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NEUROENDOCRINOLOGYNEUROENDOCRINOLOGY

IN REPRODUCTIONIN REPRODUCTION

Dr. Nusratuddin A, SpOG

DIVISI FERTILITAS

ENDOCRINOLOGI REPRODUKSI

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NEUROENDOCRINOLOGY INNEUROENDOCRINOLOGY IN

REPRODUCTIONREPRODUCTION

CELL-CELL COMMUNICATION:

Endocrine system : hormone

Nervous sytem : neurotransmitter 

Neuroendocrinology

neuroendokrin

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CHEICAL NATURE OF HORONECHEICAL NATURE OF HORONE 

 AMINE

Eine!rin" Noreine!rin" T#" dan T$

PROTEIN AND POLIPEPTIDE

%&'" L'" 'C(" T&'" ACT'" )rolactin

STEROID

Estrogen" )rogesterone" Testosterone"

cortisol

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FUNCTION OF

HORONES

 REPRODUCTION GROWTH AND

 DEVELOPMENT 

 MAINTENANCE

OF INTERNAL

 ENVIRONMENT 

 ENERGY

 PRODUCTION,

 STORAGE, AND

UTILAZATION 

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INTERACTION OF HORONEINTERACTION OF HORONE

One hormone Multile actions

One !unction Multile hormones

%unction o! endocrine system deend on :

'ormone concentration

*ecetor concentration

A!!inity+interaction o! hormone-recetor 

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HORMONE SYNTHESIS , RELEASE, ANDHORMONE SYNTHESIS , RELEASE, AND

TRANSPORTTRANSPORT

,iosynthesis occur in the cell level

&ecretion regulated y !eed ack

mechanism

 

&ome hormones need sesi!ic

transort system

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ENDOCRINE PATHOLOGYENDOCRINE PATHOLOGY

Endocrine disorders can e divided into. road categories:&unormal hormone roduction

'ormone overroduction)roduction o! anormal hormone

/isorders o! hormone recetors

/isorders o! hormone transort 0 metaolismMultile hormoneanormalities

Tumors that roduce hormone

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!IOCHEISTRY OF SE" STEROIDS!IOCHEISTRY OF SE" STEROIDS

Cholesterol is the arent comaund

,asic steroid structure is resent in gonane

Consist o! $ interconnected rings 1A","C"/23. caron atoms

Individual steroids can e distinguishes y:The numer o! caron atoms

The !unctional and methyl grous

The tye o! ond et4een caron atoms

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SE" STEROID HORONESSE" STEROID HORONES

)rogesterone : C53 se6 steroid

Androgen : C37 se6 steroid

Estrogen : C38 se6 steroid

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E S T R O G E N SE S T R O G E N S

NATURAL:

- ESTRON (E1)

- ESTRADIOL(E2)

- ESTRIOL (E3)

SYNTETI!:

- ETYNILESTRADIOL

- MESTRANOL

- !EE

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ESTROGEN PREPARATIONSESTROGEN PREPARATIONS

&9NT'ETIC E&T*O(EN

CON9U(ATE/ EUINE E&T*O(EN

E&T*A/IOL

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ACTIVE

COPO#

NENTS

IN THE

ESTROGEN

PREPARA

TIONS

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PROGESTERONEPROGESTERONE

)*O(E&TO(EN& ; )*O(E&TIN

E%%ECT:

LUTEOMIMETIC

ANTI E&T*O(EN

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PROGESTOGEN PREPARATIONSPROGESTOGEN PREPARATIONS

)*O(E&TE*ONE

/E*I

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PROGESTOGENSPROGESTOGENS

OT'E* /E*I

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