m etabolic profile and osteoporosis in postmenopausal women first author: valentina cojocaru...
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METABOLIC PROFILE AND OSTEOPOROSIS IN POSTMENOPAUSAL WOMEN
First author: Valentina Cojocaru
Coauthor: Mara-Maria Bercea
Coordinator: Associate Professor Ionela Maria Paşcanu
22 millions women and5,5 millions men in EU€ 37 bilion 1,180,000 quality-adjusted life years lost during 2010
INTRODUCTION
“Osteoporosis in the European Union: medical management, epidemiology and economic burden”, E. Hernlund, A. Svedbom, M. Ivergård , Arch Osteoporos (2013) 8:136
MATERIAL AND METHOD
Retrospective case-control study
296 postmenopausal women from Endocrinology Department between 2009-2015
196 with osteoporosis 100 without osteoporosis
Were not included patients with antihyperlipidemic agents treatment, thyroid disorders, hypercortisolism
Body mass index between 18,5 and 35 kg/m² Cut off for enumerated blood parameters and
contingency tables accordingly
RESULTS
For total cholesterol level > 200 mg/dl as a risk factor for osteoporosisOddsRatio 4,91p< 0,001
DISSCUSIONS
Yamagughi et al.: high LDL-cholesterol is associated with low bone mineral density (BMD) at radial site
Cui LH et al.: The serum levels of total cholesterol and LDL-cholesterol were inversely associated with pre- and post-menopausal women
“Plasma lipids and osteoporosis in postmenopausal women.” Yamaguchi T1, Sugimoto T, Yano S et al., Endocr J. 2002 Apr;49(2):211-7
“Association between bone mineral densities and serum lipid profiles of pre- and post-menopausal rural women in South Korea.” Cui LH1, Shin MH, Chung EK et al., Osteoporos Int. 2005 Dec;16(12):1975-81
Buizert PJ et al.: “The lipid profile that is favorable in the prevention of CVD (high levels of HDL-c and low TC/HDL-c ratio) is unfavorable for BMD”
Adami S et al. : High levels of total cholesterol, triglycerides, LDL-cholesterol, triglycerides are positively associated to BMD
“Lipid levels: a link between cardiovascular disease and osteoporosis?”. Buizert PJ1, van Schoor NM, Lips P et al., J Bone Miner Res. 2009 Jun;24(6):1103-9.
“Relationship between lipids and bone mass in 2 cohorts of healthy women and men.” Adami S1, Braga V, Zamboni M e al., Calcified Tissue International 2004 Feb;74(2):136-42.
Atherogenic lipid profile is proosteoporotic
Atherogenic lipid profile is antiosteoporotic
DISSCUSIONS
The experimental studies show:
“Bone density and hyperlipidemia: the T-lymphocyte connection.” Graham LS1, Tintut Y, Parhami F et al., J Bone Miner Res. 2010 Nov;25(11):2460-9“The Roles of Lipid Oxidation Products and Receptor Activator of Nuclear Factor-κB Signaling in Atherosclerotic Calcification.” Linda Demer, Yin TintutMay;, Circulation Research.2011; 108: 1482-1493.
DISCUSSIONS
Stendig-Lindberg G et al.: in their clinical trial, increasing the intake of magnesium in postmenopausal osteoporotic women increased the BMD
“Trabecular bone density in a two year controlled trial of peroral magnesium in osteoporosis.” Stendig-Lindberg G1, Tepper R, Leichter I., Magnes Res 1993 Jun;6(2):155-63.
Zheng et al.: Iron defficit is a risk factor for osteoporosis
Danoux CB et al.: “inorganic phosphate has a positive effect on the expression of osteogenic markers”
“Low serum levels of zinc, copper, and iron as risk factors for osteoporosis: a meta-analysis”. Zheng J, Mao X, Ling J et al., Biol Trace Elem Res 2014 Jul;160(1):15-23.
“Elucidating the individual effects of calcium and phosphate ions on hMSCs by using composite materials.”, Danoux CB, Bassett DC2, Othman Z et al., Acta Biomater 2015 Apr 15;17:1-15
Magnesium role Iron and Phosphate
CONCLUSIONS
A serum level of total cholesterol > 200 mg/dl, a HDL-cholesterol level > 45 mg/dl, a LDL-cholesterol level > 150 mg/dl are risk factors for osteoporosis
A serum level of triglycerides > 130 mg/dl and a magnesium serum level >2 mg/dl are protective factors for osteoporosis
Iron, uric acid and phosphate serum level are indifferent factors
BIBLIOGRAPHY “Osteoporosis in the European Union: medical management, epidemiology and economic burden”
E. Hernlund, A. Svedbom, M. Ivergård et al., 2013. “Plasma lipids and osteoporosis in postmenopausal women.” Yamaguchi T1, Sugimoto T, Yano S et
al., Endocr J. 2002 Apr;49(2):211-7 “Association between bone mineral densities and serum lipid profiles of pre- and post-menopausal
rural women in South Korea.” Cui LH1, Shin MH, Chung EK et al., Osteoporos Int. 2005 Dec;16(12):1975-81
“Lipid levels: a link between cardiovascular disease and osteoporosis?”. Buizert PJ1, van Schoor NM, Lips P et al., J Bone Miner Res. 2009 Jun;24(6):1103-9.
“Relationship between lipids and bone mass in 2 cohorts of healthy women and men.” Adami S1, Braga V, Zamboni M e al., Calcified Tissue International 2004 Feb;74(2):136-42.
“Bone density and hyperlipidemia: the T-lymphocyte connection.” Graham LS1, Tintut Y, Parhami F et al., J Bone Miner Res. 2010 Nov;25(11):2460-9.
“The Roles of Lipid Oxidation Products and Receptor Activator of Nuclear Factor-κB Signaling in Atherosclerotic Calcification.” Linda Demer, Yin TintutMay;, Circulation Research.2011; 108: 1482-1493
“Oxysterols regulate differentiation of mesenchymal stem cells: pro-bone and anti-fat.” Kha HT1, Basseri B, Shouhed D et al., J Bone Miner Res. 2004 May;19(5):830-40
“Trabecular bone density in a two year controlled trial of peroral magnesium in osteoporosis.” Stendig-Lindberg G1, Tepper R, Leichter I., Magnes Res 1993 Jun;6(2):155-63.
“Elucidating the individual effects of calcium and phosphate ions on hMSCs by using composite materials.”, Danoux CB, Bassett DC2, Othman Z et al., Acta Biomater 2015 Apr 15;17:1-15
“Low serum levels of zinc, copper, and iron as risk factors for osteoporosis: a meta-analysis”. Zheng J, Mao X, Ling J et al., Biol Trace Elem Res 2014 Jul;160(1):15-23.
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