introduction to osteology - lazarovnikolai.lazarov.pro/lectures/2014/medicine/cell... ·...
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INTRODUCTION TO OSTEOLOGY
1. Osteology: the scientific study of bones2. Types of bones3. Structure of mature bone4. Bone as an organ5. Osseous tissue and bone marrow6. Histogenesis of bone: osteogenesis7. Development and growth of
individual bones – ossification types8. Biological properties of bones
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Prof. Dr. Nikolai Lazarov 2
Locomotor apparatus
� passive part (skeleton):�bones – osteology,
osteologia� joints – arthrology,
arthrologia
� active part:� skeletal muscles – myology,
myologia
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Prof. Dr. Nikolai Lazarov 3
The scientific study of bones� skeleton – 206 bones in the adult human body
� individual bone structure:� compact bone, substantia compacta
cortical bone, substantia corticalis
� cancellous or spongy bone, substantia spongiosa
� periosteum or articular cartilage� endosteum
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Prof. Dr. Nikolai Lazarov 4
Types of bones
� long (trabecular) bones, ossalonga – most bones of the limbs
� short bones, ossa brevia –the bones of the wrist and ankle
� flat bones, ossa plana – most of
the bones of the skull, sternum
� irregular bones, ossairregularia – the bones of the spine, hips, and cranial base
• pneumatic (hollow) bones,ossa pneumatica –the bones of the facial skull
• sesamoid bones,ossa sesamoidea – bones embedded in tendons (patella)
� According to their shape and proportions:
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Prof. Dr. Nikolai Lazarov 5
�long (trabecular) bones, ossa longa – limbs
• a shaft, the diaphysis �
thick compact bone�medullary cavity – bone marrow,
red (in children) or yellow (in adults)
• rounded ends – epiphyses, proximal and distal
�spongy bone+thin compact bone
• metaphysis � bone growth plate(epiphyseal plate)
epiphysis vs. apophysis
Types of bones
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Prof. Dr. Nikolai Lazarov 6
�short bones, ossa brevia –wrist and ankle, tarsal bones, vertebral bodies
• thin cortical bone
• spongy bone �
red bone marrow
Types of bones
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Prof. Dr. Nikolai Lazarov 7
Types of bones
�flat bones, ossa plana – skull vault, sternum, ribs, scapula, hip bone
• two layers of compact bone
• spongy bone � red bone marrow
• diploë – variable in thickness, bones of the skull vault, calvaria
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Prof. Dr. Nikolai Lazarov 8
Types of bones
�irregular bones, ossa irregularia – vertebrae,bones of facial skull, cranial base
• spongy bone � red bone marrow
• thin compact bone� pneumatic bones, ossa pneumatica –
facial skull
� sesamoid bones, ossa sesamoidea –embedded in tendons
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Prof. Dr. Nikolai Lazarov 9
Bone structure
� Trajectory structure –at the organ level� trabecular bone
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Prof. Dr. Nikolai Lazarov 10
Alterations in bone architecture
�work-induced hypertrophy� inactivity atrophy
� degenerative joint disorders (arthroses)
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Prof. Dr. Nikolai Lazarov 11
Structure of mature bone� Lamellar structure –
at the tissue level� lamellar bone
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Prof. Dr. Nikolai Lazarov 12
Bone as an organ
� Osteon (Haversian system):�5-20 osteonic concentric
(primary) lamellae� circumferential lamellae
(secondary lamellae)� interstitial lamellae� central, Haversian canal�Volkmann’s canals
� Chemical composition:�water – 50%
�lipids – 16%
�proteins (collagen) – 12%
�inorganic constituents (bone salts) – 22%(calcium in the form of hydroxyapatite)
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Prof. Dr. Nikolai Lazarov 13
Bone as a tissue� Types of bone cells:
� osteoblasts, osteoblasti� osteocytes, osteocyti� osteoclasts, osteoclasti
� Bone (extracellular) matrix:� organic part (35%) – elasticity
• collagen type І – 95%• glycosaminoglycans – keratan sulfate,
chondroitin sulfate and hyaluronic acid
� inorganic part (65%) – hardness and rigidity; crystalline mineral salts, mostlycrystals of hydroxyapatite
• calcium phosphate – 85%• calcium carbonate – 6-10%• magnesium phosphate – up to 1.5%• calcium fluoride – traces
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Prof. Dr. Nikolai Lazarov 14
Bone marrow , medulla ossium� red bone marrow, medulla
ossium rubra – epiphyses of
long bones, spongy bone of short and flat bones: vertebrae, sternum, ribs, pelvic bones etc. ~ 1500 g
� haemopoiesis
� biological defense
� yellow (fatty) bone marrow, medulla ossium flava – in the
hollow interior of the middle portion of long bones
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Prof. Dr. Nikolai Lazarov 15
Histogenesis of bone , osteogenesis
� mesenchyme � bone tissue� intramembranous ossification,
osteogenesis membranacea� intracartilaginous ossification,
osteogenesis chondralis� perichondral – bone collar (ring)� endochondral – centers of ossification
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Prof. Dr. Nikolai Lazarov 16
Growth and remodeling of bones
� growth (epiphysial) plate, cartilago epiphysialis
� growth zones:� resting zone� proliferative zone� hypertrophic zone� ossifying cartilage
� stimulation:� STH� calcitonin� vitamine D3
deficiency � rachitis
� inhibition:� corticosteroids
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Prof. Dr. Nikolai Lazarov 17
Biological properties of bones� Bone atrophy (osteoporosis):
� immobilization osteoporosis� age-related (senile) osteoporosis� professional (excessive physical activity-induced)
� hormonal (menopause-related) osteoporosis� gravity-induced osteoporosis
� Bone hypertrophy� Mechanical properties:
� hardness and rigidity: bone fractures� strength and elasticity
� Calcium storage: 97% of the bone mass
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Prof. Dr. Nikolai Lazarov 18
Thank you…