lecture 26ashipunov.me/shipunov/school/biol_310/lec_310_26.pdf · 2018-11-15 · pharmacognosy...
TRANSCRIPT
Ethnobotany
Alexey Shipunov
Minot State University
Lecture 26
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Outline
1 PharmacognosyPlant remedies for infectious and parasitic diseases
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Pharmacognosy Plant remedies for infectious and parasitic diseases
PharmacognosyPlant remedies for infectious and
parasitic diseases
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Pharmacognosy Plant remedies for infectious and parasitic diseases
Antiprotozoal and antihelminth drugs
Most of these diseases are restricted to tropicsSometimes, control on the transmission is much more effectivethan any treatments
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Pharmacognosy Plant remedies for infectious and parasitic diseases
Cinchona, Cinhona spp., Rubiaceae, South America
Cinchonae cortexQuinoline alkaloids, such as quinine toxic to malarian parasite butin large doses also to humansExtremely bitter
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Pharmacognosy Plant remedies for infectious and parasitic diseases
Cinchona
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Pharmacognosy Plant remedies for infectious and parasitic diseases
Quinine
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Pharmacognosy Plant remedies for infectious and parasitic diseases
Lapacho, Tabebuia spp., Bignoniaceae, SouthAmerica
Large tropical trees, inner bark is usedNapthoquinones, especially lapachol are active against multipleprotozoan diseases and even cancers; cytotoxic in big doses
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Pharmacognosy Plant remedies for infectious and parasitic diseases
Tabebuia
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Pharmacognosy Plant remedies for infectious and parasitic diseases
Lapachol
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Pharmacognosy Plant remedies for infectious and parasitic diseases
Sweet wormwood, Artemisia annua, Compositae,China
Small annual herb, leaves and stems are usedSesquiterpenes like artemisinin are active against malarianparasite, PlasmodiumNon-toxic (!)
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Pharmacognosy Plant remedies for infectious and parasitic diseases
Sweet wormwood
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Pharmacognosy Plant remedies for infectious and parasitic diseases
Moringa, Moringa oleifera, Moringaceae, South Asia
Large tropical tree with edible leaves and oil-containing seedsContains multiple active compounds like alkaloid spirochin withantibacterial and antihelminth effects
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Pharmacognosy Plant remedies for infectious and parasitic diseases
Moringa
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Pharmacognosy Plant remedies for infectious and parasitic diseases
Wild bergamot, Monarda fistulosa, Labiatae, NorthAmerica
Prairie herb with large clusters of flowersContains rich set of essential oils: thymol, pinene, carvacrol,antibacterial and antihelminth
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Pharmacognosy Plant remedies for infectious and parasitic diseases
Wild bergamot
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Pharmacognosy Plant remedies for infectious and parasitic diseases
Carvacrol
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Pharmacognosy Plant remedies for infectious and parasitic diseases
Antiviral, antibacterial and antifungal agents
Unlike antibiotics, have a broad spectrum of activityMost of them can be taken in form of herbal teas (like balm teafrom Melissa)
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Pharmacognosy Plant remedies for infectious and parasitic diseases
Garlic, Allium sativum, Amaryllidaceae, Eurasia
(Covered previously)Contains allicin, and different diallyls
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Pharmacognosy Plant remedies for infectious and parasitic diseases
Tea tree, Melaleuca alternifolia, Myrtaceae, Australia
Melaleucae atheroleumMedium-sized tree from north-west coast of AustraliaOils (in form of tea) are widely used as antiseptics: contain cineoleand other essential oil monoterpenes
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Pharmacognosy Plant remedies for infectious and parasitic diseases
Melaleuca, tea tree
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Pharmacognosy Plant remedies for infectious and parasitic diseases
Urinary tract infections (cystitis)
Majority of women have some form of this infectionPlant remedies are often work better because they do not haveside effects (however, they are not recommended to patients withblood problems)
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Pharmacognosy Plant remedies for infectious and parasitic diseases
Bearberry, Arctostaphylos uva-ursi, Ericaceae, NorthHemisphere
Uvae ursi foliumSmall prostrate evergreen shrubTraditionaly used in cystitis; glycoside arbutin and its derivativeshave stable antimicrobial activity
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Pharmacognosy Plant remedies for infectious and parasitic diseases
Bearberry
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Pharmacognosy Plant remedies for infectious and parasitic diseases
Arbutin
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Pharmacognosy Plant remedies for infectious and parasitic diseases
Cranberry, Vaccinium macrocarpon, Ericaceae, NorthAmerica
Minuscule shrub from bogs and coastsContains anthocyanins which are suspected to be activecompounds: cranberry juice suppresses urinary infections
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Pharmacognosy Plant remedies for infectious and parasitic diseases
Insecticidal agents
Most derived from terpenoids and essential oilsAlkaloids like veratridine (from Veratrum spp.) were used in thepast but now abandoned due to toxicity
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Pharmacognosy Plant remedies for infectious and parasitic diseases
Pyrethrum, Chrysanthemum/Tanacetum spp.,Compositae, North America
Multiple herb species, all contain pyrethrin widely used as a spray,for fumigation etc.Synthetic pyrethrins are often subjects for increased resistancefrom insects
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Pharmacognosy Plant remedies for infectious and parasitic diseases
Pyrethrum
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Pharmacognosy Plant remedies for infectious and parasitic diseases
Pyrethrin
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Pharmacognosy Plant remedies for infectious and parasitic diseases
Quassia, Picrasma excelsa and Quassia amara,Simaroubaceae, Japan and Central America
Wood of these trees is normally used (e.g., for smoke)Quassinoids like quassin are not only insecticides but alsoanthyheminth and antibacterial drugs
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Pharmacognosy Plant remedies for infectious and parasitic diseases
Quassia
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Pharmacognosy Plant remedies for infectious and parasitic diseases
Quassin
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Pharmacognosy Plant remedies for infectious and parasitic diseases
Summary
Plant quinones and essential oils tend to be antimicrobial
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Pharmacognosy Plant remedies for infectious and parasitic diseases
For Further Reading
A. Shipunov.Ethnobotany [Electronic resource].2011—onwards.Mode of access:http://ashipunov.info/shipunov/school/biol_310
Heinrich et al. 2012.Fundamentals of Pharmacognosy and Phytotherapy.Churchill Livingstone, Edinburgh.
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