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Dosage Fo

Formulation

m Design:

onsiderations

VJ

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Dosage F

Pharmaceutics

-study on the: formulation, manufactur

Pharmaceutical ingredients or excipi

-Selective use of these non medicinal agents

- Uses

solubilize thicken stabilize flavor

suspend dilute preserve efficacious

emulsify color appealing closure forms

orm Design

, stability,

nts

.

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Requirements of

formulation oConsideration of drug substances:

Ph sical chemical & biolo ical chara

*compatible with one another - stable,

& safe

*manufactured under appropriate meas

containers to make product stable

*labeled to promote correct use & store

life

proper design &

dosage form

teristics

fficacious, attractive, easy to administer

res of quality control & packaged in

d under conditions to maximize shell

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The Need for

To protect the drug substanceatmospheric oxygen or humidity.

To protect the drug substancegastric acid after oral administrat

osage Forms

from the destructive influences of(Coated tablets)

from the destructive influence ofion. (Enteric-coated)

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The Need for

To conceal the bitter, salty orsubstance. (Capsules, Flavored

To provide liquid preparationsinsoluble or unstable in the desir

osage Forms

ffensive taste or odor of a drug

syrups)

of substances that are eitherd vehicle. (Suspension

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The Need for

To provide clear liquid dosagSolutions)

To provide rate-controlled dtablets)

To provide optimal drug action(Ointments,Creams, Transder

osage Forms

forms of substances. (Syrups,

ug action. (Controlled-release

from topical administration sites.al patches)

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The Need for

To provide for insertion of a dr(Suppositories)

To provide placement of drugbody tissues (Injections)

To provide for optimal drug a

(Inhalants, Inhalation aeros

osage Forms

g into one of the bodys orifices

s directly in the bloodstream or

tion through inhalation therapy

ls)

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General Considerations

Determine desired product t

produ

develop and examine initial

product:

- desired features: drug releclinical

- pilot plant studies and pro

in Dosage Form Design

ype - framework for

t development.

ormulations of the

se profile bioavailabilityeffectiveness

duction scale-up.

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master formula

formulation that best meets the goals of

Factors to consider before formulation of

forms Therapeutic matters (nature of the

manner it is treated (locally or thr

age and anticipated condition of t

he product

a medicinal agent in one or more dosage

illness)

ugh systemic action)

e patient.