josé luis pires sars-cov-2 report 7 august 2020 · 8/7/2020 · new cases vs 7-day average ......

7 August 2020SARS-Cov-2 ReportJosé Luis Pires

Confidential Hovione © 2020August 2020 2

SARS-Cov-2

➢ Confirmed cases by Country

➢ Deaths by Country

➢ Total confirmed Covid-19 cases and deaths per million people

➢ Daily new confirmed Covid-19 cases and deaths per million people

➢ New cases vs 7-day average

➢ Portugal

▪ Cases, Deaths and Projections

➢ Ireland


➢ New Jersey/US


➢ Recent News

Contents


Coronavirus (SARS-CoV-2 / Covid-19) – Confirmed cases by countryNote: Selected Countries, sorted by # of cases

1,9322,1332,1942,2233,3454,6215,1235,4047,0737,5329,0389,46814,51914,58620,27221,69626,37229,64436,10845,00652,06154,79757,46572,01680,05481,96788,460120,387122,754

215,224228,195231,310237,265249,204

309,796309,855

875,3782,027,074

2,912,2124,883,657

0 1,000,000 2,000,000 3,000,000 4,000,000 5,000,000 6,000,000

IcelandEstonia

LithuaniaSloveniaThailandHungaryGreeceCroatia

Luxembo…Finland

MalaysiaNorway

KoreaDenmarkAustralia

AustriaIreland

MoroccoSwitzerland

JapanPortugal

SingaporeNetherlands

BelgiumIsrael

SwedenChina

CanadaPhilippines

GermanyArgentina

FranceTurkey

ItalyUK

SpainRussia

IndiaBrazil

US

Last Updated at 7 August 2020, 9:34 AM

by the Center for Systems Science and Engineering

at Johns Hopkins University

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7 August 2020 19 June 202026 June 20203 July 202010 July 2020

In 6 weeks the number of cases doubled

17 July 202024 July 202031 July 2020

https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6


Coronavirus (SARS-CoV-2 / Covid-19) – Deaths by CountryNote: Selected Countries, sorted by # of cases

160,104

98,493

41,585

14,698

28,500

46,498

35,187

5,798

30,308

4,2519,188

2,1689,013

4,6805,766576

9,8616,173

27 1,7431,0351,9854491,768719 266 617 303 256 125 331 119 155 210 602 58 125 81 63 100

20,000

40,000

60,000

80,000

100,000

120,000

140,000

160,000

180,000

Source: https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6

Last Updated at 7 August 2020, 9:34 AM

by the Center for Systems Science and Engineering

at Johns Hopkins University



Total confirmed Covid-19 cases per million people


Daily new confirmed Covid-19 cases per million people


Total confirmed Covid-19 deaths per million people


Daily new confirmed Covid-19 deaths per million people


New

cases v

s

7-d

ay a

vera

ge

Country/CityTotal

cases

Total

deaths

New daily cases:

reported on 6 August

New daily cases:

7-day avg

New cases vs

7-day average

6 August 20202

C

o

l

New cases vs

7-day average

30 July 202022

C

o

l

New cases vs

7-day average

23 July 202022

C

ol

u

New cases vs

7-day average

16 July 202022

C

ol

u

New cases vs

7-day average

9 July 202022

C

o

l

New cases vs

7-day average

2 July 202022

C

o

l

New cases vs

7-day average

25 June 202022

C

o

l

New cases vs

7-day average

18 June 202022

C

o

l

New cases vs

7-day average

11 June 202022

C

o

l

New cases vs

7-day average

4 June 202022

C

o

l

New cases vs

7-day average

28 May 2020

Loures 2,358 11 12 Down Down Down Down Down Down Down Up Down Up UpLisbon 4,562 22 24 Down Down Down Down Down Down Down Up Up Up Up

Lisbon and Tagus V. 26,720 608 147 112 Up Up Down Down Up Up Down Up Down Up UpLTV vs PT 69% 65% Up Down Down Up Down Up Down Down Up Up Up

New Jersey 183,701 374 390 Down Down Up Down Down Up Up Up Up Down UpCork 26,372 2 1 Up Down Down Down Up Down Down Down Down Down Down

Argentina 228,195 4,251 6,792 5,740 Up Up Up Up Up Down Up Up Up Up Down

Australia 20,272 266 715 552 Up Down Up Up Down Up Up Up Down Down Down

Austria 21,696 719 103 104 Down Up Up Down Up Down Down Down Up Up Down

Belgium 72,016 9,861 - - Down Down Up Up Up Up Down Down Up Down Down

Brazil 2,912,212 98,493 51,603 45,533 Up Down Up Up Up Down Up Up Up Up Down

Canada 120,387 9,013 761 400 Up Down Up Up Down Down Down Down Down Down Down

China 88,460 4,680 122 161 Down Up Up Down Up Up Down Up Up Down Down

Croatia 5,404 155 58 65 Down Down Up Up Down Down Up Up Up Up Down

Denmark 14,586 617 112 79 Up Up Up Up Down Up Up Up Down Down Up

Estonia 2,133 63 22 10 Up Up Up Down Up Down Up Down Up Up Down

Finland 7,532 331 29 14 Up Up Up Down Down Up Up Down Down Down Up

France 231,310 30,308 1,615 1,171 Up Up Up Up Up Up Down Down Down Down Down

Germany 215,224 9,188 1,045 753 Up Down Up Up Up Down Up Up Up Down Down

Greece 5,123 210 118 91 Up Up Up Down Up Up Down Up Down Up Up

Hungary 4,621 602 11 11 Up Up Down Down Down Down Up Down Down Down Down

Iceland 1,932 10 8 9 Down Up Down Up Up Up Up Up Up Up Up

India 2,027,074 41,585 56,282 54,392 Up Up Up Up Up Up Up Up Up Up Down

Ireland 26,372 1,768 50 52 Down Down Down Down Down Down Down Down Down Up Down

Italy 249,204 35,187 384 290 Up Up Up Down Down Up Up Up Down Down Up

Japan 45,006 1,035 1,134 1316 Down Up Up Up Down Up Up Down Up Down Down

Korea 14,519 303 43 33 Up Down Up Up Down Up Down Up Up Down Up

Malaysia 9,038 125 21 10 Up Down Up Down Down Down Down Down Down Up Down

Netherlands 57,465 6,173 426 394 Up Up Up Up Up Down Down Down Down Down Up

Norway 9,468 256 29 30 Down Up Up Up Up Down Up Down Down Down Up

Philippines 122,754 2,168 3,387 4356 Down Down Down Up Up Up Down Up Up Up Up

Portugal 52,061 1,743 213 163 Up Down Up Up Up Up Up Down Down Up Up

Russia 875,378 14,698 5,267 5,342 Down Down Down Down Down Up Down Up Up Down Down

Singapore 54,797 27 908 389 Up Down Up Up Down Up Down Up Up Up Up

Spain 309,855 28,500 2,953 2,649 Up Up Down Up Down Down Down Down Up Down Down

Sweden 81,967 5,766 359 251 Up Up Up Up Down Up Up Down Up Up Up

Switzerland 36,108 1,985 181 161 Up Up Up Up Up Down Up Down Up Up Down

Thailand 3,345 58 2 4 Down Up Up Down Up Up Down Up Down Up Up

Turkey 237,265 5,798 1,178 1,027 Up Up Down Down Down Down Up Up Down Down Up

UK 309,796 46,498 891 818 Up Up Down Down Up Down Down Down Down Up Down

US 4,883,657 160,104 49,629 57,868 Down Down Up Down Down Up Up Up Down Up Up


Daily deaths of

patients diagnosed

with coronavirus

(7-day average)

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https://www.ft.com/content/a26fbf7e-48f8-11ea-aeb3-955839e06441

Portugal


Coronavirus (SARS-CoV-2 / COVID 19) – Portugal - Total cases by day

2 4 6 9132130394159781121692453314486427851,0201,2801,6002,0602,3622,9953,5444,268

5,1705,9626,408

7,4438,251

9,0349,88610,524

11,27811,73012,452

13,14113,956

15,47215,98716,58516,93417,44818,09118,84119,02219,68520,20620,86321,37921,98222,35322,79723,39223,86424,02724,32224,50525,05625,35125,19025,28225,52425,70226,18226,71527,26827,40627,58127,67927,91328,13228,31928,58328,81029,03629,20929,43229,66029,912

30,200

30,47130,62330,78831,00731,29231,596

31,946

32,20332,50032,70032,89533,26133,592

33,969

34,35134,69334,88535,30635,60035,910

36,18036,46336,69037,03637,33637,67238,089

38,46438,84139,13339,39239,73740,10440,415

40,86641,18941,64641,91242,14142,454

42,78243,15643,56943,89744,12944,41644,859

45,27745,87946,22146,51246,81847,05147,426

47,76548,07748,39048,63648,77148,89849,150

49,37949,69249,95550,16450,29950,41050,613

50,86851,07251,31051,46351,56951,68151,848

52,061

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# of cases % increase

Source: https://covid19.min-saude.pt/ponto-de-situacao-atual-em-portugal/

https://covid19.min-saude.pt/ponto-de-situacao-atual-em-portugal/


Coronavirus (SARS-CoV-2 / COVID 19) – Portugal - Confirmed cases by day

222348992181934577686

117

194143

235260

320

460

302

633

549

724

902

792

446

1035

808783

852

638

754

452

712699

815

1516

515

598

349

514

643

750

181

663

521

657

516

603

371

444

595

472

163

295

183

540

306

0

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173223228

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152165219

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421

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336

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292259

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311

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323

457

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313328374

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232

287

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233

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252229

313263

209

135111

203255

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10 July – 602 cases

The biggest increase since April 22



Coronavirus (SARS-CoV-2 / COVID 19) – Portugal – Hospital: Stable vs ICU

00 09132130384057

107107114139139

206

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156169201203

276

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418

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627

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10421058107510841099

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Hospital Stable Hospital ICU




Coronavirus (SARS-CoV-2 / COVID 19) – Portugal – Deaths vs Recoveries

0000000000000011236121423334360761001191401601872092462662953113453804094354705045355675996296576877147357627858208548809039289489739891007102310431063107410891105111411261135114411631175118411901203121812311247126312771289

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Total Confirmed Deaths Total Confirmed Recoveries




Coronavirus

(SARS-CoV-2 / COVID 19)

Portugal

6 August 2020


Coronavirus (SARS-CoV-2 / COVID 19) – Loures - Total cases by day

2428282857647284101109117126130131134138158179191196201212221231240251257260

292292301303304315315315369386393400408410420

453464464497505507

536559576591604612642656678

715

771802819828

863894

934

9821,009

1,0431,0661,0891,1141,147

1,1721,191

1,2091,2361,288

1,3311,352

1,383

1,4241,4361,4471,4921,512

1,548

1,5761,6041,623

1,6541,6801,7071,720

1,7451,756

1,7911,8121,8271,856

1,8721,8871,9101,9101,9101,9101,910

1,910

1,9101,9101,9101,910

2,0882,088

2,0882,0882,0882,088

2,1972,1972,197

2,1972,1972,1972,197

2,2842,2842,284

2,284

2,2842,2842,284

2,3582,3582,358

2,358

17%

0%0%

104%

12%13%17%

20%

8%7%8%

3%1%2%3%

14%13%7%3%

3%5%4%5%4%5%

2%1%

12%

0%3%

1%0%4%

0%0%

17%

5%2%2%2%0%

2%

8%

2%0%

7%

2%0%

6%4%3%3%2%1%5%

2%3%5%

8%4%

2%1%4%4%4%5%

3%3%2%2%2%3%2%2%2%2%4%3%2%2%3%

1%1%3%1%2%2%2%1%2%2%2%1%1%1%2%1%1%2%1%1%1%0%0%0%0%0%0%0%0%0%

9%

0%0%0%0%0%

5%

0%0%0%0%0%0%4%

0%0%0%0%0%0%3%

0%0%0%

0%

20%

40%

60%

80%

100%

120%

0

500

1000

1500

2000

2500

24

.ma

r

26

.ma

r

28

.ma

r

30

.ma

r

1.a

pr

3.a

pr

5.a

pr

7.a

pr

9.a

pr

11

.ap

r

13

.ap

r

15

.ap

r

17

.ap

r

19

.ap

r

21

.ap

r

23

.ap

r

25

.ap

r

27

.ap

r

29

.ap

r

1.m

ay

3.m

ay

5.m

ay

7.m

ay

9.m

ay

11

.ma

y

13

.ma

y

15

.ma

y

17

.ma

y

19

.ma

y

21

.ma

y

23

.ma

y

25

.ma

y

27

.ma

y

29

.ma

y

31

.ma

y

02

.ju

n

04

.ju

n

06

.ju

n

08

.ju

n

10

.ju

n

12

.ju

n

14

.ju

n

16

.ju

n

18

.ju

n

20

.ju

n

22

.ju

n

24

.ju

n

26

.ju

n

28

.ju

n

30

.ju

n

02

.ju

l

04

.ju

l

06

.ju

l

08

.ju

l

10

.ju

l

12

.ju

l

14

.ju

l

16

.ju

l

18

.ju

l

20

.ju

l

22

.ju

l

24

.ju

l

26

.ju

l

28

.ju

l

30

.ju

l

1.a

ug

3.a

ug

5.a

ug





Coronavirus (SARS-CoV-2 / COVID 19) – Loures - Confirmed cases by day

400

29

7812

17

8894134

2021

1255

1191091163

32

0

921

11

00

54

17

7782

10

33

11

0

33

82

2923

1715138

30

14

22

37

56

31

17

9

3531

40

48

2734

232325

33

251918

27

52

43

21

31

41

1211

45

20

36

2828

19

312627

13

25

11

35

2115

29

1615

23

000000000

178

00000

109

000000

87

000000

74

000

0

20

40

60

80

100

120

140

160

180

200

24

.ma

r

26

.ma

r

28

.ma

r

30

.ma

r

1.a

pr

3.a

pr

5.a

pr

7.a

pr

9.a

pr

11

.ap

r

13

.ap

r

15

.ap

r

17

.ap

r

19

.ap

r

21

.ap

r

23

.ap

r

25

.ap

r

27

.ap

r

29

.ap

r

1.m

ay

3.m

ay

5.m

ay

7.m

ay

9.m

ay

11

.ma

y

13

.ma

y

15

.ma

y

17

.ma

y

19

.ma

y

21

.ma

y

23

.ma

y

25

.ma

y

27

.ma

y

29

.ma

y

31

.ma

y

02

.ju

n

04

.ju

n

06

.ju

n

08

.ju

n

10

.ju

n

12

.ju

n

14

.ju

n

16

.ju

n

18

.ju

n

20

.ju

n

22

.ju

n

24

.ju

n

26

.ju

n

28

.ju

n

30

.ju

n

02

.ju

l

04

.ju

l

06

.ju

l

08

.ju

l

10

.ju

l

12

.ju

l

14

.ju

l

16

.ju

l

18

.ju

l

20

.ju

l

22

.ju

l

24

.ju

l

26

.ju

l

28

.ju

l

30

.ju

l

1.a

ug

3.a

ug

5.a

ug




Coronavirus (SARS-CoV-2 / COVID 19) – Lisbon - Total cases by day

175187284284

366

5946335465946346546816997547737978518678909059469629961,0201,0331,0381,060

1,1451,1691,2661,271

1,3461,4061,4131,4131,4471,4651,496

1,5671,5671,5671,5791,6271,6681,7001,7241,7351,7371,7911,8111,8351,8711,9191,9381,9622,0182,0462,0762,107

2,1462,1772,1822,2062,2542,2902,324

2,365

2,4002,4092,4472,4862,5362,555

2,595

2,6142,6402,7002,7512,7892,803

2,852

2,8522,8802,9222,9402,9793,037

3,096

3,1353,1503,1913,2383,2773,335

3,3473,4233,4533,5023,5443,573

3,5843,6453,6453,6453,6453,6453,645

3,645

3,6453,6453,645

4,0844,0844,084

4,0844,0844,084

4,2404,2404,2404,240

4,2404,2404,240

4,4084,4084,408

4,4084,4084,4084,408

4,5624,5624,562

4,562

7%

52%

0%

29%

62%

7%

0%

9%7%

3%4%3%

8%

3%3%

7%

2%

3%2%5%

2%4%

2%1%0%

2%

8%

2%

8%

0%

6%4%

0%0%2%

1%2%

5%

0%0%1%3%3%2%1%1%0%

3%1%1%2%3%

1%1%3%

1%1%1%2%1%0%1%

2%2%1%2%1%0%

2%2%2%1%2%1%1%

2%2%1%1%2%

0%1%1%1%1%2%2%1%0%1%1%1%2%0%

2%1%1%1%1%0%

2%0%0%0%0%0%0%0%0%0%

12%

0%0%0%0%0%

4%

0%0%0%0%0%0%

4%

0%0%0%0%0%0%

3%

0%0%0%

0%

10%

20%

30%

40%

50%

60%

70%

0

500

1000

1500

2000

2500

3000

3500

4000

4500

5000

24

.ma

r

26

.ma

r

28

.ma

r

30

.ma

r

2.a

pr

4.a

pr

6.a

pr

8.a

pr

10

.ap

r

12

.ap

r

14

.ap

r

16

.ap

r

18

.ap

r

20

.ap

r

22

.ap

r

24

.ap

r

26

.ap

r

28

.ap

r

30

.ap

r

2.m

ay

4.m

ay

6.m

ay

8.m

ay

10

.ma

y

12

.ma

y

14

.ma

y

16

.ma

y

18

.ma

y

20

.ma

y

22

.ma

y

24

.ma

y

26

.ma

y

28

.ma

y

30

.ma

y

01

.ju

n

03

.ju

n

05

.ju

n

07

.ju

n

09

.ju

n

11

.ju

n

13

.ju

n

15

.ju

n

17

.ju

n

19

.ju

n

21

.ju

n

23

.ju

n

25

.ju

n

27

.ju

n

29

.ju

n

01

.ju

l

03

.ju

l

05

.ju

l

07

.ju

l

09

.ju

l

11

.ju

l

13

.ju

l

15

.ju

l

17

.ju

l

19

.ju

l

21

.ju

l

23

.ju

l

25

.ju

l

27

.ju

l

29

.ju

l

31

.ju

2.a

ug

4.a

ug

6.a

ug





Coronavirus (SARS-CoV-2 / COVID 19) – Lisbon - Confirmed cases by day

12

97

0

82

228

39414840

202718

55

1924

54

162315

41

1634

2413

522

85

24

97

5

7560

70

3418

31

71

0012

484132

2411

2

54

202436

48

1924

56

28303139

31

524

4836344135

93839

50

19

40

1926

6051

38

14

49

0

2842

18

395859

39

15

414739

58

12

76

304942

2911

61

000000000

439

00000

156

0000 0

168

000000

154

000

0

50

100

150

200

250

300

350

400

450

500

24

.ma

r

26

.ma

r

28

.ma

r

30

.ma

r

2.a

pr

4.a

pr

6.a

pr

8.a

pr

10

.ap

r

12

.ap

r

14

.ap

r

16

.ap

r

18

.ap

r

20

.ap

r

22

.ap

r

24

.ap

r

26

.ap

r

28

.ap

r

30

.ap

r

2.m

ay

4.m

ay

6.m

ay

8.m

ay

10

.ma

y

12

.ma

y

14

.ma

y

16

.ma

y

18

.ma

y

20

.ma

y

22

.ma

y

24

.ma

y

26

.ma

y

28

.ma

y

30

.ma

y

01

.ju

n

03

.ju

n

05

.ju

n

07

.ju

n

09

.ju

n

11

.ju

n

13

.ju

n

15

.ju

n

17

.ju

n

19

.ju

n

21

.ju

n

23

.ju

n

25

.ju

n

27

.ju

n

29

.ju

n

01

.ju

l

03

.ju

l

05

.ju

l

07

.ju

l

09

.ju

l

11

.ju

l

13

.ju

l

15

.ju

l

17

.ju

l

19

.ju

l

21

.ju

l

23

.ju

l

25

.ju

l

27

.ju

l

29

.ju

l

31

.ju

2.a

ug

4.a

ug

6.a

ug




Coronavirus (SARS-CoV-2 / COVID 19) – Lisbon and Tagus Valley - Total

cases by day

1 2 3 4 5 6 910172346731161421802432783644485347378529921,0821,1101,2871,4781,5771,7991,9982,2072,3472,5132,9043,0703,1853,2243,451

3,8213,8343,8413,8963,9944,1024,2374,3024,4384,5004,7094,8965,0935,1945,2775,4355,5315,5565,5935,6955,8155,9396,0476,0476,1366,2416,6416,9357,0937,1667,2427,3167,4947,6477,7677,9518,0978,2358,3618,4908,688

8,8789,1069,2929,4239,5679,77810,055

10,320

10,64310,87411,14211,33511,49311,82812,137

12,47312,81813,07313,222

13,60813,87814,161

14,407

14,62214,82815,12815,36415,64615,971

16,255

16,53716,76216,92617,22517,52717,767

18,106

18,36118,75218,97719,16519,383

19,656

19,95620,27320,52720,72220,92921,256

21,58422,12622,38522,61122,86523,00823,296

23,57023,80624,04724,26124,36924,47024,685

24,85725,11025,29325,44825,54925,61725,763

25,93926,06726,23126,32326,38926,45726,573

26,720

100%

50%

33%

25%

20%

50%

11%

70%

35%

100%

59%59%

22%

27%

35%

14%

31%23%

19%

38%

16%16%

9%

3%

16%15%

7%

14%11%10%

6%7%

16%

6%4%

1%

7%11%

0%0%1%3%3%3%2%3%

1%5%4%4%

2%2%3%2%0%1%2%2%2%2%0%1%2%

6%4%

2%1%1%1%2%2%2%2%2%2%2%2%2%2%3%2%1%2%2%3%3%3%2%2%2%1%3%3%3%3%2%1%3%2%2%2%1%1%2%2%2%2%2%2%1%1%2%2%1%2%1%2%1%1%1%1%2%2%1%1%1%2%2%3%1%1%1%1%1%1%1%1%1%0%0%1%1%1%1%1%0%0%1%1%0%1%0%0%0%0%1%

0%

20%

40%

60%

80%

100%

120%

0

5000

10000

15000

20000

25000

30000





Coronavirus (SARS-CoV-2 / COVID 19) – Lisbon and Tagus Valley -

Confirmed cases by day

01111131762327

4326

38

63

35

868486

203

115

140

90

28

177191

99

222

199209

140

166

391

166

115

39

227

370

137

55

98108

135

65

136

62

209187

197

10183

158

96

2537

102120124

108

0

89105

400

294

158

737674

178

153

120

184

146138126129

198190

228

186

131144

211

277265

323

231

268

193

158

335

309

336345

255

149

386

270283

246

215206

300

236

282

325

284282

225

164

299302

240

339

255

391

225

188

218

273

300317

254

195207

327328

542

259

226

254

143

288274

236241

214

108101

215

172

253

183

155

101

68

146

176

128

164

92

6668

116

147

0

100

200

300

400

500

600




Coronavirus (SARS-CoV-2 / COVID 19) – % of new cases in Lisbon and Tagus

valley

111113176232743263863

35868486

203

115140

90

28

177191

99

222199209

140166

391

166115

39

227

370

13755

98108135

65

136

62

209187197

10183

158

96

2537

102120124108

0

89105

400

294

15873

7674

178153

120

184146138126129

198190228

186

131144

211

277265

323

231268

193158

335309

336345

255

149

386

270283246

215206

300

236282

325284282

225

164

299302

240

339

255

391

225188

218

273300317

254

195207

327328

542

259226

254

143

288274236241

214

108101

215172

253

183155

10168

146176

128164

926668

116147

2348992181934577686

117

194143

235260

320

460

302

633

549

724

902

792

446

1,035

808783

852

638

754

452

712699

815

1,516

515

598

349

514

643

750

181

663

521

657

516

603

371

444

595

472

163

295

183

540

306

92

242

178

480

533553

138175

98

234219187

264227226

173223228

252288271

152165

219

285304350

257297

200195

366331

377382342

192

421

294310270283

227

346300

336

417375377

292259

345367

311

451

323

457

266229

313328374

413

328

232

287

443418

602

342291306

233

375339

312313

246

135127

252229

313263

209

135111

203

255204

238

153106112

167213

50%

33%

25%

13%11%

33%

50%

39%

32%

68%

47%

57%

30%32%32%

24%

37%

32%

27%

44%

38%

22%

16%

4%

20%

24%22%21%

25%27%

16%

26%

52%

37%

16%

6%

28%24%

3%1%

16%19%

17%18%

36%

21%

12%

32%

36%33%

27%

19%

27%

20%

15%13%

56%

22%

41%

0%0%

37%

59%

83%

55%

29%

53%

43%

76%76%

70%

64%

70%

64%61%

73%

58%

87%

75%79%

69%

86%87%

96%97%

87%

92%

90%90%

97%

81%

92%93%

89%

90%

75%78%

92%92%91%

91%

76%

91%

87%

79%

84%

78%76%

75%77%

63%

87%

82%

77%75%

79%

86%85%82%

70%

83%

80%77%77%

84%

72%74%

78%

90%

76%78%

83%

61%

77%81%

76%77%

87%

80%80%

85%

75%

81%

70%

74%75%

61%

72%69%

63%

69%

60%62%61%

69% 69%

0%

20%

40%

60%

80%

100%

120%

0

200

400

600

800

1000

1200

1400

1600

4.m

ar

6.m

ar

8.m

ar

10

.mar

12

.mar

14

.mar

16

.mar

18

.mar

20

.mar

22

.mar

24

.mar

26

.mar

28

.mar

30

.mar

1.a

br

3.a

br

5.a

br

7.a

br

9.a

br

11

.abr

13

.abr

15

.abr

17

.abr

19

.abr

21

.abr

23

.abr

25

.abr

27

.abr

29

.abr

1.m

ai

3.m

ai

5.m

ai

7.m

ai

9.m

ai

11

.mai

13

.mai

15

.mai

17

.mai

19

.mai

21

.mai

23

.mai

25

.mai

27

.mai

29

.mai

31

.mai

2.jun

4.jun

06

.ju

n

08

.ju

n

10

.ju

n

12

.ju

n

14

.ju

n

16

.ju

n

18

.ju

n

20

.ju

n

22

.ju

n

24

.ju

n

26

.ju

n

28

.ju

n

30

.ju

n

02

.ju

l

04

.ju

l

06

.ju

l

08

.ju

l

10

.ju

l

12

.ju

l

14

.ju

l

16

.ju

l

18

.ju

l

20

.ju

l

22

.ju

l

24

.ju

l

26

.ju

l

28

.ju

l

30

.ju

l

1.a

ug

3.a

ug

5.a

ug

Lisbon and Tagus valley Portugal % of new cases




Covid-19 Projections Using Machine Learning – Portugal - Cases

Source: https://covid19-projections.com/portugal

https://covid19-projections.com/portugal


Covid-19 Projections Using Machine Learning – Portugal - Deaths

Source: https://covid19-projections.com/portugal

https://covid19-projections.com/portugal

Ireland


Coronavirus (SARS-CoV-2 / COVID 19) – Ireland - Total cases by day

10 361318192124344370901291692232923665576837859061,1251,3291,5641,8192,1212,4152,6152,9103,2353,4473,849

4,3734,6044,9945,3645,7096,074

6,5747,054

8,9289,655

10,64711,479

12,54713,271

13,98014,758

15,25115,652

16,04016,671

17,60718,184

18,56119,262

19,64819,87720,25320,61220,83321,17621,50621,77221,98322,24822,38522,54122,76022,99623,13523,24223,40123,827

23,95624,04824,11224,20024,25124,315

24,391

24,50624,58224,63924,69824,73524,803

24,841

24,87624,92924,99025,06225,06625,111

25,142

25,16325,18325,20125,20725,21525,231

25,238

25,25025,29525,30325,32125,33425,341

25,355

25,36825,37425,37925,38325,39125,396

25,405

25,41425,43725,43825,46225,47325,477

25,489

25,49825,50925,52725,53125,53825,542

25,565

25,58925,61125,62825,63825,67025,683

25,698

25,73025,75025,76025,76625,80225,819

25,826

25,84525,86925,88125,89225,92925,942

26,027

26,06526,10926,16226,20826,25326,303

26,372

100%

117%

38%

6%

11%14%

42%

26%

63%

29%

43%31%

32%31%

25%

52%

23%

15%15%

24%

18%18%16%17%14%

8%11%11%

7%

12%14%

5%8%7%6%6%8%7%

27%

8%10%

8%9%6%5%6%

3%3%2%4%6%3%2%4%2%1%2%2%1%2%2%1%1%1%1%1%1%1%1%0%1%2%1%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%

0%

20%

40%

60%

80%

100%

120%

140%

0

5000

10000

15000

20000

25000

30000

29

.fe

v

2.m

ar

4.m

ar

6.m

ar

8.m

ar

10

.ma

r

12

.ma

r

14

.ma

r

16

.ma

r

18

.ma

r

20

.ma

r

22

.ma

r

24

.ma

r

26

.ma

r

28

.ma

r

30

.ma

r

1.a

pr

3.a

pr

5.a

pr

7.a

pr

9.a

pr

11

.ap

r

13

.ap

r

15

.ap

r

17

.ap

r

19

.ap

r

21

.ap

r

23

.ap

r

25

.ap

r

27

.ap

r

29

.ap

r

1.m

ay

3.m

ay

5.m

ay

7.m

ay

9.m

ay

11

.ma

y

13

.ma

y

15

.ma

y

17

.ma

y

19

.ma

y

21

.ma

y

23

.ma

y

25

.ma

y

27

.ma

y

29

.ma

y

31

.ma

y

02

.ju

n

04

.ju

n

06

.ju

n

08

.ju

n

10

.ju

n

12

.ju

n

14

.ju

n

16

.ju

n

18

.ju

n

20

.ju

n

22

.ju

n

24

.ju

n

26

.ju

n

28

.ju

n

30

.ju

n

02

.ju

l

04

.ju

l

06

.ju

l

08

.ju

l

10

.ju

l

12

.ju

l

14

.ju

l

16

.ju

l

18

.ju

l

20

.ju

l

22

.ju

l

24

.ju

l

26

.ju

l

28

.ju

l

30

.ju

l

1.a

ug

3.a

ug

5.a

ug


Source: https://geohive.maps.arcgis.com/apps/opsdashboard/index.html#/29dc1fec79164c179d18d8e53df82e96

https://geohive.maps.arcgis.com/apps/opsdashboard/index.html#/29dc1fec79164c179d18d8e53df82e96


Coronavirus (SARS-CoV-2 / COVID 19) – Ireland - Confirmed cases by day

10014751231092720

394054

6974

191

126102

121

219204

235255

302294

200

295325

212

402424

331

390370

345365

500480

553

430

527548

657629

597630

445

401388

631

936

577

377

701

386

229

376359

221

343330

266

211

265

137156

219236

139107

159

426

129

9264

88

516476

115

765759

37

734639

596677

10

47382824259919813

46

81814816132264105111123

1241161591118

424112325231711

3214213421106

3617720241211

4014

85

38455346455069

29

.fe

v

2.m

ar

4.m

ar

6.m

ar

8.m

ar

10

.ma

r

12

.ma

r

14

.ma

r

16

.ma

r

18

.ma

r

20

.ma

r

22

.ma

r

24

.ma

r

26

.ma

r

28

.ma

r

30

.ma

r

1.a

pr

3.a

pr

5.a

pr

7.a

pr

9.a

pr

11

.ap

r

13

.ap

r

15

.ap

r

17

.ap

r

19

.ap

r

21

.ap

r

23

.ap

r

25

.ap

r

27

.ap

r

29

.ap

r

1.m

ay

3.m

ay

5.m

ay

7.m

ay

9.m

ay

11

.ma

y

13

.ma

y

15

.ma

y

17

.ma

y

19

.ma

y

21

.ma

y

23

.ma

y

25

.ma

y

27

.ma

y

29

.ma

y

31

.ma

y

02

.ju

n

04

.ju

n

06

.ju

n

08

.ju

n

10

.ju

n

12

.ju

n

14

.ju

n

16

.ju

n

18

.ju

n

20

.ju

n

22

.ju

n

24

.ju

n

26

.ju

n

28

.ju

n

30

.ju

n

02

.ju

l

04

.ju

l

06

.ju

l

08

.ju

l

10

.ju

l

12

.ju

l

14

.ju

l

16

.ju

l

18

.ju

l

20

.ju

l

22

.ju

l

24

.ju

l

26

.ju

l

28

.ju

l

30

.ju

l

1.a

ug

3.a

ug

5.a

ug

Source: https://geohive.maps.arcgis.com/apps/opsdashboard/index.html#/29dc1fec79164c179d18d8e53df82e96

https://geohive.maps.arcgis.com/apps/opsdashboard/index.html#/29dc1fec79164c179d18d8e53df82e96


Coronavirus (SARS-CoV-2 / COVID 19) – Cork - Total cases by day

101104123133154171184

208217238255272292304

343362

421431472

503

581

648

730780

829

916945

9791,0281,0471,053

1,0771,0871,0961,1031,1101,1251,1261,1361,1461,1541,1561,1641,1751,1771,1921,1971,1991,2051,2071,2321,2341,2381,2491,256

1,3461,3521,3611,3721,3761,3861,3981,4201,4281,4381,4401,4511,4581,4641,4721,477

1,5141,5171,517

1,5211,5271,5281,5291,5291,5291,531

1,5321,5331,5331,5331,5331,5331,535

1,535

1,5351,5351,5351,5351,5351,535

1,535

1,5351,5361,5361,536

1,536

1,5401,5431,5431,543

1,545

1,5451,5461,5481,550

1,550

1,5541,5571,557

1,560

1,5601,5621,5621,5631,5631,5631,563

1,563

1,5661,5691,570

1,572

3%

18%

8%

16%

11%

8%

13%

4%

10%

7%7%

7%

4%

13%

6%

16%

2%

10%

7%

16%

12%

13%

7%6%

10%

3%4%

5%

2%

1%

2%

1%1%1%1%1%

0%

1%1%1%0%

1%1%

0%

1%

0%0%1%

0%

2%

0%0%1%

1%

7%

0%1%1%0%

1%1%2%

1%1%0%

1%0%0%1%0%

3%

0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%

0%

2%

4%

6%

8%

10%

12%

14%

16%

18%

20%

0

200

400

600

800

1000

1200

1400

1600

1800

22

.ma

r

24

.ma

r

26

.ma

r

28

.ma

r

30

.ma

r

1.a

br

3.a

br

5.a

br

7.a

br

9.a

br

11

.ab

r

13

.ab

r

15

.ab

r

17

.ab

r

19

.ab

r

21

.ab

r

23

.ab

r

25

.ab

r

27

.ab

r

29

.ab

r

1.m

ai

3.m

ai

5.m

ay

7.m

ay

9.m

ay

11

.ma

y

13

.ma

y

15

.ma

y

17

.ma

y

19

.ma

y

21

.ma

y

23

.ma

y

25

.ma

y

27

.ma

y

29

.ma

y

31

.ma

y

02

.ju

n

04

.ju

n

06

.ju

n

08

.ju

n

10

.ju

n

12

.ju

n

14

.ju

n

16

.ju

n

18

.ju

n

20

.ju

n

22

.ju

n

24

.ju

n

26

.ju

n

30

.ju

n

02

.ju

l

06

.ju

l

08

.ju

l

10

.ju

l

14

.ju

l

16

.ju

l

20

.ju

l

22

.ju

l

24

.ju

l

26

.ju

l

28

.ju

l

30

.ju

l

4.a

ug

6.a

ug





Coronavirus (SARS-CoV-2 / COVID 19) – Cork - Confirmed cases by day

3

19

10

21

17

13

24

9

21

171720

12

39

19

59

10

41

31

78

67

82

5049

87

29

34

49

19

6

24

10977

15

1

10108

2

811

2

15

52

6

2

25

24

11

7

90

6911

4

1012

22

810

2

11

76

85

37

30

46

11002110000

2000000000001000

4300

20122

0

430

30

2010000

3000

312

0

10

20

30

40

50

60

70

80

90

100




Covid-19 Projections Using Machine Learning – Ireland - Cases

Source: https://covid19-projections.com/ireland

https://covid19-projections.com/ireland


Covid-19 Projections Using Machine Learning – Ireland - Deaths

Source: https://covid19-projections.com/ireland

https://covid19-projections.com/ireland

New Jersey


Coronavirus (SARS-CoV-2 / COVID 19) – New Jersey - Total cases by day

1046111523295069981782674277428901,3271,9142,8443,6754,4026,8768,82511,12413,38616,63618,696

22,25525,590

29,89534,124

37,50541,090

44,41647,437

51,02754,588

58,15161,850

64,58468,82471,030

75,31778,467

81,42085,301

88,80692,387

95,86599,989102,196

105,523109,038111,188

113,856116,264118,652121,190

123,717126,744128,269130,593131,890133,635135,454137,085138,532139,945140,743141,560142,704143,905145,089146,334148,039149,013150,399

151,472152,719153,104154,154155,092155,764156,628

157,815

158,844159,608160,445160,918161,545162,068

162,530163,336163,893164,164164,497164,796165,346

165,816

166,164166,605166,881167,103167,426167,703

168,107

168,496168,834169,142169,415169,734169,892

170,196

170,584170,873171,182171,272171,667171,928

172,356

172,742173,033173,402173,611173,878174,039

174,240

174,628174,959175,298175,522175,915176,278

176,501

176,551176,814176,783176,963177,256177,645

177,887

178,345178,858179,363179,812180,295180,766

180,970

181,660182,029182,350182,614182,970183,327

183,701

50%

83%

36%

53%

26%

72%

38%

42%

82%

50%

60%

74%

20%

49%

44%

49%

29%

20%

56%

28%26%

20%

24%

12%

19%

15%17%14%

10%10%8%7%8%7%7%6%4%7%3%6%4%4%5%4%4%4%4%

2%3%3%2%2%2%2%2%2%2%1%2%1%1%1%1%1%1%1%1%1%1%1%1%1%1%1%1%1%0%1%1%0%1%1%1%0%1%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%0%

-10%

0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

0

20000

40000

60000

80000

100000

120000

140000

160000

180000

200000

5.m

ar

7.m

ar

9.m

ar

11

.ma

r

13

.ma

r

15

.ma

r

17

.ma

r

19

.ma

r

21

.ma

r

23

.ma

r

25

.ma

r

27

.ma

r

29

.ma

r

31

.ma

r

2.a

pr

4.a

pr

6.a

pr

8.a

pr

10

.ap

r

12

.ap

r

14

.ap

r

16

.ap

r

18

.ap

r

20

.ap

r

22

.ap

r

24

.ap

r

26

.ap

r

28

.ap

r

30

.ap

r

2.m

ay

4.m

ay

6.m

ay

8.m

ay

10

.ma

y

12

.ma

y

14

.ma

y

16

.ma

y

18

.ma

y

20

.ma

y

22

.ma

y

24

.ma

y

26

.ma

y

28

.ma

y

30

.ma

y

01

.ju

n

03

.ju

n

05

.ju

n

07

.ju

n

09

.ju

n

11

.ju

n

13

.ju

n

15

.ju

n

17

.ju

n

19

.ju

n

21

.ju

n

23

.ju

n

25

.ju

n

27

.ju

n

29

.ju

n

01

.ju

l

03

.ju

l

05

.ju

l

07

.ju

l

09

.ju

l

11

.ju

l

13

.ju

l

15

.ju

l

17

.ju

l

19

.ju

l

21

.ju

l

23

.ju

l

25

.ju

l

27

.ju

l

29

.ju

l

31

.ju

2.a

ug

4.a

ug

6.a

ug


Source: https://www.nj.com/coronavirus/2020/03/see-the-spread-of-nj-coronavirus-in-charts-map-sunday-march-22-2020.html

https://www.nj.com/coronavirus/2020/03/see-the-spread-of-nj-coronavirus-in-charts-map-sunday-march-22-2020.html


Coronavirus (SARS-CoV-2 / COVID 19) – New Jersey - Confirmed cases by

day

103254862119298089160

315148

437587

930831

727

2474

1949

22992262

3347

2196

36493489

43724229

3382

3663

3361

3088

374836273563

3733

3219

4059

2625

4391

3150

2953

3881

35053581

3478

4124

2207

3327

3515

2150

2668

2408238825382527

3027

1525

2324

1297

17451819

1631

14471413

798817

1144120111841245

1705

974

1386

1073

1247

385

1050938

672

864

11871029

764837

473627

523462

806

557

271333299

550470

348441

276222323277

404389338308273319158

304388

289309

90

395261

428386291

369209267

161201

388331339224

393363223

50

263

0

180293

389242

458513505449483471

204

690

369321264356357374

0

500

1000

1500

2000

2500

3000

3500

4000

4500

5000

5.m

ar

7.m

ar

9.m

ar

11

.ma

r

13

.ma

r

15

.ma

r

17

.ma

r

19

.ma

r

21

.ma

r

23

.ma

r

25

.ma

r

27

.ma

r

29

.ma

r

31

.ma

r

2.a

pr

4.a

pr

6.a

pr

8.a

pr

10

.ap

r

12

.ap

r

14

.ap

r

16

.ap

r

18

.ap

r

20

.ap

r

22

.ap

r

24

.ap

r

26

.ap

r

28

.ap

r

30

.ap

r

2.m

ay

4.m

ay

6.m

ay

8.m

ay

10

.ma

y

12

.ma

y

14

.ma

y

16

.ma

y

18

.ma

y

20

.ma

y

22

.ma

y

24

.ma

y

26

.ma

y

28

.ma

y

30

.ma

y

01

.ju

n

03

.ju

n

05

.ju

n

07

.ju

n

09

.ju

n

11

.ju

n

13

.ju

n

15

.ju

n

17

.ju

n

19

.ju

n

21

.ju

n

23

.ju

n

25

.ju

n

27

.ju

n

29

.ju

n

01

.ju

l

03

.ju

l

05

.ju

l

07

.ju

l

09

.ju

l

11

.ju

l

13

.ju

l

15

.ju

l

17

.ju

l

19

.ju

l

21

.ju

l

23

.ju

l

25

.ju

l

27

.ju

l

29

.ju

l

31

.ju

2.a

ug

4.a

ug

6.a

ug

Source: https://www.nj.com/coronavirus/2020/03/see-the-spread-of-nj-coronavirus-in-charts-map-sunday-march-22-2020.html



The biggest increase since June 10

https://www.nj.com/coronavirus/2020/03/see-the-spread-of-nj-coronavirus-in-charts-map-sunday-march-22-2020.html


Covid-19 Projections Using Machine Learning – New Jersey - Cases

Source: https://covid19-projections.com/us-nj

https://covid19-projections.com/us-nj


Covid-19 Projections Using Machine Learning – New Jersey - Deaths

Source: https://covid19-projections.com/us-nj

https://covid19-projections.com/us-nj


Highest levels of infection, global and US


New daily infections per 1 million people


US new daily infections, current hospitalizations and daily deaths, 7 day avg


US: 24 largest states: reopening dates, infections and hospitalizations

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Recent News


• 6 August

• Moderna has priced smaller volume agreements for its potential Covid-19 vaccine at between $32 and $37 per dose. Larger volume agreements for the vaccine will be priced lower, the

company said. The vaccine candidate is currently in a Phase III trial, which is designed to enrol approximately 30,000 participants.

• The NIH launched a phase 3 trial of Gilead Sciences' antiviral remdesivir and Merck KGaA's interferon-based multiple sclerosis drug Rebif. The ACTT 3 trial aims to enroll more than 1,000

adults hospitalized with COVID-19 and test a combination of the two drugs against remdesivir alone. The idea is that Rebif—which dampens MS flares by modulating the immune system—

may work alongside remdesivir to help patients recover more quickly.

• 5 August

• Moderna's experimental vaccine protected mice who were exposed to the novel coronavirus, the National Institutes of Health reports.

• Taiwan has granted provisional authorisation to steroid drug dexamethasone as a treatment for Covid-19. The decision comes as the country faces a shortfall of the antiviral drug remdesivir,

according to Reuters. Taiwan had ordered for 2,000 doses of remdesivir to arrive by the end of July, but currently only has 78 doses in stock, which were enough to treat 54 seriously-ill

patients.

• As leading COVID-19 vaccine players advance their programs, pricing is becoming clearer, the Wall Street Journal reports. AstraZeneca has a deal with the U.S. for $4 per dose, while J&J's

Wednesday agreement is for $10 per dose. Pfizer's U.S. agreement is for $19.50 per dose, while Moderna said it'd charge a much higher price.

• 4 August

• A bipartisan coalition of 30 state AGs demanded that U.S. health agencies crack open the market for Gilead Sciences' remdesivir, the only antiviral proven to work against Sars-CoV-2. The

government should exercise its "march-in rights" under the Bayh-Dole Act to allow generic versions of the Gilead drug, which is priced at $250 per vial, the letter argued.

• In Gilead Sciences' portfolio is a drug, GS-441524, that some cat owners buy on the black market to treat feline infectious peritonitis, or FIP. It's also related to the coronavirus drug

remdesivir—and its patent expires first. In a letter to the company and four U.S. agencies, Public Citizen urged Gilead to study GS-441524 in humans for COVID-19, saying the treatment, if

effective, could be a lower-cost alternative to remdesivir. And it might actually be easier to convert to inhaled or oral form, the organization argued.

• 3 August

• A trio of rival drugmakers kicked off a joint study of three drugs that could combat the extreme immune response seen in severe coronavirus patients. The trial will test Amgen's psoriasis

drug Otezla, Takeda's anti-inflammatory Firazyr and AbbVie's HIV hopeful cenicriviroc, each in combination with Gilead Sciences' remdesivir and the low-cost steroid dexamethasone. Early

results could be ready in six weeks, the research alliance said.

The latest coronavirus updates and developments impacting the global

pharmaceutical supply chain…


• 30 July

• Gilead Sciences aims to produce more than two million doses of its Covid-19 drug remdesivir by the end of the year, according to Bloomberg. In its earnings report, the company said that it

has donated its existing stock of 1.5 million doses of the drug. Gilead expects to make several million more courses in 2021.

• A powdered formulation of Gilead Sciences' remdesivir could prove more potent and easier to administer, thanks to researchers at the University of Texas at Austin who have used their

novel thin-film-freezing technology to create an inhaled form of the antiviral COVID-19 treatment. Remdesivir is currently given to patients via IV; by developing an inhaled version, the

antiviral might reach more patients, prevent contact between infected individuals and health care workers, and lessen symptoms before they become potentially fatal, the research team said.

• 29 July

• Developed nations making advance purchase deals for Pfizer's mRNA-based coronavirus vaccine should expect to pay no less than the $19.50-per-dose price tag set under the drugmaker's

recent U.S. supply pact, CEO Albert Bourla said. The full two-dose course will run for $39 in the U.S.

• The E.U. handed over €63 million ($74 million) to Gilead Sciences for enough doses of its antiviral remdesivir to treat 30,000 COVID-19 patients. The initial supply deal will satisfy "immediate

needs," the European Commission said, adding that it hopes to secure more doses in October.

• Meanwhile, hospitals in U.S. regions hard-hit by COVID-19 reported widespread shortages of Gilead's remdesivir. While the U.S. government started sending out remdesivir shipments after

trials confirmed its benefit in COVID-19, doctors have blasted its distribution model; overwhelmed hospitals have missed out on deliveries while clinics in regions with lower case counts

received ample supply.

• 28 July

• Moderna's 2020 delivery of a safe and effective coronavirus vaccine is a "stretch goal," National Institutes of Health director Francis Collins said, "but it's the right goal for the American

people." Meanwhile, NIAID director Anthony Fauci said trial results could arrive by November, December or possibly even earlier—plus, Fauci is confident in the shot's safety after reviewing

early trial data.

• But Moderna would do well to keep quiet about its trial results timeline, CNBC's Jim Cramer said. By pinning down late-stage readouts to the early fall, the Massachusetts-based biotech

could affect political decisions about stimulus packages and other measures, Cramer said. Meanwhile, Moderna execs' stock sales could portray the company in a negative light given its

massive backing from the U.S. government.

• 27 July

• Moderna kicked off its phase 3 coronavirus vaccine study across 89 U.S. clinical research sites Monday, with results expected as early as November, government and health officials said.

Patients will receive two doses of the mRNA-based shot about four weeks apart, with researchers comparing immune response between the vaccine and placebo arms two weeks after the

second dose.

• The Biomedical Advanced Research and Development Authority (BARDA) upgraded its contract with Moderna, pledging an extra $472 million to support late-stage shot development and

fund the drugmaker's 30,000-patient phase 3 vaccine trial—set to begin Tuesday, the company said. Moderna previously snagged $483 million from BARDA to support development of its

mRNA-based coronavirus vaccine


pharmaceutical supply chain… (cont.)


• 23 July

• It may take multiple doses of an approved COVID-19 vaccine to grant immunity, Bill Gates said Wednesday, which could require over 7 billion vaccinations globally. Moderna's frontrunner

shot will require two doses a month apart, and at Tuesday's Congressional hearing, AstraZeneca R&D executive Mene Pangalos said the drugmaker was eyeing multiple doses for its

University of Oxford-partnered candidate, too.

• Pfizer and BioNTech's $1.95 billion deal to supply 100 million vaccine doses to the U.S. drew ire from watchdogs, who warned that the move could lead to price-gouging later. The agreement

includes an option for 500 million more doses at an as-yet-undetermined price. AstraZeneca and Johnson & Johnson both pledged to sell vaccines at no profit to the U.S.—which has shelled

out funding for development in both cases—while Pfizer has expressed interest in making at least a marginal return on its shot.

• Sinopharm's COVID-19 vaccine candidate could roll out for public use by the end of the year, China reported Wednesday. In June, the state-owned firm delayed its expectations for an

approved shot until 2021, citing a lack of trial participants at home. Since then, Sinopharm launched a 15,000-person phase 3 in the United Arab Emirates. Late-stage trials are set to wrap in

about three months, Sinopharm chairman Liu Jingzhen said.

• 22 July

• The University of Oxford's AstraZeneca-partnered COVID-19 vaccine could grant lasting immunity to the virus, but patients will likely need two initial doses and one to two annual boosters

after that, Vaccitech CEO Bill Enright told FiercePharma.

• Brazil aims to lock down doses of Moderna's mRNA vaccine hopeful, and talks with the U.S. biotech are already underway, the country’s interim Health Minister Eduardo Pazuello said. Brazil

has another deal in place to secure 30 million doses of AstraZeneca and the University of Oxford's shot.

• Japan's health ministry gave low-cost steroid dexamethasone the OK for use in COVID-19 patients. The drug, first shown to slash death rates in hospitalized COVID-19 patients in a widely-

publicized U.K. trial, joins Gilead Sciences' remdesivir as the second treatment approved by Japan against COVID-19.

• 20 July

• AstraZeneca and the University of Oxford's COVID-19 vaccine candidate spurred a strong immune response in a phase 1 trial that enrolled over 1,000 patients, data published Monday in the

Lancet showed.

• Mylan launched its generic form of Gilead Sciences' remdesivir in India Monday, marketed under the name Desrem. The drug is approved to treat COVID-19 in adults and children

hospitalized with severe symptoms. Indian drugmakers Cipla and Hetero Drugs have also launched licensed versions of Gilead's antiviral in the country.

• 17 July

• The European Union is hashing out advance purchase deals for COVID-19 vaccines with Moderna, Sanofi, Johnson & Johnson, CureVac and BioNTech, two E.U. sources told Reuters. The

news comes on the heels of a deal in June between four European nations and AstraZeneca to secure 400 million doses of the drugmaker's vaccine hopeful. The E.U. is reportedly furthest

along in talks with J&J, already working out dose counts. Meanwhile, Sanofi, with the aid of GlaxoSmithKline, aims to provide the bloc with 300 million doses of its shot in the second half of

2021.




• 16 July

• Executives and directors from Moderna have sold about $171 million in shares since the start of the year, CNBC reported, far outstripping other companies involved in researching COVID-19

drugs and vaccines.

• With phase 1 data on Moderna's mRNA vaccine candidate now available, UBS analyst Navin Jacob thinks Pfizer and BioNTech's rival mRNA shot could still be competitive: While Moderna's

shot proved most effective at the 100mcg dose, BioNTech's vaccine performed well at 10-35% of that dose. Paired with Pfizer's vaccine manufacturing brawn, the partners' shot has a better

chance at meeting global demand, Jacob figures.

• 15 July

• Moderna's mRNA vaccine candidate triggered "robust" levels of neutralizing antibodies in coronavirus patients, newly published phase 1 data show, but some side effects showed up, too.

Forty-five patients were given two injections of the vaccine—at three different dose levels—two weeks apart, with those on the 100 microgram dose yielding the highest antibody count when

compared against a control group of 38 people who recovered from the disease. Now, Moderna is ramping up for a 30,000-participant, phase 3 trial later this month, with plans to recruit

participants from the U.S. states hardest hit by the virus.

• A $99 million federal investment breathed new life into remdesivir early on in the pandemic, but taxpayers are being repaid with "price gouging," Rep. Lloyd Doggett said in a Wall Street

Journal op-ed. Last month, Gilead set its price for remdesivir at $520 per vial, or $3,120 for a five-day course, in a move that the president of cost watchdog group ICER called "responsible."

While Gilead also revealed a lower price for the full course under certain government programs, Doggett has called that initiative "misleading," as it excludes patients on Medicare, Medicaid,

private insurance and those who are uninsured.

• 13 July

• Jefferies analysts pegged Moderna's coronavirus vaccine candidate for a likely approval early next year and figure it could rake in billions in sales, too. The analysts predict 50 million people

will get the vaccine in 2021 at $50 per dose, netting Moderna about $2 billion in 2021 and $5 billion over the next few years. But if the shot doesn't work, the company's stock would be "hit

hard," they warned. Moderna's mRNA-based candidate is slated to enter phase 3 testing this month.

• Swiss contract manufacturer Lonza said Monday that it had licensed its gene expression system to China's Junshi Biosciences to produce its neutralizing COVID-19 antibody, JS016, which

entered an early-stage safety trial in June. Junshi is co-developing its antibody candidate with Eli Lilly and will head up clinical testing in China while Lilly tackles trial work elsewhere. Warp

Speed finalist Moderna tapped Lonza in May for a 10-year manufacturing agreement to churn out doses of its mRNA vaccine candidate.

• Analysts and health officials continued questioning Gilead Sciences' decision to release data on remdesivir Friday that compared clinical trial data with a historical, standard-of-care patient

cohort. Former FDA commissioner Scott Gottlieb called the results encouraging but said they "[need] to be confirmed in a prospective trial." Meanwhile, Raymond James analyst Steven

Seedhouse said, "The aggregate clinical data still pretty clearly point to an inconclusive impact on survival at best.”

• 10 July

• Gilead Sciences released new data Friday showing its antiviral remdesivir slashed death rates by 62% compared with standard treatment, but health experts aren't convinced. Gilead

compared 312 patients dosed with remdesivir in its phase 3 SIMPLE trial against a historical cohort of 818 patients with similar disease severity on "standard of care," but because that

comparison wasn't performed in a controlled trial, the numbers are "deeply flawed," one expert said. Gilead itself said the findings "[require] confirmation in prospective clinical trials."




• 9 July

• Officials from Merck, Moderna, Pfizer, AstraZeneca and Johnson & Johnson plan to testify before the House's Oversight and Investigation Subcommittee on July 21 to discuss their progress

on a COVID-19 vaccine. The companies are also expected to share info on upcoming plans to market and distribute those shots should they pass muster in the clinic.

• Moderna tapped contract manufacturer Laboratorios Farmacéuticos Rovi to complete fill-finish work on its mRNA vaccine candidate. Rovi will carry out the work at its Madrid, Spain, facility,

and plans to ramp up a new production line and buy new equipment to help Moderna meet its goal to churn out hundreds of millions of shot doses for deployment outside of the U.S. by early

2021. Rovi will also recruit additional staff to meet the new manufacturing demand.

• Gilead Sciences dosed the first patients in a phase 1a trial studying an inhaled formulation of remdesivir for early stage COVID-19. The drugmaker aims to recruit about 60 U.S. patients aged

18 to 45 for the trial, which will compare a nebulized version with placebo. Delivering remdesivir straight to the lungs could cut the risk of side effects and expand its use to outpatients, Gilead

said; remdesivir is currently given to hospital patients intravenously.

• Gilead plans to boost worldwide production of remdesivir to supply the antiviral in Europe based on each country's rate of infection, the company's German managing director Bettina Bauer

said. Talks are already underway with the German government, Bauer told German business magazine WirtschaftsWoche. The drugmaker aims to ramp up its monthly supply from 190,000

treatment cycles to 2 million by December, she said.

• Indian drugmaker Cipla has deployed its version of remdesivir in the country, setting the sticker price at INR 4,000 per 100mg vial, or about $53.38—one of the lowest prices globally. For

comparison, Mylan has capped its generic form of the drug at INR 4,800 ($64.05) per 100mg vial, while Hetero set a maximum retail price of INR 5,400 ($72.06). Cipla aims to dispense

80,000 vials in the first month, and will make them available through government and hospital channels, CEO Nikhil Chopra said.

• 8 July

• Cipla announced that its version of remdesivir is slated to hit Indian markets in the next few days. Cipla partnered with Mumbai-based BDR Pharma to manufacture the drug, which in turn

sub-contracted Sovereign Pharma to complete fill-finish work. The partners haven't said how much they plan to ship, but Sovereign said it can scale up to 95,000 vials per month.

• 7 July

• Moderna's shares dropped 5% last week when news surfaced that it might delay the launch of its phase 3 vaccine trial due to protocol changes. Now, some of those potential hiccups have

come to light: Moderna sparred with government experts over how to run its trial, sought a lower bar for approval than the 50% efficacy rate outlined by the FDA, and submitted trial protocols

late, three sources close to the vaccine project told Reuters. Moderna has dismissed the snags as "differences of opinion."

• 6 July

• The European Commission granted a conditional OK for Gilead's remdesivir to treat COVID-19 patients 12 years and older with pneumonia requiring oxygen support. The conditional

approval is good for one year, but the commission may extend it if the drug shows promise in trials testing it in younger patients and in earlier stages of the disease.




• https://en.wikipedia.org/wiki/Timeline_of_the_2019%E2%80%9320_Wuhan_coronavirus_outbreak

• https://www.seattletimes.com/seattle-news/health/coronavirus-timeline-how-the-outbreak-unfolded/

• https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6

• https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports

• https://www.pharmaceutical-technology.com/news/coronavirus-a-timeline-of-how-the-deadly-outbreak-evolved/

• https://www.cphi-online.com/updated-covid19-pharma-tracker-news082415.html

• https://www.dgs.pt/em-destaque.aspx

Sources

https://en.wikipedia.org/wiki/Timeline_of_the_2019%E2%80%9320_Wuhan_coronavirus_outbreak

https://www.seattletimes.com/seattle-news/health/coronavirus-timeline-how-the-outbreak-unfolded/


https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports

https://www.pharmaceutical-technology.com/news/coronavirus-a-timeline-of-how-the-deadly-outbreak-evolved/

https://www.cphi-online.com/updated-covid19-pharma-tracker-news082415.html

https://www.dgs.pt/em-destaque.aspx

josé luis pires sars-cov-2 report 7 august 2020 · 8/7/2020 · new cases vs 7-day average ......

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