts and policies: See Funding Opportunity Announcement

Page 39: Ins and Outs of NIH Career  Development Awards

K02 Independent Scientist Award K02 Independent Scientist Award

Overview:Overview:

To foster the development of To foster the development of outstanding scientists and enable outstanding scientists and enable them to expand their potential to them to expand their potential to make significant contributions to make significant contributions to their field of research.their field of research.

For newly independent scientists For newly independent scientists who can demonstrate the need for a who can demonstrate the need for a period of intensive research focus as period of intensive research focus as a means of enhancing their research a means of enhancing their research careers. careers.

Must have independent grant Must have independent grant support as Principal Investigator support as Principal Investigator (e.g. R01).(e.g. R01).

Mix of PhDs and MDs.Mix of PhDs and MDs.

Relatively few applicants.Relatively few applicants.

Program Features:

Duration: 3 to 5 years

Salary Support: Up to legislative cap (varies by Institute/Center) – Most common salary cap is $75,000

Research Support: Most Institutes/Centers do not provide research costs

Institute and Center contacts and policies: See Funding Opportunity Announcement

Page 40: Ins and Outs of NIH Career  Development Awards

K24 Mid-Career Investigator Award K24 Mid-Career Investigator Award Patient-Oriented ResearchPatient-Oriented Research

Overview:Overview:

Support for mid-career health-Support for mid-career health-professional doctorates or professional doctorates or equivalent who are typically at the equivalent who are typically at the Associate Professor level or the Associate Professor level or the equivalent for protected time to equivalent for protected time to devote to devote to

patient-oriented research patient-oriented research

act as research mentor primarily for act as research mentor primarily for clinical residents, clinical fellows clinical residents, clinical fellows and/or junior clinical faculty.and/or junior clinical faculty.

Typically Associate Professors, but Typically Associate Professors, but can continue to support those can continue to support those promoted to full professor.promoted to full professor.

Typically MDs.Typically MDs.

Program Features:

Duration: 3 to 5 years

Salary Support: Most Institutes and Centers provide salary up to the legislative cap

Research Support: Most Institutes and Centers provide up to $50,000/year

Institute and Center contacts and policies: See Funding Opportunity Announcement

Page 41: Ins and Outs of NIH Career  Development Awards

K25 Mentored Quantitative Research AwardK25 Mentored Quantitative Research Award

Overview:Overview:For investigators whose For investigators whose quantitative science and quantitative science and engineering research has thus far engineering research has thus far not been focused primarily on not been focused primarily on questions of health and disease.questions of health and disease.

Supports a period of supervised Supports a period of supervised study and research for productive study and research for productive professionals with quantitative (e.g., professionals with quantitative (e.g., mathematics, statistics, economics, mathematics, statistics, economics, computer science, imaging science, computer science, imaging science, informatics, physics, chemistry) and informatics, physics, chemistry) and engineering backgrounds to engineering backgrounds to integrate their expertise with NIH-integrate their expertise with NIH-relevant research.relevant research.

Program Features:

Duration: 3 to 5 years

Salary Support: Up to legislative cap (varies by Institute/Center)

Research Support: up to $50,000/year (varies by Institute/Center)

Institute and Center contacts and policies: See Funding Opportunity Announcement