joint epigenetics & immunology symposium

1
Joint Epigenetics & Immunology Symposium Epigenetics of immunity: mechanisms and therapeutic opportunities” Jonathan Epstein, PhD University of Pennsylvania Ellen Rothenberg, PhD Caltech Cornelis Murre, PhD University of California, San Diego Daniel De Carvalho, PhD University of Toronto Alexander Rudensky, PhD Memorial Sloan Kettering Cancer Center DATE: February 27, 2020 9:00AM -5:30PM LOCATION: RUBENSTEIN AUDITORIUM, SMILOW CENTER FOR TRANSLATIONAL RESEARCH, 3400 CIVIC CENTER BLVD., PHILADELPHIA, PA 19104 Funding for the Symposium has been provided by: The Penn Institute for Immunology, The Penn Epigenetics Institute & the Immunobiology of Normal and Neoplastic Lymphocytes Training Grant Featured Keynotes: There will be a Panel Discussion immediately following with scientific editors from Immunity, Cell, and Nature Immunology…. SPEAKERS Illustration of a functional T cell (background) and an exhausted T cell (foreground). When responding to chronic infection or cancer, T cells become exhausted and lose many of their core functions. This process involves a fundamental “rewiring” of the cellular regulation of gene expression. Thus, exhausted T cells likely represent a distinct cell lineage. See pages 1104, 1160, and 1165.Illustration: Valerie Altounian/Science

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Page 1: Joint Epigenetics & Immunology Symposium

Joint Epigenetics &Immunology Symposium

“Epigenetics of immunity: mechanisms and therapeutic opportunities”

Jonathan Epstein, PhDUniversity of Pennsylvania

Ellen Rothenberg, PhDCaltech

Cornelis Murre, PhDUniversity of California, San Diego

Daniel De Carvalho, PhD University of Toronto

Alexander Rudensky, PhD Memorial Sloan Kettering

Cancer Center

DATE: February 27, 20209:00AM -5:30PM

LOCATION: RUBENSTEIN AUDITORIUM, SMILOW CENTER FOR TRANSLATIONAL RESEARCH, 3400 CIVIC CENTER BLVD., PHILADELPHIA, PA 19104

Funding for the Symposium has been provided by: The Penn Institute for Immunology, The Penn

Epigenetics Institute & the Immunobiology of Normal and Neoplastic Lymphocytes Training Grant

Featured Keynotes:

There will be a Panel Discussion immediately following with scientific editors from

Immunity, Cell, and Nature Immunology….

SPEA

KERS

Illus

trat

ion

of a

func

tiona

l T c

ell (

back

grou

nd)

and

an e

xhau

sted

T c

ell (

fore

grou

nd).

Whe

n re

spon

ding

to c

hron

ic in

fect

ion

or c

ance

r, T

cells

be

com

e ex

haus

ted

and

lose

man

y of

thei

r cor

e fu

nctio

ns. T

his p

roce

ss in

volv

es a

fund

amen

tal

“rew

iring

” of

the

cellu

lar r

egul

atio

n of

gen

e ex

pres

sion.

Thu

s, e

xhau

sted

T c

ells

likel

y re

pres

ent a

dist

inct

cel

l lin

eage

. See

pag

es 1

104,

11

60, a

nd 1

165.

Illus

trat

ion:

Val

erie

Al

toun

ian/

Scie

nce