pharmaceutics department

للعلوم والتكنولوجياجامعة مصر Course Specificationلوم والتكنولوجيا جامعة مصر للع

وحدة ضمان الجودة2016 - 2015 ئى والتصنيع الدوا علوم الصيدليةة الكلي

Pharmaceutics Department

للعلوم والتكنولوجياجامعة مصر Course Specificationلوم والتكنولوجيا جامعة مصر للع


جامعة مصر للعلوم والتكنولوجيا Course Specificationلوم والتكنولوجيا جامعة مصر للع


PHCT111



1

Pharmaceutics department

A. Basic Information

Program (s) on which the course is given Bachelor of Pharm. Sciences

Department offering the course Pharmaceutics department

College offering the program College of Pharmaceutical Science & Drug

Manufacturing, MUST University

Dept. responsible for teaching the course Pharmaceutics department

Academic year / level First level, first semester

Course title Ethics in Pharmacy Profession

Course code PHCT 111

Contact hours ( credit hours ) 1( lec.) +0 (pract.) (Total: 1 credit hour)

Course coordinator Dr. Amna Mohamad AwadAllah Makky

Major or Minor element of program Major

Date of specification approval 1/9/2015

B. Professional Information

The course aim and intended learning outcomes are based on that mentioned in the program

specifications, with more course-related specific details.

1. Overall Aims of Course The aim of the course is to orient students and provide them with basic information about

pharmacy profession and ethics in its practice. The course also qualifies the students to judge

ethical dilemmas as well as analyzing some ethical issues and situations that they will face in

their practical life.



2

2. Intended Learning Outcomes of Course (ILOs)

a- Knowledge and Understanding: By the end of the course, the students should be able to:

a1- Know the meaning of Pharmacy, pharmacist, drugs , medicines, ethics, code of ethics,

oath, culture, cultural competence, dilemma and many other related topics.

a2- Recognize the different sciences and topics taught in different college departments.

a3- Identify the different sources of drug information.

a4-Get familiar with all scope of work of pharmacists.

a-5 Describe pharmaceutical organizations.

a-6 Report the different reasons for evolution of codes of ethics.

a-7 Identify the difference between ethical principles, rules and values.

a8- Review some ethical issues and dilemmas.

a-9 Explain the ethical rules governing the practice in every active phase of pharmacy

profession.

b- Intellectual Skills By the end of this course, the student should be able to:

b1-Employ different sources of drug information.

b2-Compare and contrast the role of pharmacists in every field of pharmacy practice.

b3-Plan a strategy for communication with other health team members.

b4-Inspect the different aspects of an ethical issue or dilemma.

b5-Organize a model for solving an ethical problem.

b6- Criticize and Judge a professional ethical behaviour in any field of pharmacy practice.

c- Professional and Practical Skills By the end of the course, the student should be able to:

c1- Deal with an ethical pharmaceutical issue.

c2- Appraise good clinical practice.

b3- Estimate " specific-situation" solutions for ethical problems.



3

d- General and Transferable Skills By the end of the course, the fresh students are:

d1-Highly attached to their college, well- oriented and more convinced with their career .

d2- Have more confidence and clearer view about their role in pharmaceutical and biomedical

fields as well as in society and environment.

d3- Having faith in cooperation and communication between all health care team members.

3. Contents Lecture

No.

Topic

1

Orientation to Pharmacy

Pharmacy Profession

Pharmacy Education

Pharmacy Careers

Information Resources in Pharmacy

1 Pharmaceutical Organizations

Selection and Rational Use of Medicines

1

Ethics in Pharmacy Profession

Ethical Codes; Historical and Evolutionary Aspects

Benefit , Core Values ,Code of Ethics of (APhA) ,

Common Elements of Early Codes of Ethics in

Pharmacy, Oath of a Pharmacist

1

Ethical Theories

Ethical Principles ,Moral Rules &Values

1

Moral Rights Versus Legal Rights

Patient's Rights

Physician-pharmacist-nurse-patient-relationship

Cultural competence

Ethical Issues & Situation; Macro, Micro and

Mixed situations

Guide to Moral Decision Making



4

1 Pharmacist independence

The institutional review board (IRB)

Informed Consent

1

Dilemmas Assisted suicide ( Euthanasia), Abortion, Placebos,

Inclusion of Women & Children in Clinical Trials,

Threats to Confidentiality.

1

Dilemmas (cont.) Medication reconciliation process, Counterfeit

medicines, Generic drugs, Orphan drugs,

Pharmacogenomics, Off-label use of drugs, Right of

pharmacist to refuse.

1 Poor ethical decisions

Ethics & community pharmacists

1 Ethics & Pharmaceutical Industries ,

1 Good Clinical Practices (GCPs)

Intellectual Property Rights

1

Ethics in Drug Research

Ethics of Drug Marketing, Promotion &

Advertisement

Post-marketing surveillance ethics

1 Revision

4. Teaching and Learning Methods

4.1- Lectures (board, data show)

4.2- Class discussion

4.4- Pre-laboratories classes

5. Student assessment:

5.1. Quiz to assess efficient study.

5.2. Written exams to assess knowledge and understanding as well as intellectual skills.

5.3. Practical exams to assess professional and practical skills.



5

5.4. Oral exams to assess all types of skills and mainly general and transferrable skills

Assessment Schedule:

Assessment 1: Q Week: upon course progression

Assessment 2: Mid Term Week: 7-8th

Assessment 4: Final exam Week: 14th

Weighting of Assessments

Quiz 20 %

Midterm 30 %

Final exam 50 %

Total 100 %

6. List of References

6.1- Course book

"Ethics in Pharmacy Profession" prepared by Dr.Amna Makky (in college bookstore)

6.2- Essential Books (Text Books)

-Rémington, The Science and Practice of Pharmacy; Laurence A.J.; 21st Edition, Lippincott

Williams & Wilkins, 2006.

-Classic Cases in Medical Ethics. Pence, McGraw-Hill, 4th edition, 2003.

-Teaching and Learning Strategies in Pharmacy Ethics by Haddad A. New York;

Pharmaceutical Products Press, 1997.

7. Facilities Required for Teaching and Learning Theatres, Microphones, Whiteboard, computer, data show

Coordinator of Course: Dr. Amna Mekky

Head of Department: Dr. Hanan Refai

Date: 1/9/2015



PHCT 211



1


A- Basic Information

Program (s) on which the course is given Bachelor of Pharmaceutical Sciences

Department offering the course Dept. of Pharmaceutics



Dept. responsible for teaching the course Dept. of Pharmaceutics

Academic year / level Second level/first semester

Course title Physical Pharmacy and Pharmaceutics I


Contact hours ( credit hours ) 2(lecture) +2(lab)+ 1(pre-lab) (3 credit hours )

Course coordinator Dr. Amna Makky



B- Professional Information



1. Overall Aims of Course The aim of this course is to introduce the students to the world of dosage forms or drug

delivery systems (DDS). Also; it provides the students with the fundamentals of physical

pharmacy that will enable them to understand related courses in pharmaceutics. This course

also qualifies the students to detect incompatibilities between drugs as well as complexation so

that to avoid or apply in formulation of drugs.



2


a- Knowledge and Understanding:

By the end of the course, the students should:

a 1- Describe the different parts of a prescription.

a2- Locate incompatibilities in prescriptions.

a3- Translate some pharmaceutical units.

a4- Describe some pharmaceutical dosage forms.

a5-Report types of pharmaceutical complexes.

a6- Learn about solubility, surface phenomenon, adsorption at solid surfaces and HLB of

surfactants


b1- Differentiate between drug dosage forms.

b2- Illustrate practical applications of some physical phenomena e.g. adsorption and

solubilization.

b3- Categorize incompatibilities.

b4- Determine and calculate some physical parameters e.g. surface tension ,solubility

parameters, HLB values of surfactants...

c- Professional and Practical Skills

By the end of the course, the student should be able to:

c1- Develop skills for dealing with prescriptions.

c2- Adjust doses for children.

c3-Inspect and Solve the incompatibility in a prescription.

c4- Apply a physical phenomenon to improve the quality of a drug product



3

d- General and Transferable Skills


d2- Develop effective communication skills and critical thinking.

d3-Improve time management and organizational skills.

d4- Organize and plan his/her future pharmaceutical career.

d5-Report clearly his/her coursework

3. Contents

Practical

No.

Lecture

No.

Topic

1

1

1

1

1

1

-The Prescription

-Pharmaceutical Calculations; Roman Numerals,

-Pharmaceutical Calculations; Common & Metric Systems.

Calculation of Doses.

-Pharmaceutical Calculations; Conversion between Systems.

-Calculation of The Child’s dose.

- Preparation of mixtures.

-Incompatibilities

1

1

1

1

1

-Introduction to Dosage Forms

-Pharmaceutical Solutions.

-Extraction

-Preparation of infusion.

-Preparation of Decoction

-Solutions & Solubility.



4

1

1

1

-Solubility problems.

- Micellar Solubilization

1

1

1

-Incompatibilities.

-Surface & Interfacial Phenomenon .

- Determination of surface tension

1

1

1

-Adsorption.

-Complexation

-Hydrophilic Lipophilic Balance Problems.

4. Teaching and learning methods:

4.1- Lectures


4.3- Laboratories

4.4- Pre-laboratories classes

5. Student assessment:





Assessment Schedule:



5

Assessment 1: Q Week: upon course progression


Assessment 3: Practical exam Week: 11-12th


Assessment 5: oral exam Week: 14th

Weighing of Assessments

Quiz 13.33 %

Mid-Term Examination 16.66 %

Final-term Examination 30 %

Oral Examination 10 %

Practical Examination 30 %

Total 100%

6- List of references:

6.1. Course Textbook: Physical Pharmacy & Pharmaceutics PHCT 211 Textbook, at

college bookstore.

6.2. Essential Textbooks:

Pharmaceutical Calculations by Stoklosa, M.J. & Ansel, H.C., Williams & Wilkins,

Middle East ed. 1997.

Rémington, the Science and Practice of Pharmacy; Laurence A.J.; 21st Edition,

Lippincott Williams & Wilkins, 2006.

Physical Pharmacy by Agarwal, S.P. & Khanna, R., CBS Publishers & Distributors

(India), 2001.

Comprehensive Pharmacy Review by Shargel, L., Mutnick, A. H., Souney, P.F.,

Swanson, L.N. and Block, L.H. , 3rd Edition, Middle East Ed. , Williams & Wilkins, The

science of Review, Mass Publishing Co.,1997.

Periodicals and web sites:

PharmInfoNet (http://www.pharminfo.com/)

http://www.pharminfo.com/



6

PharmWeb (http://www.pharmweb.net/)

7-Facilities Required for Teaching and Learning

Lecture theatres with data show

Latest editions of textbooks and others to update the education process.

Laboratories.

Course coordinator: Dr. Amna Mekky

Head of department: Dr. Hanan Refai

Date: 1/9/2015

http://www.pharmweb.net/



PHCT212



1



Program(s) on which the course is given Bachelor of Pharm. Sciences





Academic year / level Second level, second semester

Course title Physical Pharmacy & Pharmaceutics II


Contact hours ( credit hours ) 3(lec.) +2 (pract.) Total: 4 credit hours

Course coordinator Dr. Doaa Hussien Hassen






1. Overall Aims of Course The aim of the course is to provide students with a detailed knowledge and understanding of

physicochemical principal in pharmacy and their possible applications in explaining

characteristics and behavior of pharmaceutical dispersed systems such as colloids, suspensions,

emulsions and aerosols. The course also provides the students necessary knowledge of the basic

physical pharmacy concepts: buffers, rheology, phase equilibrium and phase rule. The student

will be able to do all pharmaceutical calculations required for weighing, measuring and

compounding different prescriptions.



2



a1- Understand the theoretical physicochemical principal of pharmaceutical dispersed systems

such as colloids, suspensions, emulsions and aerosols

a2- Explain the characteristics and behavior of pharmaceutical dispersed system, such as colloids,

suspensions, emulsions and aerosols

a3- Understand of the weights, measures and calculations used in pharmacy practice

a4- Explain the methods and factors, which affect the formulation of suspension, emulsion and

aerosol

a5- Identify the concept of phase equilibrium and phase role

a6- Recognize the concept of Rheology of suspensions; Rheology of emulsions; pharmaceutical

and biological applications of Rheology

b- Intellectual Skills

By the end of this course, the student should be able to:

b1- Perform different pharmaceutical calculations;

b2- Distinguish the different type of flow

b3- Solve some problems encountered in formulation of dispersion systems



c1-Formulate different dispersion system such as suspension and emulsion

c2- Design a successful formula related to different dispersion system

c3- Evaluate some dosage forms in a quality control lab especially Suspension, emulsion and

aerosols



3

d- General and Transferable Skills


d1- Work independently in different pharmaceutical labs.

d2- Apply problem-solving skills for the needs of an individual patient within the practice of

pharmacy

d3- - Develop effective communication skills and critical thinking.

3. Contents

Tutorial/

Practical no

Lecture

no

Topic

0 1 Buffer

Definition,

The buffer action,

Composition of Buffers,

Principle of buffer action,

The Buffer Equation, Buffer Capacity,

Drugs as Buffers

Buffers in Pharmaceutics and Biologic Systems

0 2 Aerosol

Definition, Aerosol products applications,

Advantages and disadvantages of

Pharmaceutical aerosols

Component of aerosol Package;(Propellants

,Container,Valves, Actuators)

Formulation

Inhaled pharmaceutical aerosols

(IPAs),Nebulizers,Dry powder inhaler



4

Manufacturing of Pharmaceutical Aerosols

Quality control of pharmaceutical aerosol

0 1 Colloid

Dispersed systems; Molecular Dispersions,

Colloidal Dispersions , Coarse Dispersions

Types of colloidal systems; Lyophilic

Colloids, Lyophobic Colloids, Association

(Amphiphilic) Colloids

Properties of colloids: Optical properties of

colloids, Kinetic properties, Electric properties

Electrokinetic

Physical stability of colloidal systems

4 2 Suspensions

definition of suspension,

pharmaceutical application of suspensions

properties of good pharmaceutical suspensions,

Theories involved in disperse phase,

Types of suspensions,

Various approaches for developing

suspensions:

Formulation of Suspensions

quality control of suspension:

4 2 Emulsion

Definition, Advantages, Types of Emulsions

Tests for identification of emulsion type

Formulation of emulsion



5

Methods of Emulsion PreparationQuality

Control tests of Emulsion

Stability of Emulsion

Stability tests of Emulsion,

Packaging of Emulsion

0 1 Solid dispersions

Definition of solid dispersions,

Types of solid dispersion

The advantageous properties of solid

dispersions

Preparation of solid dispersions: (Fusion

method, Hot melt extrusion and solvent)

1 1 Rheology

Basic Principles,

The importance of rheology,

types of flow: Newtonian flow ,Non-

Newtonian

Determination of the flow properties

0 1 Phase Rule

Phase,The number of components, Degrees of

freedom, defined.Phase diagram

Systems containing Solid and Liquid Phases

1 1 Pharmaceutical Calculation



6

4. Teaching and Learning Methods 4.1- Lectures (board and data show)

4.3- Practical sessions

5. Student Assessment Methods





Assessment Schedule Assessment 1: Q Week: upon course progression





Weighting of Assessments Quiz 15%

Practical exam 22.5 %

Midterm 17.5%

Final exam 35%

Oral exam 10%

Total 100%

6. List of References

6.1- Course Notes

"Physical Pharmacy and Pharmaceutics II" prepared by Dr.Doaa Hussien (in College Bookstore)




7

Ansel, H. C., Allen, L. V., and Popovich, N. G. Pharmaceutical dosage forms and drug delivery

systems, Philadelphia, Pa., Lippincott-Williams & Wilkins (1999).

Aulton, M. E. Pharmaceutics : the design and manufacture of medicines, Edinburgh ; New York,

Churchill Livingstone (2007).

Goodwin, J. W. Colloids and interfaces with surfactants and polymers : an introduction,

Chichester, England ; Hoboken, NJ, J. Wiley (2004).

Khan, M. A., and Reddy, I. K. Pharmaceutical and clinical calculations, Lancaster, Pa.,

Technomic Pub. Co. (2000).

Lieberman, H. A., Rieger, M. M., and Banker, G. S. Pharmaceutical dosage forms-- disperse

systems, New York, M. Dekker (1996).

Martin, A. N., Sinko, P. J., and Singh, Y. Martin's physical pharmacy and pharmaceutical

sciences : physical chemical and biopharmaceutical principles in the pharmaceutical sciences,

Philadelphia, Lippincott Williams & Wilkins

Remington, J. P. Remington, the science and practice of pharmacy.21 ed

, Mack Pub. Co., Easton,

Pa.,

6. Facilities Required for Teaching and Learning data show and laboratory equipment

Coordinator of Course: Dr. Doaa H. Hussein


Date: 1/9/2015



PHCT311



1








Academic year / level Third level, First semester

Course title Pharmaceutics -III


Contact hours ( credit hours ) 3 (lec.)+2 (pract.) Total: 4 credit hours

Course coordinator Prof. Dr. Hanan Refai






1. Overall Aims of Course

This course is designed to provide the pharmacy students with a comprehensive

theoretical and practical foundation of solid and semisolid pharmaceutical dosage

forms and cosmetics. The purpose of the course is to provide the students with the

basic information about the additives involved in the different dosage forms and the

way they influence the properties of the final product. The course gives the students

information about the skin structure for better understanding of topically applied

dosage forms.



2



By the end of the course, the students should be able to:

a1- Recall the basic information about solid dosage forms as powders, granules, tablets,

microcapsules and capsules as their methods of manufacturing and characteristics

a2- Describe types of suppository bases and their evaluation.

a3- Recognize the structure of skin to define factors affecting permeation of drugs through skin.

a4- Explain the composition and characteristics of transdermal and semisolid dosage forms.

a5- Identify the concepts of cosmetics.

b - Intellectual Skills


b1- Evaluate stability protocols for different dosage forms.

b2- Categorize different suppository bases and determine suitable methods for their preparation.

b3- Distinguish different cream bases and examine their emulsion type

b4- Deal with the chemicals and row materials used to prepare the selected dosage form.



c1- Formulate different dosage forms (effervescent granules, suppositories, creams, ointments,

pastes).

c2- Evaluate and characterize the prepared formulations.

c3- Employ quality control testing for solid dosage forms.



3

D-General and Transferable Skills


d1- Extend information gained to propose and develop pharmaceutical dosage forms.

d2- Work independently and in a team

d3- Make calculations needed to prepare the prescriptions and label the preparation correctly

d4- develop effective communication skills

d5- Be coherent with pharmaceutical ethical, legal and safety guidelines.

3. Contents

Tutorial/

Practical no

Lecture no Topic

0 1 1. Powders

Classification, types, characteristics (particle

size, flowability, density), preparation

(comminution, blending)

1 1 2. Granules

Reasons for granulation

Methods of granulation (wet - dry)

Effervescent granules

0 2 3. Tablets

Advantages and disadvantages, excipients, types

of tablets, coating (sugar – film – enteric –



4

gelatin), preparation (wet granulate - dry

granulation - direct compression), extended

release (oros – ion exchange – complex – slow

eroding – plastic matrix)

0 1 4. Microencapsulation

Classification (mononuclear – polynuclear –

matrix), methods of preparation (chemical and

physical, mechanism of drug release,

pharmaceutical applications

0 1 5. Capsules

Hard and soft gelatin capsules (manufacturing –

fill material – size – additives – advantages)

3 2 6. Suppositories

Rectal suppositories

Local and systemic action

Factors affecting absorption (physiological –

physicochemical)

Bases [fatty - hydrophilic -

miscellaneous]

Additives

Preparation

Vaginal dosage forms

Factors affecting absorption from vagina

pessaries – semisolid – tablets & capsules –



5

implants)

Urethral suppositories

0 2 7. Skin

Anatomy (skin layers –appendages)

Functions (mechanical – protective)

Routes of skin penetration

Factors influencing permeation

Maximizing permeation

0 1 8. Transdermal Patches

Designs (monolithic – membrane controlled)

Advantages and disadvantages

Clinical patches

2 2 9. Semisolid Dosage Forms

Ointments (bases- selection of bases – optimal

properties – preparation)

Creams (types – preparation)

Gels

Pastes

2 2 10. Cosmetics

Ingredients

Cosmetics for skin



6

Cosmetics for hair

Dental products

Dental problems

Dentifrices: toothpaste (ingredients) mouthwash

(ingredients)

1 11. Pharmacy legislations

4. 4-Teaching and Learning Methods 4.1- Lectures (board, data show, video films)







Assessment Schedule Quiz ……………………………………...upon course progression

Midterm……………………………………7-8th week

Practical exam………………………….11=12th week

Final exam……………………………….14th week

Oral exam………………………………..14th week


Quiz 15%

Practical exam 22.5 %

Midterm 17.5%



7

Final exam 35%

Oral exam 10%

Total 100%

6- List of References

6.1- Course Notes

"Pharmaceutics III", Dr Hanan Refai,


1. Ansel's Pharmaceutical. Dosage Forms & Drug Delivery Systems, Eighth

Edition, L.V. Allen, Jr. N.G. Popovich and H.C. Ansel (Eds), Lippincott Williams &

Wilkins 2005.

2. Pharmaceutics. The Design and Manufacture of Medicines, Third Edition, M.

Aulton. Churchill Livingstone 2007.

3. Modern Pharmaceutics. Drugs and the pharmaceutical sciences, GS Banker,

CT Rhodes, Dekker 1996

4. Pharmaceutics Dosage Form and Design. First Edition, D. Johnes.

Pharmaceutical Press 2008

5. Formulation Technology. Emulsions, Suspensions, Solid Forms. First Edition,

Mollet, A. Grubenmann, WILEY-VCH Verlag GmbH 2008

6. Handbook of Cosmetic Science and Technology, Third Edition, A. Barel, M.

Paye, H.I. Maibach, Informa healthcare, 2009

7- Facilities Required for Teaching and Learning

Data show and laboratory equipment

Course coordinator: Dr. Hanan Refai


Date: 1-9-2015

http://www.google.com.eg/search?tbo=p&tbm=bks&q=bibliogroup:%22Drugs+and+the+pharmaceutical+sciences%22&source=gbs_metadata_r&cad=8

http://www.google.com.eg/search?tbo=p&tbm=bks&q=inauthor:%22Gilbert+S.+Banker%22&source=gbs_metadata_r&cad=8

http://www.google.com.eg/search?tbo=p&tbm=bks&q=inauthor:%22Christopher+T.+Rhodes%22&source=gbs_metadata_r&cad=8

http://www.amazon.com/s/ref=ntt_athr_dp_sr_1?_encoding=UTF8&field-author=Andre%20Barel&search-alias=books&sort=relevancerank

http://www.amazon.com/s/ref=ntt_athr_dp_sr_2?_encoding=UTF8&field-author=Marc%20Paye&search-alias=books&sort=relevancerank

http://www.amazon.com/s/ref=ntt_athr_dp_sr_2?_encoding=UTF8&field-author=Marc%20Paye&search-alias=books&sort=relevancerank

http://www.amazon.com/s/ref=ntt_athr_dp_sr_3?_encoding=UTF8&field-author=Howard%20I.%20Maibach&search-alias=books&sort=relevancerank



PHCT321



1








Academic year / level Third level ,first semester

Course title Reaction kinetics and drug stability


Contact hours ( credit hours ) 2( lec.) (total 2 hours)

Course coordinator Dr. Sayed Ismail



B. Professional Information The course aim and intended learning outcomes are based on that mentioned in the program


1. Overall Aims of Course The aim of the course is to introduce the students to the concepts of reaction kinetics including

the study of the rate of chemical reactions and the factors affecting the rate with the aim of

stabilization of drug products, prediction of shelf life and estimation of optimum storage

conditions.




2


a1-explain methods to estimate rate of a chemical reaction

a2-describe different reaction kinetic orders

a3-define factors affecting the rate of a chemical reaction

a4-identify the physical and chemical factors affecting drug stability

a5-define various terms relating to stability testing studies

a6-identify the various instability problems that may be encountered in different pharmaceutical

products


b1-calculate reactions rates and rate constants.

b2- differentiate between the different orders of reactions both mathematically and graphically.

b3-evaluate factors affecting physical and chemical stability of drug products.

b4-determine expiration date for different products using real-time and accelerated storage

conditions.


c1- performa stability test for different drug products.

c2- predict shelf-life of variousdosage forms under different storage conditions.

c3- estimate decomposition pathways based on chemical structure knowledge of drug

d- General and Transferable Skills By the end of the course, the student should be able to:

d1-determine the most important attributes of a pharmaceutical product that need to be followed

in a stability study.

d2- write a stability protocol from a regulatory point of view.



3

3. Contents topic Lecture No.

General Introduction on course contents 1

Law of mass action, rate and rate constants, orders of

reactions ( Zero, first and second ) , units of rate constant

in each order, and half life for each order.

1

An introduction on general decomposition pathways,

Hydrolysis, dehydration and decarboxylation. 1

Oxidation, isomerization and epimerization

decomposition path ways. 1

Factors affecting decomposition of drugs:

1- Temperature, Arrhenius euation

2- pH, specific acid – base catalysis

3- General acid- base catalysis

4- Ionic strength and dielectric constant

4

General methods used for stabilization of drugs 2

Stability of solid dosage forms

1

Physical stability of pharmaceutical dosage forms 1

4. Teaching and Learning Methods 4.1- Lectures (board, data show)

4.2- Assignments

5. Student Assessment Methods 5.1 Quiz to assess the orientation of students to the course, the knowledge and 5.1.

Quiz to assess efficient study.




practice.



4

Assessment Schedule Quiz upon course progression

Midterm 8th week

Final exam 14th week

Oral exam 14th week


Midterm 30%

Final exam 50%

Oral exam 10%

Total 100%

6. List of References 6.1- Course Notes

Reaction Kinetics and Drug Stability, Dr Sayed Ismail,


1. “Drug Stability. Principles and Practices”. Third Edition. Edited by Jens T. Cartensen and C. T.

Rhodes. Marcel Dekker, Inc., New York.

2. "Physical Chemistry". Second Edition. Robert A. Alberty and Robert J. Silbey. John Wiley &

Sons, Inc., New York.

3. “Remington. The Science and Practice of Pharmacy”; 20th Edition. Laurence AJ; Lippincott

Williams &Wilkins

4. “Martin’s Physical Pharmacy and Pharmaceutical Sciences”. Fifth Edition. Patrick J. Sinko.

Lippincott Williams Wilkins.

Course Coordinator:Dr.Sayed Ismail

Head of Department: Dr. HananRefai

Date:1/9/2015



PHCT322



1





College offering the program College of Pharmacy, MUST University


Academic year / level Third level ,second semester

Course title Biopharmaceutics and Pharmacokinetics


Contact hours ( credit hours ) 2( lec.) +2 (pract.)(Total: 3credit hours)

Course coordinator Dr. Hanan Refai







The aim of the course is to introduce the students to the concepts of biopharmaceutics, and

pharmacokinetics. The processes of absorption, distribution, metabolism, and excretion of drugs

are discussed with the purpose of improving the evaluation of drug delivery systems, and the

therapeutic management of patients and to determine the dose and dosage regimen for patients

based on pharmacokinetic study.



2




a1- underline the scope and impact of biopharmaceutics and pharmacokinetics

a2-describe various routes of drug administration

a3-explain the factors affecting the rate and extent of drug absorption, distribution, metabolism

and excretion

a4-identify the design of a bioequivalence study

a5-define various terms related to bioavailability studies

a6-interpret the pharmacokinetic models



b1- evaluate data obtained from dissolution testing experiments

b2- distinguish appropriate integrated equations to calculate pharmacokinetic parameters from

data obtained for drugs administered via intravascular and extravascular routes using data from

various methods of measuring clinical effectiveness.

b3- use the integrated equations to perform various dose and dosing regimen calculations

b4- use graphs presenting different pharmacokinetic models to calculate pharmacokinetic

parameters

b5- evaluate data derived from bioavailability studies and correlate physicochemical properties

of the drug to its bioavailability

b6- apply biopharmaceutical knowledge to drug design and formulation



3



c1- demonstrate dissolution testing experiment and compute percent of drug released

c2- use differential equations for simple pharmacokinetic models

c3- plot manually appropriate graphs representing the different models

c4- apply computer programs to plot appropriate graphs

c5- calculate the absolute and relative bioavailability of a drug, given either plasma concentration

or urinary excretion data following different dosage forms or routes of administration.

a- General and Transferable Skills


d1-analyse selected drug level data for probability of differences in therapeutic effectiveness

based on compartmental levels of drug or release patterns from comparable dosage forms.

d2- use appropriate mathematical and kinetic estimations and verifications.

d3- derive the pharmacokinetic models and parameters that best fit to the data

d4- have the ability to calculate pharmacokinetic parameters from data obtained for drugs

administered via the intravascular and extravascular routes by using pharmacokinetic software.

d5- manage time effectively.



4

3. Contents Practical

number

Lecture

number

Lecture Topic

- 1

1- Routes of drug administration

- Enteral routes: sublingual, buccal, oral and rectal routes

- Parenteral routes: intravenous injection, intramuscular injection,

subcutaneous injection, inhalation, topical administration.

- 1

2- Factors affecting oral absorption

a) Physiological factors affecting oral absorption

A- Membrane physiology

B- Passage of drugs across membranes

Transcellular transport mechanisms

Active transport

Facilitated diffusion

Passive diffusion

Pinocytosis

Pore transport

Ion pair formation

Paracellular transport mechanism

C- Gastrointestinal physiology

GIT physiology and drug absorption

Gastric emptying time and motility

Effect of food on drug absorption

Enterohepatic circulation

First pass effect

- 1

b- Physicochemical factors affecting oral absorption

pH-partition theory

Lipid solubility of drugs

Dissolution and pH

Salts

Crystal form

Drug stability and hydrolysis in GIT

Complexation

Adsorption

c- Formulation factors affecting oral absorption

Role of dosage forms

Solutions

Suspensions

Capsules

Tablets

uncoated

coated

- 1

3- Distribution

Factors affecting distribution

Volume of Distribution (Vd)



5

Factors influencing Vd

- 1

4- Metabolism and Excretion

Rate of drug metabolism

Sites of drug metabolism

Mechanism of drug metabolism

Enzyme Induction

Enzyme Inhibition

Mechanisms of Renal Function

Mechanisms of drug excretion

2 1

5- Assessment of Bioavailability

Methods of assessment:

Plasma Data: (tmax), (Cmax), (AUC)

Urine date (Du), (dDu/dt),(t)

Absolute and relative bioavailability

Acute pharmacologic effect

Clinical Observation

In-vitro studies (drug dissolution)

Absolute and relative bioavailability

Bioequivalence study

Definitions

Pharmaceutical equivalents

Pharmaceutical alternatives

Bioequivalents

Therapeutic alternatives

1 1

A- PHARMACOKINETICS

1- Introduction to compartment model

2- One compartment open model - IV injection

Estimation of pharmacokinetic parameters (elimination rate constant, half-

life, volume of distribution, clearance)

1 1 3.-One compartment open model - IV infusion

Steady state, loading dose, concentration at steady state

1 1

4- Determination of pharmacokinetic parameters from urinary data

a- Rate method

b- Sigma minus method

1 1

5- Distribution kinetics

a- Two Compartment Open Model Determination of pharmacokinetic

parameters: Method of residuals

b- Three Compartment Open Model

1 1

6- Absorption kinetics

a- Method of residuals

b- Wagner-Nelson Method

1 1

7- Elimination kinetics

a- Renal clearance

b- Hepatic clearance




6



4.3- Assignments

4.4- Computer lab






Assessment Schedule Quiz written upon course progression

Midterm 8th week

Practical exam 12th week


Oral exam 14th week


Midterm 17%

Practical 30%

Final exam 30%

Oral exam 10%

Total 100%


Biopharmaceutics & pharmacokinetics , Dr HananRefai,



7


1. Shargel, L., and Yu, A.: Applied Biopharmaceutics and Pharmacokinetics. 4th Ed. Connecticut,

Appleton & Lange, 1999.

2. Rowland, M., and Tozer, T.: Clinical Pharmacokinetics: Concepts and Applications. 3rd

Ed.

Philadelphia, PA, Williams & Wilkins, 1995.

3. Gibaldi, M.: Biopharmaceutics and Clinical Pharmacokinetics. 4th Ed. Philadelphia, PA, Lea

&Febiger, 1991.

4. Winters, M.: Basic Clinical Pharmacokinetics. 3rd

Ed. Vancouver, WA, Applied Therapeutics,

Inc.

7. Facilities Required for Teaching and Learning Computer labs equipped with large number of computers (containing pharmacokinetic software)

Coordinator of Course:Dr.HananRefai


Date:1/9/2015



PHCT411



1







Dept. responsible for teaching the course Dept. of Pharmaceutics

Academic year / level Fourth level / 2nd

Semester

Course title Sterile Products & Radiopharmaceuticals


Contact hours ( credit hours ) 2 (lecture) + 0 (practical), total is 2 credit

hours

Course coordinator Dr. Magdi Ibrahim

Major or Minor element of program major





1. Overall Aims of Course The aim of the course is to have an idea about types of sterile products and

requirements for their preparation and methods for their evaluation and to know

the therapeutic and diagnostic applications of radioactive isotopes.



2


a. Knowledge and Understanding: By the end of the course, student should be able to:

a1- Recognize types of parenteral preparations

a2- Define routes of administration of parenteral preparations

a3- Classify sterilization techniques

a4- Recall formulations and preparations of ophthalmic products

a5- List applications of radiopharmaceuticals

b. Intellectual Skills By the end of the course, student should be able to:

b1- Outline specifications of sterile preparations

b2- Asses polarity of sterile preparations

b3- Calculate radioactivity of a radioactive sample

c. Professional and Practical Skills By the end of the course, student should be able to:

c1- Evaluate parenteral preparations

c2- Demonstrate features of components of sterile products

c3- Show factors influencing ocular bioavailability

c4- Utilize skills that enable him to work in radiopharmaceutical laboratories

d. General and Transferable Skills By the end of the course student should be able to:

d1- Extend information gained to propose and develop parenteral and

ophthalmic dosage forms.

d2- Work independently and in a team


d4- Be coherent with pharmaceutical ethical, legal and safety guidelines.



3

3. Contents Topic Lecture No

Parenteral products

Routes of parenteral administration,

Classification of parenteral products,

Components of parenteral products (active drug,

additives, solvent system and containers),

Formulation of parenterals,

Sterilization of parenterals,

Validation of sterilization process,

Production facilities for parenterals,

Quality control of parenterals,

Stability of injections

6

Ophthalmic products

Pharmacologic categories of ophthalmic drugs,

Pharmaceutical classes of ophthalmic products

(eye drops, eye ointments, eye lotions, ocular

inserts and contact lens care products),

Dosage forms of eye drops (solutions, suspensions,

powder for reconstitution),

Factors affecting ocular bioavalibility,

Eye ointment (bases, preparation and packaging),

Ocular inserts (types, advantages and

disadvantages),

Contact lens care products

3



4

Radiopharmaceuticals

Atomic structure,

Types of radionuclides (isotopes, isobars,

isotones),

Types of radiation from radioisotopes (alpha, beta

and gamma),

Types of radioactive decay,

Unites of radioactivity,

Sources of radioisotopes (natural and artificial),

Instruments for radiation measurement,

Applications of radioisotopes (diagnostic and

therapeutic),

3

4. Teaching and Learning Methods 4.1- Lectures (Board, and data show).

4.2- Class discussion.





Assessment Schedule Quiz upon course progression

Midterm 8th week


Oral exam 14th week




5

Midterm 30%

Final exam 50%

Oral exam 10%

Total 100%

6 –List of references

6.1- Course Notes:

PHCT 411, Sterile Products & Radiopharmaceuticals, by Prof. Dr Magdy Ibrahim


Remington, J. P. Remington, the science and practice of pharmacy.21 ed

, Mack Pub. Co., Easton,

Pa.,

Aulton, M. E. Pharmaceutics : the design and manufacture of medicines, Edinburgh ; New York,

Churchill Livingstone (2007).

6.3- Periodicals, Web Sites, … etc

Journal of Pharmaceutical Sciences

International Journal of Pharmaceutics

Drug Development and Industrial Pharmacy

7. Facilities Required for Teaching and Learning

7.1- Procurement of latest edition of the above mentioned texts and others to update the

education process

7.3- Computer and data show

Coordinator of course: Dr. Magdi Ibrahim


Date: 1 / 9 / 2015



BUAD 411



1




Department offering the course Pharmaceutics



Dept. responsible for teaching the course Business

Academic year / level Fourth level, First semester

Course title Pharmacy Administration

Course code BUAD 411

Contact hours ( credit hours ) 2 (lec.)+ Total: 2 credit hours

Course coordinator : Dr. Mostafa Enany







At the end of this course students should acquire managerial and business skills

related to pharmaceutical businesses such as decision making and problem solving

skills, risk management, accept responsibility, and financial analysis skills.

Additionally students should be able to evaluate and assess the health of the

business and analyze investment and financing options of managers.



2



a1. Define business management and list the goals of a pharmacy manager.

a2- Identify decision making steps.

a3- Define financial statements and state its uses and importance in financial analysis.

a4- Outline sources of risk associated with pharmaceutical businesses.

b - Intellectual Skills By the end of the course, the students should be able to:

b1 Prepare financial statement of a pharmacy.

b2- Calculate depreciation and valuate pharmacy assets..



c1- Asses and analyze the financial health of a pharmaceutical business.

c2- Apply risk management tools to pharmaceutical businesses.

c3- Analyze and evaluate new investments.

c4- plane for financing the business.



d1. Work in groups.




3

3. Contents

Lecture no Topic

1 Management Principle and concepts

1 Pharmaceutical Industry

1 Small Business Administration

1 Planning

1 Strategic Management

1 Decision Making

1 Organization Process

2 Human Resource Management

1 Motivation

1 Leadership

1 Communications

1 Controlling



Student Assessment Methods





4


Midterm 8th week



Quiz 10%

Midterm 30%

Final exam 60%

Total 100%


6.1- Course Notes

Department course notes.

6.2 Essential Books:

1- 1- Jerome Katz and Richard Green: Entrepreneurial Small Business, 3rd edition,

2010.

2- Fred R. David. 2010. Strategic Management, 13th edition.


Data show

Course coordinator: Dr. Mostafa Enany


Date: 1-9-2015



PHCT432



1




Department offering the course Pharmaceutics Department



Dept. responsible for teaching the course Pharmaceutics Department

Academic year / level 4th level/ second semester

Course title Design & Formulation of Dosage Forms (I)


Contact hours ( credit hours ) 2(lecture) + 2(practical) , total is 3 credit

hours

Course coordinator Dr. Amna Makky




The course aim and intended learning outcomes are based on that mentioned in the programme


1- Overall Aims of the Course

The aim of the course is to provide the students and enrich their minds with the stories of

discovery of drugs that had strongly changed the human history.

This course also provides students with the knowledge of the journey of drug starting from an

idea until reaching the market as a totally approved and registered safe and effective drug and

this involves designing procedures of drugs, the steps of approval worldwide and in Egypt,



2

preclinical testing and different clinical testing phases. Main ideas about formulation of a

successful dosage form are discussed. The students are directed to newer drug delivery

systems, either modified or novel .

2- Intended Learning Outcomes of the course (ILOs)


a1. Understand the way important drugs were first discovered.

a2. Recognize the steps of approval and registration of newly discovered drugs.

a3. Be familiar with main issues in formulation of drugs.

a4. Point out problems in formulation of drugs.

a5. Identify some novel drug delivery systems.

b- Intellectual Skills By the end of the course, the students should be able to:

b1. Differentiate between registration of drugs worldwide and in Egypt.

b2. Emphasize essential features for successful formulation of drug products.

b3. Solve some problems encountered in formulation of drugs.

b4. Analyze the methods by which a specific drug is designed.

b5. Evaluate factors influencing the final design and formulation of drug products.

c- Professional and Practical Skills: By the end of the course, the students should be able to:

c1. Judge a modified drug delivery systems.

c2. Design a successful formula.

c3. Evaluate some dosage forms in a quality control lab especially tablets, powders and

suspensions.

c4. Appraise the idea of possibility of designing of a “new” drug.



3

d- General and transferable skills : By the end of the course, the students should be able to:

d1. Develop his computer skills through searching the net to solve some problems arisen in class.

d2. Work in team.

d3. Appraise his role in his profession as well as in society.

3. Course Contents

Practical

No.

Lecture

No.

Topic

1

2

1

2

2

1

-Successes in Drug Discovery

-Preformulation Studies; Dissolution

-Study of Partition coefficient

-Study of Sedimentation Rate.

-Study of Powders ; Flowability and Bulk density

determination

4

-Production of pharmaceuticals in Egypt,

-FDA's Definition of a New Drug,

-Drug Nomenclature,

-Biological Characterization

- Investigational New Drug application (IND),

-Content of IND application

-Phases of a Clinical Investigation: Phase I, Phase

II, Phase III, Phase IV. -The Drug Registry Process in Egypt.



4

2

1

1

1

1

Drug Product Formulation;

-Preformulation Studies,

-Pharmaceutical Ingredients.

- Flavoring, Sweetening and Coloring of

Pharmaceuticals,

-Stability

-Sterilization and Preservation.

Modified Drug Delivery Systems; Need for Extended

Release Pharmaceuticals, Terminology, Drug

Candidates, Technology for Oral Dosage forms.

-Workshop1: Quality control testing of tablets; visit

for the educational Drug factory of MUST

1

2

-Novel Drug Delivery Systems: Benefits, Mechanisms,

Composition.

Parenteral, Vaginal & IUD products ,Topical,

Liposomes, Pilocarpine Ocusert, Osmotic Pump, Oral

Rapid-Dissolving Tablets, Fentanyl Lollipops,

Prodrugs, Gene Therapy.

-Workshop 2: Novel Drug Delivery Systems;

4- Teaching and Learning Methods 4.1-Lectures

4.2-Class discussion

4.3- Laboratories

4.4- Workshops

Others: Some related problems are arisen in class and students are invited to solve them through

external references or the net and discuss their work with the instructor in the office hours,

outstanding students are invited to show their work through a data show to their peers.

5-Student Assessment Methods





5



Assessment Schedule Assessment 1: Q Week: upon course progression





Weighing of Assessments Quiz 13.33 %

Mid-Term Examination 16.66 %


Oral Examination 10 %

Practical Examination 30%

Total 100%


6.1. Course Notes:

Design and Formulation of dosage forms (I) Dr. Amna Makky

6.2. Essential Books:

1-Ansel’s Pharmaceutical Dosage Forms And Drug Delivery Systems by Allen, Popovich &

Ansel , 2004.

2-Rémington, The Science and Practice of Pharmacy; Laurence A.J.; 21st Edition, Lippincott

Williams & Wilkins, 2006.

3-Pharmaceutics: The Science of Dosage Form Design by Aulton, M.E., 2002.



6


- Computer aided with data show

- Boards

- Laboratories

- Must drug factory

Course coordinator: Dr. Amna Makky

Head of department: Dr. hanan Refai

Date: 1 / 9 / 2015

جامعة مصر للعلوم والتكنولوجيا Course Specification جامعة مصر للعلوم والتكنولوجيا

ضمان الجودة وحدة 2016-2015 ع الدوائى والتصني علوم الصيدليةة الكلي

1

PHCT 451E


ضمان الجودة وحدة 2016-2015 ع الدوائى والتصني علوم الصيدليةة الكلي

2


ضمان الجودةوحدة 2016-2015 ع الدوائى والتصني علوم الصيدليةة الكلي

1





College offering the Program College of pharmaceutical science and

Drug Manufacturing

Dept. responsible for teaching the course Industrial Pharmacy Department

Academic year / level Fourth level /1st semester

Course title Pharmaco-economics

Course code PHCT 451E

Contact hours ( credit hours ) Contact Lecture: (2), Total 2 credit hours

Major or Minor element of Programs

Minor


B. -Professional Information

The aim of the course and the intended learning outcomes are based on that mentioned in the

programme specifications, with more course-related specific details.

1. Overall Aims of Course The aim of the course is to establish the economic value of new pharmaceutical products, the

health care industry.

Pharmaceutical dosage forms have significant potential to provide high efficacy and deceasing

cost.

Give strategies for economic assessment of new drug therapies.

Cost effectiveness of ph. Dosage forms.

Basic of Pharmaco-economics research.

Types of Pharmaco-economics analyses.

Techniques of Pharmaco-economics research.

Evaluation of Pharmaco-economics information.

Pharmaco-economics & community practice.



2


a-Knowledge and Understanding:


a1- Define the difference between the Pharmaco-economics value of controlled

release dosage forms and other ph. dosage forms.

a2- Define the basic of Pharmaco-economics research.

a3- Describe the different types of Pharmaco-economics analysis.

a4- Different techniques of Pharmaco-economics research.

a5- Evaluation of Pharmaco-economics information.

b- Intellectual Skills:


b1- Understand and deal with fundamentals of Pharmaco-economics industry.

b2-Choose the most suitable mean used for each of the various Pharmaco- economics types.

b3-Apply different equations to evaluate pharmaco-economic methods of analysis.

c- Professional and Practical Skills:


c1- Propose a suitable methodology to decease cost of drug administrative.

c2- Develop the procedural steps to give greats clinical effectiveness.

C3- Propose a suitable methods to apply the different types of Pharmaco-

economics analyses.

d- General and Transferable Skills:


d1- Work coherently and successfully as a part of a team in Pharmaco-economics students .

d2- Find effective and realistic solutions for work problems through analysis and right

anticipation.



3

3. Course Contents

Lecture

hours Topic

1 Introduction to Pharmaco-economics

1 Basics of Pharmaco-economics

1 Basics of Pharmaco-economics

1 Types of Pharmaco-economics Analyses

1 Types of Pharmaco-economics Analyses

1 Techniques of Pharmaco-economics Research

1 Techniques of Pharmaco-economics Research

1 Pharmaco-economics value of controlled-Release Dosage

Forms

1 Pharmaco-economics value of controlled-Release Dosage

Forms

1 Pharmaco-economics: identifying the issues overview and

advisory panel report summary.

1 Pharmaco-economics: further practical considerations

1 Workshop



4

4- Teaching and Learning Methods

4.1- Lectures (board, computer, screen and data show)

4.2- Tutorials and discussion sessions


5- Student Assessment Methods




Assessment Schedule

Quiz ………………………………….. upon course progression

Mid-term……………………………….. 7-8th week

Final exam……………………………… 14th week


Mid-Term Examination 30 %


Oral Examination. 10 %


6.1- Course Notes


1.Townsend RJ., Postmarketing drug research and development. Drug Intell. Clin. Pharm. 1987;

21: 134-136.

2.Cooke J., Pharmacoeconomics ln: “Clinical Pharmacy and Therapeutics”, Roger Walker and

Clive Edwards, Edts., 2nd

. 1999, churchill Livingstone, N.Y.



5

3.McGhanW., C. Rowland, J .L_ Bootman; Cost-benefit and cost-effectiveness: . methodologies

for evaluating innovative pharmaceutical services. Am. j.Hosp. Pham. 1978; 35: 133- 140.

4.Sanchez L. A., Expanding the role of pharmacists in pharmacoeconomics: how and why?

PharmacoEconomics l994;5:367-375. .

5.Sanchez L. A.; Pharmacoeconomics: Further Practical considerations. In: Principles of

Pharmacoecononiics”, Bootman J.L., R.j. Townsend and W.F., McGhan, Edts 2nd ed., 1996,

Cincinnati, OH: Harvey Whitney Book Company.

6.Drummond, M.F., B.J.o’ Brien, G.L. stoddart , and G. Torrance; Methods for the Economic

Evaluation of Health Care Programmes, Second 2nd ed., Edition. 1997, Oxford Oxford Univ.

Press.

7.Paul Radensky Regulation of phannacoeconomics and Outcomes research; Value in Health.

2001; 4 (1): 12-15.

8. Bonk, RJ., Medical Writing in Drug Development- A Practical Guide for Pharmaceutical

Research. 1998 Pharmaceutical products press, an imprint of the Haworth Press, Inc.,

Binghamton, N.Y.

9. Adamic B.A., The consumers of health care. In : “Pharmacy and the U.S. Health Care

System.” 2nd ed., J.E. Fincham and A.I. Wentheimer, eds. 1997. Pharmaceutical Products Press,

an imprint of the Haworth press, Inc., Binghamton,NY.


1. Lecture rooms with data show

2. Procurement of latest edition of the above mentioned texts and others to update the education

process.

Course coordinator:

Name: Prof. Dr. M.A. El Nabarawi

Head of department Prof.Dr.Hanan Rafaay

Date 1 / 9 / 2015



MARK 512



3




Department offering the course Pharmaceutics



Dept. responsible for teaching the course Pharmaceutics

Academic year / level fifth level, second semester

Course title Pharmaceutical Marketing

Course code MARK 512

Contact hours ( credit hours ) 2 (lec.)+ Total: 2 credit hours

Course coordinator Dr. Adel Saad







The aim of the course is to provide students with the basis of marketing, selling and

communication in the market in general and the pharmaceutical market in specific.



4




a1- Explain basics of communication.

a2- Recognize application of marketing in real life

a3- Recall different methods of selling

a4- Mention steps of the selling process

b - Intellectual Skills By the end of the course, the students should be able to:

b1- Differentiate between effective and in ineffective communication

b2- Recognize the communication styles of different people

b3- Select the most suitable approach to different personality styles

b4- Select a promotional media for any product

b5- Explain the role of marketers and salespeople in organizations..



c1- Communicate effectively in different situations

c2- Interpret the non verbal clues of a communication partner

c3- Actively listen to others.



d1- Sell any product or idea.

d2- Behave professionally in an interview



5

3. Contents

Lectures Topic

1

1- Professional Sales people

- The importance of the salesperson

- The professional salesperson

- General characteristics of professional salespersons

- Medical representative's profile

- The attributes of a top seller

3 - 4

2- Communication

- The 3 components of effective communication

- The verbal channel of communication

- The vocal channel of communication

- The visual channel of communication

- Barriers in communication

- Communication styles

2

3- Marketing

- Pharmaceutical marketing

- Marketing plan

- Marketing mix

2

4- Promotion and Advertising

- Definitions



6

- Basics of advertising and promotion

- Major methods of advertising & promotion

2 - 3

5- Selling Skills

- Definitions

- Main methods of selling

- Buying motives

- Sales Cycle and steps

- Handling Customer responses

4. Teaching and Learning Methods 4.1- Lectures (board, and data show)

4.2- Tutorials and discussion sessions

4.3- Presentations by the students every lecture to measure their understanding




5.3. Oral exams to assess all types of skills and mainly general and transferrable

skillsAssessment Schedule Quiz written upon course progression

Midterm 8th week


Oral exam 14th week



7


Quiz …………………………………….. 10%

Midterm ………………………………… 30%

Final exam………………………………. 50%

Oral exam……………………………….. 10%

………………………………………………

Total 100


6.1- Course Notes

Pharmaceutical marketing and selling

6.2 Essential Books:

" Marketing Strategy in the Pharmaceutical Industry By Marcel Corstjens"

" Communication in pharmacy Practice By William N.Tindall.-Robert S.Beardsley"

" Selling, Principles & Methods by Carlton A. Pederson and Milburn D. Wright"

" Marketing Management By Philip Kotler"


Data show

Course coordinator: Dr. Adel Saad


Date: 1-9-2015



PHCT531E



1




Department offering the course Pharmaceutics Department




Academic year / level Forth level and fifth level

Course title Design and formulation of dosage forms II

Course code PHCT 531 E

Contact hours ( credit hours ) 2 +2 (Total: 3 credit hours)

Course coordinator Dr. Hanan Refai

Major or Minor element of program Minor






The aim of the course is to introduce the students to the concepts of nanotechnology and targeted

drug delivery systems. The design of different nanocarriers for drug delivery and disease

diagnosis is discussed, in addition to the concepts of passive and active drug targeting to the

effected tissues or organs with the purpose of improving the efficacy of drug delivery systems

with least possible side effects.



2



By the end of the course, the students should be able to: a1. Be familiar with nanotechnology in nature.

a2. Recognize the perceptions of nanotechnology

a3. Understand issues in formulation of nanocarriers.

a4. Comprehend concepts of drug targeting.

a5. Point out problems and hazards in applying nanotechnology.



b1. Differentiate between different nanocarriers.

b2. Emphasize essential features for successful formulation of nanocarriers.

b3. Solve some problems encountered in formulation of nanocarriers.

b4. Analyze the methods by which the drug is targeted to active sites.


By the end of the course, the student should be able to: c1. Search for information about nanotechnology.

c2. Design an assignment about certain selected topics.

c3. Evaluate some nanocarriers and their applications in drug delivery and/or diagnosis.

c4. Appraise the idea of possibility of designing of a new nano dosage form.

a- General and Transferable Skills




3

d1. Develop his computer skills through searching the net to make assignments and

presentations.

d2. Work independently and in team.

d3- Manage time effectively

3. Contents

Practical

number

Lecture

number

Lecture Topic

- 3 Introduction to Nanotechnology

Nanotechnology in Drug Delivery

Challenges of Nano Drug Delivery

Classification of Nanomaterial

4 4 Nano Drug Delivery Systems

2 2 Introduction to drug targeting

Classification of Drug Targeting

Drug Targeting for Receptors

Carrier Mediated Drug Targeting

1 1 Brain targeting

2 2 Cancer targeting

4. Teaching and Learning Methods 4.1- Lectures (board, data show)


4.3- Assignments

4.4- Computer lab








4


Midterm 8th week

Practical exam 12th week


Oral exam 14th week


Midterm 17%

Practical 30%

Final exam 30%

Oral exam 10%

Total 100%


Nanotechnology and drug targeting, Dr Hanan Refai,


1. Ali DS. Application of Nanotechnology in Drug Delivery, InTech, 2014

2. de Villiers, Melgardt M., Aramwit, Pornanong, Kwon, Glen S. Nanotechnology in

Drug Delivery, Springer, 2009.

3. Harry F. Tibbals, Medical Nanotechnology and Nanomedicine, CRC Press, 2010

7. Facilities Required for Teaching and Learning Computer labs equipped with large number of computers

Coordinator of Course: Dr.HananRefai


Date:1/9/2015

http://www.intechopen.com/books/editor/application-of-nanotechnology-in-drug-delivery



PHCT541



1







Dept. responsible for teaching the course Pharmaceutics Dept.

Academic year / level fifth level / 1st semester

Course title Community Pharmacy and Pharmacy Practice


Contact hours ( credit hours ) 2 (lec. ) + 2 (pract.) , total is 3 credit hours

Course coordinator Prof. Dr. Abdel-Hameed I. M. Ebid



B. Professional Information:



1- Overall Aims of Course - Learn and understand: (1) principles of pharmacy practice, (2) principles of

communication skills and counseling of patients and other health care providers,

(3) principles of pharmaceutical care, (5) concepts of adherence to patient therapy

(5) concepts of non-prescription medications, (6) requirements and steps of good

prescription practice including processing and dispensing medications.

- Learn and understand: therapeutics, treatment guidelines, pharmaceutical care of



2

OTC for the common problems usually encountered such as diarrhea, constipation,

common cold, influenza, sinusitis, allergic rhinitis, . . . . . . . etc.

- Develop the gained knowledge in practicing pharmaceutical care in the community

pharmacies and how to improve patient’s adherence to his medications

- Develop the knowledge gained by studying and understanding pharmaceutical care,

counseling, communication skills, concepts of OTC products, drug adherence and

poor adherence in dealing with patient at the counter in the community pharmacies

2- Intended Learning Outcomes of Course (ILOs)


a1- Recognize principles of pharmacy practice and pharmaceutical care

a2- Describe the basics of patient counselling and adherence to therapy

a2- Name non-prescription (OTC) medications that is relevant to self-health care

a3- List common disorders, diseases, problems that are usually encountered in

community pharmacies.

a4- Discuss treatment guidelines and patient counselling for the individual studied

health problems.

a5- Relate over the counter therapeutics and the pharmaceutical care for the individual

studied health problem.

b- Intellectual Skills: By the end of the course, the students should be able to:

b1- Distinguish risk factors that may cause poor adherence

b2- Assess and evaluate patient’s condition seeking help at the counter.

b3- Organize and evaluate the gained information during patient counselling.

b4- Differentiate correctly over the counter between similar conditions.

c- Professional and Practical Skills: By the end of the course, the students should be able to:

c1- Show appropriate interaction with patients seeking help at the counter.

c2- Demonstrate ability to identify and resolve drug-related problems.

c3- Manipulate interactions with the prescriber through therapeutic intervention



3

c4- Select and differentiate prescription drugs from those OTC.

c5- Operate patient requests and problems over the counter.

d- General and Transferable Skills: By the end of the course, the students should be able to:

d1- Develop writing and presentation skills

d2- Demonstrate good information technology skills

d3- Evaluate and find effective resolution to patient’ problems at the counter

d5- The ability to practice effectively in team and independent manner

3. Course Contents:

Topics Lectures

(No)

Practical

(No)

Pharmacy practice:

An introduction to pharmacy practice

Prescription practice

Information necessary for good prescription practice, therapeutic

intervention

Pharmaceutical care, and drug related needs

3 2



4

Community pharmacy:

Activities of the community pharmacists

communication skills and patient counselling

Patient monitoring, processing & dispensing medications

Adherence, Poor-adherence; types, causes, consequences detection,

prevention

Self-Health Care and Non-prescription drugs

2 0

GIT problems:

Diarrhea; etiology, types, danger – Infectious diarrhea Dietary and

medication related diarrhea, chronic diarrhea, guidelines in assessing

diarrhea, OTC products for diarrhea, treatment guidelines,

pharmaceutical care

Constipation; etiology, danger – OTC for constipation, Treatment

guidelines of constipation, pharmaceutical care

Hemorrhoids, etiology, pathogenesis classification, differential

diagnosis, Symptoms and OTC drugs, treatment guidelines,

pharmaceutical care

Gastritis – peptic ulcers – GERD (etiology, symptoms treatment

guidelines, pharmaceutical care)

4 4

Respiratory system problems:

Common cold / influenza

Cough

Sore throat

Sinusitis

Allergic rhinitis

3 4

Exam



5

4- Teaching and Learning Methods

(√) Lectures

(√) Class discussion

(√) Training in Community Pharmacies

( ) Pre-laboratories class

(√) OTC project

5- Student Assessment Methods





Assessment Schedule Quiz ………………………………….. upon course progression

Midterm………………………………… 8th week

Practical exam ..........…………………... 12-13th week

Final exam…………………………………14th week

Oral exam………………………………….14th week


Quiz I 13.33%

Midterm 16.66%

Practical exam 30%

Final exam 30%

Oral exam 10%

Total 100%



6


6.1- Course Notes


1. Required Textbook: Nonprescription Product Therapeutics, Nonprescription product

text, Patient Counseling Handbook (American Pharmaceutical Association.

2. Extra reading list : Pharmaceutical Practice (Winfield AJ & Richards RME,

eds[Churchill Livingstone]), Remington, Communication skills in Pharmacy Practice

(Tindal WN et al)

Facilities Required for Teaching and Learning

- Computer aided with data show

- Boards

- Computer Laboratories

Coordinator of Course: Abdel-Hameed I. M. Ebid


Date: 1 / 9 / 2015


وحدة ضمان الجودة2016 - 2015 ئى والتصنيع الدوا الصيدليةعلوم ة الكلي

PHCT542



1






1. Overall Aims of Course The aim of the course is to provide the students with an adequate knowledge ondefinition, levels

and subsystems of health care system, organizational structure and facilities for pharmaceutical

department, scope of pharmaceutical services, which include product, clinical, teaching, research,

and other support services (They are further differentiated by whether they are provided to either

hospitalized patients or ambulatory patients), as well as, quality assurance of institutional care.






Academic year / level Fourth level, 2nd

semester

Course title Hospital pharmacy


Contact hours ( credit hours ) 2 (lec.)+0 (pract.) (total: 2 credit hours)

Course coordinator Dr. Howida Kamal Ibrahim

Major or Minor element of programs Major




2



a1-Explain the concept of hospital pharmacy.

a2- Discuss the different services provided by the hospital pharmacy.

a3-Recognize the standards for such services.

a4-List hospital pharmacy staff.

a5- Describe the facilities required for the hospital pharmacy.


b1-Assemble features of hospital pharmacies with different bed capacities

b2-Differentiate between clinical and product services, in- and out patients.

b3- Assess laboratory and diagnostic tests

b4-Calculate parenteral nutritional needs for patients.

b5- Estimate and solve problems in dosage calculation, powder reconstitution and

intravenous admixture.

c6-Propose the most appropriate purchase and inventory management systems.


c1- Use skills for communication with patients and other health care

team members.

c2- Practice interpreting results of laboratory and diagnostic tests.

c3- Design a total parenteral solution

c4- Select the suitable line of injection of parenteral nutrition solutions.

c5-Compute doses for patients of different ages.



3

d- General and Transferable Skills By the end of the course, the student should be able to:

D1- Work in a team.

D2- Retrieve information from a variety of sources, internet and library search.

D3- Adopt safety guidelines and implement efficient and effective working environment.

D4-Be coherent with safe handling of cytotoxic drugs.

3. Contents

Topic Lecture

No.

Health care system 1

Organizational Structure & Facilities

for the Department of Pharmaceutical

Services

1

Product Services for Hospitalized

Patients

1

Product Services for Ambulatory

Patients

1

Clinical Services for Ambulatory

Patients

1

Clinical Services for Hospitalized

Patients:

Hospital Formulary

Drug Use Evaluation

Patient Medication Profiles

Prescription Monitoring

Prescribing Advice to Medical and

Nursing Staff

4



4

Medication Errors and Adverse

Drug Reaction Reporting

Medication History Taking

Therapeutic Drug Monitoring,

Clinical Pharmacokinetics

Medication Information Services

Teaching Services & Research

Services

1

Support pharmaceutical services:

Pharmaceutical Production in

Hospitals

Repackaging

Purchasing and Inventory

Management

1

Quality Assurance of Institutional Care 1

Communication Skills for the

Pharmacist

Taking Health History

Taking Medication History

Constitutions of Dry Powders

Dosage Calculation

Intravenous Calculations

Total Parenteral Nutrition

Calculations & cases

Review of Laboratory and

Diagnostic Tests



5

4. Teaching and Learning Methods 4.1- Lectures (Board and data show).


4.3- Practical sections.

4.4- Homework assignments

4.5- Research work (practical case study)

5. Student Assessment Methods 5.1. Quiz to assess efficient study.

5.2. Written exams to assess knowledge and understanding as well as

intellectual skills.


5.4. Oral exams to assess all types of skills and mainly general and

transferrable skills

Assessment Schedule Quiz …………………………………….upon course progression

Midterm…………………………………8th week

Final exam……………………………….14th week

Oral exam………………………………..14th week


Mid-Term Examination 30 %


Oral Examination. 10 %

Total 100%


a. Hospital pharmacy, by Dr. Howida Kamal, Associate professor of Pharmaceutics and

Industrial pharmacy, Faculty of Pharmacy, Cairo University

b. Practical notes on Hospital pharmacy, by Dr. Howida Kamal.



6


1. Brown, T.R., “Handbook of Institutional Pharmacy Practice”, 3rd ed., 1992,

American Society of Hospital Pharmacists, Inc.,

2. Lecca, P.J., and Patrick harp, C., “Pharmacy in Health Care and Institutional

System”, 1978, The C.V. Mosby Company, Saint Louis.

3. Brown, M., and Mulholland, J.M., “Drug Calculations, Process and

Problems for Clinical Practice”, 7th ed., 2004, Mosby, Inc.

6.3- Recommended Books

1. Stephens, M., "Hospital Pharmacy", 2003, Pharmaceutical Press.

2. Siddiqui, A.A., and Ali, M., "Hospital and Clinical Pharmacy", 2004.

3. Jones, R.M., "Patient Assessment in Pharmacy Practice", 2003, Lippincott

Williams and Wilkins Company.

4. Knowlton, C.H., and Penna, R.P., "Pharmaceutical Care", 2nd

ed., 2003,

American Society of Health System Pharmacists.

5. Best Practices for Hospital and Health System Pharmacy", Position and

Guidance Documents of ASHP, 2005-2006, American Society of Health System

Pharmacists.

6.4- Periodicals, Web Sites, … etc

Journal of Hospital Pharmacy

7. Facilities Required for Teaching and Learning 7.1.Procurement of latest edition of the above mentioned texts and others to

update the education process.

7.2.Overhead projector and data show

Course coordinator: Dr. Howaida Kamel

Head of Department:Dr. Hanan Refai

Date: 1/9 /2015