Partners in movement

CerebellumBasal Ganglia

Movement part 2

Cerebellum and Brainstem

KW p. 363

Cerebellum

KW 10-20

Inputs: proprioceptors and balance sense

Outputs: motor pathways

Cerebellum

Functionshabit formationtimingattentioncoordination of movements

Prism Vision and the cerebellum 1

KW 10-21

Prism Vision and the

cerebellum 2

KW 10-21

Feedback to Cerebellum

KW 10-22

Inferior olive is area in brain stem opposite cerebellum

Basal Ganglia

KW 10-18

Pathways to Basal Ganglia

KW 10-19Basal Ganglia

Connections from the substantia nigra: (a) normal and (b) in Parkinson’s disease

Excitatory paths are shown in green; inhibitory are in red.

People with Parkinson’s disease show decreased initiation of movement, slow and inaccurate movement, and psychological depression.

Parkinson’s Disease

Symptoms-rigidity, muscle tremors, slow movement, difficulty initiating movement

Brain Changes-Selective loss of cells in substantia nigra and amygdala/decrease in dopamine

Possible Causesgeneticsexposure to toxins (MPTP)

Parkinson’s Disease

L-Dopa Treatmentprecursor for dopaminedemonstrates individual effectivenessdoes not stop progression of the diseasenumerous side effects (nausea, restlessness, sleep problems, low

blood pressure, hallucinations, and delusions)Therapies Other Than L-Dopa

Pallidotomy Cell transplantsDeep brain stimulation

Connections from the substantia nigra: (a) normal and (b) in Parkinson’s disease

Excitatory paths are shown in green; inhibitory are in red.

People with Parkinson’s disease show decreased initiation of movement, slow and inaccurate movement, and psychological depression.

Pathways to Basal Ganglia

KW 10-19Basal Ganglia