motor proteins. one-state model with unequal forward and backward rates

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Motor Proteins

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Page 1: Motor Proteins. One-state model with unequal forward and backward rates

Motor Proteins

Page 2: Motor Proteins. One-state model with unequal forward and backward rates
Page 3: Motor Proteins. One-state model with unequal forward and backward rates
Page 4: Motor Proteins. One-state model with unequal forward and backward rates
Page 5: Motor Proteins. One-state model with unequal forward and backward rates
Page 6: Motor Proteins. One-state model with unequal forward and backward rates
Page 7: Motor Proteins. One-state model with unequal forward and backward rates
Page 8: Motor Proteins. One-state model with unequal forward and backward rates
Page 9: Motor Proteins. One-state model with unequal forward and backward rates

One-state model with unequal forward and backward rates

Page 10: Motor Proteins. One-state model with unequal forward and backward rates

Dwell time distribution for myosin V

Page 11: Motor Proteins. One-state model with unequal forward and backward rates

Expected velocity as function of force in one-state model.Comparison to myosin V experiment.

if pulling back makes forward rate go down

if pulling back makes backward rate go up

Page 12: Motor Proteins. One-state model with unequal forward and backward rates

Pushing by polymerization

Page 13: Motor Proteins. One-state model with unequal forward and backward rates

Listeria move inside a cell by inducing polymerization of actin

Page 14: Motor Proteins. One-state model with unequal forward and backward rates
Page 15: Motor Proteins. One-state model with unequal forward and backward rates
Page 16: Motor Proteins. One-state model with unequal forward and backward rates

Interpretation as a sloping potential

Page 17: Motor Proteins. One-state model with unequal forward and backward rates

Model with 2 states at each site.

Page 18: Motor Proteins. One-state model with unequal forward and backward rates

Velocity of kinesin as a function of ATP conc and load

Page 19: Motor Proteins. One-state model with unequal forward and backward rates

In two-state model dwell time distribution is not exponential

BA ttt )/exp(1

)( AAA

AA ttp

)/exp(1

)( BBB

BB ttp

)/exp()/exp(1

)()()(0

ABAB

t

ABAAA ttttptpdttp

measured for myosin V

Page 20: Motor Proteins. One-state model with unequal forward and backward rates
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Wave motions in a swimming sperm cell.

Strokes in cilia on epithelial cells