lonza’s pivot - osisoft...accelerate optimization projects “collecting, cleansing and analyzing...

#PIWorld ©2019 OSIsoft, LLC

Lonza’s PIVOTProductivity Improvements via Operations Technology

Isabelle Lacaille

Data Infrastructure Engineer

Specialty Ingredients | Isabelle Lacaille | 18 September 2019 2

Agenda

Who is Lonza Specialty Ingredients?

The Challenge: Data Visibility

PIVOT: Productivity Improvements via Operations Technology

Results and Beyond

Conclusion

PIVOT Pilot: RCIP (Red Carpet Incubation Program)

Implementing PIVOT (post-RCIP)


Agenda




Results and Beyond

Conclusion



Lonza at a Glance

4

1Lonza Continuing Operations

excluding Water Care business as

discontinued operations

CORE definition: See appendixSpecialty Ingredients | Isabelle Lacaille | 18 September 2019

Lonza at a Glance

Capitalizing on our global footprint (overview of our manufacturing and R&D sites and our sales offices)

5Specialty Ingredients | Isabelle Lacaille | 18 September 2019

Lonza Specialty Ingredients (LSI)

◼ Microbial Control Solutions for

◼ Consumer home & personal care

◼ Professional hygiene

◼ Paints, coatings, wood and industrial material

protection

◼ Crop protection

◼ Enabling Technologies

◼ Fine Chemistry

◼ White Biotechnology

Lonza Pharma Biotech & Nutrition (LPBN)

◼ Drug substance and drug product

development and manufacturing for

◼ Chemicals – small molecules

◼ Biologics – large molecules

◼ Biologics – cell and gene technologies

◼ Consumables and research tools

◼ Consumer health and nutritional

ingredients and delivery systems

6

Lonza – The Structure

Since 1 March 2019, the scope of segments has been aligned. The former Pharma & Biotech segment and the former Consumer Health & Nutrition business unit within the Consumer Health division (formerly part of Lonza Specialty Ingredients) are now combined in the Lonza Pharma

Biotech & Nutrition (LPBN) segment. The former Consumer Product Ingredients business unit (formerly part of the Consumer Health division within Lonza Specialty Ingredients) remained part of the Specialty Ingredients segment.

Specialty Ingredients | Isabelle Lacaille | 18 September 2019

Delivering Innovation in Microbial-Control Applications

Specialty Ingredients’ focus on strengthening its market leadership

Keeping our World Healthy® Regulatory Support Bioactives

New additions to regulated

Professional Hygiene offerings

Introduction of hydrogen

peroxide-based hard surface

disinfectants and FDA-approved

non-alcohol hand sanitizers

Introduction of microbial-control alternatives, e.g. Triclosan-free antibacterial personal care, Creosate-free protection for timber, regulatory approved fungicides for open system metalworking fluids

7

Next Generation Antidandruff Active

Strengthening position as world’s

leading antidandruff active

supplier

Commenced manufacturing of

Piroctone Olamine (PO) to

broaden portfolio

Product launches for personal

care “aspirational” consumers

Introduction of naturally derived

polyglycerol esters for non-ionic

emulsifiers and surfactants, and

bioactives for scalp and skin

7

Some recent examples



Agenda




Results and Beyond

Conclusion




Overcoming Data Challenges in a global Organization

Conley, GA

Williamsport, PA

Mapleton, ILRochester, NY

Salto, BR

Visp, CH

Kouřim, CZ

Nanjing, CN

Suzhou, CN

Huddersfield, UK

New Plymouth, NZ

Production Site

Process Optimization Group



Conley, GA

Williamsport, PA


Salto, BR

Kouřim, CZ

Nanjing, CN

Suzhou, CN

Huddersfield, UK

Visp, CH

New Plymouth, NZ

Production Site


1. Accelerate optimization projects

“Collecting, cleansing and

analyzing the data for this

project will take months…”



Conley, GA

Williamsport, PA


Salto, BR

Kouřim, CZ

Nanjing, CN

Suzhou, CN

Huddersfield, UK

Visp, CH

New Plymouth, NZ

Production Site



2. Identify & evaluate new opportunities

“I have a gut feeling we could

improve productivity here…”



Conley, GA

Williamsport, PA


Salto, BR

Kouřim, CZ

Nanjing, CN

Suzhou, CN

Huddersfield, UK

Visp, CH

New Plymouth, NZ

Production Site




3. Empower local sites with tools

“We don’t have visibility

into our own process!”



Conley, GA

Williamsport, PA


Salto, BR

Kouřim, CZ

Nanjing, CN

Suzhou, CN

Huddersfield, UK

Visp, CH

New Plymouth, NZ



3. Empower local sites with tools

4. Increase overall visibility

Production Site

Process Optimization Group“We need to know the situation at every site”


Agenda




Results and Beyond

Conclusion




Before PIVOT

Raw Data collection

EX

PE

RT

time

Cleansing and

Analysis

Expert Knowledge

Process development

Execution/

Benefit generation

Travelling

Remote Plant Process Experts

Execution

Remote Support

Context

Data Collection

Data Cleansing

Analysis


PIVOT Concept

Raw Data collection

EX

PE

RT

time

Cleansing and

Analysis

Expert Knowledge

Process development

Execution/

Benefit generation

TravellingContext

Data Collection

Data Cleansing

Information

Analysis-ready data

Real-Time Data

Historical Data

Dashboards

Reports

Datasets

Analysis Tools

OT

OT

Remote Plant Process Experts

Additional Context

Analysis Results

Data Visualization

Reports


Agenda




Results and Beyond

Conclusion



◼Validate the technology

◼Evaluate the potential of a use case


What is an RCIP?

Joint offering by Microsoft and OSIsoft to jumpstart a data science initiative

Installation

Data Collection

Data Preparation

Visualization

Data Exploration

Data Cleansing

Data Selection

Modelling

2-day workshop


RCIP Use Case

Conley, GA

Williamsport, PA

Rochester, NY

Salto, BR

Visp, CH

Kouřim, CZ

Nanjing, CN

Suzhou, CN

Huddersfield, UK

New Plymouth, NZ

Mapleton, IL Visp, CH

Kouřim, CZ

Nanjing, CN

Suzhou, CN

Huddersfield, UK

New Plymouth, NZ

Business Objective:

Shift production away from older, more expensive reactor system by

increasing capacity in newer reactor systems

Data Science Objective:

Create a model of batch time, understand batch time variance to ultimately

reduce average batch time

R-540

R-560

&

R-561

R-2101 R-2121

Product A

Product B


RCIP Outcomes

Data Contextualization

Asset Hierarchy

Event Context

Asset Context

X23X23

X24

X25

X26

X27

X28

X29

X30

X31

X32

X33

X34

X35

X36

X37


RCIP Outcomes

Solving Data Challenges

Challenge: Batch time included idle time

Batch is “Active”, but reaction is complete

Batch Active

Mass

Temperature

Pressure

Reactant Flow


RCIP Outcomes

Solving Data Challenges

Challenge: Batch time included idle time

Solution: Use asset analytics to capture sub-batch operations

Compare true reaction time between batches *we’ll come back to this later!

Identify opportunities for

increased productivity*

◼ Increase in reaction time near

the end of 2016

◼ Root cause: removed trays in

distillation column never

replaced

◼ No production disruption,

coincided with start-up of

second reactor system


RCIP Outcomes

Discovered optimization potential


Agenda




Results and Beyond

Conclusion




Infrastructure & Tools Needed for PIVOT

• Local Historian

• Control Systems

Lab Data

• IIoT

Global PI System Infrastructure

PI Vision SEEQ Power BI Unscrambler


Roles & Skills Needed for a successful PIVOT

Knowledge gaps identified during RCIP

OT & Automation Data Engineering Data Science

Development Skills Process Knowledge Chemistry Knowledge


Agenda




Results and Beyond

Conclusion




Overcoming Data Challenges in a global Organization!

Conley, GA

Williamsport, PA


Salto, BR

Visp, CH

Kouřim, CZ

Nanjing, CN

Suzhou, CN

Huddersfield, UK

New Plymouth, NZ

Accelerating optimization projects

Identified & evaluating new opportunities

Empowering local sites with tools

Increased overall visibility

For more information, attend our second presentation!Journey Deploying Data Analytics for Manufacturing Insights

Tobias Merz & Brian Crandal (SEEQ)

13:45 - 14:30 Life Sciences Track


Accelerating Process Optimization Projects

Example: Mapleton Batch Time Reduction

Opportunity #1: Optimize

temperature increase during

reaction

◼ Data mining revealed golden

batches with different

temperature profile

◼ High temperature causes

evaporation of reactant, leading

to slower reaction

◼ Potential capacity increase of

15-18%

Temperature

Temperature Golden Batch

Hot Oil Flowrate

Pressure

Pressure Golden Batch

Reactant Flowrate


Accelerating Process Optimization Projects

Example: Mapleton Batch Time Reduction

Opportunity #2: Optimize timing of

reactant dosing

◼ Data mining revealed golden

batches with different pressure

profile, correlating with reactant

◼ Precise timing of reactant

dosage decreases the

occurrence of side-reactions

◼ Potential capacity increase of

16-20%

Temperature

Temperature Golden Batch

Pressure

Pressure Golden Batch

Reactant flowrate

Unit Operation


Identified & Evaluating new Opportunities

Example: Reason Codes for pounds lost during production

Long Batch, reaction complete

No visibility about the

reason!

What is the greatest

cause of lost pounds?

Idle Time between batches

Batch Active

Mass

Temperature

Pressure

Reactant

Batch Active

Mass

Temperature

Pressure

Reactant




Cycle

Cycle

X78

X45

X78

X45


Identified & Evaluating new opportunities





◼ Largest amount of lost pounds

caused by “No Storage | Other”

◼ No room for production, but

exact logistics bottleneck is

unknown

◼ Greatest opportunity is not

optimizing reaction time, but

rather logistics!

Product A Product B

#PIWorld ©2019 OSIsoft, LLC

CHALLENGES SOLUTION BENEFITS

Global Data Visibility…

▪ Accelerate optimization projects

▪ Identify & evaluate new opportunities

▪ Empower local sites with tools

▪ Increase overall visibility

36

PIVOT Initiative

▪ Strategy: Process Improvements via OT

▪ Piloted with RCIP

▪ Implemented global data infrastructure

▪ Created Operations Technology team with required skillset

Global Data Visibility!

▪ Potential capacity increase of 15-20% on two product lines

▪ Reason Codes application implemented at 3 sites

▪ SEEQ, PI Vision, Power BI used at multiple sites

▪ To be continued!

Conclusion


Disclaimer

Review and follow all product safety instructions. All information in this presentation corresponds

to Lonza’s knowledge on the subject at the date of publication, but Lonza makes no warranty as to its

accuracy or completeness and Lonza assumes no obligation to update it. All information in this

presentation is intended for use by recipients experienced and knowledgeable in the field, who are

capable of and responsible for independently determining the suitability and to ensure their compliance

with applicable law. Proper use of this information is the sole responsibility of the recipient.

Republication of this information or related statements is prohibited. Information provided in this

presentation by Lonza is not intended and should not be construed as a license to operate under or a

recommendation to infringe any patent or other intellectual property right. All trademarks belong to

Lonza or its affiliates or to their respective third parties and are used here only for informational

purposes. Copyrighted material has been produced with permissions or under license, all other

materials © 2019 Lonza.

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