MRS MRS Entrepreneurship Entrepreneurship

Challenge: Lab-on-Challenge: Lab-on-chip Sensor chip Sensor TechnologyTechnologyPresented on December 6, Presented on December 6,

2005 2005

Team BackgroundTeam Background Rachel Weaver, BME, MT Rachel Weaver, BME, MT Ryan Dempsey, BME, MTRyan Dempsey, BME, MT Charles Bloom, BME, MTCharles Bloom, BME, MT John Richardson, BME, EconomicsJohn Richardson, BME, Economics

Experienced in BioMEMsExperienced in BioMEMs Peter Shanahan, BME, MathematicsPeter Shanahan, BME, Mathematics

Experienced in BioMEMsExperienced in BioMEMs

Entrepreneurship Entrepreneurship ChallengeChallenge

Scientists and business students will form Scientists and business students will form “virtual teams” to develop a 12-slide PowerPoint “virtual teams” to develop a 12-slide PowerPoint presentation presentation

Present startup technology to a panel of venture Present startup technology to a panel of venture capitalist judges at 2006 MRS spring meetingcapitalist judges at 2006 MRS spring meeting

The grand prize is $3,000 The grand prize is $3,000 See  See  http://http://www.mrs.org/entrepreneur/index.htmlwww.mrs.org/entrepreneur/index.html

for more informationfor more information

BioMEMs TechnologyBioMEMs Technology BioMEMs: Biological micro-BioMEMs: Biological micro-

electromechanical systemselectromechanical systems Uses photolithography and soft-Uses photolithography and soft-

lithographylithography Miniaturized device potentialMiniaturized device potential

Single cell reactionsSingle cell reactions Multiple experiments per chipMultiple experiments per chip In vitro apparatus simulates in vivo In vitro apparatus simulates in vivo

cellular environmentcellular environment

Clark Oxygen SensorClark Oxygen Sensor anode & anode &

cathode cathode submersed in submersed in an electrolytic an electrolytic fluid fluid

Linear Linear relationship relationship between [Obetween [O22] ] and current and current producedproduced

Market potentialMarket potential Biological Biological

applicationsapplications Cell culturesCell cultures

Chemical Chemical applicationsapplications Chemical reaction Chemical reaction

costcost Pharmaceutical Pharmaceutical

usesuses Drug efficacyDrug efficacy

Project CostProject Cost 2” by 2” mask will cost roughly $600 2” by 2” mask will cost roughly $600

We will only use a fraction of the maskWe will only use a fraction of the mask Each design iteration will run Each design iteration will run

between $50 and $100 between $50 and $100 ~4-6 design iterations depending on ~4-6 design iterations depending on

timetime Includes 35 mm film costsIncludes 35 mm film costs

<$100 on office supplies, paper, etc. <$100 on office supplies, paper, etc.

TimelineTimeline

IWB Problem Formulation IWB Problem Formulation and Brainstorming Chartand Brainstorming Chart

ReferencesReferences Fabrication of miniature Clark oxygen sensor Fabrication of miniature Clark oxygen sensor

integrated with microstructureintegrated with microstructure Ching-Chou Wu, Tomoyuki Yasukawa, Hitoshi Shiku, Ching-Chou Wu, Tomoyuki Yasukawa, Hitoshi Shiku,

Tomokazu MatsueTomokazu Matsue http://www.bme.vanderbilt.edu/srdesign/2005/group25/http://www.bme.vanderbilt.edu/srdesign/2005/group25/

272_sdarticle.pdf272_sdarticle.pdf A BioMEMS Review: MEMS Technology for A BioMEMS Review: MEMS Technology for

Physiologically Integrated DevicesPhysiologically Integrated Devices AMY C. RICHARDS GRAYSON, REBECCA S. SHAWGO, AMY C. RICHARDS GRAYSON, REBECCA S. SHAWGO,

AUDREY M. JOHNSON, NOLAN T. FLYNN, YAWEN LI, AUDREY M. JOHNSON, NOLAN T. FLYNN, YAWEN LI, MICHAEL J. CIMA, AND ROBERT LANGERMICHAEL J. CIMA, AND ROBERT LANGER

http://www.bme.vanderbilt.edu/srdesign/2005/group25/http://www.bme.vanderbilt.edu/srdesign/2005/group25/BioMEMS_review.pdfBioMEMS_review.pdf