Institut Català de Nanociència i

Nanotecnologia

Pablo Ordejón - Director

ICN2: Contextual Background

• Move towards a knowledge-based economy (Lisbon [2000] andBarcelona [2003] EU agreements for 2020)

• Improve economic competitiveness and social welfare

• CERCA centres: Non-profit foundations created by the Catalan Government since early 2000’s to promote R&D excellence

• ICREA programme to attract talent: 240 professorships

(41% in CERCA institutes; ~10% of applicants selected;

48% foreign nationality; 62% recruited from abroad)

• Largest public Science institution in Spain; 3rd largest in Europe

• Basic and Applied R&D; Technology Transfer; Sci/Tech Consulting; Training; Dissemination of Scientific Culture, etc.

• Physical, Natural, Life and Social Sciences; Humanities; and

Food/Agriculture

• Major research infrastructure: laboratories, technical facilities, libraries, databases and public repositories

ICN2 Introduction

Mission:• To lead the advance of N&N by generating new

fundamental knowledge, concepts and ideas. • To facilitate the adoption and integration of

nanotechnologies in society and industry.

Core activities:• Excellence research in Nanoscience

• Pushing the frontiers of Nanotechnology

• Advanced Training

• Technology Transfer

• Science and Society - Public Outreach

ICN2: In numbers

Annual Budget: ~10 M€Sources: Patrons: 50%, Competitive Funding: 45%, Tech Transfer (contracts, IP): 5%

Total staff: ~ 200Demographics: 45% foreigners, 44% female, 70% are 35 or younger,

Researchers: 170 (130 staff + 40 visiting), working language is English

Research Groups: 17

Technical Divisions: 3

Distinguished Awards: 6 ERC (3 current + 3 past); “Severo Ochoa” Award

Scientific Output: ~170 indexed publications/year (average IF~6.5)

ICN2 is in the top-ten of all Spanish R&D centres in all measures of excellence,

3rd place in Excellence Rate (% of papers among the 10% most cited in their fields)**SCIMAGO Institutions Ranking 2013

Total laboratory space: ~2,000 m2

Key facilities: electron microscopes (SEM, S/TEM, TEM, STM, AFM), R2R NIL; FIB;

XPS; Nanomoke, wet chemistry labs, access to clean rooms (UAB and CNM)

Courtesy del Prof. Helmut Dosch

Max Planck Institute for Metal Research

Stuttgart (Alemania)

Manipulation at the atomic and molecular scale (Top-down and Bottom-up)

Scanning Probe MicroscopiesThin Film Technologies (PLD, MBE, CVD...)NanolithographySelf-Assembly Chemical synthesis of nano-objects

Manipulation at the atomic and molecular scale (Top-down and Bottom-up)

Scanning Probe MicroscopiesThin Film Technologies (PLD, MBE, CVD...)NanolithographySelf-Assembly Chemical synthesis of nano-objectsCharacterization of Nanostructures

Advanced Electronic NanoscopyScanning Probe Microscopies and SpectroscopiesChemical AnalysisSpectroscopies

Characterization of Nanostructures

Advanced Electronic NanoscopyScanning Probe Microscopies and SpectroscopiesChemical AnalysisSpectroscopies

Fundamental Physical Phenomena

Electronic and other excitations (electronics, spintronics, phononics, photonics, ...)Quantum confinementNon-scalable behaviour

Fundamental Physical Phenomena

Electronic and other excitations (electronics, spintronics, phononics, photonics, ...)Quantum confinementNon-scalable behaviour

Nano-materials with new properties

BiosensingActing on biological processes:

Drug DeliveryToxicity / Safety / Environment

Energy storageCatalysisOptical nano-materials

Nano-materials with new properties

BiosensingActing on biological processes:

Drug DeliveryToxicity / Safety / Environment

Energy storageCatalysisOptical nano-materials

Devices from Nanostructures

NanofabricationIntegration - nano-micro-macroDesign / function

Nanoscience and Nanotechnology

Exploring and exploiting the new phenomena that arise from the behaviour of matter at the nanoscale (1-100 nm)

ICN2 Research Lines: 17 Research Groups

ICN2 Services and

Technical Divisions

Nanoscience Instrument Development

Design and development of advanced state-of-the-art instruments for nanoscience and nanotechnology.

Nanofabrication and Flexible Printing Platform

Design and development of nanofabrication methods for nanoscienceand nanotechnology research and applications.

Nanomaterials Growth

Facility to grow nanostructured materialsby means of several growth techniques(PLD, CVD, ...), and characterize them(XDR, PES, ...)

Electron Microscopy

Scientific and technical support to the research lines of ICN2 and neighboring research centres

General Scientific Services

Instrumentation for Physical and Chemical Characterization

ICN2: Frontier research

Biosensing and Bioelectronics

Chemical Synthesis of Nanostructures

Materials at the Nanoscale

Microscopy (AFM, SEM, TEM, STM, etc.)

Nanoelectronics

Nanofabrication (FIB) & Nanolithography

Nanomagnetism

Phononics and Photonics

Theory and Simulation

Spectroscopy (Raman, XRD, XPS, etc.)

Spintronics

Surface Properties

ICN2: Materials

Biomolecules (DNA, RNA, proteins, etc.)

Carbon nanotubes

Graphene

Ferroics (magnetic, electric)

Inorganic nanoparticles

Inorganic thin films

Metal-organic frameworks

Organic polymers and O/I hybrids

Semiconductors

Thermoelectric materials

Topological insulators

Analytical instruments

Biosensors

Drugs and drug-delivery vectors

Medical diagnostics

Nanoparticles for Health and Environment

Flexible and printed electronics

Memory devices

Metamaterials and smart materials

Smart City devices

Energy harvesting, conversion and storage

Paints and coatings

Photochromes

ICN2: Devices and end-products

Nanodevices for Societal Challenges

ICN2 will use scientific knowledge generated in-house to develop new, disruptive solutions for the design, fabrication and integration of devices in three Core Areas:

Energy ICTLife

• Energy: fuel cells, thermoelectrics, photovoltaics, batteries, supercapacitors, energy harvesting, thermal management, etc.

• Life Sciences: biosensors, drug delivery, theranostics, environment, etc.

• ICT: new approaches for memory and logic devices, waveguides, LEDs, lasers, etc.

Nanodevices for Societal Challenges

ICN2 will use scientific knowledge generated in-house to develop new, disruptive solutions for the design, fabrication and integration of devices in three Core Areas:

Nanodevices for Societal Challenges

Energy ICTLife

Nanomaterials Growth

Nanofabrication

Characterization & Metrology

Theory & Simulation

Progress in the three Core Areas will be supported by four Transversal Platforms:

Collaboration with Industry

INDUSTRY PRODUCTACADEMIA

OPEN INNOVATION: TWO-WAY COLLABORATION

WORKING WITH INDUSTRY

Technology Transfer

ACADEMIA-INDUSTRY: our collaboration model…

Nephrotoxicity is the main limitation of current chemotherapy with cisplatin

Chemotherapy and Nephrotoxicity

Glomerular Filtration

Cisplatin - Au NPs (ICREA Prof. V. Puntes)

Aurocis

- Aurocis does not pass through the glomerular filter, which prevents kidney damage

- Cisplatin - NP link is pH sensitive: only breaks after cell uptake; Thus it is inactive whilecirculating through the organism, avoiding unspecific release. It also targets preferenciallytumor cells, as they have a more acid character than normal cells.

- Free Cisplatin binds to albumina, lending it inactive. Binding to gold NPs prevents this.

Cisplatin - Au NPs (ICREA Prof. V. Puntes)

Spin-off of ICN2 (V. Puntes)Novel cancer treatments using AuNPs as drug delivery vector

A specific drug-NP complex (based on Cisplatin) has been identified and is in the stage of animal testing

If tests are successful, production and commercialization will be done by Ferrer (pharma company)

Cisplatin - Au NPs (ICREA Prof. V. Puntes)

Photoprotective Coatings: Photochromes

Requirements:

Light induced conversion from colorless to colored state

T-type photochromes: transparent colored

Fast color darkening and fading kinetics

Limitations in solid matrices: steric effects provoke slow switching

Encapsulating Photochromes (Daniel Ruiz-Molina)

Microcapsules: Interfacial polymerization of oil-in-water emulsions

Encapsulating Photochromes

Protective lenses / screens

Smart Windows - Greenhouses Clothing

Ophthalmic lenses

Biocides (ICREA Prof. Daniel Maspoch)

Skin: Antiseptics

EtOH H2O2

Markets demand Biocides of long-life antimicrobial activity. 100 disinfectant companies in Europe with 10.000 employees (2011). Disinfectant production achieved a turnover of € 3 billion € in 2011.

Nosocomial infection (surgical wounds, urinary and respiratory tract). Mayor causes of death and increase morbidity in hospitalized patients. Suffered by 8.7% of hospital patients. Cost: 5-10 Bi$/year, 100.000 death/year (in the US alone).

Surfaces: Disinfectants

Encapsulating Biocides (ICREA Prof. Daniel Maspoch)

ClO2/O/W

ClO2

Oil

Water

Double emulsion technology

Encapsulating Fragrances (ICREA Prof. D. Maspoch)

Micro and Nano-encapsulation of fragrances for softeners

Licensing Agreement:• Royalties for ICN2 in sales of products• Expected ICN2 earnings: 0.1 M€/year• A plant is in production, and commercial

products are already available.• First royalties received in 2013

Encapsulating Biocides (ICREA Prof. D. Maspoch)

Micro and Nano-encapsulation for fungicidal paints

Licensing Agreement:• Royalties for ICN2 in sales of products• Product (Fungipol CP) already commercialized by Chemipol

Graphene at ICN2:The whole innovation value chain

Comunitat Emergent Grafè

ICN2

National Center Microelectronics

UAB

MATGAS

Materials Science Institute

ALBA Synchrotron

A cluster with nearly 750 scientists and technicians in the areas of

Materials, Micro and Nanotechnologies

THANK YOU

Pablo Ordejón

Director

pablo.ordejon@icn2.cat

Jordi Reverter

Technology Transfer

jordi.reverter@icn2.cat / +34 93 7372613

Institut Català de Nanociència i Nanotecnologia (ICN2)

ICN2 Building, Campus UAB – 08193 Bellaterra, Barcelona (SPAIN)

www.icn2.cat