Upload File

matthew todd, the university of sydney mattoddchem mattoddchemistry [email protected] open...

20
Open Source Drug Discovery Matthew Todd, The University of Sydney mattoddchem MatToddChemistry [email protected] http://intermolecular.wordpress.com/ Open Science Summit, Mountain View/Sydney, Sometime October 2011

Upload: cuthbert-horton

Post on 01-Jan-2016

226 views

Category:

Documents


1 download

Report

Tags:

TRANSCRIPT

Page 1: Matthew Todd, The University of Sydney mattoddchem MatToddChemistry matthew.todd@sydney.edu.au Open Science Summit,

Open Source Drug Discovery

Matthew Todd, The University of Sydney

mattoddchem

MatToddChemistry

[email protected]

http://intermolecular.wordpress.com/

Open Science Summit, Mountain View/Sydney, Sometime October 2011

Page 2: Matthew Todd, The University of Sydney mattoddchem MatToddChemistry matthew.todd@sydney.edu.au Open Science Summit,

http://www3.imperial.ac.uk/schisto; http://bit.ly/9azFHv

Praziquantel

Africa is Desperate for Praziquantel, Lancet 2010, 376, 496-498

2/20

Page 3: Matthew Todd, The University of Sydney mattoddchem MatToddChemistry matthew.todd@sydney.edu.au Open Science Summit,

Enantiopure PZQ for a low, low price

http://bit.ly/913iAm; http://bit.ly/KRdIZ; http://bit.ly/cJF1BW

GOT (10 ¢ g-1)

NEED BAD/BITTER

3/20

http://bit.ly/913iAm
http://bit.ly/KRdIZ
http://bit.ly/cJF1BW
Page 4: Matthew Todd, The University of Sydney mattoddchem MatToddChemistry matthew.todd@sydney.edu.au Open Science Summit,

Intractable Problem?

When you have a tough problem – ASK SOMEONE!

Effectiveness of Solution

(“ee” in Chemical Terms)

Resources(Person-years)

Required Usefulness

Breaking Point for Academia/Industry

4/20

Page 5: Matthew Todd, The University of Sydney mattoddchem MatToddChemistry matthew.todd@sydney.edu.au Open Science Summit,

Open Source5/20

Page 6: Matthew Todd, The University of Sydney mattoddchem MatToddChemistry matthew.todd@sydney.edu.au Open Science Summit,

How we do things

http://bit.ly/9Pv119; http://bit.ly/9VTpqj

6/20

Page 7: Matthew Todd, The University of Sydney mattoddchem MatToddChemistry matthew.todd@sydney.edu.au Open Science Summit,

Ways of Doing Science7/20

Page 8: Matthew Todd, The University of Sydney mattoddchem MatToddChemistry matthew.todd@sydney.edu.au Open Science Summit,

Problem

Pruning

Detail

Community

Holes

Kernel

The Open Cycle8/20

Page 9: Matthew Todd, The University of Sydney mattoddchem MatToddChemistry matthew.todd@sydney.edu.au Open Science Summit,

Wall Street JournalMay 26th 2010

Sharing Data is Step 1

tropicaldisease.orgNature Biotech. 2009, 27, 320-321.

9/20

Page 10: Matthew Todd, The University of Sydney mattoddchem MatToddChemistry matthew.todd@sydney.edu.au Open Science Summit,

The Synaptic Leap10/20

Page 11: Matthew Todd, The University of Sydney mattoddchem MatToddChemistry matthew.todd@sydney.edu.au Open Science Summit,

Funding11/20

Page 12: Matthew Todd, The University of Sydney mattoddchem MatToddChemistry matthew.todd@sydney.edu.au Open Science Summit,

Publicity12/20

Page 13: Matthew Todd, The University of Sydney mattoddchem MatToddChemistry matthew.todd@sydney.edu.au Open Science Summit,

Companies? Seriously?

http://www.syncom.nl/hr/index.html; http://www.solvay.com/; http://www.intervet.com/; http://www.almacgroup.com/

13/20

Page 14: Matthew Todd, The University of Sydney mattoddchem MatToddChemistry matthew.todd@sydney.edu.au Open Science Summit,

Current Solution

Details of Route: PLoS NTD 2011, 5(9): e1260 Full Description of Project: Nature Chemistry 2011, 3, 745-748

14/20

Page 15: Matthew Todd, The University of Sydney mattoddchem MatToddChemistry matthew.todd@sydney.edu.au Open Science Summit,

http://bit.ly/dtkwf0, http://bit.ly/aqHWtV, http://bit.ly/bJNZ8N, http://bit.ly/8TrvZ4

Advantages15/20

Page 16: Matthew Todd, The University of Sydney mattoddchem MatToddChemistry matthew.todd@sydney.edu.au Open Science Summit,

Diverse Inputs16/20

Page 17: Matthew Todd, The University of Sydney mattoddchem MatToddChemistry matthew.todd@sydney.edu.au Open Science Summit,

Open Source Drug Discovery?17/20

Page 18: Matthew Todd, The University of Sydney mattoddchem MatToddChemistry matthew.todd@sydney.edu.au Open Science Summit,

Start With Great Leads

ACS Med. Chem. Lett. 201110.1021/ml200135p

18/20

Page 19: Matthew Todd, The University of Sydney mattoddchem MatToddChemistry matthew.todd@sydney.edu.au Open Science Summit,

Resynthesis then Campaign 19/20

Page 20: Matthew Todd, The University of Sydney mattoddchem MatToddChemistry matthew.todd@sydney.edu.au Open Science Summit,

Michael Woelfe, Paul Ylioja, Murray Robertson (USyd), Piero Olliaro (WHO/TDR), Jean-Paul Seerden (Syncom) and many other online collaborators

Tim Wells, Paul Willis and Jeremy Burrows (MMV)Jeremy Frey and team (Uni Southampton)

20/20


Eight’s Priority Directions - University of Sydney...The University of Sydney NSW 2006 Australia T +61 2 9351 6980 E [email protected] sydney.edu.au ABN 15 211 513 464

Lecture for Sydney University Nutrition & Dietetics …sydney.edu.au/science/molecular_bioscience/NUTR4001/kba/...Lecture for Sydney University Nutrition & Dietetics Students 2008

CEO KEYNOTE - CHARLES TODD ORATION Sydney - November … · CEO CHARLES TODD ORATION – SPEECH NOTES PAGE 1 CEO KEYNOTE - CHARLES TODD ORATION Sydney - November CEO SPEECH NOTES

Volume 8, Number 21 University The liEggs September 13 ...sydney.edu.au/arms/archives/uninews/133_The University of Sydney... · enough to allow students to ... The Quadranglers,

University of The JWCRR research, education and …sydney.edu.au/medicine/rehab/education/Lisa Harvey - Physiotherapy... · University of Sydney Professor Lisa Harvey The JWCRR research,

Todd-AO in Sydney

Beauty in the Eye of the Beholder The Relativity of Visual Experience Andrew Duggins Westmead Hospital, University of Sydney [email protected]

University of Sydney School of Physics …sydney.edu.au/science/physics/pdfs/current/sphys/3yr_lab/...SUPPLEMENTARY NOTES for Senior Experimental Physics Handbook ... 5.5.2 The Poisson

The Sydney Language on Our Campuses and in Our Curriculum · R. Quinnell (B) Faculty of Science, The University of Sydney, Sydney, NSW, Australia e-mail: [email protected]

Sydney Network on Climate Change and Society & CHANGING ...sydney.edu.au/.../Coastlines-Symposium_Programme.pdf · the absorption of carbon dioxide into the world‟s oceans. My talk

THE INTERNAL DYNAMICS OF MIGRATION …sydney.edu.au/arts/transformation_migration/downloads/Sydney... · 1 THE INTERNAL DYNAMICS OF MIGRATION PROCESSES AND THEIR CONSEQUENCES FOR

2018 AEROSPACE TOPICS - University of Sydney Thesis...Thesis/Capstone project topics. 2018 AEROSPACE TOPICS Supervisor: Xiaofeng Wu [email protected] Topic: Implementing ECSS

Exploring Sustainability through the Australian Curriculum: Mathematics Judy Anderson The University of Sydney [email protected] ACSA Conference

E. Badian-Lucius Sulla_ the Deadly Reformer (Todd Memorial Lecture)-Sydney University Press (1971)

Undergraduate guide 2018 The University of Sydney … · sydney.edu.au Undergraduate guide 2018 The University of Sydney Law School ... (LLB) and Juris ... After travelling to London

The University of Sydney Wingara Mura – Bunga Barrabugu ...Email: [email protected] And don’t forget to visit our website: sydney.edu.au/ indigenous-summer-program

The University of Sydney - The University of Sydney - Occupational …sydney.edu.au/medicine/aghealth/uploaded/Chartbooks/... · 2016. 2. 12. · Poultry farming (meat) 309 217 122

PAMS SUMMIT 2017 - sydney.edu.au

Contact us - University of Sydney · 2020. 9. 10. · Contact us Business The University of Sydney Business School Undergraduate guide 2020 sydney.edu.au/business 1800 SYD UNI (1800

Sydney Southeast Asia Centre · 2020. 9. 18. · 2019–2020 Yearbook. Page 2 Photo credit: Waranont Joe sydney.edu.au/sseac The University of Sydney Sydney Southeast Asia Centre

Beyond Prevention - sydney.edu.au … · 80% increase in the proportion of mental health services provided that involve technology-enabled coordinated care . The University of Sydney

3rd International Conference on Public Policy (ICPP3) June 28 … · against SOPA and PIPA xxxxxxxxxxxxxxxxxxxxxxxxxx Author Madison Cartwright University of Sydney, Australia [email protected]

The University of Sydney - The University of Sydney - …sydney.edu.au/medicine/pharmacology/adrien-albert/images/... · 2009. 12. 10. · C Rae (1), FA Nasrallah (1) & VJ Balcar

Muse Issue 25, May 2020 - sydney.edu.au · 5/25/2020  · Sydney University Museums Chau Chak Wing Museum Opening 2020 +61 2 9351 2812 +61 2 9351 2881 (fax) [email protected]

UNESCO Survey For Universities Information ... - sydney.edu.au · The University of Sydney is one of the world’s leading, comprehensive research and teaching universities. The

First University Calendar - sydney.edu.au

The University of Sydney sydney.edu.au n It al

Food Governance Conference 2016 - University of Sydney · The University of Sydney sydney.edu.au Food Governance Conference 2016 The role of law, regulation, and policy in meeting

THE UNIVERSITY OF SYDNEY HONOURS AT GRADUATION, …sydney.edu.au/documents/about/honour-roll/2012-honour-roll.pdf · THE UNIVERSITY OF SYDNEY HONOURS AT GRADUATION, DEANS’ LISTS

sydney.edu.au The University of Sydney · 2020. 12. 15. · Dr Jovana Mijatovic Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders Dr Shekeeb Mohammad hildrens Hospital

The emergence and characteristics of the Australian Mamil · 2018-12-05 · 1University of Sydney, Sydney, NSW. 2 New South Wales Ministry of Health, Sydney, NSW. [email protected]

Reconfigurable Computing - University of Sydney Computing Finite State Machines School of Electrical and Information Engineering phwl Philip Leong ([email protected])Published

Mathematics Learning Centre - sydney.edu.au · Mathematics Learning Centre, University of Sydney 3 2.3 Assumed knowledge We assume that you are familiar with the following elementary

Contracts Subject Guide - Home - The University of …sydney.edu.au/lec/subjects/winter 2006Subject Guides... · Web viewLAW EXTENSION COMMITTEE UNIVERSITY OF SYDNEY 02 CONTRACTS

c Springer Science+Business Media B.V., part of … Broadening...Sydney School of Architecture, Design and Planning The University of Sydney 148 City Road, Darlington, Australia [email protected]