modeling and simulation for biomedical device … and simulation for biomedical device design...
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Life Sciences Applications: Modeling and Simulation for Biomedical Device Design
SGC 2013
• Biomedical device design and the regulatory agencies
• Modeling capabilities for the design of various devices • Respiratory • Medical equipment • Cardiovascular
• Fluid Structure Interaction (FSI): implicit coupling of STAR-CCM+
and Abaqus
Modeling and Simulation for Biomedical Device Design
Medical Device Application Range
Macro Devices – Stents – Pumps – Heartvalves – Artificial Organs – Catheters – Pacemakers – Respiratory Aids
Micro Devices – Lab on a Chip – Implanted sensors – Implanted drug delivery
Diagnostics – MRI/CT Scanners – Ultrasound
Life Support – Lung/Heart Machine – Dialysis
Monitors – Blood Pressure – ECG, EEG, dissolved gases
Therapeutic – Lasers – Infusion Pumps
forming a V&V committee that is application-specific to the medical device industry
Some Example Cases: – FDA CPI I – Nozzle – Hemolysis Modeling – Drug delivery to the eye, by intravitreal injection – Oscillatory Pipe Flow – Flow in a Flexible Pipe – CFD Challenge – Aneurysms – Porous media modeling (Fiber bundles) – Oxygenator – Particle tracking etc. etc…..
ASME V&V 40 Committee
Inhaler Modeling at ARUP
STAR-CCM+ at VIASYS (Carefusion) Healthcare
Mouth Cavity – Inhalation Model
Mouth Cavity
Simpleware lung demo case
Simpleware was used to obtain the complex geometry from MRI of the human body
Microfluidics
8
Formation of droplet in flow-focusing geometry
Heat Transfer, Electronics Cooling & Noise Modelling
Ventilation flow and convective cooling as required for MRI/CT scanners, ICU devices
• Surface wrapping utilized to automatically prepare surface • Volumetric heat sources • Multiple fan models with fan curves
Workflow: Meshing of Patient Specific Data
Surface Wrapping, STL Cleanup & Polyhedral Meshing Rapid Turnaround of Complex Geometry
Dissected Aorta Polyhedral Mesh, Geometry Provided by the Methodist DeBakey Heart and Vascular Center, Houston (Dr. Christof Karmonik, Dr. Mark
Davies, Dr. Alan Lumsden, Dr. Jean Bismuth)
AAA (Abdominal Aortic Aneurysm) Geometry Provided by Computational Clinical
Modeling, New Jersey (Chris Ebeling)
Cardiovascular flow wave form from applied at the inlet
Material properties of blood (Newtonian Approximation) » Density = 1056 kg m-3 » Dynamic Viscosity = 0.0035 Pas
Windkessel parameters to define the outlet condition: » Z = 1.1x107 [kg m-4 s-1] » R = 1.45x108 [kg m-4 s-1] » C = 1.45x10-8 [m4 s2 kg-1]
Laminar flow model • Implicit Unsteady model (dt = 0.001 s) • Coupled implicit solver
Simulation was run for a number of cycles to ensure a period response was achieved.
Model setup
Z2
R2
C2
Z3
R3 C
3
Z1
R1
C1
Z4
R4
C4
Analytical solution [2] • Maximum outlet pressure = 93mmHg.
Numerical solution • Maximum outlet pressure = 92.2 mmHg
Preliminary Results
Analytical Solution
[2] Brown A. G., Patient-Specific Local and Systemic Haemodynamics in the Presence of a Left Ventricular Assist Device, 2012. PhD Thesis, The University of Sheffield.
Fluid Structure Interaction
• Driven by highly compliant vessels and membranes, structurally impacted by mechanical devices.
• STAR-CCM+ couples directly to Abaqus (Simulia) through a co-simulation API fully coupled, implicit, two-way FSI
Examples include: Blood Pumps (LVADs), Vena Cava Filter, Stents, Graft Bypass, Diagnostics for Arterial Flows or Lung Models etc. etc.
Counter Intuitive: Pulse through an Extremely Flexible Tube
• Pressure pulse in fluid travels only at a speed of near 50 m/s when bulk modulus of the solid is 0.1GPa.
• For completely rigid pipe: pulse would
travel at sound speed of the fluid (1500 m/s).
• Kinetic energy is primarily being converted into radial strain energy in the solid when it travels there is nothing left to push the pulse down the pipe.
• The step size is chosen so that for the expect wave speed, the wave travels one cell down the axis. So the smaller the modulus, the smaller the wave speed, the larger the time step yet still accurate and stable!!
Damon Afkari, Universidad Politécnica de Madrid
FSI Simulation of Pulsatile Blood Flow in Aortic Arch: Coupling Abaqus and STAR-CCM+
Universidad Politécnica de Madrid, Damon Afkari: PhD Student Developed Proprietary Explicit Coupling Methodology • Now Implicit Coupling with
Abaqus • Focus on Fast Turn Around to Aid
Surgeon Decision Making
Aortic Dissection
CAD
FSI for Heart Valve Biomechanics (University of Connecticut, Prof. Wei Sun, Dr. Eric Sirois)
CFD Meshing & Morphing • Polyhedral mesh
– 0.43 mm base size
• Leaflet motion -> Star-CCM+ morphing
– Separate motion for each leaflet – Interpolated and mapped
• Arbitrary Lagrangian-Eulerian (ALE) mesh morphing
• Automated re-meshing for low quality or zero-volume cells
– “Minimum points in a gap” of 4 nodes used to control proximity
– Mesh varied from ~700k to 1.8M
Valve Leaflet
Cross-section of CFD model showing polyhedral
mesh.
FEA 1st Run
Experiment
CFD 1st Run
Leaflet Motion
FEA 2nd Run
CFD 2nd Run
Leaflet Motion
Leaflet Motion Comparison
Hemodynamics Comparison
Far-Field Pressure
CFD Velocity Magnitude and WSS Side view Top view
Bottom view
WSS
Heart Valve FSI: Edwards LifeSciences
Biomedical FSI Applications • Stent Implants: AAA, Coronary,
Carotid Arteries etc. • Vena Cava Filters • Heart Valves • Graft Bypass • Aneurysm Diagnostics Models • Respiratory/Lung Models
FSI & Overset Meshes