molecules involved in t cell activation
DESCRIPTION
Ce ll-mediated im mune response Activation of T lymphocytes by intracellular microorganisms Phases of T cell response Biochemical pathways of T cell activation Functional responses of T lymphocytes to antigens and costimulation. Molecules involved in T cell activation. TCR. TCR complex. - PowerPoint PPT PresentationTRANSCRIPT
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Cell-mediated immune response
Activation of T lymphocytes by intracellular microorganisms
Phases of T cell responseBiochemical pathways of T cell activation
Functional responses of T lymphocytes to antigens and costimulation
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TCR
TCR complex
Molecules involved in T cell activation
Costimulators
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Requirement for two signals in T cell activation
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Molecules involved in T cell activation
Adhesion molecule
Coreceptor
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Molecules involved in T cell activation
Accessory molecules
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Molecules involved in T cell activation
Immunological synapse
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Biochemical pathways ofT cell activation
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Clustering of two or more
TCRs
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Functional responses of T lymphocytes to antigens
and costimulation
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Clonal expansion of T-limphocytes
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Treg
Naivna CD4+TNaïveCD4+T
Th1
Th2
TGF-
TGF-+IL-6
IL-4
IL-12+IL-18
IFN-
IL-23…Th17
Diferentiation od CD4+ T-limphocytes
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Th17
Th1
Treg
Naivna CD4+T
Th2
TGF-
TGF-+IL-6
IL-4
IL-12+IL-18
IL-23…
T-bet
GATA-3
RORt
FoxP3
IFN-
Th17
Diferentiation od CD4+ T-limphocytes
NaïveCD4+T
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Diferentiation of naive
CD4+ T-cells
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Diferentiation od CD8+ T-limphocytes
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CD3 complex and chainsj.Main transcription factors in T cell activation are10.
T cell is not activatedi.Cytokine that is crucial for TH1 differentiation is9.
IL-12h.Activation of naive T-cells requires8.
CD3, CD4, CD8, CD28 and adhesion molecules
g.Adhesion molecules7.
CD28 and B7 moleculesf.If APC does not express costimulatory molecules
6.
NFAT, NF-B and AP1e.
T cell growth factor is 5.
two signalsd.
Costimulatory signals for T cell activation are provided by
4.
and chains of TCRc.
Accesory molecules involved in T cell activation are
3.
stabilize binding of T-cells to APC
b.
Signal transduction in T cells is mediated by2.
IL-2a.Recognition of antigen by T cells is mediated by1.
10.____9.____8.____7.____6.____5.____4.____3.____2.____1.____c j g f a i b d h e