Knowledge Exchange

at

INSTITUT PASTEUR

INSTITUT PASTEUR NETWORK

France / US Comparison2003-2005

Name of InstitutionCumulative

Adjusted

Gross

Income

License

Income

Emory Univ. $621,5 $585,6

Pasteur Institute $752,0 $156,0

New York Univ. $3,285,9 $133,8

Univ. Of California System $222,9 $92,9

Wake Forest Univ, $103,5 $49,9

Univv. Of Wisconsin at Madison N.A. $49,1

Univ. Of Minnesota $129,3 $47,1

Univ of Florida $112,9 $40,3

Massachussets Inst. Of Technology (MIT) $85,1 $39,8

Univ of Rochester $90,9 $30,5

Univ of Washington $78,7 $29,3

Univ. of Massachusetts $74,2 $28,3

Hardward Univ. $54,3 $28,0

Univ, of Colorado $64,5 $27,3

Michigan State Univ. $84,4 $23,8

Eastern Virginia Medical School $21,1 $20,3

BUSINESS DEVELOPMENT DATA

• A portfolio including more than 3,800 patents

• >200 licensing agreements signed with Industry

• 20 R&D contracts signed with Industry each Year

• 10 to 15 new license agreements each year

in 2007

Patents 2007

Disclosures of Invention 88

Patent application filings 30

Patents granted 61

Patent Filing Process (2007)

NUMBER OF PATENT FAMILY PORTFOLIOS

YEARS 2005 2006 2008

454 467 480

FAMILY PORTFOLIOS

INSTITUT PASTEUR

BUSINESS DEVELOPMENT

TYPES OF AGREEMENTS

•LICENSING CONTRACTS

•PRIVILEGED PARTNERSHIPS

(Bio-Rad, Sanofi Aventis, Sanofi Pasteur, Hybrigenics)

•RESEARCH TRANSVERSAL PROGRAMS

•RESEARCH & DEVELOPMENT CONTRACTS

•SUPPLY AGREEMENTS

•SERVICE AGREEMENTS

•MATERIAL TRANSFER AGREEMENTS

•CONSULTANCY AGREEMENTS

BUSINESS DEVELOPMENT PARTNERS

•Major companies (Abbott, Astra Zeneca,

Athena Diagnostics, Sanofi Aventis, Sanofi

Pasteur, Bayer, Bio-Rad, BioMerieux, Fort

Dodge, Genzyme, Merial, Procter & Gamble,

Danone, L'Oreal, St Gobain, Siemens, Servier,

GlaxoSmithKline, Roche, Vivendi, Novartis...)

•Biotechs companies

•Spin-off and Start-Up companies

Direction DARRI 2p

COS*

4 p

Teams up with Legal Dept

Pasteur BioTop

2 pBack Office

SAI 4 p

Office of Patents

& Inventions

SBI 9 p

Office of Licensing

& Partnering

STT 10 p

Direction des Applications de la Recherche et

des Relations Industrielles (DARRI)

Or Department of Knowledge Exchange (DKE)

31 people

* With 15 representatives within research departments

D A R R I

Research Labs

in Paris and

within the Network

SAB &

Scientific Liaison

Office of Patents

and InventionsOffice of

Licensing and Partnering

Patenting and Licensing

process

Disclosures

of Invention

Patenting

Market Studies

Industry

BioTechs and Pharma

Licensing

IP Review Scientific due-diligence

Decision

Periodic Review

Economic and

Social world

Missions of Department of

Knowledge Exchange (DARRI)

DARRI

Gal

ManagementInternational

Dept

Medical

Dpt

Scientific

Departments

BioMarkers

Missions for DKE

Identification, among Institut Pasteur's research, of results to

be transferred for development to the industry,

Identification of needs of knowledge within the industry to

set-up knowledge exchange programs,

IP Protection of the results of these programs,

License applications from pure research to the industry or

"start-ups",

Creation of value for Institut Pasteur by launching "start-

ups" derived from Pasteur research incubated at Pasteur

BioTop,

FDA new drug approvals

and Phase 3 failures,

2006-2007

• From: The Future of

Targeted Therapeutics.

Source: Nature reviews,

drug discovery

• Created for Institut

Pasteur user, Institut

Pasteur (Site License

Paris). IP Address:

82.225.247.220

• © Business Insights

Limited, 2008

Older R&D model in the industry

Do not change anything, so far it has

worked so well for us!

Clinical Pharmacology

Tradition

Marketing

Toxicology

Clinical Research

originalTranslational Medicine

/Customized design

Innovation

Modeling and Simulation

Driving decision-making process

System Biology

Understanding complexity

Biomarkers

Relevant tools

New R&D model

Innovation

truly at its coreTranslational research

jumps in

The more you spend, the

less you deliver

The new process of

Knowledge Exchange

All biopharma companies, during any research process, at

some time or another, will have to deal with stumbling blocks

based on a need for further knowledge.

In order to deal with these deadlocks, the most effective

approach for academic and industrial partners is to work

together on common research strategies and define domains of

common interest.

These Knowledge Exchanges create a wider domain of

knowledge and focuses on basic research, rather than simply

resolving a single R&D problem.

Global Research Programs

implementation

At the beginning of the Knowledge Exchange process,

potential partners meet with Institut Pasteur scientists to

identify their common areas of research, define their goals

and targets, and understand the motivation behind the process.

Institut Pasteur then identifies research units from within its

network to work with the industrial partner, and facilitates

discussions and brainstorming between its scientists and

partner scientists to define Global Research Program.

Because of the commitment required by both sides, Global

Research Programs need to last around three to five years

and have budgets of € 3-5 million. Discoveries can be patent

protected and subsequently, R&D collaborations can follow.

The Quest for the Grail

Potential

Partners

The difficult birth of R&D collaboration

Pasteur internal

due diligence

Research Programs

Design of

Development

programs

The search for an

"interested" partner

Common

brain storming

Joint design of

Research Programs

Understanding

domains of

common interest

"interested" partner with

knowledge deadlock

Knowledge Exchange

The more valuable design of

a Global Research Program

Strategic

Partner