1

Luis A. Diaz, M.D. Updated: January 8, 2009

Addresses: Department of Dermatology (Administration) Suite 3100 Thurston Building, CB# 7287 University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7287 Phone: 919-966-0785 Fax: 919-966-3898

Department of Dermatology (Research Office) Room 5101A Thurston Building, CB# 7287 University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7287 Phone: 919-843-7226 Fax: 919-843-5766 E-mail: ldiaz@med.unc.edu

Education: * Elementary School: (4/1/49 - 12/31/54)

Escuela Fiscal 103 Cascas, La Libertad, Perú * Escuela Fiscal # 455 Rimac , Lima, Peru

Secondary School-High School: (1955-1959) G.U.E. Ricardo Bentin, Rimac Lima, Peru

Undergraduate College: (4/1/60 - 12/31/61) Pre-Medicine (Undergraduate Diploma) Universidad Nacional de Trujillo, Peru

Medical School: (4/1/62 - 4/30/68) Facultad de Medicina, Universidad Nacional de Trujillo (Medical Degree) Trujillo, Peru

Postgraduate Training:

Rotating Internship (5/1/67 - 4/30/68) Hospital Regional Universitario Trujillo, Peru. (V. Rosell, M.D., Medical Education Director)

Residency (Internal Medicine) (7/1/68 - 12/31/69) Hospital Regional Universitario Trujillo, Peru. (R. Bocanergra, M.D., Chairman)

Internship (Medicine Major) (1/1/70 - 12/31/70) Ellis Hospital Schenectady, NY. G.L. Vlahides, M.D. (Medical Education Director)

Senior Intern (Medicine) (1/1/71 - 6/30/71) Ellis Hospital Schenectady, NY. G.L. Vlahides, M.D. (Medical Education Director)

Residency (Dermatology) (7/1/71 - 6/30/74) Department of Dermatology State University of New York at Buffalo Buffalo, NY. R.L. Dobson, M.D., Chairman

Postdoctoral Fellow (Clinical Immunology) (7/1/74 - 6/30/76) Departments of Immunology and Dermatology Mayo Graduate School of Medicine Rochester, MN. T.B. Tomasi, Jr., M.D., and R.E. Jordon, M.D.

2

Teaching Appointments:

From 7/1/71 to 6/30/74: Department of Dermatology SUNY at Buffalo Affiliated Hospitals Buffalo, NY. (R.L. Dobson, M.D., Chairman) Clinical Assistant Instructor (Dermatology) From 7/1/74 to 6/30/76: Department of Immunology and Dermatology Mayo Graduate School of Medicine Rochester, MN. (T.B. Tomasi, Jr., M.D., and R.E. Jordon, M.D.) Postdoctoral Fellow (Clinical Immunology) From 7/1/76 to 8/30/82 Department of Dermatology University of Michigan Ann Arbor, MI. (J.J. Voorhees, M.D., Chairman) * Assistant Professor (7/1/76 - 4/1/80) * Associate Professor (5/1/80 - 8/30/82)

From 9/1/82 to 6/30/88 Department of Dermatology The Johns Hopkins University Baltimore, MD. (T. T. Provost, M.D., Chairman) * Associate Professor (9/1/82 - 7/1/86) * Professor (7/1/86 - 6/30/88) * Visiting Professor (7/1/88 - 12/31/88) From 7/1/88 to 12/31/1999 Professor and Chairman Department of Dermatology Medical College of Wisconsin Milwaukee, WI (R.L. Cooper, M.D. (Former Dean) & M. Dunn, M.D., (Current Dean) From 1/1/2000 to date Clayton E. Wheeler Jr. Distinguished Professor & Chairman Department of Dermatology University of North Carolina at Chapel Hill Chapel Hill, North Carolina Jeffrey L. Houpt, M.D. (Former Dean) & William Roper M.D., MPH (Current Dean)

3

Consulting Positions:

Honors, Honor Societies, Scholastic Achievements:

*Doctor in Medicine Degree, 1968. Conferred with distinction to the five students having the highest academic rank (5th in a class of 60). Facultad de Medicina, Trujillo, Peru.

*Thesis (before obtaining medical degree) at the Facultad de Medicina, Universidad Nacional de Trujillo, Peru. "Clinical Examination and Exfoliative Cytology in Oral Cavity of Coqueros." Awarded the Merck Sharp and Dohme Prize, 1969.

*Standard Certificate from the Educational Council on Foreign Medical Doctors, #115-545-6, 1969. *Diplomate of the American Board of Dermatology, September 1974. *The Best Doctors in the USA. J. Pekkanen. Seaview Books, New York, 1979 *Diplomate of the American Board of Dermatological Immunology/Diagnostic and Laboratory Immunology, December 1987.

*Fogarty Senior International Fellowship (1988 - 1989) *City Hall Council, City of Cascas, Perú: Recognition as a Favorite Son. Annual Independence Day Celebration. July 27, 1990.

*Honorable City Hall Council, City of Trujillo, Perú. Gold Medal Recipient for excellence in biomedical research and medical education. Annual Independence Day Celebration. July 28,1990.

*1991 William Montagna Award and Lecturer, Annual Meeting Society for Investigative Dermatology, Seattle, WA, May 1991.

*Honorary Professor (Maestro Honorario): La Universidad Autónoma de Zacatecas. July 1992 *The Best Doctors in America. S. Naifeh & G. White Smith. Woodward/White, Aiken, SC. (1992- 1993).

*Chairman, Honorary Membership Committee of the American Dermatological Association, Inc., 1994.

From 7/1/76 to 8/30/82 Consultant Physician (Dermatology) University Hospital University of Michigan Ann Arbor, MI From 7/1/76 to 8/30/82 Consultant Physician (Dermatology) Wayne County General Hospital Wayne, MI From 7/1/79 to 7/30/82 Chief, Dermatology Service Veterans Administration Medical Center Ann Arbor, MI From 9/1/82 to 12/31/88 Attending Physician (Dermatology) The Johns Hopkins Hospital Baltimore, MD

From 1/1/89 to 12/31/99 Attending Physician (Dermatology) Froedtert Memorial Lutheran Hospital Milwaukee, WI From 1/1/89 to 1993 Attending Physician (Dermatology) Milwaukee County Medical Complex Milwaukee, WI From 1/1/89 to 12/31/99 Attending Physician (Dermatology) Veterans Administration Medical Center Milwaukee, WI From 1/1/2000 to date Attending Physician (Dermatology) University of North Carolina Medical Center Chapel Hill, North Carolina

4

* Board of Directors, Dermatology Foundation, 1994. * Board of Directors, Association of Professors of Dermatology, 1994. * President, Sociedad de Investigación Dermatológica de Latino América, 1994. *1994 Marion Sulzberger Award: Teacher of the Year. American Academy of Dermatology. Washington, DC, February, 1994.

*The Best Doctors in America. S. Naifeh & G. White Smith. Woodward/White, Aiken, SC. (1994- 1995).

*Honorary Professor of Dermatology (Profesor Honorario de Dermatología). Facultad de Medicina, Universidad Nacional de Trujillo, Perú. 1996.

*The Best Doctors in America. Midwest Region. S. Naifeh & G. White Smith. Woodward/White, Aiken, SC. (1996-1997)

*Diploma for a Distinguished Career in Research and Teaching. Facultad de Medicina, Universidad Nacional de Trujillo, Perú. March 10, 1998.

*Honored by the Graduating Class of Resident Physicians of 1999 of the University Hospital of the Universidad Nacional de Trujillo, Peru ”

*The Best Doctors in America. S. Naifeh & G. White Smith. Woodward/White, Aiken, SC. (1999). *Awarded the Simon Bolivar Medal and Diploma for a distinguished professional career, scientific contributions and collaborations with Alma Mater. Universidad Nacional de Trujillo, Perú. April 9, 1999.

* President, Society for Investigative Dermatology (2,000-2001) * Recipient of the 2001 American Skin Association Research Achievement Award (May 11, 2001) * Institute of Medicine-National Academy of Sciences (October 1, 2002) * Best Doctors in America, 2004. Best Doctors, Inc. * Best Doctors in America® 2005-2006. Best Doctors, Inc. * Elected Member, American Academy of Dermatology Board of Directors (2005) * Elected Academico Correspondiente Estranjero, Reial Academia de Medicina de Catalunya-Spain (2005)

* Recipient of the 2006 ILDS-Certificate of Appreciation by the International League of Dermatological Societies. Proposed by the American Academy of Dermatology

* Elected Miembro Academico Honorario, Academia de Medicina de Mexico (2006) * Best Doctors of North Carolina, USA (2006). Best Doctors Inc * Profesor Honorario, Universidad Ricardo Palma, Lima, Peru. Agust 9, 2006. * Profesor Visitante, Facultad de Medicina San Fernando, Universidad Nacional Mayor de San Marcos, Lima, Peru. August 24, 2006.

* Best Doctors in America® 2007-2008. Best Doctors, Inc. * 2009 Recipient of the Stephen Rothman Award, Society of Investigative Dermatology (May 2009)

Editorial and Review Panels: * Scientific Investigation Committee, Michigan Dermatological Society (1978-1982). * Member, Clinical Executive Board, VA Medical Center, Ann Arbor, MI (1980-1982). * Reviewer (ad hoc), National Allergy and Infectious Diseases (1980). * Editorial Board American Journal of Dermatopathology (1983-to date). * Permanent Member - General Medicine A Study Section, NIH (1986-1989). * Chairman, Scientific Committee, Dermatology Foundation (1988). * Elected, Board of Directors, Society of Investigative Dermatology (1989). * Editor in Chief, Autoimmunity Forum-Immunodermatology (1989). * Member, National Institute of Arthritis and Musculoskeletal and Skin Diseases Advisory Council (1992-1995).

* Member, Editorial Review Board, Journal of American Academy of Dermatology (July, 1993).

5

* Member, Scientific Assembly Council, American Academy of Dermatology (1997-2002). * Member, World Congress Fund Review Committee, American Academy of Dermatology

(1997- 2002). Chairman (2001-2002). * Member, Committee on International Affairs, American Academy of Dermatology, 1995-1998 * Editorial Board, J Am Acad Dermatol (1998). * Chairman, ACADEMY 98 Planning Committee, Academy ‘98 Summer Meeting of American Academy of Dermatology, Chicago, IL, July, 1998

* Chairman, ACADEMY 2001 Planning Committee, Annual Meeting of American Academy of Dermatology, Washington, DC, March 2-7, 2001.

* Permanent Member – National Institute of Arthritis, Musculoskeletal and Skin Diseases – Special Grant Review Committee (2000- 2002).

* Member, National Institute of Allergy and Infectious Diseases Advisory Council (2002-2005). * Member, National Scientific Advisory and Medical Advisory Boards. American Autoimmune

Related Diseases Association (AARDA) * Member, Medical Advisory Board, International Pemphigus Foundation. * Editorial Board, Journal of Autoimmunity, August 16, 2007.

Other Areas of Expertise: Fluency in English and Spanish. Good command of Portuguese language. Medical Licensure:

* North Dakota Board of Medical Examiners (FLEX & Oral Exams). August, 1972. License #3221. * New York Board of Medical Examiners. November 1973. License #118493. * Minnesota Board of Medical Examiners. November 1974. License #0141228. * California Board of Medical Examiners. December 1975. License #A-29792. * Michigan Board of Medical Examiners. May 1976. License #36429. * Maryland Board of Medical Examiners. August 1982. License #D28240. * District of Columbia Board of Medical Examiners. April 1986. License #15833. * Wisconsin Board of Medical Examiners. July 1988. License #29544. * North Carolina Medical Board. October 21, 1999. License # 0099-01397

Membership in Professional Societies (Former and Current):

Society of Investigative Dermatology American Academy of Dermatology, Fellow Mayo Fellows Association American Federation for Clinical Research Dermatology Foundation Michigan Dermatological Society Sigma XI, The Scientific Research Society Society for Experimental Biology and Medicine Washtenaw Medical Society Michigan State Medical Society New York Academy of Sciences American Association for Immunologists Maryland Dermatological Society

6

American Society of Clinical Investigation (1984) Colegio Ibero-Latino-Americano de Dermatologia American Dermatological Association (1985) Sociedad Peruana de Dermatologia Wisconsin Dermatology Society Honorary Member: Sociedad Brasileira de Dermatologia (1991) Association of American Physicians (1992) Honorary Member: Sociedad Chilena de Dermatologia (1992) International Society of Dermatology Milwaukee Academy of Medicine Association of Professors of Dermatology Honorary Member: Sociedad Colombiana de Dermatologia (1998) Honorary Member: Iowa Dermatological Society (1999)

ACADEMIC ACTIVITIES AT THE UNIVERSITY OF MICHIGAN

1976-1978 Assistant Professor 1978-1982 Associate Professor

1. University of Michigan, Department of Dermatology:

* Teaching (Dermatology and Immunology): Students and residents. * Patient care: Dermatology clinics, consultation and in-patient services. * Research: Cutaneous Autoimmunity (supported by NIH RO1 and VA grants). 2. VA Medical Center: Chief, Dermatology Service (1977-1982) 3. Director, Clinical Immunodermatology Unit 4. Reference:

J.J. Voorhees, M.D., Professor and Chairman Department of Dermatology University of Michigan, Ann Arbor, Michigan

ACADEMIC ACTIVITIES AT THE JOHNS HOPKINS UNIVERSITY

1982-1986 Associate Professor

1986-1989 Professor

1. The Johns Hopkins University, Department of Dermatology: * Teaching (Dermatology and Immunology): Students and residents. * Patient Care: Dermatology clinics, consultation and in-patient services. * Research: Cutaneous Autoimmunity (supported by NIH RO1 grants). 2. Director, Clinical Immunodermatology Unit 3. References: Thomas T. Provost, M.D. (Former Chairman)

7

Professor and Chairman Department of Dermatology The Johns Hopkins University

ACADEMIC ACTIVITIES AT THE MEDICAL COLLEGE OF WISCONSIN 1988 - 1999

Professor and Chairman, Department of Dermatology

In 1988, Dr. Diaz became the first Chairman of the newly established Department of Dermatology at the Medical College of Wisconsin. Under his direction the department expanded to become one of the leading academic programs in the Midwest. The initial faculty of 3 full time members increased to 12, including clinical dermatologists and basic scientists. NIH and the VA Central Office continuously funded the Dr. Diaz’s basic research since his arrival (1988-1999). The residency program grew from 6 to 12 residents. Several research fellows completed their training in the department and currently hold faculty appointments in different universities around the world. Some of Dr. Diaz’s academic activities at the Medical College of Wisconsin are listed below: 1) Administration: Medical College of Wisconsin and Affiliated Hospitals a) Chairman, Internal Review Committee, Preventive Medicine Department b) Chairman, Internal Review Committee, Neurosurgery Department c) Member, Search Committee, Neurosurgery Chairman d) Co-Director Dermatology Residency & Post Doctoral Research Program

. f) Administration of the dermatology clinical activities: The number of patients attended at the Dermatology Clinics (see below) increased from approximately 12,000 visits per year in 1989, when Dr. Diaz assumed the position of Chairman to approximately 38,000 during the 1997-1998 fiscal year. Patients were seen in the following facilities:

* Froedtert Memorial Lutheran Hospital * Children’s Hospital of Wisconsin * VA Medical Center, Milwaukee, WI * Sixteenth Street Community Health Center, Milwaukee, WI * Harwood Medical Associates (Multi Specialty Group), Milwaukee, WI * Family Health Plan (Capitated HMO), Milwaukee, WI * Quadraphics Health Plan (Multi Specialty Group)

2) Patient Care and Community Service: Since his arrival at the Medical College of Wisconsin in 1989, Dr. Diaz was involved in direct patient care at the FMLH-West Clinics, VA Medical Center and Harwood Medical Associates Clinics. In 1989, Diaz started an indigent clinic for Hispanics in the south side of Milwaukee (16th St. Community Health Center). He supervised the treatment of patients by dermatology residents and medical students. 3) Teaching Activities: Dr. Diaz was involved in the training of medical students, residents and postdoctoral fellows in clinical dermatology and immunological research. Under Dr. Diaz’s leadership the “International Dermatology Exchange Program” was established between the Departments of Dermatology of the Medical College of Wisconsin and the University of Sao Paulo, Brazil, the largest Dermatology Department in Latino America. As part of this very successful program, dermatology residents from Brazil spent 1-2 months in Milwaukee and Medical College of Wisconsin dermatology residents spent 2 months in Sao Paulo. The visiting resident was fully incorporated into the residency program of each department. This exchange program was one of the reasons that the Department of Dermatology received the prestigious Award for Excellence in

8

Education from the American Academy of Dermatology in 1993.

Dr. Diaz has also facilitated the exchange of medical students from the Medical College of Wisconsin and the Facultad de Medicina in Trujillo, Peru. 4) References: Michael Dunn, M.D. Dean and Executive Vice President Medical College of Wisconsin Milwaukee, Wisconsin.

ACADEMIC ACTIVITIES AT THE UNIVERSITY OF NORTH CAROLINA 2000 – To date

Upon his arrival to UNC in January 2000, Dr. Diaz assumed the position of The CE Wheeler

Jr. Distinguished Professor and Chairman, Department of Dermatology. To fulfill the education, patient care and research mission of the department he began recruiting clinical and basic science faculty. The major challenges faced during the first few years were the result of a nationwide crisis of dermatologist-academicians. The pool of physician-scientists and clinician-educators in Dermatology is extremely small and the need to fulfill the clinical, research and educational demands are overwhelming. To address these issues and as President of the Society for Investigative Dermatology (SID), in 2001 Dr. Diaz started an annual National Retreat for Dermatology Residents interested in academic medicine (Rubenstein et al, J Amer Acad Dermatol, 47:300-3003, 2002). This innovative program apparently is producing some early positive results as shown in our recruitment efforts at UNC. Additionally, as President of the SID, Dr. Diaz testified before Congress requesting that the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) convene a workshop on “the burden of skin disease”, which was held in September 2003 (Quereshi et al, J Invest Dermatol, 9:111-119, 2004). All these activities were aimed at enhancing support for our dermatology specialty in clinical, educational and research endeavors. The following paragraphs outline Dr. Diaz’s activities at UNC:

1) Administration:

Administrative duties as Chairman of the Department of Dermatology (2000) Chairman, UNC Minority Cohort Recruitment Program (2000) Member, Search Committee, Department of Cell & Physiology (2001-To date) Member Search Committee, Curriculum for Reducing Health Disparities (2001) Chair, Advisory Committee, Minority Cohort Recruitment Program (2000) Chair, Five-year review, Chairman of Ophthalmology at UNC (2005) Leading the fundraising effort, assisted by the UNC Medical Foundation, to endow the Irene

and Robert Briggaman Chair. Completed in 8 months (February, 2005) Recruitment efforts (2000-2007): Dr. Diaz hired 12 of 17 of the current faculty members,

which include 4 physician scientists and 5 Ph.D. basic scientists. 2) Patient Care and Community Service: Dr. Diaz is currently involved in patient care activities, staffing outpatient clinics and the in-patient and consultation service. 3) Teaching Activities: Dr. Diaz is involved in the teaching program for UNC medical students, dermatology residents and postdoctoral fellows. Since January 1, 2002 to June 30, 2005 Dr. Diaz was the Director of the UNC Dermatology Residency Program. The ACGME-RRC site visited our program in the spring of 2003 and approved the program without citations for five years in August

9

25, 2003 for 12 residency positions (up from 9 positions previously approved). There are two international programs that Dr. Diaz has transferred from the medical College of Wisconsin to UNC:

The International Dermatology Resident Exchange Program with the University of Sao Paulo, Brazil. Our UNC dermatology residents are able to spend 1-2 months as part of the teaching program of the Dermatology Department of the University of Sao Paulo.

The International Exchange Program for Medical Students. This ongoing program allows our UNC students to rotate in the clinical services of the Faculty of Medicine Affiliated Hospitals in Trujillo, Peru.

4) Research Interest: Human Cutaneous Autoimmunity

Following his postdoctoral fellowship at Mayo Clinic, Dr. Diaz started his research career in dermatology at the University of Michigan in 1976. He continued his investigative work at Johns Hopkins University from 1982 to 1988, at the Medical College of Wisconsin from 1988-1999, and at the University of North Carolina from 2000 to the present. He has focused his studies on defining the immunopathological mechanisms involved in three human autoimmune diseases: Pemphigus Vulgaris, Pemphigus Foliaceus and Bullous Pemphigoid. The following major scientific contributions are credited to Dr. Diaz’s research team: * Development of the first animal model of Pemphigus Vulgaris by passive transfer of human anti-epidermal autoantibodies. N. Engl. J. Med. 306:1189-1196, 1982. * Development of the first animal model of Pemphigus Foliaceus by passive transfer of human anti-epidermal autoantibodies. J. Invest. Dermatol. 85:538-541, 1985. * Development of the first animal model of Bullous Pemphigoid by passive transfer of human anti-epidermal autoantibodies in the rabbit cornea. J. Clin. Invest. 68:1097-1101, 1981. *Demonstration that Bullous Pemphigoid autoantibodies recognize epidermal basal cell hemidesmosomes. J. Invest. Dermatol. 84:47-53, 1985. * Immunochemical characterization and molecular cloning of the human hemidesmosome BP180 antigen. J. Immunol. 136:1231-1235, 1986 and J. Clin. Invest. 86:1088-1094, 1990. * Development of the first animal model of Bullous Pemphigoid in the neonatal mouse by transfer of anti-hemidesmosomal BP180 antigen antibodies. J. Clin. Invest, 92:2480-2488, 1993. * Cloning of desmoglein 3-specific T cells from Pemphigus Vulgaris peripheral blood lymphocytes. J. Clin. Invest, 99:31-40, 1997. * Cloning of desmoglein 1-specific T cells from peripheral blood lymphocytes of endemic pemphigus foliaceus (Fogo Selvagem). J. Clin. Invest. 105:207-213, 2000. * The prevalence of antibodies against desmoglein 1 in endemic pemphigus foliaceus in Brazil. N Engl J Med 343:23-30, 2000 * The Role of Intramolecular Epitope Spreading in the Pathogenesis of Endemic Pemphigus

10

Foliaceus (Fogo Selvagem). J Exp Med. 197:1501-1510, 2003 * Environmental Risk Factors in Endemic Pemphigus Foliaceus. J Invest Dermatol. 9:34-40, 2004 * Anti-desmoglein-1 antibodies in onchocerciasis, leishmaniasis and Chagas Disease suggest a possible etiological link to Fogo Selvagem. J Invest Dermatol, 123:1045-1051, 2004. * Dissecting the Anti-desmoglein Autoreactive B Cell Repertoire in Pemphigus Vulgaris Patients. J Immunol. 178: 5982-5990, 2007. * Endemic Pemphigus Vulgaris. Arch Dermatol. 143:895-899, 2007. * Rituximab and Pemphigus – A Therapeutic Advance. New Eng J Med. 357: 605-607, 2007. * E-cadherin is an additional immunological target for pemphigus autoantibodies. J Invest Dermatol.

in press, 2008 * IgM anti-desmoglein 1 Autoantibodies are the Distinguishable Immunologicaol Markers of Endemic

Pemphigus Foliaceus (fogo selvagem). J Invest Dermatol. In press, 2008.

The relevance of Dr. Diaz’s research is objectively demonstrated in three areas: a) continuous research support from the National Institutes of Health and the Department of Veterans Affairs for the last 20 years, b) the training of postdoctoral fellows from all over the world and c) the extensive list of publications and other national and international academic activities.

Current Research Support* NIH R01 AR 32081 (previous R37 MERIT) "Pemphigus and Pemphigoid" (9/7/2007 - 8/31/2012) L. A. Diaz, M.D., Principal Investigator Award: $215,000 per year (direct cost) – Continously funded for 26 years NIH RO1 AR 32599 "Etiology and Pathogenesis of Pemphigus" (4/1/08- 3/31/2013) L.A. Diaz, M.D., Principal Investigator Award: $250,000 per year (direct cost) – Continuosly funded for 26 years

NIH T32 AR07369 “Training Grant in Dermatological Research” (7/1/80 - 4/30/07) LA Diaz, M.D. Principal Investigator Award: $157,038 per year (direct cost) – Five years suppor requested (Pending review, 2009)

* Dr. Diaz has received VA Merit grants from the Veterans Administration Central Office while a faculty member at the University of Michigan (1976-1982) and the Medical College of Wisconsin (1989-2000). 5) References: Jeffrey L. Houpt M.D. (2000-2004) CEO, UNC Health Care System Dean School of Medicine Vice Chancellor for Medical Affairs University of North Carolina at Chapel Hill William L. Roper, M.D. ,MPH (2004-To date)

11

CEO, UNC Health Care System Dean School of Medicine Vice Chancellor for Medical Affairs University of North Carolina at Chapel Hill 6) Five-year Review of the Chairman, UNC Department of Dermatology (January 1, 2000 to December 31, 2004): Luis A. Diaz, M.D. The UNC Advisory Committee of the School of Medicine on executive session on October 12, 2004 unanimously approved the reappointment of Luis A. Diaz, as Chair of the Department of Dermatology, effective January 1, 2005. Dean Robert N. Golden of the UNC-SOM wrote a handwritten note on the reappointment letter commending a strong leadership of the chair during the previous five years. Chancellor James Moeser on behalf of the University of North Carolina at Chapel Hill extended the appointment of Dr. Luis A. Diaz, for another five years, effective January 1, 2005.

Postdoctoral Fellows and Visiting Scientists (1977 - 2005)

Harish P. Patel, M.D. Kasturba Medical College, India (7/1/77-12/31/78) Grant J. Anhalt, M.D. University of Manitoba, Canada (7/1/80-12/31/81) Andrew J. King, M.D U. of Mississippi School of Medicine (7/79-6/81) Katerine Freitag, M.D. University of Michigan, Ann Arbor (7/81-6/82) Thomas Y. Woo, M.D. University of Alberta, Canada (7/81-6/82) Ramsy S. Labib, M.D., Ph.D. Ain Shams University, Egypt (7/1/80-6/30/82) Yuzo Takahashi, M.D., Ph.D. Nara University, Japan (1/1/83-12/31/83) Hany Y. Halim, M.D., Ph.D. Ains Shams University, Cairo, Egypt (1/1/83-12/31/83) Diya F. Mutasim, M.D. American University, Beirut, Lebanon (4/1/83-12/31/85) Justin T. Roscoe, M.D. University of Sao Paulo, Brazil (7/1/83-6/30/85) Rafael Herrera, M.D. Universidad Autonoma de Zacatecas (7/1/83-7/30/84) Fred Eaglstein, D.O. Univ. of Tennessee College of Medicine (7/1/83-6/30/85) Esperanza Avalos, M.D. Universidad Autonoma de Zacatecas (7/1/83-7/30/84) Hiroshi Hosokawa, M.D. Kansai Medical University, Japan (1/8/85-12/31/86) Kayo Hosokawa, M.D. Kansai Medical University, Japan (1/8/85-12/31/86) Elizabeth Dugan, M.D. University of Southern California (7/1/85-6/30/87) Luis H. Squiquera, M.D. University of Buenos Aires, Argentina (7/1/86-6/30/88) Lynne Morrison, M.D. University of Oregon (8/1/86-7/31/88) Shozo Futamura, M.D. Kansai Medical University, Japan (1/1/87-12/31/89) Sergio Camargo, M.D. Faculdade Medicina, Santos, Brazil (6/1/87-to date) Barbara Rock, M.D. Johns Hopkins University (7/1/87-6/30/89) Ciro Martins, M.D. Universidade de SaoPaulo, Brazil (9/1/87-12/31/90) Mary A. Robledo, M.D. Universidad de Antioquia, Colombia (1/1/88-12/31/89) Saundrett G. Arrindell, M.D. University of Iowa College of Medicine (9/1/90 to 12/31/91) Elizabeth M. Allen, Ph.D. Marquette University, Milwaukee, WI (7/1/90 to 8/1/92) Valeria Aoki, M.D. University of Sao Paulo, Brazil (2/1/92 to 1/31/94) Tsutomu Muramatsu, M.D. Nara University, Nara, Japan (7/1/92 to 6/30/94)

12

Rosicler Rocha-Alvarez, M.D. University of Brasilia, Brazil (9/1/92 to 8/31/94) Ashwini Kamath-Loeb, Ph.D. University of Bombay, India (9/1/93 to 8/31/94 ) Xiang Ding, Ph.D. Peking University, China (12/1/94 to date) Jose Mascaro, M.D. Central University of Barcelona, Spain (1/1/95 to 12/31/96) Detlef Zillikens, M.D. University of Wurzburg, Germany (10/1/94 to 2/14/97) Agustin España-Alonso, M.D. University of Navarra, Spain (12/1/94 to 9/30/95) Ana Maria Abreu Velez, M.D. U. of Antioquia, Medellin, Colombia (8/1/95 to 7/31/97) Frederic Caux, M.D. University Paris XII, France (1/1/96 to 10/28/96) Manish Gharia, M.D. Medical College of Wisconsin (7/1/97 to date) Karen Harman, M.D. St. John’s Institute of Dermatology and Department of Oral Medicina

and St. Thomas ‘Hospital, London, England. (1/1/98- 3-30-98). Simon Warren, M.D., United Medical and Dental School, London University (7/1/98 to

6/30/2000) Luis A. Arteaga, M.D. Facultad de Medicina, Trujillo, Peru (4/8/99 to 3/31/2001) Julio Hilario, M.S., Facultad de Medicina, Trujillo, Peru (4/1/01- 4/16/2005) Erin K. Pias, PhD., LSU Health Sciences Center-Shreveport, Louisiana (5/1/02- t6/30/2004) Flor Evangelista, M.S. Facultad de Medicina, Trujillo, Peru (1/15/2005 to date) Alex Ortega, M.D. , Facultad de Medicina de San Fernando, Lima, Peru (3-7-2005- to date) David Dasher, M.D., University of North Carolina School of Medicine (7-1-2005) Gustavo Flores, M.D., Universidad Nacional de Trujillo-Facultad de Medicina (2008-2009)

Thesis Advisor Horacio Friedman, M.D.: "Contribuicao a Padronizacao da Reacao de Immunofluorescencia Indireta para Penfigo Foliaceo Endemico". Master Thesis. Departament de Biologia432 Celular da Fundacao Universidade de Brasilia, Brazil, 1988. . Horacio Friedman M.D.: “El Fogo Selvagem en Xavante Indians”. Doctoral Thesis, Departament de Biologia Celular da Fundacao Universidade de Brasilia, Brazil, 1992 Paulo Rowilson Cunha, M.D.: "Estudo Soro-Epidemiologico em Foco de Penfigo Foliaceo Endemico (Fogo Selvagem) no Estado de Sao Paulo". Doctoral Thesis. Facultade de Medicina da Universidade de Sao Paulo, Brazil, 1988. Rosicler Rocha-Alvarez, M.D.: "Penfigo Foliaceo Endemico (Fogo Selvagem) na Gravidez." Estudo Clinico e Immunopatologico (por Immunofluorescencia). Doctoral Thesis. Escola Paulista de Medicina, Sao Paulo, Brazil. 1991. Soraya Marques: Perfil Evolutivo das Subclasses de Immunoglobulina Gama no Penfigo Foliaceo Endemico. Doctoral Thesis. Universidade Federal de Minas Gerais, Belho Horizonte, Brazil. 1996. Valeria Aoki, M.D.:Perfil Serologico del Penfigo Foliaceo Endemico. Master Thesis. Universidade de Sao Paulo, Brazil. 1997 Gunter Hans Filhio, M.D.: La Frecuencia de Fogo Selvagem en los Indios Terenas de Mato Grosso do Sul, Brazil. Doctoral Thesis. Universidade de Sao Paulo, Brazil. 1998.

13

Valeria Aoki, M.D. Fatores Epidemiologicos en el Penfigo Foliaceo Endemico. Doctoral Thesis. Universidade de Sao Paulo, Brazil. 1999. Julio Empinotti, M.D. Penfigo Foliaceo en el Oeste de Parana, Brazil. Doctoral Thesis. Universidade Federal de Rio de Janeiro. 2003.

14

Publications in Refereed Journals: (1973 to date)

1. Diaz LA, Provost TT and Tomasi TB, Jr. Pustular necrotizing angiitis. Arch. Dermatol. 108:114-118, 1973.

2. Diaz LA, Calvanico NJ, Tomasi TB, Jr. and Jordon RE. Bullous pemphigoid antigen:

Isolation from normal human skin. J. Immunol. 118:455-460, 1977. 3. Diaz LA, Heaphy MR, Calvanico NJ, Tomasi TB Jr and Jordon RE. Separation of

epidermis from dermis with sodium thiocyanate. J. Invest. Dermatol. 68:36-38, 1977. 4. Diaz LA, Calvanico NJ, Tomasi TB, Jr. and Jordon RE. PBS-soluble substances with

blood group activity from human epidermis and dermis. Acta Dermatovener (Stockholm) 57:493-496, 1977.

5. Diaz LA and Marcelo CL. Pemphigoid and pemphigus antigens in cultured epidermal

cells. Brit. J. Dermatol. 98:631-637, 1978. 6. Diaz LA, Weiss H and Calvanico NJ. Phylogenetic studies with pemphigus and

pemphigoid antibodies. Acta Dermatovener (Stockholm) 58:537-540, 1978. 7. Diaz LA, Patel HP and Calvanico NJ. Bullous pemphigoid antigen. II. Isolation from the

urine of a patient. J. Immunol. 122:605-608, 1979. 8. Diaz LA. Molecular structure of the epidermal extracellular spaces. A review. Int. J.

Dermatol. 18:434-442, 1979. 9. Diaz LA, Lamkin BC and Dubin HV. Juvenile dermatitis herpetiformis: Immunopathology

and HLA typing. Arch. Dermatol. 115:584-586, 1979. 10. Mitchell AJ, Rusin LJ and Diaz LA. Circumscribed scleroderma with immunologic

evidence of systemic lupus erythematosus. Arch. Dermatol. 116:69-73, 1980. 11. Diaz LA. Molecular dissection of the dermal-epidermal junction. Amer. J.

Dermatopathol. 2:79-81, 1980. 12. Diaz LA, Glamb RW and Silva JJ. A syndrome of multiple immune autoreactivity: A

breakdown in immune regulation. Arch. Dermatol. 116:77-79, 1980. 13. Diaz LA, Patel HP and Calvanico NJ. Isolation of pemphigus antigen from human saliva.

J. Immunol. 124:760-765, 1980. 14. Good AE, Bowerman RA and Diaz LA. Basal cell carcinomas following roentgen

therapy of ankylosing spondylitis. Arthritis Rheum. 23:1065-1067, 1980. 15. Swanson NA, Mitchell AJ, Leahy MS, Headington JT and Diaz LA. Topical treatment of

alopecia areata: Contact allergen versus primary irritant therapy. Arch. Dermatol. 117:384-387, 1981.

15

16. King AJ, Schwartz SA, Lopatin DE, Voorhees JJ and Diaz LA. Autoimmunity. An overview. Int. J. Dermatol. 20(10):642-646, 1981.

17. Grekin PM, Levy GN, King AJ and Diaz LA. Some biochemical properties of pemphigoid

antigen bound to the cell surface of dissociated epidermal basal cells. J. Invest. Dermatol. 76:190-192, 1981.

18. Cowen SJ, Anhalt GJ, Wicha MS, Sugar A, Labib RS and Diaz LA. Distribution of

pemphigus and pemphigoid antigens, laminin and type IV collagen in corneal epithelium. Invest. Ophth. Vis. Sci. 21(6):879-882, 1981.

19. Anhalt GJ, Bahn CF, Labib RS, Voorhees JJ, Sugar A and Diaz LA. Pathogenic effects

of bullous pemphigoid autoantibodies on rabbit corneal epithelium. J. Clin. Invest. 68:1097-1101, 1981.

20. Patel HP, Marcelo C, Voorhees JJ and Diaz LA. In vitro alterations of epidermal cell

adhesion induced by temperature, substrate, and cations. J. Invest. Dermatol. 76:474-479, 1981.

21. Anhalt GJ, Labib RS, Voorhees JJ, Beals TF and Diaz LA. Induction of pemphigus in

neonatal mice by passive transfer of IgG from patients with the disease. N. Engl. J. Med. 306:1189-1196, 1982.

22. Avalos-Diaz E, Anhalt GJ and Diaz LA. Penfigo y penicilamina. Conceptos recientes.

Dermatologia, Revista Mexicana 26:133-140, 1982. 23. King AJ, Schwartz SA, Lopatin D, Voorhees JJ and Diaz LA. Suppressor cell function is

preserved in pemphigus and pemphigoid. J. Invest. Dermatol. 79:183-185, 1982. 24. Patel HP, Anhalt GJ and Diaz LA. Bullous pemphigoid and pemphigus vulgaris. Ann.

Allergy 50:144-150, 1983. 25. Anhalt GJ, Patel HP and Diaz LA. Mechanisms of immunological injury: Pemphigus

and bullous pemphigoid. Arch. Dermatol. 119:711-714, 1983. 26. Woo TY, Hogan VA, Patel HP, Anhalt GJ, Labib RS, Voorhees JJ and Diaz, LA.

Specificity and inhibition of the epidermal cell detachment induced by pemphigus IgG in vitro. J. Invest. Dermatol. 81:115-121, 1983.

27. Wong RC, Ellis CN and Diaz LA. Bechet's Disease. Int. J. Dermatol. 23:25-32, 1984. 28. Lee EB, Anhalt GJ, Voorhees JJ and Diaz LA. Pathogenesis of scleroderma: Current

concepts. Int. J. Dermatol. 23:85-89, 1984. 29. Avalos E, Patel H, Anhalt GJ, Diaz LA. Autoimmune injury of squamous epithelium by

pemphigus autoantibodies. Brit. J. Dermatol. III:359-365, 1984.

16

30. Robinson HN, Anhalt GJ, Patel HP, Takahashi Y, Labib RS and Diaz LA. Pemphigus and pemphigoid antigens are expressed in human amnion epithelium. J. Invest. Dermatol. 83:234-237, 1984.

31. Patel HP, Diaz LA, Anhalt GJ, Labib RS and Takahashi Y. Demonstration of pemphigus

antibodies on the cell surface of murine epidermal cell monolayers and their internalization. J. Invest. Dermatol. 83:409-415, 1984.

32. Labib RS, Anhalt GJ, Patel HP and Diaz LA. Epidermal proteins: I. Differential

extraction and quantitative polyacrylamide gel-electrophoretic analysis of basal and spinous-cell proteins of neonatal mouse epidermis. Arch. Dermatol. Res. 277:253-263, 1985.

33. Takahashi Y, Patel HP, Labib RS, Diaz LA and Anhalt GJ. Experimentally induced

pemphigus vulgaris in neonatal BALB/c mice: A time-course study of clinical, immunologic, ultrastructural and cytochemical changes. J. Invest. Dermatol. 84:41-46, 1985.

34. Mutasim DF, Takahashi Y, Labib RS, Anhalt GJ, Patel HP and Diaz LA. A pool of

bullous pemphigoid antigen(s) is intracellular and associated with the basal cell cytoskeleton-hemidesmosome complex. J. Invest. Dermatol. 84:47-53, 1985.

35. Provost TT, Herrera-Esperza R and Diaz LA. Nucleoprotein autoantibodies in lupus

erythematosus. J. Invest. Dermatol. 85:133-139, 1985. 36. Takahashi Y, Mutasim DF, Patel HP, Anhalt GJ, Labib RS and Diaz LA. The use of

human pemphigoid autoantibodies to study the fate of epidermal basal cell hemi-desmosomes after trypsin dissociation. J. Invest. Dermatol. 85:309-313, 1985.

37. Roscoe JT, Diaz LA, Sampaio SAP, Castro RM, Labib RS, Takahashi Y, Patel HP and

Anhalt GJ. Brazilian pemphigus foliaceus autoantibodies are pathogenic to BALB/c mice by passive transfer. J. Invest. Dermatol. 85:538-541, 1985.

38. Anhalt GJ, Patel HP, Labib RS, Diaz LA and Proud DA. Dexamethasone inhibits

plasminogen activator activity in experimental pemphigus in vivo but does not block acantholysis. J. Immunol. 136:113-117, 1986.

39. Herrera-Esparza R, Halim HY, Provost TT and Diaz LA. A sensitive and specific assay

to detect Ro(SS-A) and La(SS-B) antibodies. J. Invest. Dermatol. 86:217-221, 1986. 40. Diaz LA, Roscoe JT, Eaglstein NF, Labib RS, Patel HP, Mutasim DF and Anhalt GJ.

Human pemphigus autoantibodies are pathogenic to squamous epithelium. Ann. NY Acad. Sci. 475:181-191, 1986.

41. Labib RS, Anhalt GJ, Patel HP, Mutasim, DF and Diaz LA. Molecular heterogeneity of

the bullous pemphigoid antigens as detected by immunoblotting. J. Immunol. 136:1231-1235, 1986.

17

42. Herrera-Esparza R, Provost TT and Diaz LA. Molecular characterization of Ro(SS-A) and La(SS-B) proteins. J. Rheumatol. 13:327-330, 1986.

43. Roscoe JT, Naylor PH, Diaz LA, Labib RS, Patel HP, Goldstein AL, Sampaio SAP and

Anhalt GJ. Elevated thymosin alpha I levels in Brazilian pemphigus foliaceus. Brit. J. Dermatol. 115:147-150, 1986.

44. Anhalt GJ, Till GO, Diaz LA, Labib RS, Patel HP, and Eaglstein NF. Defining the role of

complement in experimental pemphigus vulgaris in mice. J. Immunol. 137:2835-2840, 1986.

45. Diaz LA, Anhalt GJ, Hosokawa H, and Takahashi, Y. Bullous pemphigoid antigens.

Keio J. Med. 35: 69-79, 1986. 46. Diaz LA. Advances in pemphigus. Jap J. Dermatol. 96:1329-1332, 1986. 47. Diaz LA. Dermatology in Latin American countries. Jap J. Dermatol. 96:1438, 1986. 48. Mutasim DF, Anhalt GJ, Diaz LA and Patel HP. Linear immunofluorescence staining of

the cutaneous basement membrane zone produced by pemphigoid antibodies: The result of hemidesmosome staining. J. Am. Acad. Dermatol. 16:75-82, 1987.

49. Anhalt GJ, Jampel HD, Patel HP, Diaz LA, Jabs DA and Mutasim DF. Bullous

pemphigoid autoantibodies are markers of corneal epithelial hemidesmosomes. Invest. Ophthalmol. Vis. Sci. 28:903-907, 1987.

50. Diaz LA, Sampaio SAP, Martins CR, Rivitti EA, Macca ML, Roscoe JT, Takahashi Y,

Labib RS, Patel HP, Mutasim DF, Dugan EM and Anhalt GJ. An autoantibody in pemphigus serum specific for the 59 kD keratin selectively binds the surface of keratinocytes: Evidence for an extracellular keratin domain. J. Invest. Dermatol. 89:287-295, 1987.

51. Matis WL, Anhalt GJ, Diaz LA, Rivitti EA, Martins CR, and Berger RS. Calcium

enhances the sensitivity of immunofluorescence for pemphigus antibodies. J. Invest. Dermatol. 89:302-304, 1987.

52. Kawana S, Diaz LA, Rivitti EA, Geoghegan WD and Jordon RE. Complement fixation by

Brazilian pemphigus foliaceus autoantibodies. Clin. Exper. Immunol. 71:464-469, 1988. 53. Morrison LH, Labib RS, Zone JJ, Diaz LA and Anhalt GJ. Herpes gestationis

autoantibodies recognize a 180 kD human epidermal antigen. J. Clin. Invest. 81:2023-2026, 1988.

54. Squiquera HL, Diaz LA, Sampaio SAP, Rivitti EA, Martins CR, Cunha PR, Lombardi C,

Lavrado C, Hans-Filho G, Borges PC, Friedman H, Labib RS, Anhalt GJ and the Cooperative Group On Fogo Selvagem Research. Serological abnormalities in patients with endemic pemphigus foliaceus (fogo selvagem), their relatives and normal donors from endemic and non-endemic areas of Brazil. J Invest. Dermatol. 91:189-191,1988.

18

55. Squiquera LH, Anhalt GJ, Sampaio SAP, Rivitti EA, Martins CR, Diaz LA and "The Cooperative Group in Fogo Selvagem Research." La Immunopatogenia de los Penfigos. Med Cutanea Ibero-Americana. 16:385-392, 1988.

56. Squiquera LH, Robledo MA, Martins CR, and Diaz LA. Estructura de la union

dermoepidermica. Med Cutanea Ibero-Americana 16:474-480, 1988. 57. Koch WM, Dugan E, Diaz LA, Richtsmeier WJ. Induction of HLA-DR antigen on human

squamous carcinoma by recombinant interferon gamma. Larymgoscope 98:511-515, 1988.

58. Diaz LA, Sampaio SAP, Rivitti EA, Martins CR, Cunha PR, Lombardi C, Almeida FA,

Martins-Castro R, Macca ML, Lavrado C Hans-Filho G, Borges PC, Minelli L, Empinotti JC, Friedman H, Campbell I, Labib RS, and Anhalt GJ. Endemic pemphigus foliaceus (fogo selvagem): II. Current and historic epidemiologic studies. J. Invest. Dermatol. 92:4-12, 1989.

59. Diaz LA, Sampaio SAP, Rivitti EA, Martins CR, Cunha PR, Lombardi C, Almeida FA,

Martins-Castro R, Macca ML, Lavrado C, Hans-Filho G, Borges PC, Minelli L, Empinotti JC, Friedman H, Campbell I, Labib RS, and Anhalt GJ. Endemic pemphigus foliaceus (fogo selvagem): I. Clinical features and immunopathology. J. Am. Acad. Dermatol. 20:657-669, 1989.

60. Mutasim DF, Morrison LH, Takahashi Y, Labib RS, Skouge J, Diaz LA and Anhalt GJ.

Definition of bullous pemphigoid antibody binding to intracellular and extracellular antigen associated with hemidesmosomes. J. Invest. Dermatol. 92:225-230, 1989.

61. Rock B, Martins CR, Theofilopoulos AN, Balderas S, Anhalt GJ, Labib RS, Futamura S,

Rivitti EA and Diaz LA. The pathogenic effect of IgG4 autoantibodies in endemic pemphigus foliaceus (fogo selvagem). N. Engl. J. Med. 320:1463-1469,1989.

62. Labib RS, Camargo S, Futamura, S, Martins CR, Rock B, Anhalt GJ and Diaz LA.

Pemphigus foliaceus antigen: Characterization of a keratinocyte envelope associated pool and preparation of a soluble immunoreactive fragment. J. Invest. Dermatol. 93:272-279, 1989.

63. Futamura S, Martins CR, Rivitti EA, Labib RS, Diaz LA, and Anhalt GJ. Ultrastructural

studies of acantholysis induced in vivo by passive transfer of IgG from endemic pemphigus foliaceus (fogo selvagem). J. Invest. Dermatol. 93:480-485, 1989.

64. Diezel W, Gruner S, Diaz LA, and Anhalt GJ. Inhibition of cutaneous contact

hypersensitivity by calcium transport inhibitors lanthanum and diltiazem. J. Invest. Dermatol. 93:322-326, 1989.

65. Friedman H, Campbell IT, Rocha-Alvarez R, Diaz LA, Martins de Castro R, Roitman I,

Parreiras RM, and Raick AN. Immunofluorescencia indireta no penfigo foliaceo endemico. Contribucao para sua Padronizacao. Rev. Inst. Med. Trop. Sao Paulo. 31:158-168, 1989.

19

66. Calvanico NJ and Diaz LA. Relevance of autoimmune research in pemphigus.

Autoimmunity Forum. Immunodermatology. 1:2-4, 1989. 67. Diaz LA. Dermatitis herpetiformis. Editorial. Autoimmunity Forum-Immunodermatology.

1:16, 1989. 68. Dugan EM, Labib RS, Anhalt GJ and Diaz LA. Selective surface radioiodination of

keratinocytes in primary culture labels a 59 kD keratin and other surface. Arch. Dermatol. Res. 281:463-469, 1989.

69. Rock B, Labib RS, Diaz LA. Monovalent Fab' immunoglobulin fragments from endemic

pemphigus foliaceus autoantibodies reproduce the human disease in neonatal BALB/c mice. J. Clin. Invest. 85:296-299, 1990.

70. Martins CR, Labib RS, Rivitti EA, Diaz LA. A soluble and immunoreactive fragment of

pemphigus foliaceus antigen released by trypsinization of viable human epidermis. J. Invest. Dermatol. 95:208-212, 1990.

71. Diaz LA, Ratrie III, H, Saunders WS, Futamura S, Squiquera HL, Anhalt GJ and Giudice

GJ. Isolation of a human epidermal cDNA corresponding to the 180 kD autoantigen recognized by bullous pemphigoid and herpes gestationis sera. Immunolocalization of this protein to the hemidesmosome. J. Clin. Invest. 86:1088-1094, 1990.

72. Empinotti JC, Diaz LA, Martin CR, Rivitti EA, Sampaio SAP, Lombardi C and Sanches

JA. Endemic pemphigus foliaceus in western Parana, Brazil (1976-1988). Brit. J. Dermatol. 123:431-437, 1990.

73. Labib RS, Rock B, Martins CR and Diaz LA. Pemphigus foliaceus antigen:

Characterization of an immunoreactive tryptic fragment from Balb/c mouse epidermis recognized by all patients' sera and major autoantibody subclasses. Clin. Immunol. Immunopathol. 57:317-329, 1990.

74. Owaribe K, Kartenbeck J, Stumpp S, Magin TM, Krieg T, Diaz LA and Franke WW. The

hemidesmosome plaque: I. Characterization of a major constituent protein as a differentiation marker for certain forms of epithelia. Differentiation 45:207-220, 1990.

75. Mutasim DF, and Diaz LA. The relevance of immunohistochemical techniques in the

differentiation of subepidermal bullous diseases. Amer. J. Dermatopathol. 13:77-83, 1991.

76. Calvanico NJ, Robledo MA and Diaz LA. Immunopathology of pemphigus. J.

Autoimmunity, 4:3-16, 1991. 77. Giudice GJ, Squiquera HL, Elias PM, and Diaz LA. Identification of two collagen

domains within the bullous pemphigoid autoantigen, BP180. J. Clin. Invest. 87:734-738, 1991.

20

78. Calvanico NJ, Martins CR and Diaz LA. Characterization of pemphigus foliaceus antigen from human epidermis. J. Invest. Dermatol. 96:815-821, 1991.

79. Moraes JR, Moraes ME, Fernadez-Vina M, Diaz LA, Friedman H, Campbell IT, Alvarez

RR, Sampaio SAP, Rivitti EA and Stastny P. HLA antigens and the risk for development of pemphigus foliaceus ("fogo selvagem") in endemic areas of Brazil. Immunogenetics, 33:388-391, 1991.

80. Fairley JA, Scott GA, Jensen KD, Goldsmith LA and Diaz LA. Characterization of

keratocalmin, a calmodulin-binding protein from human epidermis. J. Clin. Invest. 88:315-322, 1991.

81. Campbell IT, Friedman H, Alvarez RR, Campbell GAM and Diaz LA. Pemphigus foliace

endemique a Brasilia. A propos de 60 cas. Les Nouvelles Dermatol. 10:450-452, 1991. 82. Diaz LA. Pemphigus dans la jungle. Abstract Dermato HEBDO, No 110:21-25, 1991. 83. Diaz LA. The pathogenic autoantibody response in endemic pemphigus foliaceus (fogo

selvagem) is IgG4 restricted. Molec. Biol. Reports 15:102-104, 1991. 84. Ryynanen M, Knowlton RG, Kero M, Sawamura D, Li K, Giudice GJ, Diaz LA and Uitto

J. Bullous pemphigoid antigens (BPAGs): Identification of RFLPs in human BPAG1 and BPAG2, and exclusion as candidate genes in a large kindred with dominant epidermolysis bullosa simplex. Genomics 11:1025-1029, 1991.

85. Li K, Sawamura D, Giudice GJ, Diaz LA, Mattei M-G, Chu M-L and Uitto J. Genomic

organization of a collagenous domain and chromosomal assignment of human 180 kD bullous pemphigoid antigen (BPAG2), a novel collagen of stratified squamous epithelium. J. Biol. Chem., 266:24064-24069, 1991.

86. Lombardi C, Borges PC, Chaul A, Sampaio SAP, Rivitti EA, Friedman H, Martins CR,

Sanches Jr JA, Cunha PR, Hoffmann RG, Diaz LA. Environmental risk factors in endemic pemphigus foliaceus (fogo selvagem). J. Invest. Dermatol., 98:847-850, 1992.

87. Rocha-Alvarez R, Friedman H, Campbell I, Souza-Aguiar L, Martins-Castro R, Diaz LA.

Pregnant women with endemic pemphigus foliaceus (fogo selvagem) give birth to disease-free babies. J. Invest. Dermatol., 99:78-82, 1992.

88. Liu Z, Diaz LA, Haas AL, and Giudice GJ. cDNA cloning of a novel human ubiquitin

carrier protein. An antigenic domain specifically recognized by endemic pemphigus foliaceus autoantibodies is encoded in a secondary reading frame of this human epidermal transcript. J. Biol. Chem., 267:15829-15835, 1992.

89. Giudice GJ, Emery DJ and Diaz LA. Cloning and primary structural analysis of the

bullous pemphigoid autoantigen, BP-180. J. Invest. Dermatol., 99:243-250, 1992. 90. Li K, Giudice GJ, Tamai K, Choi Do H, Sawamura D, Diaz LA, and Uitto J. Cloning of

partial cDNA for mouse 180-kDa bullous pemphigoid antigen (BPAG2), a highly

21

conserved collagenous protein of the cutaneous basement membrane zone. J. Invest. Dermatol., 99:258-263, 1992.

91. Allen EM, Giudice GJ and Diaz LA. Subclass reactivity of pemphigus foliaceus

autoantibodies with recombinant human desmoglein. J. Invest. Dermatol., 100:685-691, 1993.

92. Olague-Alcala M and Diaz LA. The epitopes on bovine pemphigus foliaceus antigen are

calcium dependent and located on the peptide backbone of this glycoprotein. Chron. Dermat., 2:189-209, 1993.

93. Calvanico NJ, Swartz SJ and Diaz LA. Affinity immunoblotting studies on the restriction

of autoantibodies from endemic pemphigus foliaceus patients. J. Autoimmunity 6:145-157, 1993.

94. Giudice GJ, Emery DJ, Zelickson BD, Anhalt GJ, Liu Z, and Diaz LA. Bullous

pemphigoid and herpes gestationis autoantibodies recognize a common non-collagenous site on the BP180 ectodomain. J. Immunol., 151:5742-5750, 1993.

95. Liu Z, Diaz LA, Troy JL, Taylor AF, Emery DJ, Fairley JA and Giudice GJ. A passive

transfer model of the organ-specific autoimmune disease, bullous pemphigoid, using antibodies generated against the hemidesmosomal antigen, BP180. J. Clin. Invest., 92:2480-2488, 1993.

96. Cerna M, Fernandez-Vina M, Friedman H, Moraes JR, Moraes ME, Diaz LA and Stastny

P. Genetic markers for susceptibility for endemic Brazilian pemphigus foliaceus (fogo selvagem) in Xavante Indians. Tissue Antigens 42:138-140, 1993.

97. Esparza RH, Diaz EA and Diaz LA. Clonacion molecular de Ro/SSA de 60 kD. Revista

Mexicana de Rheumatologia 8:125-129, 1993. 98. Giudice GJ, Wilske K, Anhalt GJ, Fairley JA, Hoffmann RG, Taylor A, Emery DJ and

Diaz LA. Development of an ELISA to detect anti-BP180 autoantibodies in bullous pemphigoid and herpes gestationis. J. Invest. Dermatol., 102:878-881, 1994.

99. Olague-Alcala M, Giudice GJ and Diaz LA. Pemphigus foliaceus sera recognize an N-

terminal fragment of bovine desmoglein 1. J. Invest. Dermatol., 102:882-885, 1994. 100. Liu Z, Diaz LA and Giudice GJ. Autoimmune response against the bullous pemphigoid

180 autoantigen. Dermatology, 189:34-37, 1994. 101. Rivitti EA, Sanches JA, Miyauchi LM, Sampaio SAP, Aoki V, Diaz LA and "The

Cooperative Group on Fogo Selvagem Research." Pemphigus foliaceus autoantibodies bind both epidermis and squamous mucosal epithelium but tissue injury is detected only in the epidermis. J. Am. Acad. Dermatol., 31:954-958, 1994.

102. Mascaro JM, Giudice GJ and Diaz LA. Desmosomas y hemidesmosomas en

enfermedades ampollares autoinmunes. Med. Cutanea. I.L.A., 22:193-205, 1994.

22

103. Cunha, PR, Focaccia RR, and Diaz LA. Evolution of endemic pemphigus foliaceus (fogo

selvagem) after HIV-1 infection. J. Am. Acad. Dermatol. 32:809-811, 1995. 104. Emery DJ, Diaz LA, Fairley JA, Lopez A, Taylor AF and Giudice GJ. Pemphigus

foliaceus and pemphigus vulgaris autoantibodies react with the extracellular domain of desmoglein-1. J. Invest. Dermatol. 104:323-328, 1995.

105. Giudice GJ, Liu Z, and Diaz LA. An animal model of bullous pemphigoid: What can it

teach us? Proceed. Assoc. Am. Phys., 107:237-241, 1995. 106. Friedman H, Campbell I, Rocha-Alvarez R, Ferrari I, Coimbra CEA, Moraes JR, Flowers

NM, Stastny P, Fernandez-Vina M, Olague-Alcala M and Diaz LA. Endemic pemphigus foliaceus (fogo selvagem) in native Americans from Brazil. J. Am. Acad. Dermatol. 32:949-956, 1995.

107. Fairley JA, Heintz PW, Neuburg M, Diaz LA and Giudice GJ. Expression pattern of the

bullous pemphigoid-180 antigen in normal and neoplastic epithelia. Brit. J. Dermatol. 133:385-391, 1995.

108. Liu Z, Diaz LA, Swartz SJ, Troy JL, Fairley JA, Emery DJ and Giudice GJ. Molecular

mapping of a pathogenically relevant epitope associated with experimentally induced murine bullous pemphigoid. J. Immunol., 155:5449-5454, 1995.

109. Liu Z, Giudice GJ, Swartz S, Fairley JA, Till GO, Troy JL and Diaz LA. The role of

complement in experimental bullous pemphigoid. J. Clin. Invest., 95:1539-1544, 1995. 110. Santi CG, Maruta CW, Aoki V, Sotto MN, Rivitti EA, Diaz LA, and “The Cooperative

Group on Fogo Selvagem Research.” Pemphigus herpetiformis is a rare clinical expression of non-endemic pemphigus foliaceus, fogo selvagem and pemphigus vulgaris. J. Am. Acad. Dermatol., 34:40-46, 1996.

111. Liu Z, Haas AL, Diaz LA, Conrad CA, and Giudice GJ. Characterization of a novel

keratinocyte ubiquitin carrier protein. J. Biol. Chem., 271:2817-2822, 1996. 112. Caux FA, Giudice GJ, Diaz LA and Fairley JA. Cicatricial pemphigoid. J. Geriat Derm.,

4:42-46, 1996. 113. Zillikens D, Giudice GJ, and Diaz LA. Bullous pemphigoid: An autoimmune blistering

disease of the elderly. J. Geriat. Derm., 4:35-44, 1996. 114. Hans-Filho G, dos Santos V, Katayama JH, Aoki V, Rivitti EA, Sampaio SAP, Friedman

H, Moraes JR, Moraes ME, Eaton DP, Lopez AL, Hoffmann RG, Fairley JA, Giudice GJ, Diaz LA and the “Cooperative Group on Fogo Selvagem Research.” An active focus of high prevalence of fogo selvagem on an Amerindian reservation in Brazil. J. Invest. Dermatol., 107:68-75, 1996.

23

115. Balding SD, Prost C, Diaz LA, Bernard P, Bedane C, Aberdam D and Giudice GJ. Cicatricial pemphigoid autoantibodies react with multiple sites on the BP180 extracellular domain. J. Invest. Dermatol., 106:141-146, 1996.

116. Zillikens, D., Kawahara, Y., Mayer, J., Ishiko, A., Liu, Z., Shimizu, H., Diaz, L.A., and

Hashimoto, T. A novel IgG-mediated subepidermal blistering disease with autoantibodies against a 200-kD antigen of the basement membrane zone. J. Invest. Dermatol. 106: 1333-1338, 1996.

117. Lin MS, Mascaro JM, Liu Z, Espana A and Diaz LA. The desmosome and

hemidesmosome in cutaneous autoimmunity. Clin. Exp. Immunol., 107:9-15, 1997. 118. Lin MS, SJ Swartz, A Lopez, X Ding, MA Fernandez-Vina, P Stastny, JA Fairley and LA

Diaz. Development and characterization of desmoglein-3 specific T cells from patients with pemphigus vulgaris. J. Clin. Invest., 99:31-40, 1997.

119. Moraes, ME, Fernandez-Vina M, Lazaro A, Diaz LA, Hans-Filho G, Friedman H, Rivitti E,

Aoki V, Stastny P, Moraes JR. An epitope in the third hypervariable region of the DRB1 gene is involved in the susceptibility to endemic pemphigus foliaceus (“fogo selvagem”) in three different Brazilian populations. Tissue Antigens, 49:35-40, 1997.

120. Bedane C, McMillan JR, Balding S, Bernard P, Prost C, Bonnetblanc J, Diaz LA, R Eady

and Giudice GJ. Bullous pemphigoid and cicatricial pemphigoid autoantibodies react with ultrastructurally separable epitopes on the BP180 ectodomain: Evidence that BP180 spans the lamina lucida. J. Invest. Dermatol., 108:901-907, 1997.

121. Balding SD, Diaz LA and Giudice GJ. A recombinant form of the human BP180

ectodomain forms a collagen-like homotrimeric complex. Biochemistry, 36:8821-8830, 1997.

122. Liu Z, Giudice GJ, Zhou X, Swartz SJ, Troy JL, Fairley JA, Till GO and Diaz LA. A major

role for neutrophils in experimental bullous pemphigoid. J. Clin. Invest. 100:1256-1263, 1997.

123. España A, Diaz LA, Mascaro JM Jr, Giudice GJ, Fairley JA, Till GO and Liu Z.

Mechanisms of acantholysis in pemphigus foliaceus. Clinical Immunology and Immunopathology, 85:83-89, 1997.

124. Mascaro JM Jr, España A, Liu Z, Ding X, Swartz SJ, Fairley JA and Diaz LA:

Mechanisms of acantholysis in pemphigus vulgaris: Role of IgG valence. Clinical Immunology and Immunopathology, 85:90-96, 1997.

125. Zillikens D, Rose PA, Balding SD, Liu Z, Olague-Marchan M, Diaz LA and Giudice GJ.

Tight clustering of extracellular BP180-epitopes recognized by bullous pemphigoid autoantibodies. J. Invest. Dermatol. 109:573-579, 1997.

126. Zillikens D, Mascaro JM, Rose PA, Liu Z, Ewing SM, Caux F, Hoffmann RG, Diaz LA

and Giudice GJ. A highly sensitive enzyme-linked immunosorbent assay for the

24

detection of circulating anti-BP180 autoantibodies associated with bullous pemphigoid. J. Invest. Dermatol, 109:679-683, 1997.

127. Ding X, Aoki V, Mascaro J Jr., Lopez-Swiderski A, Diaz LA and Fairley JA. Mucosal and

mucocutaneous (generalized) pemphigus vulgaris show distinct autoantibody profiles. J. Invest. Dermatol. 109:592-596, 1997.

128. Liu Z, Roopenian DC, Zhou X, Christianson GJ, Diaz LA and Anderson CL. β2

microglobulin deficient mice are resistant to bullous pemphigoid. J. Exp. Med. 186:777-783, 1997.

129. Lin MS, Swartz SJ, Lopez A, Ding X, Fairley JA and Diaz LA. T lymphocytes from a

subset of patients with pemphigus vulgaris respond to both desmoglein-3 and desmoglein-1. J Invest Dermatol 109:734-737, 1997.

130. Peñas PF, Buezo GF, Carvajal I, Dauden E, Lopez A and Diaz LA. D-penicillamine-

induced pemphigus foliaceus with autoantibodies to desmoglein-1 in a patient with mixed connective tissue disease. J. Amer. Acad. Dermatol., 37:121-123, 1997.

131. Leung DYM, Diaz LA, DeLeo V and Soter NA. Allergic and Immunologic Skin disorders.

In Primer on Allergic and Immunologic Disease. JAMA, 279:1914-1923, 1997. 132. Aoki V, Hans Filho G, Diaz LA and The Cooperative Group on Fogo Selvagem

Research. Endemic pemphigus foliaceus (Fogo Selvagem). Retinoids and Lipid Soluble Vitamins in Clinical Practice 14:1-4, 1998.

133. Eaton DP, Diaz LA, Hans-Filho G, dos Santos V, Aoki V, Friedman H, Rivitti EA,

Sampaio SAP, Gottlieb MS, Giudice GJ, Lopez A, Cupp EW and the “Cooperative Group on Fogo Selvagem Research.” Comparison of the black fly species (Diptera: Simuliidae) on an Amerindian reservation with a high prevalence of fogo selvagem to neighboring disease-free sites in the state of Mato Grosso do Sul, Brazil. J. Med. Entomol, 35:120-131, 1998.

134. Liu, Z., Shipley JM, Vu TH, Zhou X, Diaz LA, Werb Z and Senior RM. Gelatinase B-

deficient mice are resistant to experimental Bullous Pemphigoid. J Exp Med, 188:475-482, 1998.

135. Murakami H, Nishioka S, Setterfield J, Bhogal BS, Black MM, Zillikens D, Yancey KB,

Balding SD, Giudice GJ, Diaz LA, Nishikawa T, Kiyokawa C and Hashimoto T. Analysis of antigens targeted by circulating IgG and IgA autoantibodies in 50 patients with cicatricial pemphigoid. J. Dermatol. Sci. 17:39-44, 1998.

136. Bergman R, Sujov P, Peled M, Diaz L and Etzioni A. Primary persistent autoimmune

disorder in a neonate. The Lancet 353:124, 1999. 137. Diaz, LA: Editorial: Aspectos Negativos de la Dermatologia Moderna. Rev Argentina de

Dermatol, IV: 201, 1998

25

138. Nousari HC, Anhalt GJ and Diaz LA. Penfigo Paraneoplasico. Homenaje al Profesor Alejandro Cordero. Revista Argentina de Dermatology. IV:301-310, 1998.

139. Hans-Filho G, Aoki V, Rivitti E, Eaton DP, Lin MS, Diaz LA and “The Cooperative Group

on Fogo Selvagem Research”. Endemic Pemphigus Foliaceus (Fogo Selvagem)-1998. Clin Dermatol. 17:225-235, 1999.

140. Lin MS, Gharia MA, Swartz SJ, Diaz LA and Giudice GJ. Identification and

characterization of epitopes recognized by T lymphocytes and autoantibodies from patients with herpes gestationis. J. Immunol. 162:4991-4997, 1999.

141. Nousari HC, Kimyai-Asadi A, Ketabchi N, Diaz LA and Anhalt GJ. Severe nonendemic

pemphigus foliaceus presenting in the postpartum period. J Amer Acad Dermatol 40:845-846, 1999.

142. Ding X, Diaz LA, Fairley, JA, Giudice GJ and Liu Z. The anti-desmoglein 1

autoantibodies in pemphigus vulgaris sera are pathogenic. J Invest Dermatol, 112:739-743, 1999.

143. Zillikens D, Caux F, Mascaro JM, Jr., Wesselmann U, Schmidt E, Prost C, Callen JP,

Brocker E-B, Diaz LA and Giudice GJ. Autoantibodies in lichen planus pemphigoides react with a novel epitope within the C-terminal NC16A domain of BP180. J. Invest. Dermatol. 113:117-121, 1999.

144. Zillikens D, Herzele K, Georgi M, Schmidt E, Chimanovitch I, Schumann H, Mascaro JM

Jr, Diaz LA, Bruckner-Tuderman L, Brocker EB and Giudice GJ. Autoantibodies in a subgroup of patients with linear IgA disease react with the NC16A domain of BP180. J Invest Dermatol 113:947-953, 1999.

145. Lin M-S, Gharia MA, Fu C-l, Olague-Marchan M, Hacker M, Harman KE, Bhogal BS,

Black MM, Diaz LA and Giudice GJ. Molecular mapping of the major epitopes of BP180 recognized by herpes gestationis autoantibodies. Clin Immunol, 92:285-292,1999.

146. Mascaró, J.M., Jr, D. Zillikens, G.J. Giudice, F. Caux, M.G. Fleming, H.M. Katz, and,

L.A. Diaz. A subepidermal bullous eruption associated with IgG autoantibodies to a 200 kD dermal antigen: The first case report from the U.S. J Am Acad Dermatol, 42:309-315, 2000.

147. Reis VMS, Toledo RP, Lopez A, Diaz LA, Martins JEC and the Cooperative Group on

Fogo Selvagem Research. Ultraviolet B induced acantholysis in endemic pemphigus foliaceus (Fogo Selvagem). J Amer Acad Dermatol, 42:571-576, 2000.

148. Diaz LA and Giudice GJ. End of the century overview: skin blisters. Arch Dermatol, 136:

106-112, 2000. 149. Liu, Z., Shapiro SD, Zhou S, Twining SS, Senior RM, Giudice GJ, Fairley JA and Diaz

LA. Neutrophil elastase plays a critical role in experimental bullous pemphigoid. J Clin Invest, 105:113-123,2000.

26

150. Lin M-S, Fu C-L, Aoki V, Hans-Filho G, Rivitti EA, Moraes JR, Moraes ME, Lazaro AM, Giudice GJ, Stastny P and Diaz LA. Development and characterization of desmoglein-1 speficic T lymphocytes from patients with Endemic Pemphigus Foliaceus (Fogo Selvagem). J Clin Invest, 105:207-213,2000.

151. Warren SJP, Lin MS, Giudice GJ, Hoffman RG, Hans-Filho G, Aoki V, Rivitti EA, dos

Santos V and Diaz, LA: The prevalence of antibodies against desmoglein 1 in endemic pemphigus foliaceus in Brazil. N Engl J Med 343:23-30, 2000

152. Liu Z, Zhou X, Shapiro SD, Shipley JM, Twining SA, Diaz LA, Senior RM and Werb Z:

The Serpin α1-Proteinase Inhibitor is a Critical Substrate for Gelatinase B/MMP-9 In Vivo. Cell, 102:647-655, 2000.

153. Olague-Marchan M, Twining S.S., Hacker MK, McGrath JA, Diaz LA and Giudice GJ: A

disease-associated glycin substitution in BP180 (type XVII collage) leads to a local destabilization of the major collagen triple helix. Matrix Biology 19:223-233, 2000.

154. Avalos-Diaz E, Olague-Marchan M, Lopez-Swiderski A, Herrera-Esparza R and Díaz LA.

Transplacental passage of maternal pemphigus foliaceus autoantibodies induces neonatal pemphigus. J Amer Acad Dermatol, 43: 1130-1134, 2000.

155. Lin M-S, Giudice GJ, Olague-Marchan M, Lazaro AM, Stastny P and Diaz LA.

Autoimmune response in patients with bullous pemphigoid: epitopes targeted by T lymphocytes and autoantibodies map to the same sites on the BP180 ectodomain. J Invest Dermatol, 115:955-961, 2000.

156. Anhalt GJ and Diaz LA. Prospects for autoimmune disease: Research Advances in

Pemphigus. JAMA 285:652-654, 2001. [PMID: 11176877] 157. Dos Santos S.N.M.B., Patrus O.A., Fuigueira A.L. and Diaz, L.A.: Perfil evolutivo das

subclasses de imunoglobulinas gama em pacientes de penfigo foliaceo endemico. An Bras Dermatol 76:561-574, 2001.

158. Alvarado-Flores E., Avalos-Diaz E., Diaz, L.A., and Herrera-Esparza R: Anti-Idiotype

Antibodies Neutralize In vivo the Blistering Effect of Pemphigus Foliaceus IgG. Scand. J. Immunol 53:254-258, 2001. [ PMID: 11251882]

159. Stanley JR. Nishikawa T. Diaz LA. Amagai M. Pemphigus: is there another half of the

story? J Invest Dermatol 116:489-490, 2001. [PMID: 11286612] 160. Stanley JR. Nishikawa T. Diaz LA. and Amagai M. Reply “Pemphigus: An unfolding

Story”. J Invest Dermatol 117:994-995, 2001 161. Liu Z and Diaz LA: Bullous Pemphigoid: End of the Century Overview. J Dermatol

28:647-650, 2001. [PMID: 11770726] 162. Chen RY, Ning G, Zhao ML, Fleming MG, Diaz LA, Werb Z, Liu Z. Mast cells play a key

role in neutrophil recruitment in experimental bullous pemphigoid. J Clin Invest , 108:1151-1158, 2001. [PMID: 11602622]

27

163. Arteaga L.A., Prisayanh P.S., Warren S.J.P., Liu Z, Diaz L.A., Lin M-S.: A subset of

Pemphigus Foliaceus Patients Exhbits Pathogenic Autoantibodies Against Desmoglein-1 and Desmoglein-3. J Invest Dermatol. 118:806-811, 2002. [PMID: 11982757]

164. Suchniak JM, Diaz LA, Lin M.S and Fairley JA. IgM-Mediated Epidermolysis Bullosa

Acquisita. Arch Dermatol 138:1385-1386, 2002. [PMID: 12374560] 165. Chen RY, Fairley JA, Zhao ML, Giudice GJ, Zillikens A, Diaz LA and, Liu Z.

Macrophages, but not T and B lymphocytes, are critical for subepidermal blister formation in experimental bullous pemphigoid: Macrophage-mediated neutrophil infiltration depends on mast cell activation. J Immunol 169:3987-3992, 2002. [PMID: 12244200]

166. Moesta A.K., Lin M.S., Diaz L.A. and Sinha A.A. T Cell Receptor ß Chain Gene Usage

in Endemic Pemphigus Foliaceus (Fogo Selvagem). J Invest Dermatol 119: 377-383, 2002. [PMID: 12190860]

167. Warren SJP, Arteaga LA, Rivitti EA, Aoki V, Hans-Filho G, Qaquish BF, Lin MS, Giudice

GJ, and Diaz, LA: The role of subclass switching in the pathogenesis of endemic pemphigus foliaceus. J Invest Dermatol, 120:104-108, 2003. [PMID: 12535205]

168. Li N, Aoki V, Hans-Filho G, Rivitti EA and Diaz LA. The Role of Intramolecular Epitope

Spreading in the Pathogenesis of Endemic Pemphigus Foliaceus (Fogo Selvagem). J Exp Med. 197:1501-1510, 2003. [PMID: 12771179]

169. Aoki V, Millikan RC, Rivitti EA, Hans-Filho G, Eaton DP, Warren SJP, Li N, Hilario-

Vargas J, Hoffmann RG, and Diaz L.A. Environmental Risk Factors in Endemic Pemphigus Foliaceus (Fogo Selvagem). J Invest Dermatol. 9:34-40, 2004. [PMID: 14870983]

170. Pias EK, Hilario-Vargas J, Li N, Diaz LA. Humoral Autoimmunity in Pemphigus.

Autoimmunity. 37:283-286. 2004. [PMID: 15518042] 171. Diaz LA, Arteaga LA, Hilario-Vargas J, Valenzuela JG, Li N, Warren S, Aoki V, Hans-

Filho G, Eaton D, dos Santos V, Nutman TB, Antunez de Mayolo A, Qaqish BF, Sampaio SAP and Rivitti EA, for the Cooperative Group on Fogo Selvagem Research. Anti-desmoglein-1 antibodies in onchocerciasis, leishmaniasis and Chagas Disease suggest a possible etiological link to Fogo Selvagem. J Invest Dermatol, 123:1045-1051, 2004. [PMID: 15610512]

172. Sánchez-Carpintero I., España A, Pelacho B, López-Moratalla N, Rubenstein DS, Diaz

LA and López-Zabalza MJ. In vivo blockade of pemphigus vulgaris acantholysis by inhibition of intracellular signal transduction cascades. Brit J Dermatol, 151:565-570, 2004. [PMID: 15377341]

173. Liu Z, Li N, Diaz LA. Immunopathological mechanisms of acantholysis in pemphigus

vulgaris: an explanation by ultrastructural observations. J Invest Dermatol. 122, XIII-XIV. Review. 2004 [PMID: 15140250]

28

174. Gabbi TV, Bernardelli IM, Santi CG, Maruta CW, Kodani V, Sotto M, Li N, Hilario-Vargas

J, Diaz LA, Rivitti EA, and Aoki V. Pemphigus foliaceus with neutrophilic spongiosis evolving to an atypical pemphigus phenotype. J Am Acad Dermatol. 51:1012-1013, 2004. [PMID: 15583603]

175. Liu, Z., Li, N., Diaz, L.A., Shipley, J.M., Senior, R.M., and Werb, Z. Synergy between a

Plasminogen Cascade and MMP-9 in Autoimmune Disease. J. Clin. Invest. 105:879-887, 2005. [PMID: 15841177]

176. Berkowitz, P., Hu, P., Liu, Z., Diaz, L.A., Enghild, J.J., Chua, M.P., and Rubenstein, D.S.

Desmosome signaling: inhibition of p38MAPK prevents pemphigus vulgaris IgG induced cytoskeleton reorganization. J. Biol. Chem., 280:23778-23784, 2005. [PMID: 15840580]

177. Li, N., Zhao, M., Hilario-Vargas, J., Prisayanh, P., Warren, S., Diaz, L.A., Roopenian,

D.C., and Liu, Z.: Complete FcRn Dependence for Intravenous Ig Therapy in Autoimmune Skin Blistering Diseases. J. Clin. Invest. 115:3440-3450, 2005. [PMID: 16284651]

178. Liu Z, Zhao M, Li N, Diaz LA, and Mayadas TN. Differential roles of β-2 integrins in

experimental autoimmune bullous pemphigoid. Blood. 107:1063-1069, 2006. [PMID: 16234355]

179. Liu Z, Li N, and Diaz LA. Inhibition of pemphigus vulgaris by targeting of the CD40-

CD154 co-stimulatory pathway: A step toward antigen-specific therapy? J. Invest. Dermatol. 126:11, 2006. [PMID: 16417211]

180. Empinotti J.C., Aoki V., Filgueira A., Sampaio S.A.P., Rivitti E.A., Sanches Jr J.A., Li N.,

Hilario-Vargas J., Diaz L.A. and the Cooperative Group on Fogo Selvagem Research: Clinical and Serological Follow-up Studies of Endemic Pemphigus Foliaceus (Fogo Selvagem) in Western Parana, Brazil (1988-2003). Brit J Dermatol, 155:446-450, 2006. [PMID: 16882187].

181. Hilario-Vargas J, Dasher D, Li N, Aoki V, Hans-Filho G, Dos Santos V, Qaqish BF, Rivitti EA and Diaz LA for the Cooperative Group on Fogo Selvagem Research. Prevalence of anti-desmoglein-3 antibodies in Endemic Regions of Fogo Selvagem in Brazil. J Invest. Dermatol. 126: 2044-2048, 2006 [ PMID: 16763546]

182. Berkowitz, P., Hu, P., Warren, S., Liu, Z., Diaz, L.A., and Rubenstein, D.S. p38MAPK inhibition prevents disease in pemphigus vulgaris mice. Proc Natl Acad Sci. 103: 12855-12860, 2006. [PMID: 16908851]

183. Zhao, M., Trimbeger, M.E., Li, N., Diaz, L.A., Shapiro, S.D., and Liu, Z. Role of Fc

receptors in animal model of autoimmune bullous pemphigoid. J. Immunol. 177:3398-3405, 2006. [PMID: 16920981]

184. Rubenstein, D.S. & Diaz, LA. Pemphigus antibody-induced phosphorylation of

keratinocyte proteins. Autoimmunity, 39:577-586, 2006. [PMID: 17101501]

29

185. Nelson K.C., Zhao, M., Schroeder P.R., Li, N., Westel, R.A., Diaz, L.A., and Liu, Z. Role of different pathways of the complement cascade in experimental bullous pemphigoid. J. Clin. Invest. 116:2892-2900, 2006. [PMID: 17024247]

186. Qian Y, Diaz L.A., Ye J and Clarke S.H. Dissecting the Anti-desmoglein Autoreactive B

Cell Repertoire in Pemphigus Vulgaris Patients. J Imunol. 178: 5982-5990, 2007. [ PMID:17442983 ]

187. Rocha-Alvarez R., Ortega-Loayza A., Friedman H., Campbell H., Aoki V., Rivitti E.A.,

Dasher D., Li N. and Diaz L.A. Endemic Pemphigus Vulgaris. Arch Dermatol. 143:895-899, 2007.

188. Diaz L.A. Rituximab and Pemphigus – A Therapeutic Advance. New Eng J Med. 357:

605-607, 2007.

189. Leighty L, Li N, Diaz LA, and Liu Z. Autoimmune and Inflammatory Blistering disease, Bullous Pemphigoid. Arch Dermatol Res. 299:417-422, 2007.

190. Diaz L.A., Prisayanh P., Dasher D., Li N., Evangelista F., Aoki V., Hans-Filho G., dos

Santos V., Qaquish B.F., Rivitti E.A. and the Cooperative Group on Fogo Selvagem research. IgM anti-desmoglein 1 Autoantibodies are the Distinguishable Immunologicaol Markers of Endemic Pemphigus Foliaceus (fogo selvagem). J Invest Dermatol. 128:667-675, 2008.

191. Evangelista F.M., Dasher D., Diaz, L.A., Prisayanh P., and Li N. E-cadherin is an

additional immunological target for pemphigus autoantibodies. J Invest Dermatol. 128: 1710-1718, 2008. [PMID: 18219275]

192. Murrell DF, Amagai M, Barnadas MA, Borradori L, Bystryn J-C, Cianchini G, Diaz L,

Fivenson D, Goldsmith L, Hall R, Harman KE, Hashimoto T, Hertl H, Hunzelmann N, Iranzo P, Joly P, Jonkman MF, Kitajima Y, Korman N, Martin LK, Mimouni D, Payne A, Pandya A, Rubenstein D, Shimizu H, Sinha A, Sirois D, Dick S, Werth VP. Consensus Statement on Definitions of Disease Endpoints and Therapeutic Response for Pemphigus. J Am Acad Dermatol. 58: 1043-1046, 2008.

193. Berkowitz P, Diaz LA, Hall R, and Rubenstein DS. Induction of p38MAPK and HSP27

phosphorylation in pemphigus patient skin. J Invest Dermatol. 128: 738-740, 2008. [PMID: 17928890].

194. Dasher D, Rubenstein D, Diaz LA. Pemphigus foliaceus. Curr Dir Autoimmun. 10:182-

194, 2008. [PMID: 18460886]

195. Qaqish BF, Prisayanh P, Qian Y, Andraca E, Li N, Aoki V, Hans-Filho G, dos Santos V, Rivitti EA, and Diaz LA for the Cooperative Group on Fogo Selvagem Research. Development of an IgG4-based predictor of endemic pemphigus foliaceus (Fogo Selvagem). J Invest Dermatol, 129: 110-118, 2009. [PMID: 18704107]

196. Lessey E, Li N, Diaz LA, Liu Z. Complement and Cutaneous Autoimmune Blistering

Diseases. Immunol Immunol Res. 2008; 41:223-32. [PMID: 18641925]

30

197. Li N, Zhao M, Wang J, Liu Z, Diaz LA. Involvement of the apoptotic mechanism in

pemphigus foliaceus autoimmune injury of the skin. J Immunol. 182:711-717, 2009. [PMID: 19109205].

198. Berkowitz P, Chua M, Liu Z, Diaz LA, Rubenstein DS. Autoantibodies in the

autoimmune disease pemphigus foliaceus induce blistering via p38 mitogen-activated protein kinase-dependent signaling in the skin. Am J Pathol. 173:1628-36, 2008. [PMID: 18988808].

199. Liu Z, Sui W, Zhao M, Li Z, Li N, Thresher R, Giudice GJ, Fairley JA, Sitaru C, Zillikens

D, Ning G, Marinkovich MP, Diaz LA. Subepidermal blistering induced by human autoantibodies to BP180 requires innate immune players in a humanized bullous pemphigoid mouse model. J Autoimmun. 31:331-338, 2008. [PMID: 18922680].

200. Culton DA, Qian Y, Li N, Rubenstein D, Aoki V, Filhio GH, Rivitti EA, Diaz LA.

Advances in pemphigus and its endemic pemphigus foliaceus (Fogo Selvagem) phenotype: A paradigm of human autoimmunity. J Autoimmun. 31:311-324, 2008. [PMID: 18838249]

201. Moriconi A, Xu W, Li N, Groben P, Diaz LA, Allegretti M, and Liu Z. Dual targeting of

mast cells and neutrophils in autoimmune disease by a small molecule inhibitor. Submitted, 2009.

202. Leighty L, Li Z, Berkowitz P, Zhao M, Li N, Rubenstein D, Diaz LA, and Liu Z. C5a-C5a

receptor signaling pathway is critical for experimental bullous pemphigoid. In preparation, 2009.

203. Wagner N, Gleason, D., Chen, R., Vilen B, Diaz L.A., and Liu, Z.: Critical role of tumor

necrosis factor, IL-1, and IL-6 in experimental autoimmune blistering disease, bullous pemphigoid. In preparation, 2009.

204. Gleason, D., Chen, R., Diaz, L.A., and Liu, Z.: Transmission of experimental bullous

pemphigoid/herpes gestationis from mother to neonates is mediated by FcRn receptor. In preparation, 2009.

205. Hu, P., Xiao, H., Rubenstein, D., O’Keefe, E., Jennette, J., Diaz, L.A., and Liu, Z.:

Myeloperoxidase-deficient mice are resistant to experimental bullous pemphigoid. In preparation, 2009.

206. Liu, Z., Betsuyaku, T., Rubenstein, D.S., Diaz, L.A., and Senior, R.M. BP180 (BPAG2) is

a neutrophil chemoattractant in vitro and in vivo after proteolysis by neutrophil elastase. In preparation, 2009.

207. Eaton DP, Friedman H, Rivitti EA, A oki V, Sanches JA Jr, Hans-Filho G, Cunha PR,

Cupp E and Diaz LA. Species composition of black flies (Diptera: Simuliidae) near disease foci of endemic pemphigus foliaceus (fogo selvagem) in Brazil. In preparation, 2009.

31

208.

32

Book Chapters and Books: (1980 - To date) 1. Diaz LA and Provost TT. Bullous Dermatoses. In: Cutaneous Aspects of Internal Disease.

JP Callen, Editor, Year Book Medical Publishers, Inc., Chicago, IL, 1980. 2. Diaz LA and Provost TT. Pemphigus, pemphigoid and dermatitis herpetiformis. In:

Dermatological Signs of Internal Disorders. JP Callen, Editor, Year Book Medical Publishers, Chicago, IL, 1981.

3. Anhalt GJ and Diaz LA. The dermal-epidermal junction in normal and disease states. In:

Progress in Diseases of the Skin, Vol. I. R. Fleischmajer, Editor, Grune & Stratton Inc. 1981, pp. 161-176.

4. Diaz LA and Yaoita H. The basement membrane zone. In: Proceedings of the XVIth

International Congress of Dermatology, Tokyo, Japan. University of Tokyo Press, 1983, pp. 587-589.

5. Diaz LA and Provost TT. Pemphigus. In: Current Therapy in Allergy and Immunology.

LM Lichtenstein and AS Fauci, Editors. BC Decker, Inc., Publisher, 1983, pp. 166-170. 6. Diaz LA and Provost TT. Bullous pemphigoid. In: Current Therapy in Allergy and

Immunology. LM Lichtenstein and AS Fauci, Editors. BC Decker, Inc., Publisher, 1983, pp. 171-172.

7. Anhalt GJ, Labib RS, Patel HP and Diaz LA. Animal models. In: Clinics in Dermatology.

AR Ahmed, Editor, JP Lippincott Company, 1983, pp. 98-105. 8. Labib RS, Patel HP, Anhalt GJ and Diaz LA. The pemphigus antigens. In: Clinics in

Dermatology. AR Ahmed, Editor, JP Lippincott Company, 1983, pp. 82-91. 9. Patel HP, Anhalt GJ, Provost TT and Diaz LA. Immunopathology of pemphigus vulgaris,

bullous pemphigoid and related bullous dermatoses. In: Clinical Immunology Reviews, Vol. II. RE Rockin, Editor, 1984, pp 157-186.

10. Diaz LA and Provost TT. Dermatologic diseases. In: Basic and clinical immunology.

Stites, Stobo, Fundenberg and Wells, Editors. Lange Publishers, 5th Edition, 1984, pp. 580-597.

11. Diaz LA and Provost TT. Pemphigus. In: Current Therapy in Internal Medicine,

1984-1985. Bayless, Brain and Cherniack, editors. B.C. Decker, Inc., 1984 pp. 106-110. 12. Diaz LA and Provost TT. Bullous Pemphigoid. In: Current Therapy in Internal Medicine,

1984-1985. Bayless, Brain and Cherniack, editors. B.C. Decker, Inc., 1984 pp. 111-112. 13. Diaz LA and Provost TT. Pemphigus. In: Current Therapy in Dermatology, 1985-1986.

Provost and Farmer, editors. BC Decker, Inc., publishers, 1984, pp. 57-61. 14. Diaz LA and Provost TT. Bullous Pemphigoid. In: Current Therapy in Dermatology,

1985-1986. Provost and Farmer, editors. BC Decker, Inc., publishers, 1984, pp. 61-63.

33

15. Anhalt GJ and Diaz LA. Bullous diseases in animals. In: Models in Dermatology, Vol. 1. Maibach HI and Lowe NJ (Editors), Karger Publishing, Inc., New York, NY, 1985, pp 1-11.

16. Anhalt GJ, Bahn CF and Diaz LA. Bullous diseases. In: International Ophthalmology

Clinics. Vol. 25, No. 1. Callen J. (Editor). Little Brown and Co., Publishers, Boston, MA, 1985, pp. 37-59.

17. Diaz LA, Anhalt GJ, Patel HP and Provost TT. Autoimmune cutaneous diseases. In:

Autoimmune Diseases. NR Rose and IR Mackay, Editors, Academic Press, 1985, pp. 443-467.

18. Anhalt GJ, Patel HP and Diaz LA. Pemphigus vulgaris. In: Pathogenesis of Skin Disease.

Thiers BH and Dobson RL (Editors). Churchill Livingstone Inc., New York, NY, 1986, pp. 131-142.

19. Dermatology Scholars of the World: Professor. Luis A. Diaz, M.D., Nishi-Nihon-Hifu,

49:148-149, 1987. 20. Diaz LA and Anhalt GJ. Bullous Pemphigoid and other Basement Membrane Antigens. In:

Clinics in Dermatology. AR Ahmed, Editor, JP Lippincott Company, Vol 5. 1987, pp, 93-109.

21. Anhalt GJ and Diaz LA. Animal models for Bullous Pemphigoid. In: Clinics in

Dermatology. AR Ahmed, Editor, JP Lippincott Company. Vol 5. 1987, pp, 117-125. 22. Eaglstein NF, Anhalt GJ, Patel HP and Diaz LA. Herpes Gestationis. In: Immunopathology

of the Skin. Beutner EH and Chorzelski TP (Editors). John Wiley & Sons, New York, NY, 1987, pp. 371-378.

23. Roscoe JT, Anhalt GJ, Patel HP and Diaz LA. Recent advances in passive transfer studies

of bullous diseases. In: Immunopathology of the Skin. Beutner EH and Chorzelski TP (Editors). John Wiley & Sons, New York, NY, 1987, pp. 281-293.

24. Morrison LH and Diaz LA. Bullous Diseases of the Skin. In: Conn's Current Therapy, (RE

Rakel, Editor), WB Saunders Company. 1988, pp. 727-729. 25. Martins CR, Squiquera HL and Diaz LA. Pemphigus vulgaris and pemphigus foliaceus.

Curr. Probl. Dermatol. 17-61, 1989. 26. Anhalt GJ, Martins CR, Rivitti EA and Diaz LA. Endemic pemphigus foliaceus (fogo

selvagem). In: Advances in Dermatology. Callen JP (Editor) Year Book Medical Publishers. Vol. 4, 1989, pp. 73-94.

27. Anhalt GJ and Diaz LA. In vivo studies of antibody dependent acantholysis. In: Immune

Mechanisms in Cutaneous Diseases. Norris DA (Editor), Marcel Dekker, New York. 1989, pp. 291-316.

34

28. Morrison LH, Diaz LA and Anhalt GJ. Bullous Pemphigoid. In: Management of Blistering Diseases (Briggaman RA and Wojnarowska F, Editors). Chapman & Hall Ltd. London, England. pp. 63-82, 1990.

29. Dugan EM, Anhalt GJ and Diaz LA. Pemphigus. In: Immunologic Diseases of the Skin.

(RE Jordon Editor), Appleton-Century-Crofts. pp. 279-291, 1991. 30. Robledo MA, Diaz LA. Pathophysiology of Pemphigus. In: Pathophysiology of

Dermatologic Diseases. Second Edition. NA Soter and HP Baden (Editors). McGraw-Hill Book Company, New York. pp. 179-191. 1991.

31. Martins CR and Diaz LA. Therapeutic Guidelines for Pemphigus. In: Current Therapy in

Allergy, Immunology, and Rheumatology. Lichtenstein LM and Fauci AS (Editors). B.C. Decker Inc., Toronto, Philadelphia. pp. 69-72, 1992.

32. Diaz LA. The pathogenic autoantibody response in Endemic Pemphigus Foliaceus (Fogo

Selvagem) is IgG4-Restricted. In: Molecular Biology Reports. Bautz EKF, Kalden Jr, Homma M, Shulman LE and Tan EM (Editors) Kluwer Academic Publishers. The Netherlands, pp. 102-104, 1993.

33. Calvanico NJ and Diaz LA: Pemphigus. In The Molecular Pathology of Autoimmune

Diseases. Bona CA, Siminovitch, Zanetti M and Theofilopoulos AN (Editors). Harwood Academic Publishers, USA. 1993 pp 563-574

34. Crosby DL and Diaz LA. (Editors) Bullous Diseases (Dermatologic Clinics). W.B.

Saunders Company, Philadelphia, 1993. 35. Crosby DL and Diaz LA. Autoimmune Diseases of the Skin. In: Immunology and Allergy

Clinics of North America. Vol 13, 2:395-419, May, 1993. 36. Giudice GJ and Diaz LA. New laboratory methods in the investigation of bullous disease.

Dermatologic Clinics 11:419-427, 1993. 37. Crosby DL, Diaz LA and Giudice GJ. Endemic pemphigus foliaceus: Fogo selvagem.

Dermatologic Clinics 11:453-462, 1993. 38. Calvanico NJ and Diaz LA. Pemphigus. In: Pemphigus in Molecular Pathology of

Autoimmunity. Bona CA, Siminovitch K, Theofilopoulos AN and Zanetti M (Editors). Harwood Academic Publishers. Chur, London, Paris, New York, Melbourne, pp 563-574, 1993.

39. Crosby DL and Diaz LA. Pemphigus. In: Clinical Dermatology. Demis DJ (Editor). JB

Lippincott Company, Philadelphia, 1993. 40. Crosby DL and Diaz LA. Pemphigus Vegetans. In: Clinical Dermatology. Demis DJ

(Editor). JB Lippincott Company, Philadelphia, 1993. 41. Crosby DL and Diaz LA. Pemphigus Foliaceus. In: Clinical Dermatology. Demis DJ

(Editor). JB Lippincott Company, Philadelphia, 1993.

35

42. Crosby DL and Diaz LA. Pemphigus Erythematosus. In: Clinical Dermatology. Demis DJ

(Editor). JB Lippincott Company, Philadelphia, 1993. 43. Crosby DL and Diaz LA. Endemic Pemphigus Foliaceus. In: Clinical Dermatology. Demis

DJ (Editor). JB Lippincott Company, Philadelphia, 1993. 44. Crosby DL and Diaz LA. Drug-induced and Paraneoplastic Pemphigus. In: Clinical

Dermatology. Demis DJ (Editor). JB Lippincott Company, Philadelphia, 1993. 45. Sampaio SAP, Rivitti EA, Aoki V, Diaz LA, and the "Cooperative Group on Fogo Selvagem

Research." Brazilian pemphigus foliaceus, endemic pemphigus foliaceus or fogo selvagem (wild fire). In: Dermatologic Clinics 12:765-776, 1994.

46. Mascaro JM Jr., Fairley JA, Giudice GJ, Diaz LA. Autoantibodies in paraneoplastic

pemphigus. In Autoantibodies. Peter JB and Schoenfeld Y (Editor). Elsevier, Amsterdam, 1996, pp. 759-761.

47. Espana-Alonso A, Fairley JA, Giudice GJ, Diaz LA. Autoantibodies in pemphigus foliaceus.

In Autoantibodies. Peter JB and Schoenfeld Y (Editor). Elsevier, Amsterdam, 1996, pp. 754-758.

48. Mascaro JM, Jr., Fairley JA, Giudice GJ, Diaz LA. Autoantibodies in pemphigus vulgaris.

In Autoantibodies. Peter JB and Schoenfeld Y (Editor). Elsevier, Amsterdam, 1996, pp. 749-753.

49. Diaz LA, España-Alonso A, Fairley JA, Giudice GJ, Mascaro Jr JM and Liu Z. Skin

diseases autoantibodies. In: Autoantibodies. Peter JB & Shoenfeld Y, (Editors). Elsevier, Amsterdam, pp. 746-748, 1996.

50. Giudice GJ and Diaz LA. Autoantibodies in bullous pemphigoid, herpes gestationis and

cicatrical pemphigoid. In: Autoantibodies. Peter JB & Shoenfeld Y (Editors). Elsevier, Amsterdam, pp. 762-766, 1996.

51. Mascaro Jr JM and Diaz LA. Pemphigus. In: Current Therapy in Allergy, Immunology and

Rheumatology, Lichtenstein LM and Fauci AS, (Editors). Mosby Year Book, Philadelphia, pp. 90-93, 1996.

52. Mascaro Jr JM and Diaz LA. New concepts in the pathogenesis of pemphigus foliaceus.

In Current Opinion in Dermatology, Rapid Science Publishers, Philadelphia. Vol 3, pp 10-15, 1996.

53. Mascaro JM, Jr. And Diaz LA: Pemphigus In Current Therapy in Adult Medicine . 4th

Edition, Kassirer JP & Greene HL (Editors). Mosby-Year Book, Inc. St Louis, Missouri, 1997. pp1337-1339

54. Caux, FA, Giudice GJ, Diaz LA, Fairley JA. Autoimmune subepithelial blistering diseases

with ocular involvement. In: Immunology and Allergy Clinics of North America. Bielory L (ed) pp. 139-159, 1997.

36

55. Fairley JA, Ding X, Giudice GJ, Diaz LA. Pemphigus foliaceus and pemphigus vulgaris. In:

Textbook of Molecular Medicine. Jameson JL (Editor) Humana Press, Inc., Totowa, NJ, 1998, pp. 811-816.

56. Lin MS, Liu Z, Drolet B and Diaz LA. Cutaneous autoimmune diseases. In: The

Autoimmune Diseases, 2nd Edition, Rose N & Mackay I (Editors). Academic Press, 1998, pp. 545-570.

57. Zillikens D, Diaz LA. Autoimmune bullous diseases. In: Strategies for Immunointervention

in Dermatology. Burg and Dummer (Editors). Springer-Verlag, Berlin, Heidelberg, New York, 1998, pp 217-226.

58. Rocha-Alvarez R and Diaz LA. Erupcoes Vesico-Bolhosas. In: Dermatologia Basica.

Sampaio SAP and Rivitti EA (Editors). Editora Artes Medicas Ltda. Sao Paulo, 1998. 59. Aoki V. and Diaz LA. Metodos Imunodiagnosticos nas Dermatoses Bolhosas Auto-Imunes.

In: Dermatologia Basica. Sampaio SAP and Rivitti EA (Editors). Editora Artes Medicas Ltda. Sao Paulo, 1998.

60. Avalos E and Diaz LA. Afeccoes Vasculares. In: Dermatologia Basica. Sampaio SAP and

Rivitti EA (Editors). Editora Artes Medicas Ltda. Sao Paulo, 1998. 61. Herrera R and Diaz LA. Alteraciones de Morfologia. In: Dermatologia Basica. Sampaio

SAP and Rivitti EA, (Editors). Editora Artes Medicas Ltda. Sao Paulo, 1998. 62. Foley S and Diaz LA: Bullous Diseases of the Skin. In 51st Edition of Conn’s Current

Therapy. RE Rakel, M.D. (Editor), W.B. Saunders Co., Philadelphia, 1999, pp 861-866. 63. Gharia MJ, Fairley JA, Lin M-S, Liu Z, Giudice GJ and Diaz LA: Autoimmune Diseases of

the Skin. In Texbook of the Autoimmune Diseases. Lahita RG, Chiorazzi N, Reeves WH (Editors). Lipincott Williams & Wilkins, Philadelphia, Baltimore, 2000, pp 407-428.

64. Mascaro JM, Jr, Gharia M, Lin M-S, Liu Z and Diaz LA. Pemphigus Foliaceus. In Atlas of

Bullous Diseases. Jordon RE (Editor). Churchill Livingstone/W.B. Saunders. 2000, pp 17-27.

65. Mascaro JM Jr., Abreu-Velez AM and Diaz LA. Pemphigus. In: Dermatology in

Pigmented Skin. Hashimoto, Moiin and Boyd Sarog (Editors). Churchill Livingstone, London, UK, 2000.

66. Lin MS, Arteaga LA, and Diaz LA. Herpes gestationis. In Clin Dermatol, (Ghohestani R,

Editor). Elsevier Science Inc. 19:697-702, 2001.

67. Lin MS, Arteaga LA, Warren SJP, and Diaz LA. Pemphigus. In The Molecular Pathology of Autoimmune Diseases. Chapter 46. (Argyrios N. Theofilopoulos, Constantin A. Bona, Editors). Taylor Francis, New York. 2002. pp. 799-816.

68. Thomas N. and Diaz, L.A.: Pruritus. In 2002 Conn’s Current Therapy. R.E Rakel and E.T.

Bope (Editors). W.B. Saunders Company, 2002. 36-38.

37

69. Rubenstein, DS and Diaz, L.A. Pemphigoid: Bullous and Cicatricial. In Current Therapy in

Allergy, Immunology and Rheumatology, 6th Edition. (Lichtenstein LM, Busse WW and Geha RS (Editors), Mosby an Affiliated of Elsevier. 2002. pp 100-104.

70. Rubenstein DS and LA Diaz. Bullous Skin Diseases. In Netter’s Textbook of Internal

Medicine Chapter 148. (M.S. Runge and M. A. Greganti, Editors). Icon Learning Systems LLC, 2003. pp. 996-1001.

71. Liu, Z., Zhao, M-L., and Diaz, L.A. Passive transfer and active induction of autoimmune

diseases. In Animal Models of Human Inflammatory Skin Diseases. Lawarence S. Chan, ed. CRC Press, 169-177, 2004.

72. Liu Z. and Diaz, L.A. Experimental Mouse Model of Bullous Pemphigoid: Passive Transfer of anti-BP180 Type XIV Collage antibodies. In Animal Models of Human Inflammatory Skin Diseases. Chapter 13. (Lawrence S. Chan, editor). CRC Press, Boca Raton. 2004. pp 213-223.

73. Rubenstein DS, SJ Warren, S., N Li, Z Liu and Diaz, L.A. Experimental Mouse Model of

Pemphigus Foliaceus: Passive Transfer of Desmoglein-Targeting Antibodies. In Animal Models of Human Inflammatory Skin Diseases. Chapter 21. (Lawrence S. Chan, editor). CRC Press, Boca Raton. 2004. pp 321-328

74. Rubenstein DS and LA Diaz. “Vesiculo-bullous diseases” in Pocket Diagnosis in Internal

Medicine (Mack C. Mitchell, Editor.), 2004. 75. España A, Sánchez-Carpintero I, Díaz LA. “Penfigo Vulgar”. In

EnfermedadesAmpollosas. España A, Mascaró-Galy (Editors). Aula Médica, 2004. pp 105-128.

76. España A, Díaz LA. “Pénfigo Foliaceo”. In Enfermedades Ampollosas. . España A,

Mascaró-Galy J. (Editors). Aula Médica, 2004. pp 85-104. 77. Rubenstein D.S. and Diaz, L.A. Immunobiologics in the Treatment of Skin Disease. In North

American PharmacoTherapy. 2004. 78. España A, Mascaró JM, Diaz LA. “Enfermedades Ampollosas Autoinmunes”. In

Dermatología Practica Ibero-Latinoamericana. Primera Edicion. V Torres-Lozada, Camacho F.M., Mihn MC, Sober A, Sanchez-Carpintero I (Editors). Aula Médica IMPRELIBROS, Colombia. pp 762-780, 2005.

79. Rivitti E, Aoki V, Hams Filho G, Hilario-Vargas J and Diaz LA. Fogo Selvagem (Endemic

Pemphigus Foliaceus. In Tropical Dermatology. Sk Tyring, O Lupi and UR Hengge (Editors). Elsevier Churchill Livingstone. Chapter 33, pp421-427, 2006

80. Li N, Liu Z, Hilario-Vargas J, and Diaz LA. Bullous Skin Diseases: Pemphigus and

Pemphigoid. In The Autoimmune Diseases, 4th Edition. ELSEVIER-Academic Press. Noel R. Rose and Ian R. Mackay (eds.), 789-806, 2006.

38

81. Diaz L.A. and Goldsmith L (Section Editors): XII-Dermatology: Principles of Molecular Medicine, 2nd Edition (Marschall S. Runge and Winston C. Patterson, editors). Humana Press. 934-1069, 2006.

82. Li N, DS Rubenstein, Liu Z, and Diaz L.A. Chapter 98: “Pemphigus Foliaceus, Pemphigus

Vulgaris, Paraneoplastic Pemphigus, Bullous Pemphigoid Herpes Gestationis and Cicatricial Pemphigoid” in Principles of Molecular Medicine, 2nd Edition (Marschall S. Runge and Winston C. Patterson, editors). Humana Press. 959-969, 2006.

83. Sawalha A.H. Diaz, L.A. and Harley J.B. Chapter 99: “Systemic Lupus Erythematosus” in

Principles of Molecular Medicine, 2nd Edition (Marschall S. Runge and Winston C. Patterson, editors). Humana Press. 970-978, 2006.

84. Aoki V, Rivitti EA and Diaz LA. “Joao Paulo Viera-Pemphigus brasiliensis” in Pantheon der

Dermatologie - Pantheon of Dermatology. (Christoph Loeser and Gerd Plewig, editors) Springer, Pages 1072-1074, 2008

85. Nelson K, Li N, Liu Z, and Diaz LA. “The Pemphigoid Spectrum” in Clinical

Immunodermatology (Stephen K. Tyring and Anthony Gaspari, editors) Springer Verlag, Pages 751-761, 2008.

86. Burkhart CN, Rubenstein D, and Diaz LA. “Bullous Diseases” in 2009 Conn’s Current

Therapy, 61st Edition. (Robert E. Rakel and Edward T. Bope, editors) Elsevier, pp 866-870, 2009.

87. Rubenstein DS and LA Diaz. “Bullous Skin Diseases” in Netter Textbook of Internal

Medicine, 2nd Edition (A Greganti & M Runge, eds), 1221-1226, 2009.

39

Abstracts, Preliminary Communications :(1975 - To date) 1. Diaz LA, Calvanico NJ, Tomasi TB, Jr. and Jordon RE. Pemphigus and pemphigoid

saline soluble antigens from skin: Detection by passive hemagglutination. Clin. Res. 23:228A, April, 1975.

2. Diaz LA, Calvanico NJ, Tomasi TB, Jr. and Jordon RE. Purification of epidermal

antigens reacting with pemphigus and pemphigoid antibodies. Fed. Proc. 35:513, 1976.

3. Diaz LA, Calvanico NJ, Tomasi TB, Jr. and Jordon RE. Saline soluble antigens

common to epidermis, esophagus, saliva, and urine. Clin. Res. 24:425A, 1976. 4. Diaz LA and Medley NE. Identification of pemphigoid antigen in pemphigoid blister

fluid. Clin. Res. 25:280A, 1977. 5. Diaz LA and Marcelo CL. Pemphigus and pemphigoid antigens in cultured epidermal

cells. Clin. Res. 25:461A, 1977. 6. Diaz LA, Patel HP and Calvanico NJ. Immunologic relationship of pemphigoid and

pemphigus antigens. Clin. Res. 26:489A, 1978. Oral Presentation, ASCI. 7. Diaz LA, Weiss H and Calvanico NJ. Phylogenetic studies on pemphigoid and

pemphigus antigens. Clin. Res. 26:569A, 1978. 8. Diaz LA, Patel HP, Calvanico NJ. Purification of pemphigus antigen from human saliva.

Clin. Res. 27:241A, 1979. Oral presentation, AFCR. 9. Diaz LA, Patel HP, Calvanico NJ and Lopatin DE. Lymphocyte response to pemphigus

antigen. Clin. Res. 27:525A, 1979. 10. Cowen SJ, Grekin PM, Goldstein IJ and Diaz LA. Ricinus communis lectin binds

pemphigoid antigen and impairs the binding of pemphigoid antibodies. Clin. Res. 28:566A, 1980.

11. Carey TE, Ott RW, Diaz LA, Regezi JA and Krause CJ. Tissue culture and serologic

analysis of human squamous cell carcinoma. Int. Head Neck Oncol. Res. Conf., Rosslyn, VA, August 10, 1980.

12. Carey TE, Diaz LA, Ott RW, Schwartz DR and Krause CJ. Human squamous

carcinoma cell lines express an epidermal differentiation antigen (pemphigus antigen). Clin. Res. 29:281A, 1981.

13. King AJ, Schwartz SA, Lopatin DE, Voorhees JJ and Diaz LA. Suppressor T cell

function is preserved in pemphigus and pemphigoid. Clin. Res. 29:283A, 1981. 14. Patel H, Marcelo CL, Voorhees JJ and Diaz LA. Effects of Ca+++ and Mg+++ on

epidermal cell adhesion. Clin. Res. 29:610A, 1981.

40

15. Bahn CF, Anhalt GJ, Sugar A, Diaz LA. Pathogenicity of bullous pemphigoid autoantibodies in rabbit cornea. Ocular Microbiol. Immunol. Grp. Meet., Atlanta, GA, October 1981.

16. Woo TY, Hogan VA, Patel H, Anhalt GJ and Diaz LA. Effects of pemphigus antibodies

on epidermal cell adhesion, in vitro. Clin. Res. 29:706A, 1981. 17. Anhalt GJ, Labib RS, Voorhees JJ and Diaz LA. Induction of pemphigus in neonatal

BALB/c mice by passive transfer of human pemphigus immunoglobulins. 18. Accepted for presentation, ASCI plenary session. Clin. Res. 30:488A, 1982. 19. Woo TY, Hogan VA, Patel H, Anhalt GJ, Labib RS and Diaz LA. Specificity of

epidermal cell detachment induced by pemphigus IgG in vitro. Clin. Res. 30:615A, 1982.

20. Freitag-Laing KB, Anhalt GJ, Bahn CF, Wicha M, Dobbins III, WO and Diaz LA.

Corneal epithelial cell surface markers during healing. Clin. Res. 30:584A, 1982. 21. Carey TE, Diaz LA, Kimmel KA, Schwartz DR, Richter DE and Krause CJ. Cell surface

antigens of human squamous cell carcinoma. Clin. Res. 30:579A, 1982. 22. Sugar A, Bahn C, Anhalt GJ, Labib R and Diaz LA. Effects of pemphigoid

autoantibodies on corneal epithelium. Invest. Ophthalmol. Vis. Sci. 22:135, 1982. 23. Woo TY, Barouski-Miller PA, Gelehrter TD, Anhalt GJ and Diaz LA. Molecular

mechanisms of pemphigus antibody action. Clin. Res. 30:719A, 1982. 24. Anhalt GJ, Labib RS, Patel H and Diaz LA. Dexamethasone effect on experimental

pemphigus in mice. Clin. Res. 31:554, 1983. 25. Woo TY, Barowski-Miller PA, Gelehrter GJ, Anhalt GJ, Hogan VA, Patel H and Diaz LA.

Effector proteases and pemphigus antibody action. Clin. Res. 31:610A, 1983. 26. Labib RS, Anhalt GJ, Patel HP and Diaz LA. Changes in epidermal proteins during

keratinocyte differentiation in vivo. Clin. Res. 32:596A, 1984. 27. Takahashi Y, Patel HP, Labib RS, Diaz LA and Anhalt GJ. Immunological and

ultrastructural evolution of acantholysis in experimentally-induced pemphigus in mice. Clin. Res. 32:618A, 1984.

28. Patel HP, Diaz LA, Anhalt GJ, Labib RS and Takahashi Y. Demonstration of

pemphigus antibody-antigen (receptor) complexes on the cell surface of epidermal cells in culture and their internalization. Clin. Res. 32:608A, 1984.

29. Robinson HN, Anhalt GJ, Patel HP, Takahashi Y, Labib RS and Diaz LA. Pemphigus

and pemphigoid antigens expressed in human amnion epithelium. Clin. Res. 32:612A, 1984.

41

30. Roscoe JT, Takahashi Y, Labib RS, Sampaio SAP, Castro RM, Patel HP, Diaz LA and Anhalt GJ. Fogo selvagem (Brazilian pemphigus foliaceus) autoantibodies are pathogenic to neonatal BALB/c mice in vivo. Clin. Res. 32:258A, 1984.

31. Mutasim DF, Takahashi Y, Labib RS, Anhalt GJ, Patel HP and Diaz LA. Intracellular

localization of bullous pemphigoid antigen(s) in close association with basal cell hemidesmosomes and cytoskeleton. Clin. Res. 32:482A, 1984.

32. Eaglstein NF, Till G, Diaz LA, Labib RS, Patel HP and Anhalt GJ. Defining the role of

complement in experimental pemphigus vulgaris in mice. Clin. Res. 33:297A, 1985. 33. Burek CL, Avalos E, Rose NR, Mutasim DF, Labib RS, Patel HP, Anhalt GJ and Diaz

LA. Rat-Mouse hybridomas producing monoclonal antibodies reactive with a basal cell hemidesmosome antigen similarly to human bullous pemphigoid autoantibodies. Clin. Res. 33:297A, 1985.

34. Labib RS, Patel HP, Anhalt GJ and Diaz LA. Molecular heterogeneity of the bullous

pemphigoid antigens detected by immunoblotting. Clin. Res. 33:531A, 1985. 35. Labib RS, Mutasim DF, Patel HP, Anhalt GJ and Diaz LA. Partial purification and

characterization of the major bullous pemphigoid (BP) antigens as intermediate filament associated proteins. Clin. Res. 33:659A, 1985.

36. Roscoe JT, Naylor PH, Diaz LA, Labib RS, Patel HP, Goldstein AL, Sampaio SAP and

Anhalt GJ. Brazilian pemphigus foliaceus patients have elevated thymosin alpha-1 levels. Clin. Res. 33:302A, 1985.

37. Anhalt GJ, Patel HP, Labib RS, Diaz LA and Proud D. Dexamethasone inhibits

plasminogen activation but does not block pemphigus IgG induced acantholysis in vivo. Clin. Res. 33:623A, 1985.

38. Mutasim DF, Patel HP, Labib RS, Anhalt GJ and Diaz LA. The linear immuno-

fluorescence staining of the cutaneous basement membrane zone produced by pemphigoid antibodies is the result of hemidesmosome staining. Clin. Res. 33:668A, 1985.

39. Mutasim DF, Takahashi Y, Diaz LA, Anhalt GJ, Labib RS and Patel HP. Studies on

hemidesmosome-cytoskeleton interactions using bullous pemphigoid autoantibodies. Clin. Res. 33:668A, 1985.

40. Herrera-Esparza R, Halim HY, Provost TT and Diaz LA. A sensitive and specific assay

to detect and quantitate Ro (SSA) and La (SSB) antibodies. Clin. Res. 33:645A, 1985. 41. Patel HP, Diaz LA, Labib RS and Takahashi Y. Loss of Desmosomes during induction

of pemphigus vulgaris in mice in vivo. Clin. Res. 33:773A, 1985. 42. Roscoe JT, Mutasim D, Labib RS, Patel HP, Diaz LA and Anhalt GJ. Autoantibodies

from a patient with herpes gestationis identify a bullous pemphigoid antigen by immunoblotting. Clin. Res. 33:773A, 1985.

42

43. Anhalt GJ, Patel HP, Jampel H, Jabs DA, Labib RS, Diaz LA and Mutasim DF. Bullous

pemphigoid autoantibodies react with corneal epithelial hemidesmosomes. Ocular Microbiol. Immunol. Grp. Meeting, San Francisco, CA, September 27, 1985.

44. Diaz LA. Advances in pemphigus. American Dermatological Association Annual

Meeting, White Sulphur Springs, WV. May 23-28, 1986. 45. Dugan EM, Patel HP, Labib RS, Anhalt GJ and Diaz LA. Selective surface

radioiodination of keratinocytes with I125 labels a 56.5 kD keratin. Clin. Res. 34:747A, 1986.

46. Diaz LA, Sampaio SAP, Rivitti EA, Macca ML, Roscoe JT, Labib RS, Patel HP and

Anhalt GJ. Immunoaffinity-purified human autoantibody specific for the 56.5 K epidermal keratin binds the surface of murine keratinocytes in culture and decorates the intercellular spaces of murine epidermis. Clin. Res. 34:639A, 1986.

47. Mutasim DF, Patel HP, Labib RS, Diaz LA and Anhalt GJ. Binding of bullous

pemphigoid IgG to intra- and extracellular antigens, and differential complement fixation properties. Clin. Res. 34:417A, 1986.

48. Roscoe JT, Mutasim D, Labib RS, Patel H, Diaz LA and Anhalt GJ. Autoantibodies

from a patient with herpes gestationis identify bullous pemphigoid antigens by immunoblotting. Clin. Res. 34:777A, 1986.

49. Mutasim DF, Anhalt GJ, Woodley DT, Briggaman RA, Diaz LA and Patel HP.

Immunological and ultrastructural characterization of a unique subepidermal bullous disease. Clin. Res. 34:770A, 1986.

50. Dugan EM, Richtsmeier, WJ, Labib, RS, Anhalt GJ and Diaz LA. The 59 Kd Keratin is

expressed on the surface of keratinocytes and squamous carcinoma cell lines. Clin. Res. 34:885A, 1986.

51. Diaz LA. Study of hemidesmosomes using pemphigoid autoantibodies and

immuno-electron microscopy. XVII World Congress of Dermatology, Berlin, Germany, May 24-29, 1987.

52. Squiquera HL, Anhalt GJ, Rivitti EA, Martins CR, Cunha PR and Diaz LA. Serologic

abnormalities in patients with Brazilian pemphigus foliaceus (fogo selvagem), their relatives and normal donors from endemic and nonendemic regions. Clin. Res. 35:719A, 1987.

53. Dugan EM, Richtsmeier WJ, Labib RS, Anhalt GJ and Diaz LA. The 59 kD keratin is

expressed on the surface of murine keratinocytes and squamous carcinoma cell lines. Clin. Res. 35:680A, 1987.

54. Diaz LA, Anhalt GJ, Rivitti EA, Lavrado C, Borges PC, Martins CR, Lombardi C and

Sampaio SAP. Epidemiological features of Brazilian pemphigus foliaceus. Clin. Res. 35:679A, 1987.

43

55. Matis WL, Anhalt GJ, Diaz LA, Rivitti EA and Berger RS. Ca+2 enhances sensitivity of

immunofluorescence for pemphigus antibodies. Clin. Res. 35:702A, 1987. 56. Morrison L, Anhalt G, Rivitti E, Martins CR, Sampaio S and Diaz LA. Binding of fogo

selvagem autoantibodies to murine epidermal proteins. Clin. Res. 35:389A, 1987. 57. Diaz LA, Anhalt GJ, Rivitti EA, Lavrado C, Borges P, Martins CR, Lombardi C, Cunha

PR, and Sampaio SAP. Inmunopatologia y epidemiologia del penfigo foliaceo endemico. XI Congr. Ibero-Latino-Amer. Dermatol. Madrid, Spain, May 1987.

58. Diaz LA and Anhalt GJ. Pathogenesis of pemphigus. XI Congr. Ibero-Latino-Amer.

Dermatol. Madrid, Spain, May 1987. 59. Diaz LA. Fotoinmunidad en el lupus eritematoso. XI Congr. Ibero-Latino-Amer.

Dermatol. Madrid, Spain, May 1987. 60. Morrison LH, Diaz LA, Zone JJ, and Anhalt GJ. Herpes Gestationis Recognize a

180,000 Dalton Epidermal Antigen. Clin. Res., 35:795A, 1987. 61. Roth J, Anhalt GJ, Diaz LA, Morrison L. Herpes gestationis and bullous pemphigoid

autoantibodies detect a 180 Kd antigen in human amnion. Clin. Res., 36:690A, 1988. 62. Morrison LH, Diaz LA, Zone JJ and Anhalt GJ. Herpes gestationis sera recognize a

180 Kd antigen. Clin. Res. 36:677A, 1988. 63. Martins CR, Rivitti EA, Rock B, Anhalt GJ, Labib RS, Theofilopoulus AN, Diaz LA.

Autoantibodies in endemic pemphigus foliaceus in remission-IgG subclass analysis. Clin. Res. 36:672A, 1988.

64. Rock B, Martins CR, Rivitti EA, Anhalt GJ, Labib RS, Theofilopoulus AN and Diaz LA.

Restricted heterogeneity of IgG subclass response in endemic pemphigus foliaceus. Clin. Res. 36:689A, 1988.

65. Futamura S, Martins CR, Rivitti EA, Labib RS, Diaz LA and Anhalt GJ. Ultrastructural

studies of acantholysis induced in vivo by passive transfer of endemic pemphigus foliaceus IgG. Clin. Res. 36:647A, 1988.

66. Labib RS, Camargo S, Futamura S, Martins CR, Rock B, Anhalt GJ and Diaz LA.

Characterization of a soluble immunoreactive 50 Kd proteolytic fragment of the endemic pemphigus foliaceus antigen. Clin. Res. 36:377A, 1988.

67. Diezel W, Gruner S, Diaz LA, and Anhalt GJ. Suppression of cutaneous contact

hypersensitivity by calcium transport inhibitors lanthanum and diltiazem. Clin. Res. 36:813A, 1988.

68. Diezel W, Gruner S, Strunk D, Siems W, Diaz LA, and Anhalt GJ. Suppression of

cutaneous contact hypersensitivity by calcium transport inhibitors lanthanum and diltiazem. Clin. Res. 37:349A, 1989.

44

69. Moraes JR, Moraes ME, Rivitti EA, Friedman H, Diaz LA, and Stastny P. Brazilian

pemphigus: Susceptibility and resistance associated with HLA. Clin. Res. 37:529A, 1989.

70. Diaz LA, Futamura S, Squiquera HL, Ratrie III H, Sanders WS, Anhalt GJ and Giudice

GJ. Generation of an E. coli lysogen that synthesizes an epitope of the 180 KD epidermal protein recognized by pemphigoid autoantibodies. Clin. Res. 37:623A, 1989.

71. Futamura S, Anhalt GJ, Diaz LA and Giudice GJ. Herpes gestationis sera recognize a

recombinant bullous pemphigoid antigen. Clin. Res. 37:623A, 1989. 72. Alvarez RR, Friedman H, Martins CR, Rock B, Theofilopoulus AR, and Diaz LA.

Pemphigus neonatorum, is absent in fogo selvagem. Clin. Res. 37:622A, 1989. 73. Martins CR, Labib RS, and Diaz LA. Release of an immunologically active epitope of

fogo selvagem antigen during trypsinization of viable human epidermis. Clin. Res. 37:625A, 1989.

74. Rock B, and Diaz LA. Monovalent Fab' IgG4 fragments from endemic pemphigus

foliaceus serum reproduce the human disease in neonatal Balb/C mice. Clin. Res. 37:354A, 1989.

75. Giudice, G.J. and Diaz, L.A. Isolation of human epidermal cDNAs corresponding to two

distinct hemidesmosomal proteins. J. Cell Biol. 109:201a, 1989. 76. Rivitti EA, Sanches JA, Martins CR and Diaz LA. Immunopathological findings in the

skin and oral mucosa of patients with endemic pemphigus foliaceus. Clin. Res. 38:606A, 1990.

77. Giudice GJ, Elias P, Squiquera HL and Diaz LA. Identification of two collagen-like

domains on the bullous pemphigoid antigen, BP180. Clin. Res. 38:604A, 1990. 78. Fairley JA, Scott GA, Jensen K, Goldsmith LA, Diaz LA. Identification of a human

desmosomal calmodulin binding protein. Clin. Res. 38:610A, 1990. 79. Liu Z, Diaz LA and Giudice GJ. Isolation of a human epidermal cDNA encoding a

fusion protein recognized by pemphigus foliaceus sera. Clin. Res. 38:605A, 1990. 80. Fairley JA, Ghaneian MR and Diaz LA. Identification and characterization of

keratocalmin in keratinocytes in vitro. Clin. Res. 38:858A, 1990. 81. Squiquera HL, Diaz LA, Anhalt GJ and Giudice GJ. Bullous pemphigoid and herpes

gestationis sera recognize the same 41 amino acid antigenic domain on the BP180 autoantigen. Clin. Res. 38:858A, 1990.

82. Calvanico NJ, Martins CR and Diaz LA. Characterization of pemphigus foliaceus

antigen from human epidermis. Clin. Res. 38:858A, 1990.

45

83. Ryynanen M, Knowlton RG, Sawamura D, Li K, Giudice GJ, Diaz LA and Uitto J. Molecular genetics of human bullous pemphigoid antigens: Polymorphic genes for 230-kD and 180-kD proteins are excluded as the candidate genes in a large kindred with dominant simplex epidermolysis bullosa. Clin. Res. 39:480A, 1991.

84. Giudice GJ, Emery DJ, Olague-Alcala MC, Squiquera HL, Anhalt GJ and Diaz LA.

Molecular genetic characterization of a BP180 epitope recognized by both bullous pemphigoid and herpes gestationis autoantibodies. Clin. Res. 478A, 1991.

85. Liu Z, Diaz LA, Haas AL and Giudice GJ. Pemphigus foliaceus autoantibodies

recognize a ubiquitin carrier protein. Clin. Res. 39:480A, 1991. 86. Gates R, Eyers A, Olague-Alcala M, Diaz LA and King L. Antibodies against epidermal

growth factor receptor in bullous pemphigoid serum. Clin. Res. 478A, 1991. 87. Calvanico NJ, Martins CR and Diaz LA. Characterization of pemphigus foliaceus

antigen from human epidermis. Clin. Res. 477A, 1991. 88. Calvanico NJ and Diaz LA. Restriction of the autoantibody response in endemic

pemphigus foliaceus. Clin. Res. 477A, 1991. 89. Uitto J, M Ryynanen, MG Parente, LC Chung, D Sawamura, K-H Li, GJ Giudice, LA

Diaz, MG Mattei, ML Chu and RG Knowlton. Cloning and chromosomal assignment of human type VII collagen (COL7A1), and bullous pemphigoid antigens 1 and 2 (BPAG1 and BPAG2) genes. 8th International Congress of Human Genetics, Washington D.C. Oct. 1991.

90. Giudice GJ, Emery DJ and Diaz, LA. Protein domain organization of the bullous

pemphigoid-180 autoantigen. Clin. Res. 39:740A, 1991.Liu Z, 91. Diaz LA, Haas AL and Giudice GJ. Cloning and sequence analysis of an antigen

recognized by pemphigus foliaceus autoantibodies. Clin. Res. 39:739A, 1991. 92. Allen EM, Giudice GJ and Diaz LA. Production of human DG1 fusion proteins and their

reactivity with pemphigus foliaceus autoantibodies. Clin. Res. 39:739A, 1991. 93. Calvanico NJ and Diaz LA. Restriction of the specificity of autoantibodies in endemic

pemphigus foliaceus. Clin. Res. 39:739A, 1991. 94. Giudice GJ, Emery DJ and Diaz LA. Primary structure of the hemidesmosomal protein

BP-180 reveals a putative transmembrane domain and a long collagenous region with interrupted triple helical domains. J. Cell Biol. 115:134A, 1991.

95. Giudice GJ, Emery DJ and Diaz LA. Molecular characterization of hemidesmosomal

proteins. J. Invest. Dermatol. 98:398A, 1992. 96. Calvanico NJ and Diaz LA. Spectrotype restriction of endemic pemphigus foliaceus

autoantibodies. Clin. Res. 40:448A, 1992.

46

97. Allen EM, Giudice GJ and Diaz LA. Production of human DG1 fusion proteins and their reactivity with pemphigus foliaceus autoantibodies. Clin. Res. 40:447A, 1992.

98. Liu Z, Diaz LA, Haas AL and Giudice GJ. A novel ubiquitin carrier protein is a marker

for keratinocyte differentiation. Clin. Res. 40:516A, 1992. 99. Friedman H, Campbell I, Rocha-Alvarez R, Coimbra C, Moraes JR, Flowers N, Stasny

P, Fernandez-Vina M, Cerna M, Olague-Alcala M and Diaz LA. Description of a new focus of fogo selvagem in Xavante Indians from North-Central Brazil. Clin. Res. 40:456A, 1992.

100. Liu Z, Diaz LA, Haas AL, and Giudice GJ. A novel epidermal terminal differentiation

marker is an enzyme that supports ubiquitin-dependent proteolysis. Clin. Res. 40:708A, 1992.

101. Liu Z, Diaz LA, Haas AL, and Giudice GJ. A novel epidermal terminal differentiation

marker is an enzyme that supports ubiquitin-dependent proteolysis. J. Invest. Dermatol., 100:523A, 1993.

102. Heintz PW, Giudice GJ, Zelickson BD, Diaz LA, Fairley JA. Tissue distribution of the

bullous pemphigoid-180 autoantigen. Clin. Res. 40:707A, 1992. 103. Olague-Alcala M, Aoki V, Taylor A, and Diaz LA. Characterization of bovine pemphigus

foliaceus antigen(s). Clin. Res. 40:708A, 1992. 104. Aoki V, Olague-Alcala M, Taylor A, and Diaz LA. Immunological studies of Brazilian

families with multiple cases of fogo selvagem. Clin. Res. 40:707A, 1992. 105. Aoki V, Olague-Alcala M, Taylor AF, and Diaz LA. Serologic profile of familial fogo

selvagem. Clin. Res. 41:408A, 1993. 106. Giudice GJ, Emery DJ, Liu Z, Fairley JA, and Diaz LA. A bullous pemphigoid and

herpes gestationis autoantibody-reactive site on the ectodomain of the human BP180 autoantigen is not present on the murine BP180 homologue. Clin. Res. 41:409A, 1993.

107. Giudice GJ, Emery DJ, Liu Z, Fairley JA, and Diaz LA. A bullous pemphigoid and

herpes gestationis autoantibody-reactive site on the ectodomain of the human BP180 autoantigen is not present on the murine BP180 homologue. J. Invest. Dermatol. 100:531A, 1993.

108. Heintz PW, Giudice GJ, Diaz LA, and Fairley JA. Distribution of the bullous pemphigoid-

180 autoantigen in normal and transformed tissue. Clin. Res. 41:410A, 1993. 109. Olague-Alcala M, Aoki V, Taylor AF, and Diaz LA. Characterization of the epitopes

recognized by pemphigus foliaceus (PF) autoantibodies on bovine epidermal PF antigen. Clin. Res. 41:411A, 1993.

110. Wikner NE, James JA, Diaz LA, and Robinson BR. Fogo selvagem sera do not

recognize linear epitopes of desmoglein. Clin. Res. 41:412A, 1993.

47

111. Liu Z, Diaz LA, Haas AL, and Giudice GJ. A novel epidermal E2 enzyme is a late

differentiation marker and functions in targeting substrate proteins for selective degradation. Clin. Res. 41:481A, 1993.

112. Giudice GJ, Emery DJ, Zelickson BD, Anhalt GJ, Liu Z and Diaz LA. Bullous

pemphigoid and herpes gestationis autoantibodies recognize a common non-collagenous site on the BP180 ectodomain. Presented to the Tricontinental Meeting of the JSID, SID and ESDR, Kyoto, Japan, 1993.

113. Giudice GJ, Wilske K, Anhalt G, Taylor AF, Fairley JA, Hoffmann RG, Emery DE and

Diaz LA. Development of an ELISA to detect anti-BP180 autoantibodies in bullous pemphigoid and herpes gestationis patients. Presented to the Tricontinental Meeting of the JSID, SID and ESDR, Kyoto, Japan, 1993.

114. Emery DJ, Diaz LA, and Giudice GJ.. The use of desmoglein 1-transfectants to

characterize endemic pemphigus foliaceus autoantibodies. J. Invest. Dermatol. 102:534, 1994.

115. Liu Z, Diaz LA, Swartz SJ, Taylor AF, Emery DJ, Troy JL, Fairley JA, and Giudice GJ.

Defining the animal model of bullous pemphigoid and herpes gestationis by passive transfer to anti-BP180 antibodies. J. Invest. Dermatol. 102:558, 1994.

116. Olague-Alcala M, Giudice GJ, and Diaz LA. The 80 kD pemphigus foliaceus antigen

extracted from the epidermal envelope fraction is a fragment of desmoglein 1. J. Invest. Dermatol. 102:608, 1994.

117. Muramatsu T, Putzer KP, Diaz LA, Giudice GJ, and Fairley JA. Mapping the extra- and

intracellular calcium binding sites on the pemphigus vulgaris antigen (desmoglein 3). J. Invest. Dermatol. 102:563, 1994.

118. Balding SD, Diaz LA, Bernard P, Prost C, and Giudice GJ. Cicatricial pemphigoid

autoantibodies react with extracellular sites on the hemidesmosomal protein, BP180. Mol. Biol. Cell., 5:200A, 1994.

119. Liu Z, Diaz LA, Swartz S, Fairley JA and Giudice GJ. Development and

characterization of an animal model for bullous pemphigoid. Mol. Biol. Cell. 5:200A, 1994.

120. Liu Z, Diaz LA, Swartz S, Troy JL, Taylor AF, Emery DJ, Fairley JA and Giudice GJ.

Bullous pemphigoid mouse model: A time course study of the inflammatory response during subepidermal blister formation. Clin. Res. 42:429A, 1994.

121. Balding SD, Diaz LA, Bernard P, Prost C and Giudice GJ. The bullous pemphigoid-180

autoantigen is a major target of cicatricial pemphigoid autoantibodies. Clin. Res. 42:3:429A, 1994.

122. Aoki V, Diaz LA, Taylor AF, Witman PM and Fairley JA. Immunological specificity of

pemphigus vulgaris autoantibodies. J. Invest. Dermatol. 103:564A, 1994.

48

123. Liu Z, Diaz LA, Swartz S, Zillikens D, Troy JL, Fairley JA and Giudice GJ. Bullous

pemphigoid mouse model: Dissection of the inflammatory response. J. Invest. Dermatol. 104:558A, 1995

124. Balding SD, Diaz LA, Bernard P, Prost C and Giudice GJ. Cicatricial pemphigoid

autoantibodies react with multiple sites on the BP180 ectodomain. J. Invest. Dermatol. 104:558A, 1995

125. Liu Z, Diaz LA, Swartz S, Fairley JA and Giudice GJ. Molecular mapping of a BP180 peptide that can block sub-epidermal blistering in experimental bullous pemphigoid. J. Invest. Dermatol. 104:559, 1995.

126. Muramatsu T, Putzer KP, Diaz LA, Giudice GJ and Fairley JA. Identification of a

conserved calcium binding site on the intracellular domain of cadherins. J. Invest. Dermatol. 104:557A, 1995.

127. Zillikens D, Kawahara Y, Mayer J, Ishiko A, Liu Z, Shimizu H, Diaz LA and Hashimoto

T. A novel IgG-mediated subepidermal blistering disease with autoantibodies against a 200-kD antigen of the basement membrane zone. J. Invest. Dermatol. 104:603A, 1995.

128. Bedane C, Balding S, Bernard P, Giudice GJ, McMillan JR, Prost C, Diaz LA and Eady

RAJ. Ultrastructural mapping of the 180 kD bullous pemphigoid antigen. J. Invest. Dermatol. 104:603A, 1995.

129. Moraes ME, Lazaro A, Hans-Filho G, Vina MF, Aoki V, Rivitti E, Chamone D, Diaz LA,

Stastny P, and Moraes JR. Endemic pemphigus foliaceus (fogo selvagem) and HLA alleles in Brazilian Terena Indians. Human Immunology 44:36, 1995.

130. Moraes ME, Lazaro A, Fernandez-Vina M, Gouvea C, Romero M, Nakano R, Hans-

Filho G, Friedman H, Dorlliac P, Chamone D, Diaz LA, Stastny P, and Moraes JR. HLA class I and class II alleles in Brazilian Terena Indians. Human Immunology 44:61, 1995.

131. Bedane C, Balding S, Bernard P, Giudice GJ, McMillan JR, Prost C, Diaz LA and Eady

RAJ. Cicatricial pemphigoid autoantibodies recognize the C-terminal part of the BP180 ectodomain by indirect immunoelectron microscopy. J. of Invest. Derm., 104:603, 1995.

132. Espana A, Diaz LA, Giudice GJ, Fairley JA, Till, GO and Liu Z. The role of complement

in experimental pemphigus foliaceus. J. Invest. Dermatol. 105:872A, 1995. 133. Liu Z, Twining S, Giudice GJ, Zhou X, Fairley JA, Troy JL and Diaz LA. Elastase plays

a direct role in blister formation in experimental bullous pemphigoid. FASEB 10:A1407, 1996.

134. Zillikens D, Diaz LA, Rose PA, Emery DJ, Liu A and Giudice GJ. Identification of new

autoantibody-reactive sites on the 180-kD bullous pemphigoid ectodomain. J. Invest. Derm. 106:850A, 1996.

49

135. Liu Z, Giudice GJ, Swartz SJ, Zillikens D, Troy JL, Fairley JA and Diaz LA. Bullous pemphigoid mouse model: Dermal-epidermal separation induced by anti-BP180 antibodies is dependent on neutrophil Fc receptor activity, J. Invest. Derm. 106:811A, 1996.

136. Balding SD, Diaz LA and Giudice GJ. A secreted form of the BP180 ectodomain forms

a multimeric complex. J. Invest. Derm. 106:816A, 1996. 137. Mascaro JM Jr, Espana-Alonso A, Liu Z, Swartz SJ, Fleming MG, Giudice GJ, Fairley

JA and Diaz LA. Monovalent Fab fragments from pemphigus vulgaris IgG are pathogenic in neonatal BALB/c mouse model. J. Invest. Derm. 106:812A, 1996.

138. Lin M-S, Swartz SJ, Lopez A, Fairley JA and Diaz LA. Development and

characterization of T cell lines responding to desmoglein-3. J. Invest. Derm. 106:832A, 1996.

139. Lin MS, Swartz SJ, Lopez A, Fairley JA and Diaz LA. Development and

characterization of desmoglein-3 specific T lymphocytes. FASEB J 10:A1305, 1996. 140. Ding X, Mascaro J Jr, Goldberg E, Fleming MG, Diaz LA and Fairley JA. IgG from a

subset of PV patients with oral disease is not pathogenic in neonatal balb/c mice. J. Invest. Derm. 106:850A, 1996.

141. Liu Z, Twining S, Giudice GJ, Zhou X, Fairley JA, Troy JL and Diaz LA. Bullous

pemphigoid mouse model: Neutrophil elastase plays a major role in subepidermal blister formation. J. Invest. Med. 44:402A, 1996.

142. Lin M-S, Swartz SJ, Zillikens D, Emery DJ, Giudice GJ and Diaz LA. Identification of

epitopes located on the BP180 antigen recognized by T cells from bullous pemphigoid patients. J. Invest. Med. 44:402A,1996.

143. Liu Z, Giudice GJ, Zhou X, Fairley JA and Diaz LA. Interleukin-1 and -6 are required for

subepidermal blistering in experimental bullous pemphigoid. J. Invest. Derm. 108:538A, 1997.

144. Abreu-Velez AM, Olague-Marchan M, Lopez-Swiderski A, Mascaro JM Jr, Giudice GJ

and Diaz LA. Characterization of a 45 kD epidermal tryptic peptide recognized by pemphigus foliaceus sera. J. Invest. Derm. 108:541A, 1997.

145. Lin M-S, Swartz SJ, Lopez A, Ding X, Fairley JA and Diaz LA. Characterization of

desmoglein-1 epitopes recognized by T cells from patients with fogo selvagem. J. Invest. Derm. 108:544A, 1997.

146. Liu Z, Twining S, Giudice GJ, Zhou X, Fairley JA, Troy JL and Diaz LA. Neutrophil

elastase is essential for subepidermal blistering in experimental bullous pemphigoid. J. Invest. Derm. 108:556A, 1997

50

147. Lin M-S, Swartz SJ, Lopez A, Ding X, Fairley JA and Diaz LA. Development of Dsg1-specific long-term B cell lines from patients with pemphigus foliaceus. J. Invest. Derm. 108:560A, 1997.

148. Seitz CS, Marinkovich MP, Tran H, Janoff M, Diaz LA, O’Toole EA, Woodley DT,

Giudice GJ and Khavari PA. BP180 gene transfer and expression in benign junctional epidermolysis bullosa. J. Invest. Derm. 108:588A, 1997.

149. Caux F, Olague-Marchan, Balding SD, Rose PA, Prost C, Zillikens D, Diaz LA and

Giudice GJ. The target tissues of cicatricial pemphigoid contain the two epitopes described on BP180. J. Invest. Derm. 108:601A, 1997.

150. Zillikens D, Rose PA, Balding SD, Olague-Marchan M, Mascaro JM Jr, Liu Z, Diaz LA

and Giudice GJ. Tight clustering of extracellular BP180 epitopes recognized by bullous pemphigoid autoantibodies. J. Invest. Derm. 108:622A, 1997.

151. Herzele K, Zillikens D, Schmidt E, Krenig H, Mascaro JM, Messer G, Chan LS, Olague-

Marchan M, Lin MS, Diaz LA, Brocker EB and Giudice GJ. Autoantibodies in a subgroup of patients with linear IgA disease react with the NC16A domain of BP180. J. Invest. Derm 110:510,1998.

152. Lin MS, Swartz SJ, Giudice GJ and Diaz LA. Development and characteriation of

BP180-specific T cells from patients with bullous pemphigoid. J. Invest. Derm 110:483,1998.

153. Lin MS, Swartz SJ, Gharia MJ, Fairley JA, Giudice GJ and Diaz LA. Autoimmune

responses of linear IgA disease: Both T cells and autoantibodies recognize the NC16A domain of BP180. J. Invest. Derm 110:483, 1998.

154. Rose, P.A., Z. Liu, L.A. Diaz, and G.J. Giudice. Functional differences between

pathogenic and non-pathogenic anti-BP180 antibodies in experimental bullous pemphigoid. Mol. Biol. Cell. 8 (supplement):419a, 1997.

155. Liu, Z., X. Zhou, G.J. Giudice, and L.A. Diaz. The role of mast cells in experimental

bullous pemphigoid. J. Invest. Dermatol. 110:483, 1998. 156. Zillikens, D., F. Caux, J.M. Mascaro, C. Prost, H. Krenig, E. Schmidt, J.P. Callen, E.B.

Brocker, L.A. Diaz, and G.J. Giudice. A novel epitope within the NC16A domain is targeted by autoantibodies in lichen planus pemphigoides. J. Invest. Dermatol. 110:514, 1998.

157. Gharia MJ, Swartz SJ, Giudice GJ, Fairley JA, Diaz LA and Lin MS: T cells from a

mother with Herpes Gestationis but not the newborn, specifically respond to BP180. J Invest Dermatol 110:507, 1998.

158. Ding X, Diaz LA, Fairley JA, Giudice GJ and Liu Z. The anti-desmoglein 1

autoantibodies in PV sera are pathogenic. J Invest Dermatol 110:507, 1998.

51

159. Rose, P.A., G.J. Giudice, X. Zhou, L.A. Diaz, and Z. Liu. Experimental bullous pemphigoid: Pathogenic and non-pathogenic anti-BP180 antibodies differ in effector functions. FASEB J. 12(4) part I:A291, 1998.

160. Olague-Marchan M, Hacker MK, Diaz LA and Giudice GJ: A BP180 disease-associated

mutation (G627V) causes a local destabilization of the triple-helix and increases its sensitivity to proteolysis in vitro. Molec Biol of the Cell (Amer Soc Cell Biol). 9:6a,1998.

161. Liu Z, Zhou X, Chen R and Diaz LA. Transmission of experimental bullous

pemphigoid/herpes gestationis from mother to neonate. J. Invest. Dermatol 112:532 (Abst 058), 1999.

162. Liu Z, Zhou X, Chen R, Shapiro SD, Senior RM and Diaz LA. Proteinase/proteinase

inhibitor imbalance in experimental bullous pemphigoid. J. Invest. Dermatol. 112:533 (Abst 061), 1999.

163. Liu Z, Zhou X, Fleming M, Giudice GJ and Diaz LA. Cellular events in experimental

bullous pemphigoid: mast cells, but not T or B lymphocytes, natural killer cells, or macrophages, play a major role in the early stage of subepidermal blistering. J. Invest. Dermatol., 112:556 (Abst 202), 1999.

164. Lin M-S, Giudice GJ and Diaz LA. Analysis of the humoral and cellular immune

reactions of patients with bullous pemphigoid. J. Invest. Dermatol.112:615 (Abst 554), 1999.

165. Olague-Marchan M, Hacker MK, Diaz LA, Twining SS and Giudice GJ. Structural

defects of the BP180 protein caused by a point mutation (G627V) that is linked to a novel form of junctional epidermolysis bullosa. J. Invest. Dermatol., 112:615 (Abst 556) 1999.

166. Lin M-S, Fu C-L, Gharia M, Marchan MO, Hacker MK, Harman KE, Bhogal BS, Black

MM, Diaz LA and Giudice GJ. Detailed mapping of BP180 epitopes recognized by herpes gestationis IgG. J. Invest. Dermatol., 112:615 (Abst 558),1999.

167. Liu Z, Zhou X, Ding X, Chen R, Shapiro SD, Senior RM, Giudice GJ, Fairley JA and

Diaz LA. The role of neutrophil elastase, gelatinase B, and plasmin/plasminogen activators in pemphigus foliaceus and pemphigus vulgaris in mice. J. Invest. Dermatol.,112:616 (Abst 562), 1999.

168. Warren S.J., Lin M.S., Giudice G.J., Hoffmann R., Hans-Filho G., Aoki V., Rivitti E.A.,

dos Santos V. and Diaz L.A.: Environmentally Induced Production of Anti-Dsg1 Autoantibodies Precedes Onset of Fogo Selvagem. J Invest Dermatol 114: 753, 2000

169. Chen R., Diaz L.A., Giudice G.J., and Liu Z.: The Role of C5a in Mast Cell Activation

during Subepidermal Blistering in Experimental Bullous Pemphigoid. J Invest Dermatol 114: 762, 2000

170. Liu Z., R. Chen, L. Diaz, R. Senior, and Z. Werb: Plasminogen/Plasmin System in

Experimental Bullous Pemphigoid. J Invest Dermatol 114: 778, 2000

52

171. Lin M.S. and Diaz L.A.: Cloning Desmoglein-1-Epitope-Specific T Lymphocytes from

Patients with Fogo Selvagem. J Invest Dermatol 114: 798, 2000 172. Arteaga L.A., S. Warren, Z. Liu, M. Lin, and L. Diaz: Desmoglein-1 Epitopes Recognized

by Autoantibodies from Patients with Fogo Selvagem. J Invest Dermatol 114: 804, 2000 173. Avalos-Diaz E., M. Olague-Marchan, A. Lopez-Swiderski, R. Herrera-Esparza, and L. A.

Diaz: Transplacental Passage of Maternal Pemphigus Foliaceus Autoantibodies Induces Neonatal Pemphigus. J Invest Dermatol 114: 845, 2000

174. Arteaga L.A., S J P Warren, P Prisayanh, Z Liu, L A Diaz and M S Lin A: Subset of Pemphigus Foliaceus Patients Possess Both Pathogenic anti-Desmoglein-1 and anti-Desmoglein-3 Antibodies. J Invest Dermatol 117:460A, 2001

175. Hu P., H Xiao , M Lin , D S Rubenstein , E J O'Keefe , J C Jennette , L A Diaz and Z Liu: Myeloperoxidase-deficient Mice Are Resistant to Experimental Bullous Pemphigoid. J Invest Dermatol 117:442A, 2001

176. Lin M.S., L A Arteaga, P S Prisayanh, S J Warren, Z Liu and L A Diaz: Isotype and Epitope Profiles of Anti-Desmoglein-1 Autoantibodies in Patients and Normal Subjects in an Endemic Focus of Fogo Selvagem. J Invest Dermatol 117:460A, 2001

177. Liu Z., T Betsuyaku, D S Rubenstein, L A Diaz and R M Senior BP180 (BPAG2) is a neutrophil chemoattractant in vitro and in vivo after proteolysis by neutrophil elastase. J Invest Dermatol 117:442A, 2001

178. Moesta A.K., M S Lin, L A Diaz and A A Sinha Analysis of T-Cell Receptor V � and J �

usage in Pemphigus Foliaceus. J Invest Dermatol 117:460, 2001.

179. Rubenstein D.S., M S Lin, P Berkowitz, L Arteaga, P Hu, Z Liu, L A Diaz and E J O'Keefe Pemphigus foliaceus IgG activates transmembrane desmosomal signaling. J Invest Dermatol 117:473A, 2001

180. Warren S.J., Arteaga L.A. , Rivitti E.A., Aoki V., Han-Filho G., Giudice G.J., Diaz L.A. and Lin M.S.: The Role of IgG Subclass Switch in the Pathogenesis of Fogo Selvagem. J Invest Dermatol 117:460, 2001.

181. Zhao M., Lin M., Fritz R.B., Diaz L.A. and Liu Z.: Development of an Active Autoimmune Disease Model for Bullous Pemphigoid. J Invest Dermatol 117:461, 2001.

182. Zhao, M., Diaz, L.A., and Liu, Z.: Experimental bullous pemphigoid induced by active immunization is dependent on both T and B cells and medicated by MHC class II-restricted responses. J. Invest. Dermatol. 118:302A, 2002.

183. Carter, K.E., Rose, P.A., Diaz, L.A., and Liu, Z.: The classical pathway of the

complement cascade plays a major role in subepidermal blistering in experimental bullous pemphigoid. Soluble complement receptor 1 inhibits the development of the disease. J. Invest. Dermatol. 118:316A, 2002.

184. Liu, Z., Zhao, M., Carter, K., and Diaz, L.: Role of IgE in subepidermal blistering in

experimental bullous pemphigoid. . J. Invest. Dermatol. 118:319A, 2002.

53

185. Li, N., Liu, Z., and Diaz, L.A.: Pemphigus foliaceus autoantibodies recognize two dominant pathogenic epitopes located in EC1 and EC2 domains of desmoglein-1. L. Invest. Dermatol. 118:305A, 2002

186. Diaz LA, Warren SJP, and Li N. Pathogenicity of anti-desmoglein-1 antibodies is

modulated by epitope spreading in Fogo Selvagem. J. Invest. Dermatol. 119:305A, 2002.

187. Olivry, T., Dunston, S., Warren, S., Li, N., and Liu, Z. Canine pemphigus IgG

autoantibodies cause epidermal blistering when passively transferred into neonatal mice. J. Invest. Dermatol. 118:301A, 2002.

188. Trimberger, M.E., Diaz, L.A., and Liu, Z. Role of Fc receptors in autoimmune bullous

pemphigoid. J. Invest. Dermatol. 121:69A, 2003. 189. Rubenstein, D.S., Berkowitz, P., Hu, P., Liu, Z., and Diaz, L.A. Cellular phosphorylation

initiated by pemphigus vulgaris IgG binding to the desmosomal cadherin desmoglein 3. J. Invest. Dermatol. 121:242A, 2003.

190. Li, N., Diaz, L.A., Roopenian, D.C., and Liu, Z. Mice deficient in neonatal Fc receptor

(FcRn) are resistant to pemphigus foliaceus. J. Invest. Dermatol. 121:292A, 2003. 191. Zhao, M., Diaz, L.A., and Liu, Z. Antigen-specific modulation of experimental bullous

pemphigoid induced by active immunization. J. Invest. Dermatol. 121:991A, 2003. 192. Liu, Z., Zhao, M., Anderson, C.L., Diaz, L.a., and Roopenian, D.C. Protection of

experimental bullous pemphigoid by IVIG is mediated through the IgG protection receptor FcRn. J. Invest. Dermatol. 121:1242A, 2003.

193. Li N, Qaqish BF, and Diaz LA. Correlation of anti-desmoglein-1 epitope profiles with

disease status in endemic pemphigus foliaceus. J. Invest. Dermatol. 122: A10, 2004 194. Li N, Liu J, Zhao M, Hilario-Vargas J, Prisayanh P, Warren S, Roopenian DC, Diaz LA,

and Liu Z. Mechanisms of IVIG action in human autoimmune blistering diseases. Clini. Invest. Med. (CIM). 27: 5C (Abst. W5.27), 2004

195. Zhao, M., Carter, K.E., Diaz, L.A., and Liu, Z. Role of TNF-�, IL-1, and IL-6 in

experimental autoimmune bullous pemphigoid. J. Invest. Dermatol. 122:A13, 2004. 196. Rubenstein, D.R., Berkowitz, P., Hu, P., Liu, Z., Diaz, L.A., and Enghild, J. Pemphigus

vulgaris IgG induces desmosomal transmembrane signaling. J. Invest. Dermatol. 122:A34, 2004.

197. Liu, Z., Zhao, M., Diaz, L.A., and Mayadas, T.N. The �2 integrin CD11b/CD18 plays a

critical role in neutrophil infiltration and elimination in the skin in experimental autoimmune bullous pemphigoid. J. Invest. Dermatol. 122:A35, 2004.

198. Liu, J., Zhao, M., Hilario-Vargas, J., Li, N., Prisayanh, P., Warren, S., Diaz, L.A.,

54

Roopenian, D.C., and Liu, Z. Universal Mechanism of IVIG Action in Pemphigus and Pemphigoid. J. Invest. Dermatol. 122:A49, 2004.

199. Berkowitz, P Hu, PS Prisayanh, LA Diaz, and DS Rubenstein. Desmoglein-3 trafficking

through keratinocyte desmosomes suggests dynamic instability: a kinetic model for PV IgG acantholysis. J Invest Dermatol 124: A28, 2005.

200. Rubenstein DS, P Berkowitz, P Hu, Z Liu, LA Diaz, JJ Enghild and MP Chua. Inhibition

of p38MAPK Prevents Pemphigus Vulgaris IgG Induced Cytoskeleton Reorganization. J Invest Dermatol 124: A28, 2005.

201. Feng F, M Zhao, C Wright, DS Rubenstein, LA Diaz, and Z Liu. Synergy between IL-1

and IL-6 in experimental autoimmune bullous pemphigoid. J Invest Dermatol 124: A11, 2005.

202. Li N, Liu Z, Zhao M, Hilario-Vargas J, and Diaz LA. Two galactose-specific lectins block

experimental pemphgus in mice. J. Invest. Dermatol. 124:A31, 2005 203. Liu, Z., Zhao, M., Li, N., Diaz, L.A., and Mayadas, T.N. Role of β2 Integrins in

Experimental Autoimmune Bullous Pemphigoid. J. Invest. Dermatol. 124:A12, 2005. 204. Zhao, M., Warren, S., Diaz, L.A., and Liu, Z. Fcγ receptors on both Neutrophils and Mast

Cells Mediate Tissue Injury in Autoimmune Bullous Pemphigoid. J. Invest. Dermatol. 124:A12, 2005.

205. Li N, Liu Z, Zhao M, Hilario-Vargas J, and Diaz LA. Two galactose-specific lectins block experimental pemphgus in mice. J. Invest. Dermatol. 124:A31 (Abst. 184), 2005.

206. Li N, Liu Z, Zhao M, Hilario-Vargas J, and Diaz LA. Two galactose-specific lectins block experimental pemphgus in mice. J. Invest. Dermatol. 124:A31 (Abst. 184), 2005.

207. Evangelista F, Dasher DA, Diaz LA, and Li N. The prevalence of autoantibodies against

E-cadherin in pemphigus. J. Invest. Dermatol. 126: S9, 2006 (Abst. 51). 208. Dasher D, Hilario-Vargas J, Li N, Aoki V, Hans-Filho G, dos Santos V, Qaqish BF, Rivitti

EA, and Diaz LA. Prevalence of anti-desmoglein-3 antibodies in endemic regions of fogo selvagem in Brazil. J. Invest. Dermatol. 126: S9, 2006 (Abst. 53).

209. Ortega-Loayza A, Rocha-Alvarez R, Campbell I, Friedman H, Aoki V, Rivitti EA, Li N,

and Diaz LA. Characterization of an endemic form of pemphigus vulgaris in Brazil. J. Invest. Dermatol. 126: S9, 2006 (Abst. 54).

210. Li N, Zhao M, Liu Z, and Diaz LA. Pathogenic role of apoptosis in experimental

pemphigus. J. Invest. Dermatol. 126: S29, 2006 (Abst. 173). 211. Li Z, Zhao M, Rubenstein DS, Diaz LA, and Liu Z. Activation of p38 MAPK is required for

experimental bullous pemphigoid. J Invest Dermatol, 126: S11, 2006 (Abst. 64) 212. Zhao, M., Xu, W., Abrink, M., Sui, W., Li, Z., Rice, S., Diaz, L.A., Pejler, G., Werb, Z.,

and Liu, Z. Role of the chymase, mouse mast cell proteinases 4 in experimental bullous pemphigoid. J. Invest. Dermatol. 126:S11, 2006 (Abst. 63)

55

213. Berkowitz, P., Hu, P., Liu, Z., Diaz, L.A., and Rubenstein, D.S. p38 MAPK inhibition

blocks disease in pemphigus vulgaris mice. J. Invest. Dermatol. 126:A9, 2006.

214. Qian Y, Clarke SH, and Diaz LA. Etiology of autoimmune skin disease revealed by probing the anti-Dsg1 autoantibody repertoire. J Invest Dermatol 127: S16,2007 (Abst. 92)

215. Berkowitz P, Liu Z, Diaz LA, Rubenstein DS. Autoantibodies in the autoimmune disease

pemphigus foliaceus induce blistering in vivo via p38MAPK dependent signaling. J Invest Dermatol, 127:S34, 2007 (Abst 201).

216. Berkowitz P, Diaz LA, Hall R, Rubenstein DS. Increased phosphorylation of p38MAPK

and HSP27 in pemphigus vulgaris patient skin. J Invest Dermatol, 127:S11, 2007 (Abst. 62)

217. Diaz LA, Prisayanh P, Dasher D, Li N, Evangelista F, Aoki V, Hans-Filho G, dos Santos

V, Qaqish BF, Rivitti EA. IgM anti-desmoglein 1 autoantibodies are the distinguishable immunological markers of Fogo Selvagem. J Invest Dermatol, 127:S12,2007 (Abst. 71)

218. Liu Z, Leighty L, Zhao M, Li N, Fu C, Giudice GJ, Fairley JA, Sitaru C, Zillikens D,

Marinkovich P, and Diaz LA. Identification of BP180 Pathogenic Epitope Using Humanized BP180NC16A Mice. J Invest Dermatol, 127:S12, 2007 (Abst. 70)

219. Li N, Liu Z, Wang J, Warren SJP, and Diaz LA. Inhibition of experimental pemphigus by

the p53 inhibitor pifithrin-alpha. J Invest Dermatol, 127:S11, 2007 (Abst. 64)

220. Li N, Liu Z, Park M, and Diaz LA. p53-knockout mice are resistant to the induction of skin blisters and acantholysis by pemphigus autoantibodies. Annual Meeting SID-Japan, 2008

221. Qian Y, Prisayanh P, Andraca E, Qaqish BF, Aoki V, Hans-Filho G, Rivitti EA, and Diaz

LA for the Cooperative Group on Fogo Selvagem Research. IgE and IgG4 anti-desmoglein 1 autoantibodies in endemic pemphigus foliaceus. Annual meeting SID-Japan, 2008.

222. Qaqish BF, Prisayanh P, Qian Y, Andraca E, Li N, Aoki V, Hans-Filho G, dos Santos V,

Rivitti EA, and Diaz LA for the Cooperative Group on Fogo Selvagem Research. Development of an IgG4-based classifier/ predictor of endemic pemphigus foliaceus (Fogo Selvagem). Annual meeting SID-Japan, 2008.

223. Leighty L, Li Z, Berkowitz P, Zhao M, Li N, Rubenstein D, Diaz LA, and Liu Z. C5a/C5a

receptor signaling pathway is critical for experimental bullous pemphigoid. Annual meeting SID-Japan, 2008.

224. Xu W, Moriconi A, Li N, Groben P, Diaz LA, Allegretti M, and Liu Z. Dual targeting of the

innate immune system players mast cells and neutrophils in autoimmune disease. Annual meeting SID-Japan, 2008.

56

225. Lee H-E, Berkowitz P, Chua MP, Liu Z, Diaz LA, and Rubenstein DS. Biphasic p38 MAPK activation in the pemphigus foliaceus mouse model. International Investigational Dermatology Meeting. Annual meeting SID-Japan, 2008.

57

Presentations at National and International Meetings (1976 - To date)

Pemphigus and Pemphigoid Antigens. First Annual Westwood Conference on Clinical Dermatology, Buffalo, NY, April 27, 1976.

Immunochemistry of Pemphigus and Pemphigoid. American Academy of Dermatology,

Chicago, IL, December 6, 1976

Clinical Immunopathology - Recent Advances. Immunodermatology. University of Michigan, Towsley Center, May 26, 1977.

Current Trends in Therapy in Immunological Disorders. Laboratory Technology and

Immunodermatology. Michigan Dermatological Society, Traverse City, MI, June 26, 1977.

Workshop on Dermal-Epidermal Junction. International Congress of Dermatology,

Mexico City, October 1977.

Pemphigus and Pemphigoid Antigen. Advanced Immunology Course. American Academy of Dermatology, Dallas, TX, December 1977.

Dermatitis-Eczema in Children. Advances in Pediatrics. American Academy of

Pediatrics, Ann Arbor, MI, March 14-16, 1979.

Immunologic Aspects of Non-atopic Skin Diseases. Current Topics in Allergy and Clinical Immunology. University of Michigan, Ann Arbor, MI, April 20-May 2, 1979.

Second Workshop in Immune Mechanisms of Cutaneous Disorders. Special invitation

from the NIAMDD, Brook Lodge, MI, September 5-7, 1979.

Dermal-Epidermal Junction. Fourth World Congress, International Society of Tropical Dermatology, New Orleans, LA, September 23-27, 1979.

Necrotizing Angiitis. Heritage Hospital, Taylor, MI, April 16, 1980.

Immunofluorescence in Dermatology. University of Michigan, Towsley Center. Ann

Arbor, MI, April 21, 1980.

Immunopathology of the Skin. Upjohn Company, Kalamazoo, MI, April 28, 1980.

Immunodermatology. Beyer Memorial Hospital. Ypsilanti, MI, May 7, 1980.

Visiting Professor. X Congreso Mexicano de Dermatologia, Zacatecas, Mexico, October 1981.

Chairman, Dermal-Epidermal Junction Workshop. XVI International Congress of

Dermatology, Tokyo, Japan, May 23-28, 1982.

58

Visiting Professor, Department of Pathology, New York State College of Veterinary Medicine, Cornell University, Ithaca, NY, May 19, 1983.

Visiting Professor, Department of Dermatology, University of Rochester, Rochester, NY,

May 20, 1983.

Visiting Professor, Basic Pharmacology Branch, Department of the Army, United States Army Medical Research, Institute of Chemical Defense, Aberdeen Proving Ground, September 26, 1983.

Visiting Professor, Infectious Disease and Immunology, Diagnostics Division, Abbott

Laboratories, North Chicago, IL, November 11, 1983.V

Visiting Professor, Research Division, Gillette Corporation, Rockville, MD, November 1983.

Visiting Professor, The Institute of Dermatology, Homerton Grove, London, England,

February 29, 1984.

Director, Symposium, Collagen Vascular Diseases, V World Congress of Tropical Dermatology, Mexico City, Mexico, October 16-20, 1984.

Guest Speaker, Special Lecture: Recent Advances in Immunodermatology, V World

Congress of Tropical Dermatology, Mexico City, Mexico, October 16-20, 1984.

Guest Speaker, Special Lecture: Photosensitivity in Lupus Erythematosus. V World Congress of Tropical Dermatology, Mexico City, Mexico, October 16-20, 1984.

Guest Speaker, Special Lecture: Advances in Bullous Pemphigoid. V World Congress of

Tropical Dermatology, Mexico City, Mexico, October 16-20, 1984.

Visiting Professor, XV Congreso Colombiano de Dermatologia. Organized by the Sociedad Colombiana de Dermatologia, Bucaramanga, Colombia, November 1-4, 1984.

Guest Lecturer, Autoimmunity and Epidermis. Clinica Anglo-Americana, Lima, Peru,

November 6, 1984.

Visiting Professor, Pathogenic Role of Pemphigus Autoantibodies. Facultad de Medicina, Universidad de Trujillo, Trujillo, Peru. November 12, 1984.

Guest Speaker, Pemphigus. Annual Meeting of the American College of Physicians,

Washington, DC, May 1985.

Chairman, Bullous Dermatoses Workshop. Joint International Meeting of The Society of Investigative Dermatology and The Japanese Society of Investigative Dermatology, Washington, DC, May 1985.

Invited Lecturer, Conference on Autoimmunity: Experimental and Clinical Aspects, New

York Academy of Sciences, New York, NY, June 1985.

59

Visiting Professor, Sociedad Paulista de Dermatologia, Sao Paulo, Brazil, September

1985.

Visiting Professor, Annual Meeting - Sociedad Brasilera de Dermatologia, Florianapolis, Brazil, September 1985.

Visiting Professor, Universidad de Uruguay, Montevideo, Uruguay, September 1985.

Visiting Professor, Universidad de Buenos Aires, Buenos Aires, Argentina, September

1985.

Visiting Professor, Hospital Militar de Lima, Lima, Peru, September 1985.

Visiting Professor, University of Cincinnati, Cincinnati, Ohio, October 1985.

Visiting Professor, Annual Meeting - Japanese Society of Dermatology, Kyoto, Japan, May 1986.

Visiting Professor, XI Cogreso Ibera-Latino-Americano de Dermatologia, Madrid, May,

1987.

Visiting Professor, XVII World Congress of Dermatology, Berlin, May 1987.

Visiting Professor, Institute of Cell and Tumor Biology, German Cancer Research Center, Heidelberg, Federal Republic of Germany, May 29, 1987.

Visiting Professor, Annual Meeting Brazilian Congress of Dermatology, Goiania, Goias,

September, 1987.

Guest Lecturer, "The Walter Lever Lecture: Advances in Pemphigus," Boston Dermatological Society, May 16, 1988.

Visiting Professor, University of Sao Paulo, Brazil, August 16-19, 1988.

Dermatology in the Developing World: International Society of Dermatology, Symposium

on the Management of Blistering Diseases Worldwide, Lecture: "The Epidemiology and Immunopathology of Endemic Pemphigus Foliaceus (Fogo Selvagem),” Oxford, England, September 4-8, 1988.

Guest Lecturer, The Herbert Z. Lund Lectureship, "In Search of the Etiology of

Pemphigus," Southeastern Consortium for Dermatology, Chapel Hill, NC, October 8, 1988.

Guest Lecturer, Central Society of Investigative Dermatology, "Advances in the

Immunopathology of Pemphigus,” Chicago, IL, November 10, 1988.

Guest Lecturer, University of Pennsylvania, Department of Dermatology, "Immunopathology of Pemphigus," Philadelphia, PA, December 1, 1988.

60

Symposium Director, Immunopathology, Annual Meeting, American Academy of

Dermatology, Washington, D.C., December 6, 1988.

Guest Lecturer, La Crosse, Wisconsin, Jan 30, 1989.

Guest Lecturer, Wisconsin Medical Society, April 15, 1989.

Guest Lecturer, V World Congress of Dermatology, Rio de Janeiro, Brazil, May 4, 1989.

Guest Lecturer, Chicago Dermatological Society, May 17, 1989.

Guest Lecturer, University of Wisconsin at Madison, May 26, 1989.

Guest Lecturer, XII Annual Reunion of Dermatology, Departamento de Dermatologia, Hospital General Dr. Manuel Gea Gonzales, Mexico City, Mexico, September 28-29, 1989.

Guest Lecturer, Universidad de Zacatecas, Zacatecas, Mexico, October 2-4, 1989.

Symposium Director, Immunopathology, Annual Meeting, American Academy of

Dermatology, San Francisco, California, December 4, 1989.

Guest Lecturer, VII Annual Winter Colloquium on Clinical Dermatology, Naples, Florida, January 24-28, 1990.

Chairman, Symposium: Cell Adhesion Molecules on Autoimmunity, Society for

Investigative Dermatology Annual Meeting, Washington, D.C., May 1-6, 1990.

Speaker, Monovalent Fab' fragments from Fogo Selvagem IgG are pathogenic, American Dermatological Association Annual Meeting, Sea Island, Georgia, May 11-15, 1990.

Guest Lecturer, International Symposium: Recent Developments in Keratinocyte Biology,

Ann Arbor, Michigan, May 18-19, 1990 (Prof. I. Bernstein).

Guest Lecturer, The Westwood Conference on Clinical Dermatology, Buffalo, New York, "What's New in Pemphigus," June 13-17, 1990.

Guest Lecturer, Brazilian Congress of Dermatology, Sao Paulo, Brazil, September 1-5,

1990.

Guest Lecturer, Directions in Dermatology: Pemphigus Disease, Annual Meeting, American Academy of Dermatology, Atlanta, GA, December 2, 1990.

Guest Lecturer, Clinically Oriented Symposium "Bullous Disorders," Eur. Soc. Dermatol.

Res., Regent's College, London, January 24-25, 1991.

The 1991 William Montagna Lecturer, Annual Meeting Society for Investigative Dermatology, Seattle Washington, May 2, 1991.

61

Guest Lecturer, The 5th Annual Summer Seminars in Dermatology, Cleveland Clinic

Foundation, Cleveland, Ohio, August 3, 1991.

Guest Lecturer, 46o Congresso Brasileiro de Dermatologia, Belo Horizonte, Minas Gerais, Brazil, September 1-4, 1991.

Guest Lecturer, 2nd International Workshop on the Molecular and Cell Biology of

Autoantibodies and Autoimmunity, San Diego, September 19-21, 1991.

Guest Lecturer, The Ronald O Perlman Department of Dermatology, New York University Medical Center, March 13, 1992.

Guest Lecturer, Jornada Paranaense de Dermatologia, Cascavel, Parana, Brazil, March

20-21, 1992.

Guest Lecturer, Department of Dermatology, University of Toronto, April 9, 1992.

Guest Lecturer, Department of Dermatology, University of Cincinnati Medical Center, April 21, 1992.

Guest Lecturer, XIV Reunion Anual de Dermatologos Latinoamericanos del Cono Sur,

Santiago, Chile, May 9-12, 1992.

Lecturer, 18th World Congress of Dermatology, New York City, June 12-18, 1992

Chairman, Workshop: Diseases of Cell-Cell Adhesion, 18th World Congress of Dermatology, New York City, June 17, 1992.

Guest Lecturer, Department of Dermatology and Immunology, Universidad Autonoma de

Zacatecas, Mexico, July 16-17, 1992.

Guest Lecturer, Annual Meeting Sociedad Argentina de Dermatologia, Ciudad de Mar del Plata, Argentina, September 17-20, 1992.

Guest Lecturer, Department of Dermatology, Hospital General Dr. Manuel Gea Gonzales,

Mexico City, November 7-8, 1992.

Guest Lecturer, VIII Congreso Centroamericano de Dermatologia, San Salvador, El Salvador, November 28 - December 2, 1992.

Director, Forum: Human Autoimmunity and the Skin, American Academy of Dermatology

Annual Meeting, San Francisco, CA, December 8, 1992.

Guest Lecturer, Mini-Symposium: "Frontier in Extracellular Matrix Biology and Genetic Skin Disease," in honor of Dr. Arthur Z. Eisen, M.D., Washington University School of Medicine, St. Louis., MO, December 11, 1992.

62

Guest Lecturer, Third Dermatological Meeting of CILAD, Bogota, Colombia, March 19, 1993.

Guest Lecturer, University of Trujillo, Trujillo, Peru, March 22, 1993.

Guest Lecturer, 9th Student Forum for Scientific Research, Puerto Rico, April 23, 1993.

Guest Lecturer, Dermatology Branch, NCI-Bethesda, MD, June 4, 1993.

Guest Lecturer, Brasilian Congress of Dermatology, Curitiba, Parana, September 4-9,

1993.

Guest Lecturer, Autoimmunity Symposium, Kyoto, Japan, November 1, 1993.

Guest Lecturer, The Donald and Margaret Ruch Lecture, University of Rochester, New York, May 17, 1994.

Guest Lecturer, Henry M. Lewis Memorial Lecture, University of Colorado, Denver,

Colorado, June 6-7, 1994.

Guest Lecturer, Spanish Academy of Dermatology, Madrid, Spain, June 9-11, 1994.

Invited Lecturer, Brazilian Congress of Dermatology. Sao Paulo, Brazil, September 5-8, 1994

Guest Lecturer, Northwestern University, Chicago, Illinois, December 7, 1994.

Director, Human Autoimmunity and the Skin, Annual Meeting, American Academy of

Dermatology, New Orleans, Louisiana, 1995.

Lecturer, Advances in Biological Science in Relation to Dermatology, American Academy of Dermatology, New Orleans, Louisiana, 1995.

Marion B. Sulzberger Memorial Speaker, San Francisco Dermatological Society, Stanford

University School of Medicine, California, 1995.

Herb Lund Lecturer, Southeastern Consortium for Dermatology, University of North Carolina, Chapel Hill, North Carolina, 1995.

Yale Visiting Professor, Department of Dermatology, Yale University, January, 1996.

The 1996 Marion B. Sulzberger Memorial Award Lecturer, 54th Annual Meeting of the

American Academy of Dermatology, Washington D.C., February 12, 1996.

Director, Human Autoimmunity and the Skin, Annual Meeting, American Academy of Dermatology, Washington, D.C., February 1996.

Annual Ted Marcus Lecture, Division of Dermatology, Washington University School of

Medicine, St. Louis, Missouri, March, 1996.

63

Guest Lecturer, “New Frontiers in Immunobiology of the Skin and Recent Advances in

Cellular Reconstitution and Genetic Engineering” sponsored by SUNY at Buffalo, San Diego, CA, March, 1996.

Guest Lecturer, NIAMS Tenth Anniversary Symposium, “Progress and Promise in

Chronic Disease” and Keynote Speaker at Workshop, “Enhancing Career Development,” Bethesda, MD, April 1996.

Guest Lecturer, Sociedad Mexicana de Dermatologia, Monterey, Mexico, April, 1996

Guest Lecturer, XVII Annual Meeting of Latin American Dermatologists (RADLA),

Montevideo, Uruguay, May 1996.

Guest Lecturer, Kentucky Dermatological Association, University of Louisville, Louisville, KY, May 1996.

Director, Symposium on Bullous Diseases, Clinical Dermatology in the Year 2000,

Vancouver, May 1996.

Visiting Professor, Department of Dermatology, Mayo Clinic, Rochester, MN, June, 1996.

Guest Lecturer, 25th Anniversary of Department of Dermatology, Universitario del Valle, Cali, Colombia, July 1996.

Guest Lecturer, 2nd Dermatology Days at Clinica Alemana in Advances in Dermatology,

Santiago, Chile, July 1996.

Guest Lecturer, Hospital de Pediatria “Prof. Dr. Juan P. Garrahan”, Buenos Aires, Argentina, July 1996.

Guest Lecturer, Emory Dermatology 1996 Summer Games Symposium, Atlanta, GA.

July, 1996.

Lecturer, Symposium on Basic Science, American Academy of Dermatology, Summer Meeting, Orlando, FL. July 1996.

Invited Speaker, American Dermatological Association Meeting, Montreal, Canada,

September 1996.

The William Montagna Visiting Professor, Department of Dermatology, Oregon Health Sciences University, Portland, OR. October 1996.

Guest Speaker, Oregon Dermatological Society Meeting, Portland, OR, October 1996.

Guest Speaker, Annual Meeting Sociedad Peruana de Dermatologia. Lima, Peru.

November 7-9, 1996

64

Gust Speaker, Department of Dermatology, Facultad de Medicina, Trujillo, Peru. November 13-15, 1996

Invited Speaker, Pamplona, Spain. Il Curso de avances en fisiopatologia de las

enfermedades cutaneas, March 1997.

Gerald Levene Memorial Lecturer, Royal Society of Medicine, London, England, April, 1997.

Guest Dermatologist and William B. Moores Lecturer, Indiana Dermatological Society,

Indianapolis, Indiana, May 1997.

Invited Speaker, Dermatologia 97, Dermatologia Guatemalteca, Guatemala City, Guatemala, July 1997.

Invited Speaker, Brazilian Congress of Dermatology, Brasilia, Brazil. September 1997.

Invited Speaker, Biology and Therapy of Inflammatory Skin Diseases, Dead Sea, Israel,

November, 1997

Invited Speaker, Department of Dermatology, Hadassah-Hebrew University Medical Center. Jerusalem, Israel. November, 1997

Guest Speaker, Grand Rounds, Henry Ford Hospital, Detroit, Michigan, January, 1998

Invited Speaker, Department of Dermatology, University of Michigan, January, 1998

Guest Speaker, Work-In-Progress Visitor, Oklahoma Medical Research Foundation,

Oklahoma City, Oklahoma, February 1998.

Guest Speaker, Department of Dermatology, University of Oklahoma. Oklahoma, February, 1998

The 13th Annual James N. Gilliam Memorial Lecturer, University of Texas Southwestern

Medical Center, Dallas, Texas, April, 1998

Visiting Professor, Facultad de Medicina, Universidad Nacional de Trujillo, Peru. April, 1998.

The 15th Annual Herbert A. Luscombe Lecturer, Thomas Jefferson University,

Philadelphia, Pennsylvania, April, 1998

Invited Speaker, Satellite Symposium on Hereditary and Acquired Bullous Dermatoses. International Investigative Dermatology. Salzburg, Austria, May, 1998

Invited Speaker, Advances in Dermatology (A Tribute to Richard L. Dobson, M.D.),

Charleston, South Carolina, June, 1998

65

Invited Speaker, Immunodermatology Symposium, Mexican Academy of Dermatology, Mexico City, Mexico. July 24-25, 1998.

Chairman Introductory Remarks, Academy ‘98 Summer Meeting of American Academy of

Dermatology, Chicago, IL, July, 1998.

Invited Speaker, Annual Meeting of the Sociedad Argentina de Dermatologia. Buenos Aires, Argentina. August 6-8, 1998.

Invited Speaker, 31st Annual Meeting Pennsylvania Academy of Dermatology. “Bullous

Pemphigoid: From Walter Lever to the Present”. September 18, 1998.

Invited Speaker, 31st Annual Meeting Pennsylvania Academy of Dermatology. Duhring Lecture: “In Search of the Etiology of Pemphigus“. September 19, 1998.

Invited Speaker, VII Congreso Peruano de Dermatologia. Lima, Peru. September 24-27,

1998.

Invited Speaker, XXII Congreso Colombiano de Dermatologia. Santa Marta, Colombia. October 7-11, 1998.

Invited Speaker, Department of Dermatology, Mount Sinai School of Medicine. January

21, 1999

Invited Speaker, Department of Dermatology, Harvard Medical School. January 25-26, 1999.

Invited Speaker, I Congreso Internacional de Dermatologia. Cuenca, Ecuador. February

13, 1999.

Invited Speaker, Department of Dermatology, Cincinnati Medical School. February 25, 1999.

Lecturer at the Annual Meeting of the American Academy of Dermatology. Forum:

International Dermatology. New Orleans. March 19, 1999

Lecturer at the Annual Meeting of the American Academy of Dermatology. Course: Immunology. New Orleans. March 19, 1999

Invited Speaker, I Congreso Peruano de Medical Residents, Trujillo, Peru. April 9-11,

1999.

Invited External Reviewer: Department of Dermatology, University of Texas-Houston. May 11-12, 1999.

The 1999-George Odland Lecturer. Department of Medicine-Division of Dermatology.

University of Washington School of Medicine. Seattle, WA. June 3, 1999.

Guest Lecturer: Washington State Dermatology Association. Seattle, WA. June 4, 1999.

66

Guest Lecturer: Department of Dermatology, Boston University. June 9, 1999.

Invited Keynote Speaker: Colegio Ibero-Americano de Dermatologia. Malaga, Spain.

June 25, 1999.

67

The 1999 Nomland-Carney Memorial Lecturer. Department of Dermatology University of Iowa and Iowa Dermatological Society. September 25, 1999

Guest Speaker: Spanish American Medical Dental Society of New York. October

8-11, 1999.

Guest Speaker. Hispanic Heritage Month Celebration: Scientific Symposium. Pfizer Central Research Division. October 11, 1999.

Guest Lecturer: Wisconsin Dermatological Society. November 6, 1999.

Guest Lecturer: Atlanta Dermatological Society. Atlanta, Georgia. January 2000

Guest Lecturer: North Carolina Dermatological Society. Wrightsville, NC.

January 2000

Guest Lecturer: Korean Society for Investigative Dermatology. Seoul, Korea. March 18, 2000

2000 Pillsbury Lecturer: University of Pennsylvania, Department of Dermatology.

May 24, 2000

Guest Lecturer, Hong Kong Dermatology Group, Hong Kong, China. August 2000

Guest Lecturer: Pemphigus 2000. Bangkok, Thailand, August 2000.

Guest Lecturer: RCMI International Symposium organized by NIAMS (NIH). San Juan, Puerto Rico. November 12-15, 2000

Guest Lecturer: The 100th Annual Meeting of the Japanese Dermatological

Association, April 6-8, 2001

Organizer and Lecturer: Pemphigus, As a Model of Organ-Specific Humoral Autoimmune Diseases. Organized by The Pemphigus Foundation and Sponsored by NIAMS (NIH). April 20-21, 2001.

Guest Lecturer: The Irwin M Braverman Symposium. Dermatology Department,

Yale University. April 27, 2001.

Organizer and participant: The First Dermatology Resident Retreat. Warrenton, Virginia. June 17, 2001. Organized and supported by the Society for Investigative Dermatology, Dermatology Foundation, Herzog Foundation and NIAMS (NIH).

Guest Lecturer: Annual Meeting: Peruvian American Medical Society Annual

Meeting. University of Trujillo, Peru. July 2-4, 2001.

Guest Lecturer: Satellite Meeting on Skin Immunology. Karolinska Hospital, Stockholm, Sweden. July 21-22, 2001.

68

Guest Lecturer: Clinica Alemana. Santiago, Chile. November 17, 2001. The Health Care Revolution in America.

Guest Lecturer. Jornadas Anuales de Dermatologia- Sociedad Chilena de

Dermatologia. Pucon, Chile. November 23-24, 2001.

Guest Lecturer. DF Winter Colloquium, Naples, Florida. January 19, 2002

Guest Lecturer. Advances in Therapeutics in Dermatology" and "XVI International Meeting of Clinical Dermatology" Barcelona, March 23-24, 2002

Guest Lecturer. World Congress of Dermatology, Paris, France. July 4-8, 2002

Guest Lecturer. 51st Annual Montagna Symposium. Snowmass, Colorado.

August 17-20, 2002

The 2002 Sven Hellerström Memorial Lecturerer . Stockholm, Sweden. September 5, 2002.

Guest Lecturer: International Workshop on Autoantibodies as predictors of

disease, September 12-13, 2002. National Institute of Allergy and Infectious Diseases. Bethesda, MD.

Guest Lecturer: Cutaneous Autoimmunity. Department of Pathology, University of

North Carolina. February 6, 2003.

Guest Lecturer. Immunology and Skin Disease. Harvard Medical School. Boston, MA. March 28-30, 2003.

Guest Lecturer. Avances Recientes en Penfigoide. Mexico, DF July 10-15, 2003

Guest Lecturer. Circulo Dermatologico del Peru Simposio Internacional “La Piel

como Modelo Iimmunologico”. July 16, 2003. Lima, Peru.

Guest Lecturer. Brazilian Congress of Dermatology. Vitoria, Brazil. September 7

– 8, 2003.

Guest Lecturer. Duke University School of Medicine, Department of Dermatology. Bullous Pemphigoid. Durham, N.C. September 24, 2003.

Guest Lecturer. Bullous Diseases. 12th European Academy of Dermatology.

Barcelona, Spain. October 15-18, 2003.

Guest Lecturer. Southeastern Consortium, University of North Carolina School of Medicine, Chapel Hill, N.C. October 24, 2003.

Guest Lecturer: Incontri Annuali di Deramtologia. Milan, Italy. February 20-21,

2004.

Guest lecturer: VIII Advances in Dermatology. Sevilla, Spain. April 15-17, 2004.

69

Guest Lecturer: XXII Reunion Anual de Dermatologos Latinoamericanos del Cono

Sur. Lima, Peru. May 1-4, 2004.

Invited Guest Moderator: Facultad de Medicina, Universidad de Trujillo, Peru. Strategic Plan Workshop. May 7-9, 2004

Guest Lecturer: Hawaii Dermatological Society. Honolulu, Hawaii, October, 1-4,

2004.

Guest Lecturer: Dermatology Symposium: Manuel Gea Gonzales Hospital. Mexico City. July 21-23, 2005.

Guest Lecturer: Dermatology Seminar: Universidad de Zacatecas. Cacatecas,

Mexico. July 24-25, 2005.

Guest Lecturer: XVI Colegio Iberoamericano de Dermatologia (CILAD) Meeting, Cartagena, Colombia. November 16-20, 2005.

Guest Lecturer: Societad Ecuatoriana de Dermatologia. Cuenca, Ecuador.

March 16-18, 2006.

Guest Lecturer: Sociedad Dermatologica de Puerto Rico. Ponce, June 23-24, 2006.

Guest Lecturer: Sociedad Peruana de Dermatologia. Lima, August 30-31, 2006

Guest Lecturer: Sociedade Brasileria de Dermatologia. Curitiba, September 7-9,

2006.

Guest Lecturer, San Diego Dermatological Society. San Diego, April 7-10, 2007

Guest Lecturer, American Autoimmune Related Diseases: “Cell and Tissue Damage & Autoimmune Response”. Baltimore, April 27-29, 2007.

24th Stiefel Lecturer: Dermatological Section-Royal Society of Medicine, Bristol

Royal Infirmary (Brsitol, UK), Southampton General Hospital (Winchester, UK), Churchill Hospital & Amersham Hospital (Oxford, UK), St John Institute (London, UK). May 17-23, 2007.

Guest Lecturer, Cuantenous Autoimmunity. Manuel Gea Gonzales Hospital,

Mexico City. July 20-21, 2007

Guest Speaker, In Search of the Etiology of pemphigus Foliaceus. Mayo Clinic. August 6, 2007

Guest Speaker, Fogo Selvagem. 3rd Symposium on Biomedical Research,

University of Sao Paulo, Brazil. September 28, 2007.

Visiting Professor. Advances in the therapy of pemphigus. Universidade Federal de Goias. September 29, 2007

70

Guest Speaker, Autoimmune Bullous Diseases. World Congress of Dermatology,

Buenos Aires, Argentina. October 2, 2007.

Guest Speaker, Update in Pemphigus-Systemic Immunomodulation Symposium. World Congress of Dermatology, Buenos Aires, Argentina. October 4, 2007.

Invited participant and orgnainizer, Reunion Cumbre. Facultad de Medicina de la

Universidad Nacional de Trujillo. November 26-27, 2007.

Visiting Professor and Lecturer. Advances in Pemphigus. Department of Dermatology, University of Cincinnati. January 24, 2008.

Visiting Professor and lecturer, The Overproduction of Physicians in

Latinoamerica and Peru. Facultad de Medicina de Trujillo, Peru. March 29, 2008.

Visiting Professor and Lecturer, Gifu School of Medicine, Gifu, Japan. Advances in Bullous Pemphigoid. May 12, 2008

Lecturer, Meeting of the Autoimmune Blistering Diseases Group. The Immune

Response in Fogo Selvagem. Otsu, Japan. May 19, 2008.

Visiting Professor and Lecturer, Department of Dermatology, Brown University. The Etiology of Endemic Pemphigus. June 12, 2008.

Invited Professor and Lecturer, Joint Meeting of the American Academy of Oral &

Maxillofacial Pathology (AAOMP) and the International Association of Oral Pathologists (IAOP), San Francisco, California. June 22-26, 2008

Visiting Professor and Lecturer. Puerto Rico Society of Dermatology. Advances on the Therapy of Pemphigus and Etiology of Endemic Pemphigus. San Juan, Puerto Rico. June 27, 2008.

Invited Lecturer. Congreso del Colegio Iberoamericano de Dermatologia, Quito,

Ecuador, October 10, 2008.

Visitng Professor and Lecturer. Wisconsin Dermatological Society. Milwaukee, Wisconsin. November 8, 2008