Nanotechnology in Drug

Development

Submitted by

Sukanta DasMsc. 1st sem.

Introduction

Nanotechnology can be define in a variety

of ways, but the one common component is

technology that deals with materials smaller than

100 nanometers.

One definition states that nanotechnology

is the art and science of manupulating matter at

the nanoscale to create new and unique materials

and products. How small is nanometer? Really,

really small too small to see even with light

microscope.

Nanotechnology

• Nanotechnology breakthrough research in

Pharmaceutical & Biopharmaceutical Industry.

• Nanotechnology, is a field of science and

technology. The aim of nanotechnology is to

control matter at the atomic and molecular

level.

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Use of NanotechnologyNanotechnology has produced a variety

of nonmaterial's, including nano composites

use in building materials, naocrystals used in

solar panels at semiconductors. Nanoparticals

are used in stain-repellent clothing and

sunscreens, nanocatalysis in drug

development.

Nanotechnology will provide the next

new wave of products, with promises of food

that can adjust its colour, flavour and nutrient

content.

Drug Discovery and Development

• Validate specific targets

• Discover the right molecule (potential drug) to

interact with the target chosen

• Test the new compound in the lab and clinic for

safety and efficacy and

• Gain approval and get the new drug into the hand of

doctors and patients.5

Drug Discovery and Development

• Success requires immense resources

The best scientist minds, highly sophisticated

technology and complex project management.

It is also takes persistence and sometimes luck.

Ultimately the process of drug discovery brings hope

and relief to millions of patients

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Drug Development and Delivery

• The multi-disciplinary field of nanotechnology

is making small device, closer and closer to

reality.

• Manipulate and organize matter on the nano-

scale.

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Drug Development and Delivery

• Drug filled nano-capsules, release their

biological compounds on contact with cancers

only.

• Nanotechnology will be applied at all stages of

drug development, from formulations for

optimal delivery to diagnostic applications in

clinical trials.

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Successful Therapy Combines

Drug Discovery and Delivery

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Nanotech Components

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Nanotechnology Collaboration

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Targeted Drug Delivery

Drug Delivery Carriers

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Drug Delivery

System

Liposome's

Niosomes

Ethosomes

Aquasome

TransfersomesDendrimers

Polymeric Nanoparticles

Bilosomes

Carbon Nanotube

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Carbon Nanotube

Carbon nanotubes are adept at entering the nuclei of cells and may one day be used to deliver drugs and vaccines.

The modified nanotubes have so far only been used to ferry a small peptide into the nuclei of fibroblast cells.

Polymeric Nanoparticles

In recent years, biodegradable

polymeric nanoparticles have

attracted considerable attention as

potential drug delivery devices in

view of their applications in drug

targeting to particular organs/tissues,

as carriers of DNA in gene therapy,

and in their ability to deliver

proteins, peptides and genes.

Research Priorities

SOME SIGNIFICANT ACHIEVEMENTS OF NANODEVICES

Development of one dose a day ciprofloxacin using nanotechnology

Tumor targeted taxol delivery using nanoparticles in Phase 2 clinical trial stage

Improved ophthalmic delivery formulation using smart hydrogel nanoparticles

Oral insulin formulation using nanoparticles carriers.

Liposomal based Amphotericin B formulation

Drug Delivery Technology Important to Pharma Industry

Drug delivery formulations involve low costresearch compared that for discovery of new molecule,

Minimizing the drug use would significantly reducethe effective cost of drug which would give financialrelief to the patients.

ConclusionThe use of nanotechnology in medicine in

general and drug delivery in particular is spreading rapidly. For quite some time past nanoparticles are being use in pharmaceutical industry to reduce toxicity and side effects of drugs. However it is also realized now that these drug carriers systems may appears to be risky to patient. Therefore further research is necessary. More over in feature collaborative programs are to launched as nanotechnology study is very costly which requires very qualified and trained scientist and modern instruments.

THANKING YOU

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