kuliah 1. effector mechanism - versi ringkas 2013

7/26/2019 Kuliah 1. Effector Mechanism - Versi Ringkas 2013

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MEKANISME EFEKTOR

SISTEM IMUNTonang Dwi Ardyanto

FK UMS April 2013


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Pl! t"or #$ll!


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AP%


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Figr$ 1&1'Macrophages engulf bacteria and produce

inflammatory cytokines


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("oral E))$#tor

M$#*ani!"


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Consequences of Antibody Binding


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Consequences of Antibody Binding


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Effector Functions of Antibodies


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Neutralization of Microbes by Antibodies


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Neutralization of Toins by Antibodies


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Antibody!"ependent Cellular Cytotoicity #A"CC$


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Functions of Complement


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Antibody %esponse After Eposure to

Antigen


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%$lllar E))$#tor

M$#*ani!"


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Types of T cells&' T (elper #T($ Cells) Central role in immune response

+ Most are C"*+

+ %ecognize antigen on the surface of antigen presenting cells #e'g')macrophage$'

+ Acti,ate macrophages

+ -nduce formation of cytotoic T cells

+ .timulate B cells to produce antibodies'

T Cells and Cell Mediated

-mmunity


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Types of T cells #Continued$/' Cytotoic T #Tc$ Cells) "estroy target cells'

+ Most are C"* negati,e #C"*!$'

+ %ecognize antigens on the surface of all cells)

+ 0ill host cells that are infected 1ith ,iruses or bacteria'

+ %ecognize and kill cancer cells'

+ %ecognize and destroy transplanted tissue'

+ %elease protein called perforin1hich forms a pore in target cell2

causing lysis of infected cells'

+ 3ndergo apoptosis 1hen stimulating antigen is gone'


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Central %ole of (elper T Cells


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T Cells 4nly %ecognize Antigen Associated

1ith M(C Molecules on Cell .urfaces


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EFFE%TOR OPTIONS OF %D, AND

%D' T %E--S FO--O.IN/ ANTI/EN A%TIATION

+ %D, #o""itt$d to $#o"ing #ytotoi# $))$#tor #$ll!

+ %D' T #$ll! #an di))$r$ntiat$ along two pat*way!+ T(1 or T(2

+ M$#*ani!"! o) di))$r$ntiation not w$ll nd$r!tood+ Mo!t i""n$ r$!pon!$! inol$ ot* T(1 and T(2

+ %D' T(1 #$ll! *$lp wit* #$ll&"$diat$d i""n$ r$!pon!$

+ %D' T(2 #$ll! *$lp wit* *"oral i""n$ r$!pon!$


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Spoplation! o) T* %$ll!

+ Spoplation!a!$d on #yto4in$pro)il$!+ T*0

+ T*1+ T*2

+ Di))$r$ntiationd$t$r"in$d y#yto4in$!+ In)l$n#$d y antig$n

+ I-&' & T*2 #$ll!+ I-&12 5 T*1#$ll!


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Spoplation! o) T* %$ll!

+ T*1 #$ll #yto4in$!+ A#tiat$ "a#rop*ag$!

+ /$n$ration o) T#

+ T*2 #$ll #yto4in$!+ A#tiat$ o) 6 #$ll!

+ A#tiat$ granlo#yt$!

+ R$glation

Antig$nINF&7 in*iit!

proli)$ration o) T*2 #$ll!

I-&10 in*iit! prod#tion

o) INF&7


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%D' T %E-- RESPONSE TO M8%O6A%TERIUM

-EPRAE

+ My#oa#t$ri" l$pra$ i! an intra#$lllar pat*og$n9 ag$nt

o) l$pro!y and dir$#t! $it*$r T(1 or T(2 r$!pon!$

+ Mo!t $))$#ti$ i""n$ r$!pon!$ i! "$diat$d y T(1 #$ll!

+ I""n$ r$!pon!$ "$diat$d y T(1 #$ll! r$!lt! in+ Tuberculoid leprosy

+ I""n$ r$!pon!$ "$diat$d y T(2 #$ll! r$!lt! in+ 5epromatous leprosy


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/$n$ration o) %T-!

+ Di))$r$ntiat$ in

r$!pon!$ to two

!ignal!+ Sp$#i)i# antig$n

a!!o#iat$d wit* #la!!I M(% "ol$#l$!

+ %yto4in$! prod#$d

y T*1 #$ll!


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F$atr$! o) %T- Killing

+Antig$n !p$#i)i#+ Targ$t #$ll "!t $ar t*$ !a"$ antig$n a!!o#iat$d wit* #la!! I M(%

a! did t*$ pr$&%T-

+ R$:ir$! #$ll #onta#t

+ En!r$! t*at n$ary #$ll! ar$ not 4ill$d

+ %T-! ar$ #apal$ o) 4illing "any targ$t!+ %T-! ar$ not in;r$d w*$n t*$y 4ill a targ$t

.teps in CT5 0illing


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.teps in CT5 0illing

Tc cell

1. Tc recognizes antigen on

target cellTarget cell

Tc cell

2. A lethal hit is delivered by

the Tc using agents such asgranzymes or TNF

Target cell

Tc cell

3. The Tc detaches

from the target cellTarget cell

4. Target cell dies

by apoptosis

Target cell


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M$#*ani!"! o) %T- Killing

+%T- granl$&"$diat$d 4illing

+ /ranl$! #ontaining p$r)orin and

gran $nt$r

t*rog* #*ann$l! and a#tiat$ #a!pa!$!

r$!lting in apopto!i!


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Cytotoic T Cells 5yse -nfected Cells


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%T-&Killing


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Figr$ 1&2?iral antig$n pr$!$ntation to %D,@ T #$ll! ia M(% #la!! I "ol$#l$!


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%8TOTOINS AND %8TOKINES OF T %E--S

+ T #$ll! ar$ di!tingi!*$d y+ Cytokines and cytotoins produced and the effects on

immune response

+ %D' T #$ll! prod#$ and a#t pri"arily t*rog* #yto4in$!+ Macrophage stimulating #T(&$

+ B cell acti,ating #T(/$

+ %D, T #$ll! prod#$ and a#t pri"arily t*rog* #ytotoin!+ 6erforin and 7ranzymes


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1B Antiody Prod#tion

T&D$p$nd$nt Antig$n!C+ Antiody prod#tion r$:ir$! a!!i!tan#$ )ro" T *$lp$r #$ll!B

+ A "a#rop*ag$ #$ll! ing$!t antig$n and pr$!$nt! it to T(#$llB

+ T(#$ll !ti"lat$! 6 #$ll! !p$#i)i# )or antig$n to $#o"$ pla!"a #$ll!B

+ Antig$n! ar$ "ainly prot$in! on ir!$!9 a#t$ria9 )or$ign r$d lood

#$ll!9 and *apt$narri$r "ol$#l$!B

T&Ind$p$nd$nt Antig$n!C+ Antiody prod#tion do$! not r$:ir$ a!!i!tan#$ )ro" T #$ll!B

+ Antig$n! ar$ "ainly poly!a##*arid$! or lipopoly!a##*arid$! wit*

r$p$ating !nit! =a#t$rial #ap!l$!>B

+ .$a4$r i""n$ r$!pon!$ t*an )or T&d$p$nd$nt antig$n!B

%elationship Bet1een Cell!Mediated and

(umoral -mmunity


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(umoral %esponse to T "ependent Antigens


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2B Antiody D$p$nd$nt %$ll M$diat$d %ytotoi#ity+ Targ$t #$ll i! #o$r$d wit* antiodi$!9 l$aing F# portion !ti#4ing

otward!B

+ Natral 4ill$r and ot*$r non!p$#i)i# #$ll! t*at *a$ r$#$ptor! )or F#

r$gion ar$ !ti"lat$d to 4ill targ$t$d #$ll!B

+ Targ$t organi!" i! ly!$d y !!tan#$! !$#r$t$d y atta#4ing #$ll!B

+ U!$d to d$!troy larg$ organi!"! t*at #annot $ p*ago#yto!$dB

%elationship Bet1een Cell!Mediated and

(umoral -mmunity

"estruction of 5arge 6arasites by A"CC


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"estruction of 5arge 6arasites by A"CC


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kuliah 1. effector mechanism - versi ringkas 2013

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