department of pharmaceutics courses specifications

Department of Pharmaceutics

Courses Specifications

2017-2018

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Contents

Orientation to pharmacy .................................................................................... 2

Pharmaceutical calculations ............................................................................... 6

Pharmaceutics-1 ................................................................................................ 10

Pharmaceutics-2 ................................................................................................ 16

Physical pharmacy ............................................................................................ 22

Biopharmaceutics and Pharmacokinetics ....................................................... 27

Drug Delivery Systems and Targeting ............................................................ 33

Pharmaceutical Technology-1 .......................................................................... 37

Pharmaceutical Technology-2 .......................................................................... 42

Radiopharmaceutics .......................................................................................... 48

Fundamentals of Cosmetology ......................................................................... 53

Dosage form design ........................................................................................... 56

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Delta University for Science and Technology

Quality Assurance Center

Course Specifications

1. Basic Information:

Course Title: Orientation to pharmacy

Course Code: PH 101

Program on which the course is given: B. Pharm.

Department offering the course: Pharmaceutics

Academic year/ level: Fall Semester 2017/2018 Level one

Prerequisite: None

Credit hours: Lecture: 1 Practical: 0 Total: 1

2. Course Aims:

To provide student with knowledge about the principles of basics and ethics of pharmacy

practice; recognize the different types of pharmaceutical dosage forms and drug delivery

systems. In addition to knowledge about different types of prescriptions. Describe the

different pharmacy careers and the role of pharmacist in each. Recognize international and

national pharmaceutical organizations. Know simple idea about history and development of

pharmacy profession.

3. Intended Learning Outcomes (ILOs):

a. Knowledge and understanding:

At the end of this course, student should be able to:

A21

a1. Describe the principles of basics and ethics of pharmacy practice

a2.

Identify the different pharmacy careers and role of pharmacist as a member

in health care team in community, hospital, governmental, military

pharmacies and pharmaceutical industries.

a3. Summarize the different pharmaceutical dosage forms and drug delivery

systems, routes of drug administration and different types of prescriptions.

a4. Recognize international and national pharmaceutical organizations.

a5. Outline the history and development of pharmacy profession.

b. Intellectual Skills:


B1 b1. Specify the role of pharmacist in different pharmaceutical organizations

B4 b2. Assess different types of prescriptions and how to deal with each type.

c. Professional and Practical Skills:


C1 c1. Utilize pharmaceutical and medical terms properly

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c2 Collect pharmaceutical data about drugs from reliable information sources

d. General and Transferable Skills:

At the end of this course, student should be able to

D3 d1. Work effectively as a part of a team

D9 d2 Manage time effectively

4. Contents:

4.1. Lectures:

4.2. Practical: N/A.

5. Teaching and Learning Methods:

5.1. Lectures

5.2. LMS

6. Student Assessment Methods:

6.1. Assessment methods:

1. Written exam To assess knowledge, understanding, intellectual and professional

skills.

2. Course work To assess knowledge, understanding, intellectual skills, general&

transferable skills.

3. Oral exam To assess knowledge, understanding, intellectual skills, and general

skills.

Study

week Topics

No. of

Credit Hours

1. Introduction for pharmacy ethics and pharmacy career 1

2. International and local pharmaceutical organizations 1

3. Role of pharmacist in different pharmaceutical work areas 1

4. Types and properties of oral dosage forms + Quiz 1 1

5. Types and properties topical dosage forms 1

6. Types and properties of sterile dosage forms 1

7. Primary and secondary sources of pharmaceutical

information 1

8. Quiz 2

9. Types of prescriptions 1

10. Narcotic prescriptions 1

11. Routes of administrations 1

12. History of pharmacy profession 1

13. History of pharmacy profession 1

14. Final Exam

Total:

1 credit hours 15.

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4. Quizzes To assess knowledge, understanding and intellectual skills.

6.2. Assessment schedule:

Assessment 1 Quiz 1 4th week


Assessment 3 Assignment/activity all over the term

Assessment 4 Oral exam 14th &15th weeks

Assessment 5 Written exam 14th &15th weeks

6.3. Weighing of Assessments:

1. Course work:

- Quiz 1 10

- Quiz 2 10

- Assignment/activity (research) 5

2. Final-Term Exam 65

3. Oral Exam 10

Total 100%

7. List of References:

No. Reference Type

1.

Allen, Loyd, and Howard C. Ansel's pharmaceutical dosage forms

and drug delivery systems. Lippincott Williams & Wilkins,

Philadelphia, 2013.

textbook

2.

Aulton, Michael E., and Kevin MG Taylor, eds. Aulton's

Pharmaceutics E-Book: The Design and Manufacture of

Medicines. Elsevier Health Sciences, 2017.

textbook

3. https://aihp.org/historical-resources/teaching-the-history-of-

pharmacy website

8. Matrix of course contents versus ILOs:

8.1. Lectures:

Study

week Course Contents

ILOs

K&U IS P&PS G&TS

1. Introduction for pharmacy ethics and

pharmacy career a1,a4 -- c1 --

2. International and local

pharmaceutical organizations a4 -- c1 --

3. Role of pharmacist in different

pharmaceutical work areas a2 -- c1, c2 d1, d2

4. Types and properties of oral dosage

forms a3 b1 c1 d1, d2

https://aihp.org/historical-resources/teaching-the-history-of-pharmacy

https://aihp.org/historical-resources/teaching-the-history-of-pharmacy

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5. Types and properties topical dosage


6. Types and properties of sterile dosage


7. Primary and secondary sources of

pharmaceutical information a3 -- c2 d1, d2

9. Types of prescriptions a1, a2,a3 b2 c1, c2 d1, d2

10. Narcotic prescriptions a1, a2,a3 b2 c1, c2 d1, d2

11. Routes of administrations a3 b2 c1 d1, d2

12. History of pharmacy profession a4 -- -- d1, d2

13. History of pharmacy profession a4 -- -- d1, d2

Name Signature

Course Coordinator: Dr. Enas Ibrahim El Zahaby

Head of Department: Prof. Dr. Ahmed Talaat Nouh

Approval Date 29/8/2017

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Course Title: Pharmaceutical calculations

Course Code: PH 211


Department offering the course: pharmaceutics

Academic year/ level: Fall Semester 2017/2018 Level two

Prerequisite: Mathematics (PC 101)

Credit hours: Lecture:2 Practical: 0 Total:2

2. Course Aims:

To provide the student with the knowledge and skills required of pharmaceutical calculations

to perform different mathematical treatments required for dose calculations and preparation

of different dosage forms.




A17

a1. Define the different measuring systems used in pharmacy

a2. Outline the different methods of calculations involved in preparation of

pharmaceutical products

a3. State equivalent measures between the international system of units and

other systems of measure used in pharmacy practice

a4. Describe different approaches for calculation of pediatric and adult doses

a5. Illustrate the bases of dose adjustment



B10

b1. Convert measures between the international system and other systems of

measure used in pharmacy

b2. Calculate the proper dose of drugs for adults and pediatrics

b3. Calculate the proper dose of chemotherapeutic agents

b4. Specify the bases of dose adjustment

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C3

c1. Apply the international system of units correctly in calculations

c2. Perform basic calculations for preparation of different pharmaceutical

formulations

c3 Perform calculations for the preparation and use of stock solutions.

c4 Apply alligation medial and alligation alternate in problem-solving



D1 d1. Communicate effectively with other health care professionals


4. Contents:

4.1. Lectures:

Study

week Topics

No. of

Credit Hours

1. Fundamentals of pharmaceutical measurements and

calculations 2

2. Metric and common system 2

3.

Interpretation of prescription or medication order

1) The apothecariesˋ

2) Avoirdupois measures

3) Household measures

Reducing and enlarging formulas

2

4. Density, specific gravity and specific volume + Quiz 1 2

5. Weight and volume of liquids and percentage preparation 2

6. Ratio strength

Simple conversion from percentage to ratio strength 2

7. Dilution and concentration 2

8. Quiz 2

9. Stock solution

Dilution of alcohol 2

10. Allegation medial 2

11. Allegation alternate 2

12. Calculation of pediatric dose according to body weight, age

and body surface area 2

13. Calculation of chemotherapeutic dose according to body

weight, age and body surface area 2

14. Final Exam

Total:

2 credit hours 15.

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4.2. Practical: N/A


5.1. Lectures

5.2. Home work

5.3 LMS




skills.







Assessment 3 Assignment/activity (make a summary of the

course problems and solving examples) all over the term



1. Course work:

- Quiz 1 10

- Quiz 2 10

- Assignment/activity (make a summary of the

course problems and solving examples) 5


Total 100%


No. Reference Type

1.



China, 2013.

textbook

2. Robert M. Fulcher and Eugenia M. Fulcher. Pharmaceutical

Calculations. Elsevier, First Edition, China, (2014), textbook

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8.1. Lectures:

Study


ILOs

K&U IS P&PS G&TS

1. Fundamentals of pharmaceutical

measurements and calculations a1, a2 b1 c1 --

2. Metric and common system a3 b1, b2 c1 --

3.

Interpretation of prescription or

medication order

4) The apothecariesˋ

5) Avoirdupois measures

6) Household measures

Reducing and enlarging formulas

a2, a3 b1, b2 c1 d1, d2

4. Density, specific gravity and specific

volume a1, a2 b1 c1 d1, d2

5. Weight and volume of liquids and

percentage preparation a2, a3 b1 c1 d1, d2

6.

Ratio strength

Simple conversion from percentage to

ratio strength

a1, a2,

a3 b1, b2 c1, c2 d1, d2

7. Dilution and concentration a2, a3 b1, b2 c1, c2 d1, d2

9. Stock solution

Dilution of alcohol a2, a3 b1, b2

c1, c2,

c3 d1, d2

10. Allegation medial a1, a2,

a3 b1, b2

c1, c2,

c4 d1, d2

11. Allegation alternate a1, a2,

a3 b1, b2

c1, c2,

c4 d1, d2

12.

Calculation of pediatric dose according

to body weight, age and body surface

area

a4, a5 b2, b3,

b4 c1 d1, d2

13.

Calculation of chemotherapeutic dose

according to body weight, age and body

surface area

a2, a4,

a5

b2, b3,

b4 c1 d1, d2

Name Signature

Course Coordinator: Dr. Enas Ibrahim

Head of Department: Prof. Dr. Ahmed Talaat Nouh


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Course Title: Pharmaceutics-1

Course Code: PH 212



Academic year/ level: Spring Semester 2017/2018 Level one

Prerequisite: Orientation to Pharmacy (PH 101)


2. Course Aims:

To provides the students with the basic physicochemical principles in the formulation and

preparation of liquid dosage forms used via the different routes of administration. Methods of

preparation and evaluation of solution and suspension and emulsions, creams and ointments.




A2 a1. Define the properties of different types of liquid and semisolid dosage forms

A6

a2. Describe the different types of solutions, suspension, emulsion, colloids and

semisolids.

a3. Recognize the differences between solution, suspensions and emulsions as

an example for dispersed system.

A22 a4. Summarize the proper pharmaceutical terminology and abbreviations used in

formulation of liquid and semisolid dosage forms.



B4

b1. Apply Stoke, s law and theory of sedimentation in formulation and stability

of suspension and emulsion

b2. Select the proper excipients for formulations for solution; suspensions,

emulsions and semisolids.

b3. Predict the stability of various dispersed systems.

b4. Evaluate solutions, suspensions, emulsions and semisolid dosage forms

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C3

c1. Design and prepare different liquid dosage forms (solution, suspension,

emulsions) and semisolid dosage forms

c2.

Resolve drug-related problems during formulation of liquid dosage forms

(solution, suspension, emulsions) and semisolid dosage forms

c3. Perform different quality control testing of liquid dosage forms (solution,

suspension, emulsions) and semisolid dosage forms

c4 Perform experiments to differentiate between different type of emulsion



D10 d1. Write a report concerning topics of the course.

d2. Present reports, in the class, related to the course topics.

4. Contents:

4.1. Lectures:

Study

week Topics

No. of

Credit Hours

1. Introduction to solution as an oral dosage form. Approaches

to improve drug aqueous solubility 2

2. Non-aqueous solutions, properties of non-aqueous vehicles 2

3. Types of solution, manufacture of solutions and stability 2

4. Pharmaceutical applications of suspensions, Formulation and

stability of suspensions + Quiz 1 2

5. Electrical double layer and Nernst and Zeta potentials and

suspension formulation and stability 2

6. Promotion of flocculation and flocculating agents 2

7. Suspending agents. Problem of using suspending agents and

Formulation additives 2

8. Quiz 2

9. Pharmaceutical application of emulsions, types of emulsion 2

10. Tests for identification of emulsion type. Formulation of

emulsions and formulation additives, Stability of emulsions 2

11. Micro-emulsions 2

12. Creams 2

13. Ointments 2

14. Final Exam

Total:

2 credit hours 15.

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4.2. Practical:

Study

week Topics

No. of

Credit Hours

1. Introduction preparation of aromatic water 1

2. Preparation of cough syrup 1

3. Preparation of strong Iodine solution 1

4. Preparation of calamine lotion 1

5. Preparation of suspensions

(black wash and Mist alba suspension) 1

6. Effect of electrolyte onto sedimentation volume of suspension

containing a positive drug 1

7. Emulsion (differentiating between w/o and o/w emulsion ) 1

8. Quiz 2

9. Castor oil emulsion (wet method and Dry Method) 1

10. Olive oil emulsion (Wet method and Dry method) 1

11. Ointment bases (absorption bases) and White field ointment

and (Oleaginous base) Zinc oxide ointment 1

12 Vanishing Cream and Cold Cream 1

13. Practical Exam 1

14. Final Exam

Total:

1 credit hour 15.


5.1. Lectures

5.2. Class discussions and brain storming

5.3. Laboratories

5.4 LMS




skills.

2. Practical exam To assess professional and practical skills.



4. Oral exam To assess knowledge, understanding, intellectual skills, general skills

and confidence.


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Assessment 3 Assignment/activity (research) all over the term

Assessment 4 Practical exam 13th week




1. Course work:

- Quiz 1 10

- Quiz 2 10



3. Oral Exam 10


Total 100%


No. Reference Type

1.



Philadelphia, 2013.

textbook

2.




textbook


8.1. Lectures

Study

week Lectures

ILOs

K&U IS P&PS G&TS

1.

Introduction to solution as an oral

dosage form. Approaches to improve

drug aqueous solubility

a1 b2 c1, c2 --

2. Non-aqueous solutions, properties of

non-aqueous vehicles a1, a2 b2 c1, c2 --

3. Types of solution, manufacture of

solutions and stability a1, a2 b4 c1, c2 d1

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4.

Pharmaceutical applications of

suspensions, formulation and stability

of suspensions

a1, a2, a4 b1, b2,

b3 c1, c2, c3 d2

5.

Electrical double layer and Nernst

and Zeta potentials and suspension

formulation and stability

a2 b2, b3 c1, c2 d1, d2

6. Promotion of flocculation and

flocculating agents a1, a2

b1, b2,

b3, b4 c1, c2, c3 d1, d2

7.

Suspending agents. Problem of using

suspending agents and Formulation

additives

a1, a2, b1, b2,

b3, b4 c1, c2 d1, d2

9. Pharmaceutical application of

emulsions, types of emulsion a1, a2, a3 b1, b2 c1, c2, c4 d1, d2

10.

Tests for identification of emulsion

type. Formulation of emulsions and

formulation additives, Stability of

emulsions

a1, a2, a3,

a4 b3, b4

c1, c2, c3,

c4 d1, d2

11. Micro-emulsions a1, a2, a3 b2, b4 c1, c2 d1, d2

12. Creams a1, a2, a4 b2, b4 c1, c2, C3 d1, d2

13. Ointments a1, a2, a4 b2, b4 c1, c2, C3 d1, d2

8.2. Practical

Study

week Practical

ILOs

K&U IS P&PS G&TS

1. Introduction and preparation of

aromatic water a1 b1 c1 d1, d2

2. Preparation of cough syrup a1, a2 b1, b2 c1, c2 d1, d2

3. Preparation of strong Iodine solution a1, a2 b1, b2 c1, c2 d1, d2

4. Preparation of calamine lotion a1, a2 b1, b2 c1, c2 d1, d2

5. Preparation of suspensions (black wash

and Mist alba suspension) a1, a2 b1, b2 c1, c2 d1, d2

6.

Effect of electrolyte onto sedimentation

volume of suspension containing a

positive drug

a1, a2 b2 c1, c2 d1, d2

7. Emulsion (differentiating between w/o

and o/w emulsion ) a1, a2 b1, b2 c1, c2, c4 d1, d2

9. Castor oil emulsion (wet method and

Dry Method) a1, a2 b2 c1, c2, c4 d1, d2

10. Olive oil emulsion (Wet method and

Dry method) a1, a2 b2 c1, c2, c4 d1, d2

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11.

Ointment bases (absorption bases) and

White field ointment and (Oleaginous

base) Zinc oxide ointment

a1, a2 b2 c1, c2 d1, d2

12. Vanishing Cream and Cold Cream a1, a2 b2 c1, c2 d1, d2

Name Signature

Course Coordinator: Dr. Osama Amin

Head of Department: Prof. Dr. Ahmed Talat Nouh


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Course Title: Pharmaceutics-2

Course Code: PH 213



Academic year/ level: Fall Semester 2017/2018 Level two

Prerequisite: Pharmaceutics-1 (PH 212)


2. Course Aims:

To provide the students with the basic physicochemical principles in the formulation and

preparation of rectal, vaginal suppositories, aerosols, sterile parenteral and ophthalmic dosage

forms. It also covers the different sterilization methods as well as the quality control of the

finished products.




A2

a1. Define the properties of different types of suppositories, aerosols, sterile

parenteral and ophthalmic dosage forms

a2. Describe and explain the different types of suppositories, aerosols, sterile

parenteral and ophthalmic dosage forms

A6 a3. Understands the principles of sterilization of parenteral and ophthalmic

preparations.

A10 a4. Summarize the advantage and disadvantages of suppositories, aerosols,

sterile parenteral and ophthalmic dosage forms



B4

b1.

Design different formulations of suppositories, aerosols, sterile parenteral

and ophthalmic dosage forms

b2. Utilize the basic requirements for preparation of sterile products

b3. Predict the required essential additives for preparation of sterile parenteral

and ophthalmic dosage forms

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C3

c1. Design and prepare different dosage forms of rectal and vaginal suppositories

c2. Resolve drug-related problems during formulation of sterile dosage forms,

pharmaceutical aerosol and suppositories.

c3. Perform different quality control testing of sterile dosage forms,

pharmaceutical aerosol and suppositories.



D10 d1. Write a report concerning topics of the course.

d2. Discuss and present reports, in the class, related to the course topics.

4. Contents:

4.1. Lectures:

Study

week Topics

No. of

Credit

Hours

1 Anatomy and physiology of the rectum

Types of Suppository Bases (Fatty Bases, Cocoa Butter) 2

2 Cocoa butter Substitute: Synthetic Bases 2

3 Water miscible bases 2

4 Specific problems in formulating suppositories + (quiz 1) 2

5 Quality control of suppositories 2

6 The advantages and disadvantages parenteral preparations, 2

7 Formulations of parenteral preparations (Components, vehicles and

added substances) 2

8 Quiz 2

9 Containers for parenteral preparations (Glass; Plastics and Rubber

closures; sealing of ampoules. Production facilities and sterilization 2

10 Ophthalmic Preparation (Routes of ocular drug delivery

Factors affecting the bioavailability of topically drugs) 2

11 Formulation and manufacturing of ocular inserts and contact lenses 2

12 Pharmaceutical aerosol (advantages and disadvantages,

components of aerosols. + Types of aerosols) 2

13 Quality control of aerosols package 2

14. Final exams

Total:

2 credit hours 15.

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4.2. Practical:

Study

week Topics

No. of

Credit

Hours

1. Suppository bases (Determination of the displacement value) 1

2. Determination of water number of suppository base 1

3. Cocao butter suppositoires 1

4. Cocao butter suppositoires + Quiz 1 1

5. Glycerogelatin suppositories 1

6. Zinc oxide pessaries 1

7. Soap glycerin suppositories 1

8. Quiz 2

9. Polyethylene glycol suppositories 1

10. Sterile parenteral preparations (Group presentation) 1

11. Ophthalmic preparations Group presentation) 1

12. Pharmaceutical aerosol (Group presentation) 1

13. Practical exam 1

14. Final Exam

Total:

1 credit hour 15.


5.1. Lectures

5.2. Class discussions (Indirect learning)

5.3. Laboratories

5.4. LMS



1. Written exam To assess knowledge, understanding, intellectual and professional skills.





and confidence.


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Assessment 3 Assignment/activity (research) all over the term





1. Course work:

- Quiz 1 10

- Quiz 2 10



3. Oral Exam 10


Total 100%


No. Reference Type

1.

Allen, Loyd, and Howard C. Ansel. Ansel's pharmaceutical dosage

forms and drug delivery systems. Lippincott Williams & Wilkins,

2013.

textbook

2.




textbook


8.1. Lectures and practical:

Study

week Lectures

ILOs

K&U IS P&PS G&TS

1.

Anatomy and physiology of the rectum

Types of Suppository Bases (Fatty Bases,

Cocoa Butter)

a1, a2 b1 c1, c2 --

2. Cocoa butter Substitute: Synthetic Bases a1, a2 b1 c1, c2 --

3. Water miscible bases a1, a2 b1 c1, c2 d1, d2

4. Specific problems in formulating

suppositories + (quiz 1) a1, a2 b1 c1, c2 d1, d2

5. Quality control of suppositories a1, a2,

a4 b1

c1, c2,

c3 d1, d2

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6. The advantages and disadvantages parenteral

preparations, a1, a2 b1, b2 c1, c2 d1, d2

7. Formulations of parenteral preparations

(Components, vehicles and added substances)

a1, a2,

a3

b1, b2,

b3 c2 d1, d2

9.

Containers for parenteral preparations (Glass;

Plastics and Rubber closures; Sealing of

ampoules, production facilities and

Sterilization

a1, a2,

a3, a4

b1, b2,

b3 c2 d1, d2

10.

Ophthalmic Preparation (Routes of ocular

drug delivery

Factors affecting the bioavailability of

topically drugs)

a1, a2,

a3, a4

b1, b2,

b3 c2 d1, d2

11. Formulation and manufacturing of ocular

inserts and contact lenses

a1, a2,

a3

b1, b2,

b3

c2 d1, d2

12.

Pharmaceutical aerosol (advantages and

disadvantages, components of aerosols. +

Types of aerosols)

a1, a2,

a4 b1 c2, c3 d1, d2

13. Quality control of aerosols package a1, a2,

a4 b1 c2, c3

d1, d2

8.2. Practical

Study

week

Practical

ILOs

K&U IS P&PS G&TS

1. Suppository bases (Determination of the

displacement value) a1, a2 b1 c1, c2 d1, d2

2. Determination of water number of suppository

base a1, a2 b1 c1, c2 d1, d2

3. Cocao butter suppositoires a1, a2 b1 c1, c2,

c3 d1, d2

4. Cocao butter suppositoires a1, a2 b1 c1, c2,

c3 d1, d2

5. Glycerogelatin suppositories a1, a2 b1 c1, c2,

c3 d1, d2

6. Zinc oxide pessaries a1, a2 b1 c1, c2,

c3 d1, d2

7. Soap glycerin suppositories a1, a2 b1 c1, c2,

c3 d1, d2

9. Polyethylene glycol suppositories a1, a2 b1 c1, c2,

c3 d1, d2

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10. Sterile parenteral preparations

(Group presentation) a1, a2

b1,

b2, b3 c2, c3 d1, d2

11. Ophthalmic preparations

(Group presentation) a1, a2

b1,

b2, b3

c2, c3 d1, d2

12. Pharmaceutical aerosol

(Group presentation) a1, a2 b1, b2 c2, c3 d1, d2

Name Signature




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Course Title: Physical pharmacy

Course Code: PH 314



Academic year/ level: Fall Semester 2017/2018 Level three

Prerequisite: Physical chemistry (PC 102)


2. Course Aims:

To recognize the physic-chemical properties of drugs (solubility, properties of solutions,

isotonic solutions, viscosity, surface tension and interfacial tensions, adsorption, buffering

systems) and their applications in medicine and pharmacy.




A2 a1. Recognize the importance of physicochemical properties of solid and liquid

drugs

A6

a2. Identify the impact of physicochemical properties of drugs on drugs in their

final dosage forms.

a3. Introduce the basic concepts of the different physicochemical properties and

how they affect the stability and efficacy of the drug.



B4

b1. Suggest a suitable method to improve water solubility of different drugs

b2. Utilize the principles of surface phenomena in enhancing solubility of

insoluble drugs

b3. Determine appropriate method for characterization of different surfactants

for proper applications.

B20 b4. Specify a suitable equipment for viscosity measurement

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C3

c1. Determine the rheological properties of different dosage forms.

c2. Utilize the surface tension, interfacial tension and critical micelle

concentration.

C13

c3. Assess the solubility of pharmaceutical materials

c4. Prepare isotonic solutions and measure their tonicity.

c5. Select the proper buffer system in pharmaceuticals preparation



D3. d1. Work effectively in a team

D4 d2. Present data to group

4. Contents:

4.1. Lectures:

Study

week Topics

No. of

Credit Hours

1. Solutions and their properties 2

2.

Solubility and dissolution rate (Solubility, factors affecting

solubility, phase equilibria, phase rule and critical solution

temperature)

2

3. Colligative properties of solutions 2

4. Buffers + Quiz 1 2

5.

Rheology and flow of fluids (rheological behaviour of

different liquids, factors affecting rheology, techniques used

in measuring rheology)

2

6.

Determination of rheological properties of different

pharmaceutical dosage forms. 2

7. Surface and interfacial phenomena 2

8. Quiz 2

9. Measurement of surface and interfacial tensions 2

10.

Surfactants, micellar solubilization and its application in

pharmacy 2

11. Adsorption at solid liquid interface 2

12. Adsorption at liquid-liquid interface 2

13. Application of adsorption 2

14. Final Exam

Total:

2 credit hours 15.

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4.2. Practical:

Study

week Topics

No. of

Credit Hours

1. Concentration expression 1

2. Problems on isotonisty 1

3. Buffers 1

4. Buffers problems 1

5. Rheology 1

6. Determination of partition coefficient 1

7. Surface tension 1

8. QUIZ 2

9. Critical micelle concentration 1

10. Hydrophilic lipophilic balance 1

11. Problems on HLB 1

12. Adsorption 1


14. Final Exam

Total:

1 credit hour 15.


5.1. Lectures

5.2. Discussion sessions and problem solving

5.3. Experimental work and laboratories




skills.





and confidence.


25 | P a g e




Assessment 3 Assignment/activity (A written report

about physical properties of a drug) all over the term





1. Course work:

- Quiz 1 10

- Quiz 2 10

- Assignment/activity (A written report about

physical properties of a drug) 5


3. Oral Exam 10


Total 100%


No. Reference Type

1. Singh, Yashveer. "Martin’s physical pharmacy and pharmaceutical

sciences." Rutgers, The State University of New Jersey (2012). textbook

2.


Pharmaceutics E-Book: The Design and Manufacture of Medicines.

Elsevier Health Sciences, 2017

textbook

3. Aulton, Michael E., and Diana M. Collet. Pharmaceutical practice.

Churchill Livingstone, 2001. textbook


8.1. Lectures:

Study


ILOs

K&U IS P&PS G&TS

1. Solutions and their properties a1 b3 c2 --

2. Solubility and dissolution rate a1, a2,

a3 b1,b3 c2 --

3. Colligative properties of solutions a1, a2,

a3 b3 c 2 --

4. Buffers a1, a2,

a3 b3 c2 d1, d2

26 | P a g e

5. Rheology and flow of fluids a2, a3 b2 c1 d1, d2

6. Determination of rheological properties of

different pharmaceutical dosage forms. a1, a2 B2 c1 d1, d2

7. Surface and interfacial phenomena a1 ,a3 b1 c1 d1, d2

9.

Measurement of surface and interfacial

tensions a1, a3 b1, b4 c1 d1, d2

10.

Surfactants, micellar solubilization and

its application in pharmacy a1, a2 b1, b4 c5 d1, d2

11. Adsorption at solid liquid interface a1, a2,

a3 b1, b4 c5 d1, d2

12. Adsorption at liquid-liquid interface a1, a3 b1, b4 c3 d1, d2

13. Application of adsorption a1, a3 b1, b4 c3 d1, d2

8.2. Practical:

Study


ILOs

K&U IS P&PS G&TS

1. Concentration expression a1,a2, b3 -- --

2. Problems on isotonisty a1, a3 b3 c4 --

3. Buffers a3 -- c5 --

4. Buffers problems a3 -- c5 d1, d2

5. Rheology a2,a3 b2 c1 d1, d2

6. Determination of partition coefficient a1 b2 c1 d1, d2

7. Surface tension a1,a2 b1 c2 d1, d2

9. Critical micelle concentration a1 b4 c2 d1, d2

10. Hydrophilic lipophilic balance a1,a2 b4 c2 d1, d2

11. Problems on HLB a1,a2 b4 c2 d1, d2

12. Adsorption a2,a3 b4 c2 d1, d2

Name Signature


Head of Department: Prof. Dr Ahmed Nouh

Approval Date 29.8.2017

27 | P a g e





Course Title: Biopharmaceutics and Pharmacokinetics

Course Code: PH 321



Academic year/ level: Spring Semester 2017/2018 Level three

Prerequisite: Physical Pharmacy (PH 314)


2. Course Aims:

To provide students with the theoretical basis and basic principles of pharmacokinetics

concerning drug absorption, distribution and elimination in the body. Explore various

parameters affecting bio-availability of drugs to correlate the dosage form of the drug to its

bioavailability.




A8

a1. Define the basics and distinguish the terms biopharmaceutics,

pharmacokinetics and pharmacodynamics.

a2.

Summarize the effects of various physicochemical, biochemical,

physiological and pathological processes on the kinetics and extent of drug

absorption, distribution, and elimination.

A9

a3. Illustrate pharmacokinetic parameters used in clinical pharmacokinetics

using plasma and urine drug level data.

a4. Recognize empirical pharmacokinetic models used to devise and optimize

dosage regimens.



B9 b1. Investigate the ways of drug absorption, distribution and elimination of some

selected drugs

B10 b2. Estimate dosage and dosage regimen based on pharmacokinetic principles

b3. Predict time of administration regarding time of eating.

B20 b4. Calculate pharmacokinetic parameters regarding bioavailability and

bioequivalence according to different pharmacokinetic models.

28 | P a g e



C11

c1. Monitoring patient` medical conditions with his medications based on basic

pharmacokinetics

c2. Determine patient` dose according to his pathological state

c3. Conduct effectively with the patient to find out his problem with the

medication adherence.



D3 d1. Work effectively as a part of a team.

D4 d2. Collect and evaluate data in accordance with standard mathematical

methods

D11 d3. Use reasonable solutions for solving problems.

4. Contents:

4.1. Lectures:

Study

week Topics

No. of

Credit Hours

1. Introduction to Pharmacokinetics. 2

2. Order of reaction and reaction rate. 2

3. Drug Kinetics Following an Intravenous bolus dose. 2

4. Drug Kinetics following a Single Oral Dose.+ Quiz 1 2

5. Bioavailability and Bioequivalence. 2

6. Steady State Principle and Drug Kinetics during Constant-

Rate Infusion. 2

7. Introduction to Bio-pharmaceutics

Factors affecting drug absorption after oral administration 2

8. Quiz 2

9. Mechanisms of drug absorption and absorption window 2

10. Physiological factors affecting drug absorption

Drug transporters 2

11.

Physicochemical factors affecting drug absorption

Drug dissolution techniques

Dosage form factors affecting drug absorption

2

12. Factors affecting Distribution 2

13. Kinetics of plasma protein binding and its importance 2

14. Final Exam

Total:

2 credit hours 15.

29 | P a g e

4.2. Practical:

Study

week Topics

No. of

Credit Hours

1. Introduction to bio pharmaceutics and Pharmacokinetics 1

2. Order of elimination kinetics and elimination rate.

First order versus zero order kinetics 1

3. Problems using Cartesian and semi log papers 1

4. Drug Kinetics Following an Intravenous bolus dose 1

5. Drug Kinetics Following an Intravenous bolus dose (Problems

one compartment) 1

6. Drug Kinetics following a Single Oral Dose. 1

7. Introduction to bio pharmaceutics and Pharmacokinetics 1

8. Quiz 2

9. Order of elimination kinetics and elimination rate.

First order versus zero order kinetics 1

10. Problems using Cartesian and semi log papers 1

11. Drug Kinetics Following an Intravenous bolus dose 1

12. Drug Kinetics Following an Intravenous bolus dose (Problems

one compartment) 1


14. Final Exam

Total:

1 credit hour 15.


5.1. Lectures

5.2. Class discussions through brain storming

5.3. Practical classes

5.4. Moodle




skills.





and confidence.


31 | P a g e




Assessment 3

Assignment/activity (A report about

pharmacokinetics of some drugs) each 5

students write one report

all over the term





1. Course work:

- Quiz 1 10

- Quiz 2 10

- Assignment/activity (A report about

pharmacokinetics of some drugs) each 5

students write one report (problems)

5


3. Oral Exam 10


Total 100%


No. Reference Type

1.

Shargel L, Wu-Pong S, Yu A B C. Applied Biopharmaceutics and

Pharmacokinetics,New York: Appleton & Lange Reviews/McGraw-

Hill. (2005).

Textbook

2. Winter M E. Basic Clinical Pharmacokinetics, 4th ed. Philadelphia:

Lippincott Williams and Wilkins. (2003) Textbook

3. Hedaya, Mohsen A. Basic pharmacokinetics. CRC Press, 2012. Textbook

4.

Ritschel, Wolfgang A., and Gregory L. Kearns. Handbook of basic

pharmacokinetics--including clinical applications. Washington, DC:

American Pharmacists Association, 2004.

Textbook


8.1. Lectures:

Study


ILOs

K&U IS P&PS G&TS

1. Introduction to Pharmacokinetics. a1, a2 b1,b2 c1,c3 -

Order of reaction and reaction rate. a3, a4 b1, b4 c1,c2 -

2. Drug Kinetics Following an

Intravenous a1, a3 b3 c2 d2,d3

31 | P a g e

3. Drug Kinetics following a Single Oral

Dose. a1, a4 b1,b3 c1-c3 d1,d2,d3

4. Bioavailability and Bioequivalence. a1 b1,b2,b3 c1,c2 d2

5. Steady State Principle and Drug

Kinetics during Constant-Rate Infusion. a1 b2,b3 c1,c3 d2,d3

6.

Multiple Dosing and Dosage Regimens.

Metabolite and Urinary Excretion

Kinetics.

Measurement of kidney function

a1,a3,a4 b2,b4 c1 d1,d2

7.

Introduction to Bio-pharmaceutics

Factors affecting drug absorption after

oral administration

a1,a2 b1,b2,b3 c1,c3 d1,d3

9. Mechanism of drug absorption and

absorption window a3 b3 c1,c2 d1,d3

10. Physiological factors affecting drug

absorption. Drug transporters a2 b2 c3 d1,d2,d3

11.

Physicochemical factors affecting drug

absorption

Drug dissolution techniques

Dosage form factors affecting drug

absorption

a1,a2,a3 b1,b4 c3 d2,d3

12. Factors affecting Distribution

a1,a2 b1,b2,b3 c2,c3 d1, d3

13. Kinetics of plasma protein binding and

its importance

8.2. Practical:

Study


ILOs

K&U IS P&PS G&TS

1. Introduction to bio pharmaceutics and

Pharmacokinetics

a1, a2,

a3 b1 c1, c3 --

2.

Order of elimination kinetics and

elimination rate.

First order versus zero order kinetics

a1, a2 b3 c1, c2 --

3. Problems using Cartesian and semi-log

papers a1 b1, b2 c2 d1, d3


Intravenous bolus dose a1, a2 b2 c1-c3 d3

5.

Drug Kinetics Following an

Intravenous bolus dose (Problems one

compartment)

a1, a2 b2, b3 c1, c2 d1,d2

6. Drug Kinetics following a Single Oral

Dose. a1, a2 b2, b3 c1, c3 d1, d2

7. Introduction to bio pharmaceutics and

Pharmacokinetics a1, a2 b1 c1 d2,d3

32 | P a g e

9.

Order of elimination kinetics and

elimination rate.

First order versus zero order kinetics

a1, a2 b3, b4 c1, c2 d1,d2,d3

10. Problems using Cartesian and semilog

papers a1 ,a2 b1 c3 d2, d3


Intravenous bolus dose a1, a2 b2, b3 c3

d1, d2,

d3

12.

Drug Kinetics Following an

Intravenous bolus dose (Problems one

compartment)

a1, a2 b3, b4 c2, c3 d2, d3

Name Signature

Course Coordinator: Prof. Dr. Mohamed Nasr

Head of Department: Prof. Dr. Ahmed Nouh


33 | P a g e





Course Title: Drug Delivery Systems and Targeting

Course Code: PH 422



Academic year/ level: Fall Semester 2017/2018 Level four

Prerequisite: Pharmaceutics-1 (PH 212)


2. Course Aims:

To provide students with knowledge about importance of drug delivery systems in improving

therapeutic activity of drugs. Formulation and characterization of sustained, controlled and

targeted release drug delivery systems.




A6

a1. Illustrate the prosperities of active and inactive ingredients on the design of

different dosage forms

a2. Describe the properties of pharmaceutical dosage forms

a3. Identify the different routes of drug administration

a4. Describe the advantages and disadvantages of different drug delivery system



B1

b1. Estimate the differences between methods of formulations for various

controlled release preparations

b2. Design of safe and effective drug delivery systems.

b3. Formulate and evaluate controlled and targeted drug delivery system



C15

c1. Illustrate the basic concepts of controlled drug delivery and targeting

c2. Monitor the methods of development of colloidal carriers for targeting of

drugs

34 | P a g e



D1 d1. Communicate effectively with patients and health care professionals


D4 d3. Collect and present data clearly in oral or written reports

4. Contents:

4.1. Lectures:

4.2. Practical: N/A


5.1. Lectures

5.2. Home works

5.3. LMS

Study

week Topics

No. of

Credit Hours

1. Controlled and modulated release drug delivery systems

(definition, advantages, disadvantages, theory, methods) 2

2. Colloidal drug delivery systems (Liposomes) 2

3. Therapeutic applications of liposomes. 2

4. Advantages of proliposomes as a controlled release drug

delivery systems + Quiz 1 2

5. Colloidal drug delivery systems (Niosomes) 2

6. Therapeutic applications of niosomes. 2

7. Advantages of niosomes as controlled drug delivery systems. 2

8. Quiz 2

9. Different controlled release drug delivery systems. 2

10. Nanoparticles as controlled drug delivery systems. 2

11. Microemulsions. 2

12.

Controlled drug delivery systems" coated beads,

microencapsulation, complex formation, resonated

drugs,.etc"

2

13. Microspheres and microcapsules.

Different types of microspheres. 2

14. Final Exam

Total:

2 credit hours 15.

35 | P a g e




skills.




and confidence.





Assessment 3 Assignment/activity (Scientific reports) all over the term




1. Course work:

- Quiz 1 10

- Quiz 2 10

- Assignment/activity (Scientific reports) 5


3. Oral Exam 10

Total 100%


No. Reference Type

1. Wilson, Clive G., and Patrick J. Crowley, eds. Controlled release in

oral drug delivery. Springer Science & Business Media, 2011. textbook

2. Li, Xiaoling. Design of controlled release drug delivery systems.

McGraw Hill Professional, 2005. textbook

3.

Rathbone, Michael J., Jonathan Hadgraft, Michael S. Roberts, and

Majella E. Lane. Modified-release drug delivery technology. CRC

Press, 2008.

textbook

4.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951594/

https://www.sciencedirect.com/book/9780444820273/advances-in-

drug-delivery-systems-6

Periodicals and

website

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951594/

https://www.sciencedirect.com/book/9780444820273/advances-in-drug-delivery-systems-6

https://www.sciencedirect.com/book/9780444820273/advances-in-drug-delivery-systems-6

36 | P a g e


8.1. Lectures:

Study


ILOs

K&U IS P&PS G&TS

1.

Controlled and modulated release drug

delivery systems (definition,

advantages, disadvantages, theory,

methods)

a1, a2,

a3 b1 c1 --

2. Colloidal drug delivery systems(

Liposomes )

a1, a2,

a4 b2 c1-c2 --

3. Therapeutic applications of liposomes. a1, a2,

a4 b3 c2 d3

4.

Advantages of proliposomes as a

controlled release drug delivery

systems.

a4 b1, b3 c1,c2 d1-d3

5. Colloidal drug delivery systems

(Niosomes ) a1,a2 b1, b3 c2 d2

6.

Therapeutic applications of niosomes.

Advantages of proniosomes as

controlled drug delivery systems.

a2 b1, b2,

b3 c1 d3

7. Advantages of niosomes as controlled

drug delivery systems. a1 b1 c1, c2 d1

9. Different controlled release drug

delivery systems. a2, a3 c1, c2 d1-d3

10. Nanoparticles as controlled drug

delivery systems. a1 b1 c1 ,c2 d1

11. Micro-emulsions. a2 b1 c1, c2 d1, d2

12.

Controlled drug delivery systems"

coated beads, microencapsulation,

complex formation, resonated

drugs,.etc"

a2 b1 c1,c2 d1-d3

13. Microspheres and microcapsule-

Different types of microspheres. a1, a2 b1 c1,c2 d2

Name Signature

Course Coordinator: Dr: Yasser Abdelalim



37 | P a g e





Course Title: Pharmaceutical Technology-1

Course Code: PH 431



Academic year/ level: Spring Semester 2017/2018 Level four

Prerequisite: None

Credit hours: Lecture:2 Practical:1 Total:3

2. Course Aims:

To provides the students with the basic principles, concepts, and theories of various unit

operations related to pharmaceutical technology and energy consumption. The course covers

most of the equipment utilized in heat transfer, evaporation, drying and crystallization to

achieve the maximum outcomes and proper manufacturing. The course also covers how to

select the most suitable equipment for manufacturing certain drugs.




A7

a1. Describe the theory behind different pharmaceutical operations

(Crystallization, Drying, evaporation and heat transfer).

a2. Acquire knowledge about different types of machinery used for different unit

operation.

a3. Enumerate factors affecting the different operation process.

a4. Define different industrial operations involved in the production of

pharmaceutical products.



B2

b1. Interpret the concept and theory of different unit operations for

Crystallization, Drying, evaporation and heat transfer

b2. Select the most suitable equipment for certain operations.

b3. Design the appropriate protocol for manufacturing different dosage forms

b4. Integrate the equipment to improve the performance of certain operation.

38 | P a g e



C4 c1. Utilize the studied equipment for different unit operations.

C8 c2.

Analyze and perform experiment for certain unit operations to find out the

proper technique for pharmaceutically accepted production.

c3. Analyze the results obtained from each unit operation.



D3 d1. Work in team


4. Contents:

4.1. Lectures:

Study

week Topics

No. of

Credit Hours

1. Introduction and definitions.

Layouts for manufacture of pharmaceutical products. 2

2. Heat Transfer (Concept and Heat transfer equipment) 2

3. Single pass heater and Multiple pass heater

Liquid-Liquid Heat Exchanger 2

4. Evaporation + Quiz 1

(Concept and applications) 2

5. Evaporation (Forced Circulation and Film evaporators) 2

6. Evaporation Accessories 2

7. Drying (Concept and Equilibrium Moisture Contents)

Drying behavior for materials 2

8. Quiz 2

9 Equipment for solid and liquid drying 2

10 Crystallization (Fundamentals and Theories) 2

11. Factors affecting crystallization process, - Fractional

Crystallization 2

12 Equipment (Cooler Crystallizers and evaporative crystallizers 2

13 Vacuum Crystallizers 2

14. Final Exam

Total:

2 credit hours 15.

39 | P a g e

4.2. Practical:

Study

week Topics

No. of

Credit Hours

1. Fundamentals to pharmaceutical technology 1

2. Heat transfer problems 1



5. Evaporation problems 1

6. Evaporation problems 1

7. Drying problems 1

8. Quiz 2

9. Evaluation of capsules 1

10. Evaluation of capsules 1

11. Evaluation of tablets 1

12. Evaluation of tablets 1

13. Practical exam 1

14. Final Exam

Total:

1 credit hour 15.


5.1. Lectures

5.2. Class discussion

5.3. Equipment simulation

5.4. Laboratories




skills.


3. Course work To assess knowledge, understanding, intellectual skills, general &



and confidence.


41 | P a g e




Assessment 3 Assignment/activity (Drawing sketches) all over the term





1. Course work:

- Quiz 1 10

- Quiz 2 10

- Assignment/activity (Drawing sketches) 5


3. Oral Exam 10


Total 100%


No. Reference Type

1. Essential books (text books):

Lachman, Leon, Herbert A. Lieberman, and Joseph L. Kanig. The

theory and practice of industrial pharmacy. Philadelphia: Lea &

Febiger, 2015.

Broadhead, Joanne, and Mark Gibson. "Parenteral dosage forms."

Pharmaceutical Preformulation and Formulation: A Practical

Guide from Candidate Drug Selection to Commercial Dosage

Form (2001): 331-354.

Textbook


8.1. Lectures:

Study

week Lectures

ILOs

K&U IS P&PS G&TS

1.

Introduction and definitions.

Layouts for manufacture of pharmaceutical

products.

a1 b1 , b2 c1, --

2. Heat Transfer (Concept and Heat transfer

equipment) a2 b1 , b2 c1, c2 ---

3. Single pass heater and Multiple pass heater

Liquid-Liquid Heat Exchanger a2 b1 , b2 c1 d2

4. Evaporation

(Concept and applications) a1 , a2 b1 , b2 c1, c3 d2

41 | P a g e

5. Evaporation (Forced Circulation and Film

evaporators) a1 , a2 b1, b4 c1, c3 d2

6. Evaporation accessories a2 b1, b4 c2, c3 d2

7.

Drying (Concept and Equilibrium Moisture

Contents)

Drying behavior for materials

a2 b1, b2 c1-c3 d1, d2

9. Equipment for solid and liquid drying a1 , a2 b1, b2 c1 d1, d2

10. Crystallization (Fundamentals and Theories) a1 , a2 b1, b2 c1, c2 d1, d2

11. Factors affecting crystallization process, -

Fractional Crystallization a3 , a4 b1, b2 c2, c3 d1, d2

12. Equipment (Cooler Crystallizers and evaporative

crystallizers)- a3 , a4 b1, b3 c2,c3 d1, d2

13. Vacuum Crystallizers a1 , a2 b1, b3 c2,c3 d1, d2

8.2. Practical

Study

week Practical

ILOs

K&U IS P&PS G&TS

1. Fundamentals to pharmaceutical technology part a1 b1, b2 c1, c2 --

2. Heat transfer problems a2 b1, b2 c1, c2 --

3. Heat transfer problems a2 b1, b2 c1, c3 --

4. Heat transfer problems a1, a2 b1, b2 c1, c3 d1 , d2

5. Evaporation problems a1, a2 b1, b4 c1, c3 d1 , d2

6. Evaporation problems a2 b1, b4 c1, c3 d1 , d2

7. Drying problems a2 b1, b2 c1, c2,

c3 d1 , d2

9. Evaluation of capsules a1, a2 b1, b2 c1 d1 , d2

10. Evaluation of capsules a1, a2 b1, b2 c1, c2 d1 , d2

11. Evaluation of Tablets a3, a4 b3, b4 c2, c3 d1 , d2

12. Evaluation of Tablets a3, a4 b3, b4 c3 d1 , d2

Name Signature

Course Coordinator: Prof. Dr. Ahmed Nouh



42 | P a g e





Course Title: Pharmaceutical Technology-2

Course Code: PH 532



Academic year/ level: Fall Semester 2017/2018 Level five

Prerequisite: Pharmaceutical Technology-1 (PH 431)

Credit hours: Lecture:2 Practical:1 Total:3

2. Course Aims:

The course provides the students with the basic principles, concepts and equipment of

various unit operations related to particle size reduction, particle size enlargement, solid

mixing, liquid mixing, semisolid mixing, filtration and centrifugation to achieve the

maximum outcomes and proper manufacturing.




A7

a1.

Describe the theory behind different pharmaceutical operations (particle size

reduction, particle size enlargement, solid mixing, liquid mixing, semisolid

mixing, filtration and centrifugation).

a2.

Acquire knowledge about different types of machinery used for particle size


mixing, filtration and centrifugation

a3. Enumerate factors affecting the different operation process.

a4. Describe the importance of each part of the instrument stressing on its

significance and the way of improving its function.



B2

b1.

Interpret the concept and theory of different unit operations for particle size


mixing, filtration and centrifugation

b2.

Select the most suitable equipment for particle size reduction, particle size

enlargement, solid mixing, liquid mixing, semisolid mixing, filtration and

centrifugation

b3. Design the appropriate protocol for manufacturing different dosage forms

43 | P a g e



C4 c1. Recognize the studied equipment for different unit operations.

C8 c2.

Analyze and perform experiments for certain unit operations to find out the

proper technique for pharmaceutically accepted production.

c3. Manage the different instruments of each unit operation.



D3 d1. Work in team


4. Contents:

4.1. Lectures:

Study

week Topics

No. of

Credit Hours

1.

Particle size reduction

Objectives of size reduction

Influence of material products on size reduction

Influence of size reduction on size distribution

Size reduction methods

2

2.

Compression between different methods (Roller mill)

Attrition methods (Roller mill)

Combined Attrition and Impaction methods (Pin mill & Fluid

energy mill)

Colloid mill

Selection of particle size reduction methods

2

3. Theory, concept, reasons and importance of size enlargement 2

4. Equipment for dry and wet granulation + QUIZ 1 2

5. Size separation, importance and equipment 2

6. Theory, concept and importance of mixing

Mixing of liquids (Equipment) 2

7. Mixing of solids and semisolids (Equipment) 2

8. Quiz 2

9. Theory, concept and importance of filtration 2

10. Equipment of filtration 2

11. Theory, concept and importance of centrifugation 2

12. equipment of centrifugation 4

13.

14. Final Exam

Total:

2 credit hours 15.

44 | P a g e

4.2. Practical:

Study

week Topics

No. of

Credit Hours

1. Size reduction theories 1

2. Size reduction by impaction 1

3. Size reduction by compression 1

4. Size reduction by attrition 1

5. Size reduction by impaction and attrition 1

6. Equipment reducing coarse particles 1

7. Equipment reducing intermediate particles 1

8. Quiz 2

9. Equipment reducing fine particles 1

10. Equipment for mixing of solid 1

11. Equipment for mixing of semisolid 1

12. Equipment for pelletizer 1


14. Final Exam

Total:

1 credit hour 15.


5.1. Lectures

5.2. Class discussion

5.4. Laboratories




skills.





and confidence.


45 | P a g e




Assessment 3 Assignment/activity (Sketch book) all over the term





1. Course work:

- Quiz 1 10

- Quiz 2 10

- Assignment/activity (sketch book) 5


3. Oral Exam 10


Total 100%


No. Reference Type

1.

Essential books (text books):

Lachman, Leon, Herbert A. Lieberman, and Joseph L. Kanig. The theory and

practice of industrial pharmacy. Philadelphia: Lea & Febiger, 2013.

Broadhead, Joanne, and Mark Gibson. "Parenteral dosage forms." Pharmaceutical

Preformulation and Formulation: A Practical Guide from Candidate Drug

Selection to Commercial Dosage Form (2001).

textbook


8.1. Lectures:

Study


ILOs

K&U IS P&PS G&TS

1.

Particle size reduction

Objectives of size reduction

Influence of material products on size

reduction

Influence of size reduction on size

distribution

Size reduction methods

a1 b1 , b2 c1 , c2 --

46 | P a g e

2.

Compression between different methods

(Roller mill)

Attrition methods (Roller mill)

Combined Attrition and Impaction methods

(Pin mill & Fluid energy mill)

Colloid mill

Selection of particle size reduction methods

a1, a2 b1, b2,

b3 -- --

3. Theory, concept, reasons and importance of

size enlargement a1, a2 b1, b2 c1, c3 d2

4. Equipment for dry and wet granulation a1, a2 b1, b2,

b3 c1, c3 d2

5. Size separation, importance and equipment a1, a2 b1 c1, c3 d2

6. Theory, concept and importance of mixing

Mixing of liquids (Equipment) a1, a3 b1, b3 c1 , c3 d2

7. Mixing of solids and semisolids

(Equipment) a1, a2

b1,

b2,b3

c1, c2,

c3 d1 , d2

9. Theory, concept and importance of filtration a1, a2 b1, b2 c1, c2,

c3 d1 , d2

10. Equipment of filtration a2 b2,b3 c1 d1 , d2

11. Theory, concept and importance of

centrifugation

a1, a2,

a3, a4 b1 , b3 c3 d1 , d2

12. Equipment of centrifugation a2, a3, a4 b1 , b3 c3 d1 , d2

13.

8.2. Practical:

Study


ILOs

K&U IS P&PS G&TS

1. Size reduction theories a1 , a2 b1 , b2 c1 --

2. Size reduction by impaction a1 , a2 b1 , b2 c1 --

3. Size reduction by compression a1 , a2 b1 , b2 c1 d1

4. Size reduction by attrition a1 , a2 b1 , b2 c1, c3 d1, d2

5. Size reduction by impaction and

attrition a1 , a2 b1 , b2 c1 d2

6. Equipment reducing coarse particles a1 , a2 b1 , b2 c1, c3 d1, d2

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7. Equipment reducing intermediate

particles a1 , a2 b2 , b3

c1, c2,

c3 d1, d2

9. Equipment reducing fine particles a1 , a2 , b2, b3 c2, c3 d1, d2

10. Equipment for mixing of solid a3 , a4 b2, b3 c3 d1, d2

11. Equipment for mixing of semisolid a3 , a4 b2, b3 c3 d1, d2

12. Equipment for pelletizer a3 , a4 b2, b3 c3 d1, d2

Name Signature

Course Coordinator: Prof. Dr. Ahmed Nouh



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Course Title: Radiopharmaceutics

Course Code: PH 521



Academic year/ level: Spring Semester 2017/2018 Level five

Prerequisite: None


2. Course Aims:

Providing students with fundamentals, uses and danger of radiopharmaceuticals. In addition,

increasing the skills required for pharmacists to deal with radiopharmaceuticals dosage form.

Preparation and characterization of radiopharmaceuticals used in treatment and diagnosis of

some diseases.




A2

a1. Identify the radioisotopes and radiopharmaceuticals

a2. Define the characteristics of ideal isotopes in medical field and how they

are produced

A6 a3. Describe the different aseptic manufacturing processes for

radiopharmaceuticals.



B1 b1. Design and plan for quality control in Nuclear Medicine Department.

B4 b2. Formulate guidelines for nuclear pharmacy practice.

B20 b3. Evaluate guidelines for proper sewage disposal in a nuclear facilaties



C2 c1. Validate and conduct quality control tests of sterile dosage forms.

c2. Perform experiments to differentiate between different types preparations.

C13 c3. Utilize different methods for preparation of sterile radiopharmaceuticals

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D10 d1. Write a report concerning topics of the course

d2. Discuss and present reports in the class related to the course topics.

4. Contents:

4.1. Lectures:

4.2. Practical: N/A


5.1. Lectures

5.2. Class discussion and brain storming




skills.

2. Course work To assess knowledge, understanding, intellectual skills, general &



and confidence.


Study

week Topics

No. of

Credit Hours

1. Introduction to atom and radioisotopes 2

2. Factors affecting formulation of radiopharmaceuticals 2

3. Production of and types of official radiopharmaceuticals 2

4. Types of radioactivity + Quiz 1 2

5. Radioactive decay 2

6. Generators for radiopharmaceuticals 2

7. Pharmaceutical uses of generators 2

8. Quiz 2

9. Quality control of radiopharmaceuticals 2

10. Applications of radiopharmaceutical in treatments 2

11. Applications of radiopharmaceutical in diagnosis 2

12. Official examples of radiopharmaceuticals for treatments 2

13. Official examples of radiopharmaceuticals for diagnosis 2

14. Final Exam

Total:

2 credit hours 15.

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Assessment 3 Assignment/activity (Written reports

prepared groups of students) all over the term

Assessment 4 Oral exam 14th & 15th weeks

Assessment 5 Written exam 14th & 15th weeks


1. Course work:

- Quiz 1 10

- Quiz 2 10

- Assignment/activity (Written reports prepared

groups of students) 5


3. Oral Exam 10

Total 100%


No. Reference Type

1.

Taylor, Andrew, David M. Schuster, and Naomi P. Alazraki. A

clinician's guide to nuclear medicine. Society of Nuclear Medicine,

Incorporated, 2006.

textbook

2.

Allen, Loyd, and Howard C. Ansel. Ansel's pharmaceutical dosage

forms and drug delivery systems. Lippincott Williams & Wilkins,

2013.

textbook

3.

Joseph, Usha A. "A Clinician's Guide to Nuclear Oncology: Practical

Molecular Imaging and Radionuclide Therapies." The Journal of

Nuclear Medicine 51, no. 3 (2010): 492.

Periodical


8.1. Lectures:

Study


ILOs

K&U IS P&PS G&TS

1. Introduction to atom and radioisotopes a1, a2 b1 c1 --

2. Factors affecting formulation of

radiopharmaceuticals a3 b2 c2 --

3. Production of and types of official

radiopharmaceuticals a1, a2 b1 c2 d1

4. Types of radioactivity a3 b3 c3 d1

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5. Radioactive decay a1 b3 c3 d1

6. Generators for radiopharmaceuticals a2 b2 c1, c3 --

7. Pharmaceutical uses of generators a2 b2 c3 d1

9. Quality control of radiopharmaceuticals a1, a2 b2 c3 d2

10. Applications of radiopharmaceutical in

treatments a2,a3 b2 c3 d2

11. Applications of radiopharmaceutical in

diagnosis a2,a3 b2 c3 d2

12. Official examples of

radiopharmaceuticals for treatments a2, a3 b2 c3 d2

13. Official examples of

radiopharmaceuticals for diagnosis a2,a3 b2 c3 d2

Name Signature



Approval Date 10-2-2018

52 | P a g e

Other Courses Not Opened for Registration

at Academic Year (2017-2018)

Final Approval 2016-2017

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Course title: Fundamentals of Cosmetology

Course code: PH 415


Department: Pharmaceutics

Academic level: Faculty Elective

Prerequisite: None

Credit hours: Lecture: 2 Practical: - Total: 2

2. Course aims:

Define different cosmetic preparations, mention ideal characters of different active and

inactive excipients used in cosmetic preparations, describe the ideal properties of different

dosage forms as cleansing creams, cold, vanish and foundation creams, hair preparations,

cosmetic posers, nail lacquers and polishers, dental pastes…. Etc., and demonstrate different

methods for preparation of cosmetic preparations.


a. Knowledge and understanding: At the end of this course, student should be able to:

A6

a1 Describe preparations properties and Mention Ideal characters of each

cosmetic preparations.

a2 Describe the ideal properties of excipients used in cosmetics.

a3 Mention the advantages and disadvantages of cosmetic preparations.

A17 a4 Describe the procedures used for the preparation of cosmetics.

b. Intellectual Skills: At the end of this course, student should be able to:

B1

b1 Compare between different methods of formulations for different cosmetic

preparations

b2 Design appropriate formulations for cleansing creams; lipsticks, toilet powder,

shampoos, tooth pastes and depilatories.

c. Professional and Practical Skills: At the end of this course, student should be able to:

C3 c1 Utilize appropriate excipient properties to enhance cosmetic formulation.

C11 c2 Utilize appropriate information to differentiate between cosmetic preparations.

d. General and Transferable Skills: At the end of this course, student should be able to:

D3 d1 Work efficiently as a part of a team

D4 d2 Collect, evaluate and present data I accordance with standard mathematical

and statistical methods

54 | P a g e

4. Contents

4.1. Lectures

No. of

week Topic No. of credit hours

1 Cosmetic preparations (definition and overview) 2

2 Cleansing creams (Definition, types, and Application) 2

3 Cold and Vanishing cream 2

4 Foundation cream 2

5 Toilet powders “cosmetic Posers”

Quiz 2

6 Deodorants 2

7 Midterm Exam ---

8 Shampoos, and Shaving preparations 2

9 After shave preparation 2

10 Lipstick 2

11 Nail lacquers 2

12 Hair removers (Depilatories and Depilatories) Dental

pastes 2

13 Practical exam 2

14 Final exam 2 credit hours

15

4.2. Practical/Tutorial: N/A


5.1 Lectures

5.2 Class discussions.



1. Written exam to assess knowledge, understanding, intellectual and professional skills

2. Quizzes to assess knowledge, understanding and intellectual skills


Assessment 1 Mid-term 7th week

Assessment 2 Quiz 5th week

Assessment 3 Written 14th &15th weeks

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Mid-Term Exam & course work 25

Final-Term Exam 75

Total 100%


No. Reference type

1.

H.C. Ansel; Pharmaceutical Dosage Forms and drug

Delivery Systems’ Lea & Febiger; Philadelphia; London

(Latest Edition)

Textbook

2. Milady S Standard Textbook of Cosmetology

by Milady Publishing Company

Textbook

8. Matrix of learning and skills:

Study

week Course contents

ILOs

knowledge

and

understanding

intellectual

skills

professional

and

practical

skills

general and

transferable

skills

1 Cosmetic preparations (definition and overview)

a1-a2 b1 c1, c2 d1- d2

2 Cleansing creams (Definition, types, and Application)

a1-a4 b1, b2 c1, c2 d1- d2

3 Cold and Vanishing cream a1 b1 c1, c2 d1- d2

4 Foundation cream a1-a3 b1 c1, c2 d1- d2

5 Toilet powders “cosmetic Posers” Quiz

a1-a4 b1, b2 c1, c2 d1- d2

6 Deodorants a1-a4 b1 – b2 c1 , c2 d1- d2

8 Shampoos, and Shaving preparations

a1-a4 b1 – b2 c1 , c2 d1- d2

9 After shave preparation a1-a4 b1 – b2 c1 , c2 d1- d2

10 Lipstick a1-a2 b1 – b2 c1 , c2 d1- d2

11 Nail lacquers a1-a3 b1 c1 , c2 d1- d2

12 Hair removers (Depilatories and Depilatories)

a1-a2 b1 – b2 c1 , c2 d1- d2

13 Dental pastes a1-a4 b1 – b2 c1 , c2 d1- d2

Name Signature

Course Coordinator: Dr. Osama Amin Mahmoud

Head of Department: Dr. Ahmed Talat Ibrahim Nouh


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Course title: Dosage form design Course code: PH 522


Department: Pharmaceutics

Academic level: Faculty Elective

Prerequisite: None

Credit hours: Lecture: 2 Practical:- Total: 2

2. Course Objectives:

Providing students by reasons for the incorporation of drugs into various dosage forms.

Compare and contrast the properties of various drug dosage forms. Categorize various

pharmaceutical ingredients and excipients. Providing students with the information needed in

pre-formulation studies to characterize a drug substance for possible inclusion into a dosage

form. Summarize approaches employed to stabilize drugs in pharmaceutical dosage forms


a. Knowledge and understanding: At the end of this course, student should be able to:

A6 a1 Describe the properties of different types of pharmaceutical dosage forms

A8

a2 Define the basics and distinguish the terms biopharmaceutics, pharmacokinetics

and pharmacodynamics.

a3

Summarize the effects of various physicochemical, biochemical, physiological

and pathological processes on the kinetics and extent of drug absorption,

distribution, and elimination.

b. Intellectual Skills: At the end of this course, student should be able to:

B9 b1 Investigate the ways of drug absorption, distribution and elimination of some

selected drugs

B10 b2 Estimate dosage and dosage regimen based on pharmacokinetic principles

c. Professional and Practical Skills: At the end of this course, student should be able to:

C3

c1 Utilize appropriate laboratory techniques in preparing different types of

pharmaceutical dosage forms

c2 Perform experiments to enhance liquid stability

C11 c3 Monitoring patient` medical conditions with his medications based on basic

pharmacokinetics

d. General and Transferable Skills: At the end of this course, student should be able to:

D1 d1. Develop a rational thinking in formulation and production of different types

of pharmaceutical dosage forms

D4 d2. Collect and evaluate data in accordance with standard mathematical methods

D11 d3. Use reasonable solutions for solving problems based on phamakokinetic data.

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4. Contents 4.1. Lectures

Week

No. Topic No. of credit hours

1 THE NEED FOR DOSAGE FORMS 2

2 GENERAL CONSIDERATIONSIN DOSAGE

FORM DESIGN 2

3 PREFORMULATION STUDIES 2

4 Drug Stability: Mechanismsof Degradation 2

5 Drug and Drug Product Stability:Kinetics and Shelf

Life 2

6 Q10 Method of Shelf Life Estimation 2

7 Midterm Exam --

8 Enhancing Stability of Drug Products 2

9 Standard Curves 2

10 PHARMACEUTICAL INGREDIENTSAND

EXCIPIENTS 2

11 Flavoring Pharmaceuticals 2

12 Sweetening Pharmaceuticals 2

13 Coloring Pharmaceuticals 2

14 Final exam 2 credit hours

15 Final exam

4.2. Practical/Tutorial: N/A


5.1 Lectures

5.2 Class discussions



1. Written exam to assess knowledge, understanding, intellectual and professional skills

2. Quizzes to assess knowledge, understanding and intellectual skills


Assessment 1 Quiz 5th week

Assessment 2 Mid-term 7th week

Assessment 3 Written 14th &15th weeks

58 | P a g e


Mid-Term Exam & course work 25

Final-Term Exam 75

Total 100%


No. Reference type

1. FDA/ICH Regulatory Guidance on Stability. In: Federal Register, vol 63,

Washington: Food & Drug Administration, 1998:9795–9843. Textbook

2. Sheinin EB. ICH Guidelines: History, Present Status, Intent. Athens, GA:

International Good Manufacturing Practices Conference, 1998.

Textbook

8. Matrix of learning and skills:

Study

week Course contents

ILOs

knowledge

and

understanding

intellectual

skills

professional

and

practical

skills

general and

transferable

skills

1 THE NEED FOR DOSAGE FORMS a1-a3 b1,b2 c1-c3 d1-d3

2 GENERAL CONSIDERATIONSIN

DOSAGE FORM DESIGN a1-a3 b1,b2 c1-c3 d1-d3

3 PREFORMULATION STUDIES a1-a3 b1,b2 c1-c3 d1-d3

4 Drug Stability: Mechanismsof

Degradation a1-a3 b1,b2 c1-c3 d1-d3

5

Drug and Drug Product

Stability:Kinetics and Shelf Life a1-a3 b1,b2 c1-c3 d1-d3

6 Q10 Method of Shelf Life Estimation a1-a3 b1,b2 c1-c3 d1-d3

8 Enhancing Stability of Drug Products a1-a3 b1,b2 c1-c3 d1-d3

9 Standard Curves a1-a3 b1,b2 c1-c3 d1-d3

10 PHARMACEUTICAL

INGREDIENTSAND EXCIPIENTS a1-a3 b1,b2 c1-c3 d1-d3

11 Flavoring Pharmaceuticals a1-a3 b1,b2 c1-c3 d1-d3

12 Sweetening Pharmaceuticals a1-a3 b1,b2 c1-c3 d1-d3

13 Coloring Pharmaceuticals a1-a3 b1,b2 c1-c3 d1-d3

Name Signature

Course Coordinator: Dr. Rashad Kaoud

Head of Department: Dr. Ahmed Talat Ibrahim Nouh


department of pharmaceutics courses specifications

Documents