main findings from the substance abuse treatment to hiv care … · heather j. gotham, kate speck,...

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*Bryan R. Garner; Stephen J. Tueller, Steve Martino, Heather J. Gotham, Kate Speck, Michael Chaple, Denna Vandersloot, Michael Bradshaw , Elizabeth Ball, Alyssa Toro, Marianne Kluckmann, Mat Roosa, and Jay Ford Main findings from the Substance Abuse Treatment to HIV Care (SAT2HIV) Project: A type 2 effectiveness-implementation hybrid trial *Presented by: Bryan R. Garner, PhD Senior Implementation Research Scientist RTI International 3040 E. Cornwallis Rd. Research Triangle Park, NC 27709-2194 Phone: (919) 597-5159 Email: [email protected] Funding provided by the National Institute on Drug Abuse (NIDA; R01-DA038146; PI: Garner)

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Page 1: Main findings from the Substance Abuse Treatment to HIV Care … · Heather J. Gotham, Kate Speck, Michael Chaple, Denna Vandersloot, Michael Bradshaw , Elizabeth Ball, Alyssa Toro,

*Bryan R. Garner; Stephen J. Tueller, Steve Martino, Heather J. Gotham, Kate Speck, Michael Chaple, Denna

Vandersloot, Michael Bradshaw , Elizabeth Ball, Alyssa Toro, Marianne Kluckmann, Mat Roosa, and Jay Ford

Main findings from the Substance Abuse Treatment to HIV Care (SAT2HIV) Project: A type 2 effectiveness-implementation hybrid trial

*Presented by:Bryan R. Garner, PhD

Senior Implementation Research ScientistRTI International

3040 E. Cornwallis Rd.Research Triangle Park, NC 27709-2194

Phone: (919) 597-5159Email: [email protected]

Funding provided by the National Institute on Drug Abuse (NIDA; R01-DA038146; PI: Garner)

Page 2: Main findings from the Substance Abuse Treatment to HIV Care … · Heather J. Gotham, Kate Speck, Michael Chaple, Denna Vandersloot, Michael Bradshaw , Elizabeth Ball, Alyssa Toro,

The Problem:Integrating HIV services with other health services

“In summary, given the existing evidence that largely supports HIV integration from a public health and clinical perspective, the findings of this review support further efforts to integrate. However, significant evidence gaps remain. Unfortunately, few of the studies found adequately address the central questions currently concerning many programme managers at this moment in time: not whether to integrate, but when to, how to, and which model is most efficient in which setting?”

Page 3: Main findings from the Substance Abuse Treatment to HIV Care … · Heather J. Gotham, Kate Speck, Michael Chaple, Denna Vandersloot, Michael Bradshaw , Elizabeth Ball, Alyssa Toro,

The Setting:Community-based AIDS Service Organizations (ASOs)

Substance use can negatively impactASOs ability to achieve goals of the

HIV Care Continuum

Substance Use

Integration of Motivational Interviewing-based brief

intervention for substance use

Page 4: Main findings from the Substance Abuse Treatment to HIV Care … · Heather J. Gotham, Kate Speck, Michael Chaple, Denna Vandersloot, Michael Bradshaw , Elizabeth Ball, Alyssa Toro,

The Substance Abuse Treatment to HIV Care (SAT2HIV) Project:A doubly randomized type 2 effectiveness-implementation hybrid trial

Garner, B. R., Gotham, H. J., Tueller, S. J., Ball, E. L., Kaiser, D., Stilen, P., ... Martino, S. (2018). Testing the effectiveness of a motivational interviewing-based brief intervention for substance use as an adjunct to usual care in community-based AIDS service organizations: study protocol for a multisite randomized controlled trial. Addiction Science & Clinical Practice, 13, 9.

Garner, B. R., Zehner, M., Roosa, M. R., Martino, S., Gotham, H. J., Ball, E. L., ... Ford, J. H. (2017). Testing the implementation and sustainment facilitation (ISF) strategy as an effective adjunct to the Addiction Technology Transfer Center (ATTC) strategy: Study protocol for a cluster randomized trial. Addiction Science & Clinical Practice, 12(1), 32.

Page 5: Main findings from the Substance Abuse Treatment to HIV Care … · Heather J. Gotham, Kate Speck, Michael Chaple, Denna Vandersloot, Michael Bradshaw , Elizabeth Ball, Alyssa Toro,

The Method:A doubly randomized 39-site type 2 effectiveness-implementation hybrid trial

The ISF Experiment

The MIBI Experiment

Page 6: Main findings from the Substance Abuse Treatment to HIV Care … · Heather J. Gotham, Kate Speck, Michael Chaple, Denna Vandersloot, Michael Bradshaw , Elizabeth Ball, Alyssa Toro,

The Method:A doubly randomized 39-site type 2 effectiveness-implementation hybrid trial

The ISF Experiment

The MIBI Experiment

Page 7: Main findings from the Substance Abuse Treatment to HIV Care … · Heather J. Gotham, Kate Speck, Michael Chaple, Denna Vandersloot, Michael Bradshaw , Elizabeth Ball, Alyssa Toro,

Proficiency demonstrated when “at least half of the MI-consistent items rated average or above in

terms of adherence and competence.”Martino et al., 2008

Staff-level Proficiency(Miller et al., 2004; Martino et al. 2008)

Page 8: Main findings from the Substance Abuse Treatment to HIV Care … · Heather J. Gotham, Kate Speck, Michael Chaple, Denna Vandersloot, Michael Bradshaw , Elizabeth Ball, Alyssa Toro,

Staff-level Implementation Effectiveness(Klein & Sorra, 1996; Klein, Conn, & Sorra, 2001)

“Implementation effectiveness refers to the consistency and quality of targeted organizational

members’ use of a specific innovation.”Klein & Sorra, 1996

Page 9: Main findings from the Substance Abuse Treatment to HIV Care … · Heather J. Gotham, Kate Speck, Michael Chaple, Denna Vandersloot, Michael Bradshaw , Elizabeth Ball, Alyssa Toro,

Staff-level of Sustainment(Aarons et al., 2011; Hunter et al., 2014)

“use the term sustainment to denote thecontinued use of an innovation in practice.”

Aarons et al. 2011

Page 10: Main findings from the Substance Abuse Treatment to HIV Care … · Heather J. Gotham, Kate Speck, Michael Chaple, Denna Vandersloot, Michael Bradshaw , Elizabeth Ball, Alyssa Toro,

The Method:Participant Flow

Page 11: Main findings from the Substance Abuse Treatment to HIV Care … · Heather J. Gotham, Kate Speck, Michael Chaple, Denna Vandersloot, Michael Bradshaw , Elizabeth Ball, Alyssa Toro,

The Method:Participant Flow

Page 12: Main findings from the Substance Abuse Treatment to HIV Care … · Heather J. Gotham, Kate Speck, Michael Chaple, Denna Vandersloot, Michael Bradshaw , Elizabeth Ball, Alyssa Toro,

The Method:Participant Flow

Page 13: Main findings from the Substance Abuse Treatment to HIV Care … · Heather J. Gotham, Kate Speck, Michael Chaple, Denna Vandersloot, Michael Bradshaw , Elizabeth Ball, Alyssa Toro,

The Method:Implementation Conditions

1. Name it

2. Define it

3. Specify ita) The Actorb) The Actionc) Action Targetd) Temporalitye) Dosef) Implementation Outcomeg) Justification

Page 14: Main findings from the Substance Abuse Treatment to HIV Care … · Heather J. Gotham, Kate Speck, Michael Chaple, Denna Vandersloot, Michael Bradshaw , Elizabeth Ball, Alyssa Toro,

The Method:Addiction Technology Transfer Center

(ATTC) implementation strategyA. Centralized technical

assistanceB. Develop educational

materialsC. Develop and organize

quality monitoring systems

D. Develop tools for quality monitoring

E. Distribute educational materials

F. Conduct educational meetings

G. Make training dynamic

H. Audit & Provide feedback

I. Provide ongoing consultation

J. Create a learning collaborative

Page 15: Main findings from the Substance Abuse Treatment to HIV Care … · Heather J. Gotham, Kate Speck, Michael Chaple, Denna Vandersloot, Michael Bradshaw , Elizabeth Ball, Alyssa Toro,

The Method:Implementation & Sustainment Facilitation

K. Use an improvement and implementation advisor

L. Develop tools for quality improvement

M. Organize implementation team meetings

N. Identify and prepare champions

O. Assess for readiness and identify barriers

P. Conduct local consensus discussions

Q. Conduct cyclical small tests of change

Page 16: Main findings from the Substance Abuse Treatment to HIV Care … · Heather J. Gotham, Kate Speck, Michael Chaple, Denna Vandersloot, Michael Bradshaw , Elizabeth Ball, Alyssa Toro,

The Method:Addiction Technology Transfer Center

(ATTC) implementation strategy

Page 17: Main findings from the Substance Abuse Treatment to HIV Care … · Heather J. Gotham, Kate Speck, Michael Chaple, Denna Vandersloot, Michael Bradshaw , Elizabeth Ball, Alyssa Toro,

The Method:Addiction Technology Transfer Center

(ATTC) implementation strategy

Page 18: Main findings from the Substance Abuse Treatment to HIV Care … · Heather J. Gotham, Kate Speck, Michael Chaple, Denna Vandersloot, Michael Bradshaw , Elizabeth Ball, Alyssa Toro,

Strategy dose during preparation phase

Page 19: Main findings from the Substance Abuse Treatment to HIV Care … · Heather J. Gotham, Kate Speck, Michael Chaple, Denna Vandersloot, Michael Bradshaw , Elizabeth Ball, Alyssa Toro,

Strategy dose during implementation phase

Page 20: Main findings from the Substance Abuse Treatment to HIV Care … · Heather J. Gotham, Kate Speck, Michael Chaple, Denna Vandersloot, Michael Bradshaw , Elizabeth Ball, Alyssa Toro,

Strategy dose during sustainment phase

Page 21: Main findings from the Substance Abuse Treatment to HIV Care … · Heather J. Gotham, Kate Speck, Michael Chaple, Denna Vandersloot, Michael Bradshaw , Elizabeth Ball, Alyssa Toro,

The Substance Abuse Treatment to HIV Care (SAT2HIV) Project:A doubly randomized type 2 effectiveness-implementation hybrid trial

Garner, B. R., Gotham, H. J., Tueller, S. J., Ball, E. L., Kaiser, D., Stilen, P., ... Martino, S. (2018). Correction to: Testing the effectiveness of a motivational interviewing-based brief intervention for substance use as an adjunct to usual care in community-based AIDS service organizations: study protocol for a multisite randomized controlled trial. Addiction Science & Clinical Practice, 13, 9.

Garner, B. R., Zehner, M., Roosa, M. R., Martino, S., Gotham, H. J., Ball, E. L., ... Ford, J. H. (2017). Testing the implementation and sustainment facilitation (ISF) strategy as an effective adjunct to the Addiction Technology Transfer Center (ATTC) strategy: Study protocol for a cluster randomized trial. Addiction Science & Clinical Practice, 12(1), 32.

Page 22: Main findings from the Substance Abuse Treatment to HIV Care … · Heather J. Gotham, Kate Speck, Michael Chaple, Denna Vandersloot, Michael Bradshaw , Elizabeth Ball, Alyssa Toro,

Organizational-levelassignment to ISF condition

Staff-level Proficiency

Staff-level Implementation

Effectiveness

Client-level Substance Use

Client-level assignment to

UC+MIBI condition

OR = 1.92**

OR = 0.98

OR = 0.11*

* p < .05; ** p < .01

Results:Main Findings

Page 23: Main findings from the Substance Abuse Treatment to HIV Care … · Heather J. Gotham, Kate Speck, Michael Chaple, Denna Vandersloot, Michael Bradshaw , Elizabeth Ball, Alyssa Toro,

Discussion:Key Takeaways, Lessons Learned, and Next Steps

Page 24: Main findings from the Substance Abuse Treatment to HIV Care … · Heather J. Gotham, Kate Speck, Michael Chaple, Denna Vandersloot, Michael Bradshaw , Elizabeth Ball, Alyssa Toro,

Discussion:Key Takeaways

39 Distinct ASOs

Page 25: Main findings from the Substance Abuse Treatment to HIV Care … · Heather J. Gotham, Kate Speck, Michael Chaple, Denna Vandersloot, Michael Bradshaw , Elizabeth Ball, Alyssa Toro,

39 Distinct ASOs 39 Distinct ASOs(100%)

Discussion:Key Takeaways

Page 26: Main findings from the Substance Abuse Treatment to HIV Care … · Heather J. Gotham, Kate Speck, Michael Chaple, Denna Vandersloot, Michael Bradshaw , Elizabeth Ball, Alyssa Toro,

39 Distinct ASOs 39 Distinct ASOs(100%)

34 Distinct ASOs(87%)

Discussion:Key Takeaways

Page 27: Main findings from the Substance Abuse Treatment to HIV Care … · Heather J. Gotham, Kate Speck, Michael Chaple, Denna Vandersloot, Michael Bradshaw , Elizabeth Ball, Alyssa Toro,

Organizational-levelassignment to ISF condition

Staff-level Implementation

Effectiveness

Client-level Substance Use

Client-level assignment to

UC+MIBI condition

OR = 1.92**

OR = 0.11*

* p < .05; ** p < .01

ISF had a significant impact on an implementation outcome

ISF had a significant impact on a client outcome

Discussion:Key Takeaways

Page 28: Main findings from the Substance Abuse Treatment to HIV Care … · Heather J. Gotham, Kate Speck, Michael Chaple, Denna Vandersloot, Michael Bradshaw , Elizabeth Ball, Alyssa Toro,

Discussion:Lessons Learned

Type 2 effectiveness-implementation hybrid trials are not for the faint of heart

Page 29: Main findings from the Substance Abuse Treatment to HIV Care … · Heather J. Gotham, Kate Speck, Michael Chaple, Denna Vandersloot, Michael Bradshaw , Elizabeth Ball, Alyssa Toro,

Discussion:Lessons Learned

Type 2 effectiveness-implementation hybrid trials are possible… with the right infrastructure and team

Page 30: Main findings from the Substance Abuse Treatment to HIV Care … · Heather J. Gotham, Kate Speck, Michael Chaple, Denna Vandersloot, Michael Bradshaw , Elizabeth Ball, Alyssa Toro,

Common Goal

Research

Practice

Discussion:Lessons Learned

Page 31: Main findings from the Substance Abuse Treatment to HIV Care … · Heather J. Gotham, Kate Speck, Michael Chaple, Denna Vandersloot, Michael Bradshaw , Elizabeth Ball, Alyssa Toro,

iNodOther grants testing the ISF strategy

Discussion:Next Steps

Page 32: Main findings from the Substance Abuse Treatment to HIV Care … · Heather J. Gotham, Kate Speck, Michael Chaple, Denna Vandersloot, Michael Bradshaw , Elizabeth Ball, Alyssa Toro,