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Evogene’s Ag-Biologicals Division Microbiome driving crop productivity Introduction Ido Dor, EVP & GM, Ag-Biologicals Jan 2018 Confidential

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Page 1: Microbiome driving crop productivity - Evogene · Ag Biologicals Market 38% 62% ~$3.2B* in 2015 Rapid growth sector * Source: Phillips McDougall , 2015 2015 2020 ~$8B ~$3.2B Source

Evogene’s Ag-Biologicals DivisionMicrobiome driving crop productivityIntroduction

Ido Dor, EVP & GM, Ag-Biologicals Jan 2018

Confidential

Page 2: Microbiome driving crop productivity - Evogene · Ag Biologicals Market 38% 62% ~$3.2B* in 2015 Rapid growth sector * Source: Phillips McDougall , 2015 2015 2020 ~$8B ~$3.2B Source

Safe Harbor Statement

This presentation contains "forward-looking statements" relating to future events, and we may from time to time make other statements, regardingour outlook or expectations for future financial or operating results and/or other matters regarding or affecting Evogene Ltd. or its subsidiaries(collectively, “Evogene” or “we”), that are considered “forward-looking statements” as defined in the U.S. Private Securities Litigation Reform Act of1995 (the “PSLRA”). Such forward-looking statements may be identified by the use of such words as “believe,” “expect,” “anticipate,” “should,”“planned,” “estimated,” “intend” and “potential” or words of similar meaning. For these statements, Evogene claims the protection of the safeharbor for forward-looking statements contained in the PSLRA.

Such statements are based on current expectations, estimates, projections and assumptions, describe opinions about future events, involve certainrisks and uncertainties which are difficult to predict and are not guarantees of future performance. Therefore, actual future results, performance orachievements, and trends in the future of Evogene may differ materially from what is expressed or implied by such forward-looking statements dueto a variety of factors, many of which are beyond Evogene's control, including, without limitation, those described in greater detail in our Periodicaland Annual Reports, including our Registration Statement on Form F-1, Annual Report on Form 20-F and in other information we file and furnishwith the Israel Securities Authority and the U.S. Securities and Exchange Commission, including under the heading “Risk Factors.”

All written and oral forward-looking statements attributable to us or persons acting on our behalf are expressly qualified in their entirety by theprevious statements. Except for any obligations to disclose information as required by applicable securities laws, Evogene disclaims any obligation orcommitment to update any information contained in this presentation or to publicly release the results of any revisions to any statements that maybe made to reflect future events or developments or changes in expectations, estimates, projections and assumptions.

The information contained herein does not constitute a prospectus or other offering document, nor does it constitute or form part of any invitationor offer to sell, or any solicitation of any invitation or offer to purchase or subscribe for, any securities of Evogene or any other entity, nor shall theinformation or any part of it or the fact of its distribution form the basis of, or be relied on in connection with, any action, contract, commitment orrelating thereto or to the securities of Evogene.

The trademarks included herein are the property of the owners thereof and are used for reference purposes only. Such use should not be construedas an endorsement of the products or services of Evogene.

Page 3: Microbiome driving crop productivity - Evogene · Ag Biologicals Market 38% 62% ~$3.2B* in 2015 Rapid growth sector * Source: Phillips McDougall , 2015 2015 2020 ~$8B ~$3.2B Source

AGENDA

‘Evogene Inside’ – introduction to Evogene

Evogene’s Ag-Biologicals Division

Summary

1

Page 4: Microbiome driving crop productivity - Evogene · Ag Biologicals Market 38% 62% ~$3.2B* in 2015 Rapid growth sector * Source: Phillips McDougall , 2015 2015 2020 ~$8B ~$3.2B Source

What We Do

2

We develop novel products for life-science markets…

…through the use of a unique computational predictive biology

platform

Page 5: Microbiome driving crop productivity - Evogene · Ag Biologicals Market 38% 62% ~$3.2B* in 2015 Rapid growth sector * Source: Phillips McDougall , 2015 2015 2020 ~$8B ~$3.2B Source

Evogene at a Glance

3

5

Computational Predictive Biology (CPB) Platform - applied to identify: Genetic elements for improved seeds Chemical compounds for innovative Ag-Chemicals Microbes for novel Ag-Biologicals

Strategic collaborations with world-leading agriculture companies -including BASF, DuPont, Monsanto, Syngenta, ICL

Revenue model - based on licensing agreements, which typically include three main revenue streams:

R&D payments - short term Milestone payments - mid term Royalties from product sales - longer term

Subsidiaries - Evofuel (100%) - Castor Seeds Biomica (90%) - Human Microbiome

Financial fundamentals - Cash position - $76 million (September 30th, 2017), no debt Listed on TASE (2007) and NASDAQ (2013)

Improved Seeds

InnovativeAg-Chemicals

NovelAg-Biologicals

Geneticelements

MicrobesChemical compounds

CPB

Page 6: Microbiome driving crop productivity - Evogene · Ag Biologicals Market 38% 62% ~$3.2B* in 2015 Rapid growth sector * Source: Phillips McDougall , 2015 2015 2020 ~$8B ~$3.2B Source

Computational Predictive Biology (CPB) Platform

Interconnected data hub

Science: unique multidisciplinary scientific

approach

Tailored big data

Analysis platforms using machine learning/AI to identify

candidates

Chemical discovery

Stack discovery

Target discovery

Gene discovery

Gene optimization

Toxin discovery

Microbial Discover/ Optimization

Driving Innovation ‘Connecting the Dots’

150K20K

150K15K

CPB

Page 7: Microbiome driving crop productivity - Evogene · Ag Biologicals Market 38% 62% ~$3.2B* in 2015 Rapid growth sector * Source: Phillips McDougall , 2015 2015 2020 ~$8B ~$3.2B Source

7

Predictive Analysis and Development System

Page 8: Microbiome driving crop productivity - Evogene · Ag Biologicals Market 38% 62% ~$3.2B* in 2015 Rapid growth sector * Source: Phillips McDougall , 2015 2015 2020 ~$8B ~$3.2B Source

Corporate Structure

6

Evogene

Ag Divisions

Seeds

Biologicals

Chemicals

Subsidiaries

Computational Predictive Platform

Biologicals

Page 9: Microbiome driving crop productivity - Evogene · Ag Biologicals Market 38% 62% ~$3.2B* in 2015 Rapid growth sector * Source: Phillips McDougall , 2015 2015 2020 ~$8B ~$3.2B Source

AGENDA

‘Evogene Inside’ – introduction to Evogene

Evogene’s Ag-Biologicals Division

Ag-Biologicals Market

Vision & Strategy

Technology

Pipeline & Collaborations

Summary

7

Page 10: Microbiome driving crop productivity - Evogene · Ag Biologicals Market 38% 62% ~$3.2B* in 2015 Rapid growth sector * Source: Phillips McDougall , 2015 2015 2020 ~$8B ~$3.2B Source

Industry Challenges & Opportunity

8

Green and Safe

• Awareness, regulations and practices

Need for innovation

• Increasing resistance • Regulation pressure • Decline in product introductions

Time To Market

• Shorter time and lower cost compared to alternatives –

Ag Chemicals

Ag Biologicals

Ag-Biologicals - a new pillar in agriculture productivity

FertilizersSeeds & Traits Ag-Chemicals Ag-Biologicals

~$40B ~$50B ~$100B

Page 11: Microbiome driving crop productivity - Evogene · Ag Biologicals Market 38% 62% ~$3.2B* in 2015 Rapid growth sector * Source: Phillips McDougall , 2015 2015 2020 ~$8B ~$3.2B Source

Ag-Biologicals

Products derived of natural sources

Bio-Pesticides

Support the plant by reducing pest damage to the plant

Plant Extracts Microbial Macrobials

Pest natural enemies

e.g. bacteria or fungi

Plant derivedchemistry

Ag-Biologicals Sources:

Bio-Stimulants

Mediating plants’ response to optimize yield potential

9

Page 12: Microbiome driving crop productivity - Evogene · Ag Biologicals Market 38% 62% ~$3.2B* in 2015 Rapid growth sector * Source: Phillips McDougall , 2015 2015 2020 ~$8B ~$3.2B Source

10

Ag Biologicals Market

38%62%

~$3.2B* in 2015 Rapid growth sector

* Source: Phillips McDougall , 2015

2015 2020

~$8B

~$3.2B

Source – 2022 estimation based on integrated information of BCC Research, marketsandmarkets, Agropages and Phillips McDougall

Bio-stimulants

Bio-pesticides2022 E

Fast growing sector with potential to complementAg-Inputs market

Page 13: Microbiome driving crop productivity - Evogene · Ag Biologicals Market 38% 62% ~$3.2B* in 2015 Rapid growth sector * Source: Phillips McDougall , 2015 2015 2020 ~$8B ~$3.2B Source

Industry Recognition of the Microbiome Opportunity

11

Major Ag companies – actively invest in order to build position

Emerging startups – significant investments in recent 2-3 years

Page 14: Microbiome driving crop productivity - Evogene · Ag Biologicals Market 38% 62% ~$3.2B* in 2015 Rapid growth sector * Source: Phillips McDougall , 2015 2015 2020 ~$8B ~$3.2B Source

The Microbiome OpportunityBillions of Microbes Matter!

12

Human microbiome understanding Leveraged to plant microbiome research

Microbiome is driving crop’s productivity

In and on the plant Below and above ground

Page 15: Microbiome driving crop productivity - Evogene · Ag Biologicals Market 38% 62% ~$3.2B* in 2015 Rapid growth sector * Source: Phillips McDougall , 2015 2015 2020 ~$8B ~$3.2B Source

The Microbiome OpportunityPotential Microbiome Derived Ag-Biological Products

15

Microbiome

Ag-Biological Products

Microbes ExtractsNatural

Molecules

Page 16: Microbiome driving crop productivity - Evogene · Ag Biologicals Market 38% 62% ~$3.2B* in 2015 Rapid growth sector * Source: Phillips McDougall , 2015 2015 2020 ~$8B ~$3.2B Source

AGENDA

‘Evogene Inside’ – introduction to Evogene

Evogene’s Ag-Biologicals Division

Ag-Biologicals Market

Vision & Strategy

Technology

Pipeline & Collaborations

Summary

13

Page 17: Microbiome driving crop productivity - Evogene · Ag Biologicals Market 38% 62% ~$3.2B* in 2015 Rapid growth sector * Source: Phillips McDougall , 2015 2015 2020 ~$8B ~$3.2B Source

Ag-Biologicals Division’s GoalIncreasing crop’s productivity through productive microbiome

14

To introduce environmentally safe and effective microbiome based

Ag-Biological products driving crop’s productivity

Addressing Key Challenges

Bio-Stimulants Bio-Pesticides

Short time to market

End to end capabilities for product development

Position on Value Chain

Partner

Addressing key challenges of :

efficacy, stability and commercial viability

Efficacy Stability Commercial

viability

Significant improvement / protection of

yield

Consistency across

germplasms / geographies

Shelf-lifeCOGS

Page 18: Microbiome driving crop productivity - Evogene · Ag Biologicals Market 38% 62% ~$3.2B* in 2015 Rapid growth sector * Source: Phillips McDougall , 2015 2015 2020 ~$8B ~$3.2B Source

Product OfferingEvogene’s Ag-Biologicals Product Strategy

18

Maintain a balance between Row and Specialty crops & market access• Establish Crop X Product focus to

support direct market accessSpeciality Row

Balance product programs to include both Bio-stimulants and Bio-pesticides• Leverage of existing assets• Aim to build a ‘plant health’

product concept

Bio

Sti

mu

lan

tsB

io P

est

icid

es

Pla

nt

Hea

lth

Cost effective application paths

Seed treatment

Seed treatment

Seed treatmentand other applications

Seed treatmentand other applications

Product focus • Leverage existing programs to

address new product types• Option to address all activity space

area through funded collaborations

Enabling technology to drive product stability and performance

Page 19: Microbiome driving crop productivity - Evogene · Ag Biologicals Market 38% 62% ~$3.2B* in 2015 Rapid growth sector * Source: Phillips McDougall , 2015 2015 2020 ~$8B ~$3.2B Source

16

Model A

Model B

Model A – Indirect Market Access

• Focus mainly on row crops

• Go-to-market based on partners channel

Model B – Direct Market Access

• Focus mainly on high value specialty

crops

• Commercialization through distributors

/ strategic licensing agreements

Partner

Distributor

Position on Value Chain

Page 20: Microbiome driving crop productivity - Evogene · Ag Biologicals Market 38% 62% ~$3.2B* in 2015 Rapid growth sector * Source: Phillips McDougall , 2015 2015 2020 ~$8B ~$3.2B Source

AGENDA

‘Evogene Inside’ – introduction to Evogene

Evogene’s Ag-Biologicals Division

Ag-Biologicals Market

Vision & Strategy

Technology

Pipeline & Collaborations

Summary

17

Page 21: Microbiome driving crop productivity - Evogene · Ag Biologicals Market 38% 62% ~$3.2B* in 2015 Rapid growth sector * Source: Phillips McDougall , 2015 2015 2020 ~$8B ~$3.2B Source

18

Approach

Decoding complex plant - pest - microbiome interaction for the identification of genetic elements with desired features for the development of microbial

based products

Plant

Pest

Microbiome

COGS

Page 22: Microbiome driving crop productivity - Evogene · Ag Biologicals Market 38% 62% ~$3.2B* in 2015 Rapid growth sector * Source: Phillips McDougall , 2015 2015 2020 ~$8B ~$3.2B Source

Technology – Computational Predictive Biology Platform

22

Utilizing a proprietary Computational Predictive Biology (CPB) Platform harnessing the power of plant’s, pest’s & microbiome OMIC BIG DATA through

advanced informatics

Novel Ag-BiologicalsProducts

- Interconnected - 5 Petabytes- 10’s OMIC data

types - K’s proprietary

experiments: Lab>>GH>>Field

- Lab>> GH>> Field- Y&ABST, Fungi, Insects- Advanced phonemics

- Analysis & machine learning modules for product research and development

- Proprietary sets of genetic elements and functions

Page 23: Microbiome driving crop productivity - Evogene · Ag Biologicals Market 38% 62% ~$3.2B* in 2015 Rapid growth sector * Source: Phillips McDougall , 2015 2015 2020 ~$8B ~$3.2B Source

Technology – Computational Predictive Biology Platform

19

Utilizing a proprietary Computational Predictive Biology (CPB) Platform harnessing the power of genotypic & phenotypic BIG DATA through advanced

informatics

Novel Ag-BiologicalsProducts

Page 24: Microbiome driving crop productivity - Evogene · Ag Biologicals Market 38% 62% ~$3.2B* in 2015 Rapid growth sector * Source: Phillips McDougall , 2015 2015 2020 ~$8B ~$3.2B Source

CPB Platform to Support Product Development

Novel Ag-Biologicals

Products

Strains & functions discovery

OptimizationAdvanced

formulation & fermentation

Utilizing a proprietary Computational Predictive Biology (CPB) platform harnessing the power of genotypic & phenotypic BIG DATA through advanced

informatics

20

Page 25: Microbiome driving crop productivity - Evogene · Ag Biologicals Market 38% 62% ~$3.2B* in 2015 Rapid growth sector * Source: Phillips McDougall , 2015 2015 2020 ~$8B ~$3.2B Source

AGENDA

‘Evogene Inside’ – introduction to Evogene

Evogene’s Ag-Biologicals Division

Ag-Biologicals Market

Vision & Strategy

Technology

Pipeline & Collaborations

Summary

21

Page 26: Microbiome driving crop productivity - Evogene · Ag Biologicals Market 38% 62% ~$3.2B* in 2015 Rapid growth sector * Source: Phillips McDougall , 2015 2015 2020 ~$8B ~$3.2B Source

Ag – Biological Product PortfolioPipeline

22

Bio

-Sti

mu

lan

ts

1 Corn

2 Wheat

Bio

-In

sect

icid

es

3 Corn Root Worm

4 Stink-Bug - soy

5 Lepidoptera -specialty

Bio

-Fu

ngi

cid

es

6 Fusarium bio-fungicide -

Corn

7 Mildews Bio-Fungicide -

grapes

Page 27: Microbiome driving crop productivity - Evogene · Ag Biologicals Market 38% 62% ~$3.2B* in 2015 Rapid growth sector * Source: Phillips McDougall , 2015 2015 2020 ~$8B ~$3.2B Source

ResultsBio-Stimulants examples

23

None - inoculated EVO004

Stem below ear R2 Stem below ear R2

Ear R3 Ear R3

14 1 16 1

10% Yield improvement in field trials (2016, 2017)

Under moderate drought

Page 28: Microbiome driving crop productivity - Evogene · Ag Biologicals Market 38% 62% ~$3.2B* in 2015 Rapid growth sector * Source: Phillips McDougall , 2015 2015 2020 ~$8B ~$3.2B Source

ResultsBio-Stimulants examples

24

18% yield increase in field (2017)

EVO33394+EVO33393

13% yield increase in field (2017)

EVO33394+EVO33402

Under moderate drought Under moderate drought

Page 29: Microbiome driving crop productivity - Evogene · Ag Biologicals Market 38% 62% ~$3.2B* in 2015 Rapid growth sector * Source: Phillips McDougall , 2015 2015 2020 ~$8B ~$3.2B Source

DuPont-Pioneer - Evogene Collaboration

25

Page 30: Microbiome driving crop productivity - Evogene · Ag Biologicals Market 38% 62% ~$3.2B* in 2015 Rapid growth sector * Source: Phillips McDougall , 2015 2015 2020 ~$8B ~$3.2B Source

26

Results Bio-Insecticides examples (initial Lab, Greenhouse)

EVO30013

BL

Fall Army WarmLeaf disk assay results

Western corn root worm~85% increase in leaf area

~60% reduction in insect survival

Page 31: Microbiome driving crop productivity - Evogene · Ag Biologicals Market 38% 62% ~$3.2B* in 2015 Rapid growth sector * Source: Phillips McDougall , 2015 2015 2020 ~$8B ~$3.2B Source

27

ResultsBio-Fungicides examples (Greenhouse)

EVO4918 Mock

Fusarium in corn - ~70% reduction in disease severity

Page 32: Microbiome driving crop productivity - Evogene · Ag Biologicals Market 38% 62% ~$3.2B* in 2015 Rapid growth sector * Source: Phillips McDougall , 2015 2015 2020 ~$8B ~$3.2B Source

AGENDA

‘Evogene Inside’ – introduction to Evogene

Evogene’s Ag-Biologicals Division

Summary

28

Page 33: Microbiome driving crop productivity - Evogene · Ag Biologicals Market 38% 62% ~$3.2B* in 2015 Rapid growth sector * Source: Phillips McDougall , 2015 2015 2020 ~$8B ~$3.2B Source

Value Creation Roadmap

29

Val

ue

(illu

stra

tio

n)

• Phase advancement Bio-Stimulants & Pesticides

• New collaboration

• Additional strategic collaboration

• Patent grant - strains• New product program

• Early commercialization of Technology

• Milestone payment • Patent grant - technology

• Initial revenue from first product

• Expansion into new territories and product types

2018 2019 2020 2021

Page 34: Microbiome driving crop productivity - Evogene · Ag Biologicals Market 38% 62% ~$3.2B* in 2015 Rapid growth sector * Source: Phillips McDougall , 2015 2015 2020 ~$8B ~$3.2B Source

Summary

5

2

3

4

Initiated in 2015, Evogene already generated valuable product pipelines for bio-stimulants & bio-

pesticides is in place – potential 1st product launch in 2021

1 Ag–Biologicals - fastest growing sector in Agriculture inputs, expected to reach $8B in 2022

Evogene’s Computational Predictive Biology platform (CPB), combining biological understanding and

cutting-edge computational technology is key for next generation product development

Microbiome is a promising opportunity to drive Ag-Biologicals market’s expansion

Ag-Biologicals time to market is relatively short due to favorable regulatory landscape

30

Page 35: Microbiome driving crop productivity - Evogene · Ag Biologicals Market 38% 62% ~$3.2B* in 2015 Rapid growth sector * Source: Phillips McDougall , 2015 2015 2020 ~$8B ~$3.2B Source

Evogene’s Ag-Biologicals DivisionMicrobiome driving crop productivityIntroduction

Ido Dor, EVP & GM, Ag-Biologicals Jan 2018

Confidential


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