nat. prod. rjg allstaff 01.10.2012
TRANSCRIPT
Opportunities and challenges in an expanding industry
What are “Natural Products”? “Substances produced by
organisms found in nature”
Diverse sources, structures, and activities
Most of economic interest
are bioactive
Diverse Sources and Activities Bioactive Natural products
found in all Kingdoms Animals Insects Microbes
Bacteria Fungi Yeast Algae Cyanobacteria
Plants
Botanicals Remains primary source of
Natural Product discovery Traditional and modern source of medicines
Huge biological diversity Highly efficient producers
Opportunities New drug discovery “Lead Principles” found through bio-prospecting
Extracted Synthesized Analogs Derivatives
Marketed as pharmaceuticals
Drug Discovery Amrubicin Anidulafungin Apomorphine Artemotil Aztreonam Biapenem Blaxin Bivalirudin Bleomycin Calcineurin Capsaicin Captopril Caspofungin
Cefditoren Cilazapril Codinaeopsin Colchicine Cyclosporine Daptomycin Dimethyltryptamine Docetaxel Doripenem Dronabinol Erythomycin Ergotamine Ertapenem Everolimus Exenatide
Fumagillin Galantamine Ixabepilone Lisdexamfetamine Mescaline Methylnaltrexone Micafungin Miglustat Morphine Mycophenolate Nitisinone Orlistat Paclitaxel Penicillin Phenethylamine Pimecrolimus
Retapamulin Rifamycin Romidepsin Rosuvastatin Spiruchostatins Telavancin Telithromycin Temsirolimus Tetracycline Tigecycline Tiotropium Trabectedin Ziconotide Zithromax Zotarolimus
Agriculture
Bio-pesticides Herbicides Insecticides Fungicides Bactericides
Fertilizers
Opportunities
Opportunities
Food Science Flavoring agents
Preservatives
Binding agents
Nutraceuticals
Opportunities
Bio-Energy Biofuels
Bio-alcohols Bio-diesels Algal Hydrocarbons Bio-gasses
Opportunities Industry
Catalysts Bio-plastics Cryo-protectants Pigments
The Natural Products Lab Specialize in
Botanicals Focus on dietary supplements
Analysis for GMP labeling Quality assurance New product development Research
Other botanical commodities
Hops Other food products Oils
Challenges Providing meaningful data
Client-driven method development Diverse sample matrices Little available literature
Business vs. Science oriented
clients
Offering context without conclusions
287.956 µg/ml
97.54 mgVCE/g
7.59% w/w α-acids
Challenges Managing Client
Expectations “CSI” Effect “Test This” Is it Good? Synergistic effects
“Out of the box” clientele
Challenges
Overcoming stereotypes
Establishing and maintaining credibility
KEEPING UP!
The Good News
Never a dull moment Positive impact for a growing industry in NC One foot in the past… One foot in the future
Thank you for your Time. I’ll try to answer any questions I can.