jurnal chd.pptx

8/11/2019 jurnal chd.pptx

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DOSE RESPONSE BETWEEN

PHYSICAL ACTIVITY AND RISK

OF CORONARY HEART DISEASE

A META ANALYSIS


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No reviews have quantified the specific

amounts of physical activity required for

lower risk of coronary heart disease (CHD)

when assessing the dose response relation.

Previous reviews have used, instead,

qualitative estimates such as low, moderate

and high physical activity.

BACKGROUND


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METHODS

Meta-Analysis of Observational Studies in Epidemiology

(MOOSE)

The final collection of selected articles was chosen based

on the following a priori inclusion criteria : the article,

published in English between January 1, 1995 and July 31,

2009, reported a prospective cohort study among human

adults that measured effect sizes (relative risk) of CHD by

level of physical activity. All types of physical activity,

including leisure time physical activity (LTPA), time spent

walking, walking pace, occupational physical activity,

transport physical activity, non-leisure physical activity

and total physical activity were include.


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Exclution criteria : articles from the main

analysisi studies wherein all participants were

diabetic at baseline

Generelized least squares (GLST) regression

models was used to assess the pooled dose-

response relation between physical activity

and risk of CHD across prospective cohort

studies that had heterogeneous

categorizations of physical activity


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Splint models was used to conduct GLST amalyses for

LTPA which allowed the relation between physical

activity and CHD to vary across the range of physical

activity dose in kcal/wk, but assumed linier relations

between designated dose

Guidelines from the 2008 US Physical Activity

Guidelines were used to assign the first two dose of

physical activity at which to assess relative risk.

STATA 10.0 (College Station, TX), with two tailed

alpha set at p


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RESULTS

Highest to the lowest categories of physical activity using

random effect pooled relative risk, the majority of

physical activity types were associated with significantly

lower risk of CHD, which varied between 6 and 51

The majority of physical activity types, the relative risk

among the most active women was lower than the

corresponding value among men by approximately 0.10.

among all studies that assessed LTPA, those conduucted

in men showed a 22 lower risk comparing most with

least active; in women, a 33 lower risk


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Relation between quantitative estimates of

LTPA in kcal/wk and CHD risk :

Individuals who met the basic guidline had a 14

lower risk of CHD than those who engaged in no

LTPA

Those who met the advanced guidline had a 20

lower risk

Those with higher physical activity levels there

was a 25 lower risk for those active at five times

the basic guideline

Person who were physically active at half the

basic guideline level had a 14 lower risk of CHD


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Significant interaction by gender

Men who met basic and advanced guidelines

were at 9 and 18 lower risk of CHD than men

with no LTPA. There was a 21 lower risk among

men who were physically active at five times the

basic guideline.

Women who met the basic guideline were at 20

lower risk of CHD than women who engaged in

no LTPA, women who met advanced guideline

28 lower risk.


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CONCLUSIONS

These findings provide quantitative data

supporting US physical activity guidelines that

stipul te

some physic l ctivity is better th n

none nd ddition l benefits occur with more

physic l ctivity


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