n e u r o a n a l y s i s neuroanalysis.org.il. doctor, i am depressed, and sad. what do i have,...
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N E U R O A N A L Y S I S neuroanalysis.org.il
Doctor, I am depressed, and sad. What do I have, doctor?Please tell me.
You have depression.
Doctor, my stomach hurts. What do I have, doctor ?Please tell me.
You have gastritis.
Doctor, I am depressed, and sad. What do I have, doctor?Please tell me.
You have depression.
Doctor, my stomach hurts. What do I have, doctor?Please tell me
Doctor, I am depressed, and sad. What do I have, doctor ?Please tell me.
You have depression. ?
?
?
Place in the body
What happened to it?It is infected
How to treat itAntibiotics
You have gastritis.
“ .…
we are at the epicycle stage of psychiatry
where astronomy was before Copernicus
and biology before Darwin
.…”
Allen Frances
Neuroscience
NeuroAnalysis Rational
Neuroscience Phenomenology
NeuroAnalysis Rational
Neuroscience Phenomenology
Enormous gapThe clinician sees a patient
not neuronal networks or neurotransmitters
NeuroAnalysis Rational
Neuroscience Phenomenology
Enormous gapThe clinician sees a patient
not neuronal networks or neurotransmitters
NeuroAnalysis Rational
Why we failed ?
Neuroscience Phenomenology
NeuroAnalysis Rational
Why we failed ? NeuroAnalysis Rational
Where did we fail?
Ignoring complexity
NeuroAnalysis Rational
Proposed RDoCNeuroAnalysis Rational
Clinical Brain ProfilingCBP
NeuroAnalysis Rational
Clinical Brain ProfilingCBP
Explanatory power
NeuroAnalysis Rational
Clinical Brain ProfilingCBP
For example DISC1
NeuroAnalysis Rational
Clinical Brain ProfilingCBP
Future intervention power cureOptogenetics
NeuroAnalysis Rational
Clinical Brain ProfilingCBP
Translation matrix
NeuroAnalysis Rational
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
NeuroAnalysis Rational
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
NeuroAnalysis Rational
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Psychosis Disconnection
Syndrome
NeuroAnalysis Rational
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
NeuroAnalysis Rational
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
NeuroAnalysis Rational
Neuroscience Phenomenology Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Based on Literature Publications
Based on Neural
network simulations
Based on 20 years of
theoretical work
NeuroAnalysis Rational
Sign 1Sign 2Sign 3Sign 4Sign 5Sign 6Sign N
Symptom 1Symptom 2Symptom 3Symptom 4Symptom 5Symptom N
Cs Disconnection
Ci Over connection
De-optimization
Hyper-optimization
Constrain frustration
Disturbed DMN
Clinical Brain Profiling
CBP
Predicted disturbance
CF(b) = 2
DMN =5
Cs =10
Ci =3
Hbu =7
Htd =1
D = 13
O =0
CF =5
NeuroAnalysis Rational
NeuroAnalysis Validation
Clinical phenomena
Network disturbances How to detect, diagnose & monitor
Personality disorders
Disturbances to development of default mode network
Age-related changes resting-state functional connectivity MRI (rs-fcMRI) (Van Dijk KR et al 2010) Age related Matching complexity, Free energy estimations, Entropy measurements integrated information theory
Mood & AnxietyDisturbances to Optimization dynamics
Short-term over time Dynamics of Matching complexity, Free energy estimations, Entropy measurements integrated information theory
Schizophrenia delusions and abolition
Hierarchal (top-down bottom-up) disorders
Small world network analysis for hub composition, Estimating hierarchy, k-shell decomposition percolation theory and fractal geometry
Schizophrenia Disorganization deficiency
Connectivity imbalancesDisconnection over-connection
Correlations, Synchrony, Granger causality, Mutual information, Dimension estimation, Bayesian statistics Dynamic Causal Modeling, Independent components analysis Neural complexity (Correlation matrix), overall Small world network analysis
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Cardiac Insufficiency
Brain Insufficiency
Diagnose
Diagnose
Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Phenomenology
Brain disturbance
Brain Insufficiency
Cardiac Insufficiency
Diagnose Algorithm of Disturbance
Correct with Pacemaker
Algorithm of Disturbance
Correct with Brain Pacemaker
Clinical Brain Profiling
CBP
N E U R O A N A L Y S I S neuroanalysis.org.il
N E U R O A N A L Y S I S neuroanalysis.org.il