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Postage & Fees Paid PHSlNlHlOD

Permit No. G-291

Vol. 17, No. 16 Apri l 29, 1988

Vol. 17, No. 16, April 29, 1988

DATED ANNOUNCEMENTS (RFPs AND RFAs)

RESOURCE FOR COLLECTION AND EVALUATION OF HUMAN TISSUES AND CELLS FROM DONORS WITH EPIDEMIOLOGICAL PROFILES (RFP)....................... 1 National Cancer Institute Index: CANCER

DENTIST SCIENTIST AWARD - INSTITUTIONAL (K16) (RFA) ......................... 1 National Institute of Dental Research Index: DENTAL RESEARCH

DEVELOPMENT AND CHANGE IN PLANNING SKILLS THROUGHOUT THE LIFE SPAN (RFA)......................................................... 2 National Institute of Child Health and Human DevelopmentNational Institute on AgingIndex: CHILD HEALTH ANI) HUMAN DEVELOPMENT; AGING

IRON OVERLOAD: COOLEY'S ANEMIA AND OTHER DISORDERS (RFA). . . . . . . . . . . . . . . . . . . 4National Heart, Lung, arid Blood Institute Index: HEART, LUNG, AND BLOOD

NCI COMPREHENSIVE MINORITY BIOMEDICAL PROGRAM CANCER CENTERS MINORITY ENHANCEMENT AWARDS (RFA).................................................... 4 National Cancer Institute Index: CANCER

IMPROVEMENT OF HOLDING FACILITIES FOR HIV-INFECTED CHIMPANZEES (RFA)... ..... 5 4' Division of Research Resources Index: RESEARCH RESOURCES

DATED ANNOUNCEMENTS (RFPs AND RFAs)

'3

RESOURCE FOR COLLECTION AND EVALUATION OF HUMAN TISSUES AND CELLS FROM DONORS WITH EPIDEMIOLOGICAL PROFILES

RFP AVAILABLE: NCI-CP-85646-13

P.T. 34; K.W. 0780015, 0780020, 0785055, 0715035

N a t i o n a l Cancer I n s t i t u t e

The Labora tory o f Human Carc inogenes i s o f t h e D i v i s i o n o f Cancer E t i o l o g y , N a t i o n a l Cancer I n s t i t u t e , Na t iona l I n s t i t u t e s o f Hea l th , i s recompeting a t i s s u e - c o l l e c t i o n c o n t r a c t which i s c u r r e n t l y be ing performed by t h e U n i v e r s i t y o f Maryland. P roposa l s are now b e i n g s o l i c i t e d from q u a l i f i e d f i r m s t o p rov ide t h e n e c e s s a r y r e s o u r c e s f o r t h e c o l l e c t i o n o f v i a b l e s u r g i c a l , b iopsy , and au topsy specimens from a v a r i e t y o f human t i s s u e s and ce l l s ( l u n g , bronchus, co lon , l i v e r , p a n c r e a s ) and o t h e r b i o l o g i c a l specimens ( p l e u r a l e f f u s i o n s , b lood and u r i n e ) from donors wi th ep idemio log ica l p r o f i l e s prepa red i n s p e c i f i c a l l y des igned p a t i e n t q u e s t i o n n a i r e s which i n c l u d e t h e r e l e v a n t medical r e c o r d s . The Labora tory o f Human Carc inogenes i s s u b j e c t s t h e s e t i s s u e s and ce l l s t o i n v i t r o a d a p t a b i l i t y , c a r c i n o g e n e s i s , and biochemica l c h a r a c t e r i z a t i o n s f o r chemical and oncogene-induced micromolecular a l t e r a t i o n s . These s t u d i e s f a c i l i t a t e development o f i n n o v a t i v e methods f o r biochemica l and ep idemio log ica l s t u d y o f p o p u l a t i o n s a t r i s k f o r chemical c a r c i n o g e n e s i s . Relevant s t u d i e s a r e expanded by x e n o t r a n s p l a n t a t i o n t e c h n i q u e s f o r d e f i n i t i v e a s s a y o f chemica l ly s t i m u l a t e d t u m o r i g e n e s i s .

It is p lanned t h a t RFP No. NCI-CP-85646-13 w i l l be a v a i l a b l e on o r about May13, 1988. P r o p o s a l s w i l l be due approximate ly 45 days fo l lowing t h e a c t u a l d a t e o f RFP i s s u a n c e . The Na t iona l Cancer I n s t i t u t e w i l l c o n s i d e r p r o p o s a l s from a l l r e p o n s i b l e s o u r c e s . However, o f f e r o r s must demonst ra te i n t h e i r t e c h n i c a l p r o p o s a l t h e i r a b i l i t y t o f a c i l i t a t e d e l i v e r y o f t h e nonfrozen v i a b l e t i s s u e s t o t h e N a t i o n a l Cancer I n s t i t u t e i n Bethesda, Maryland, w i t h i n two hour s o f c o l l e c t i o n as a mandatory requi rement o f t h e RFP. F a i l u r e t o demonst ra te t h i s e lement w i l l r e s u l t i n t h e o f f e r o r ' s e l i m i n a t i o n from f u r t h e r c o n s i d e r a t i o n . It i s a n t i c i p a t e d t h a t approximate ly 13,840 s t a f f hour s w i l l b e r e q u i r e d a n n u a l l y f o r t h i s four -year c o n t r a c t .

Copies o f t h e RFP may be o b t a i n e d by sending a w r i t t e n r e q u e s t t o :

Sharon A . Miller, Con t rac t S p e c i a l i s t Nat iona l Cancer I n s t i t u t e , RCB B l a i r Bu i ld ing , Room 114 Nat iona l I n s t i t u t e s o f Hea l th Bethesda, Maryland 20892 Telephone: (301) 427-8888

DENTIST SCIENTIST AWARD - INSTITUTIONAL (K16)

RFA AVAILABLE: 88-DE-4

P.T. 34; K.W. 0785040, 0710030, 0720005

N a t i o n a l I n s t i t u t e o f Denta l Research

A p p l i c a t i o n Rece ip t Date: October 14, 1988

The N a t i o n a l I n s t i t u t e o f Denta l Research ( N I D R ) i n v i t e s a p p l i c a t i o n s f o r new and c o m p e t i t i v e renewals o f t h e i n s t i t u t i o n a l ( o r program) D e n t i s t S c i e n t i s t Award (DSA).

The purpose of t h e i n s t i t u t i o n a l DSA i s t h e development o f o u t s t a n d i n gindependent d e n t a l c l i n i c a l s c h o l a r s f o r r e s e a r c h c a r e e r s . The i n s t i t u t i o n s r e c e i v i n g t h i s award w i l l be t h o s e judged most a b l e t o p r e p a r e d e n t i s t s w i t h s e r i o u s career commitments t o o r a l h e a l t h r e s e a r c h and h i g h p o t e n t i a l f o r such careers.

T h i s award w i l l e n a b l e d e n t i s t s s e l e c t e d by t h e program d i r e c t o r of each i n s t i t u t i o n a l award t o unde r t ake f i v e y e a r s o f s t u d y t o p r e p a r e f o r c a r e e r s i n o r a l h e a l t h r e s e a r c h . There are t h r e e d i s t i n c t bu t ove r l app ing and i n t e g r a t e d components t o t h e DSA program o f f e r e d t o each c a n d i d a t e : advanced basic s c i e n c e development, advanced c l i n i c a l s c i e n c e development, and a s u p e r v i s e dr e s e a r c h e x p e r i e n c e . The advanced b a s i c s c i e n c e component is des igned t o deve lop knowledge and r e s e a r c h s k i l l s i n b a s i c s c i e n c e a r e a s r e l e v a n t t o d e n t i s t r y . T h i s component w i l l i n c l u d e b o t h d i d a c t i c and l a b o r a t o r y t r a i n i n g

1

i n a fundamental s c i e n c e . Th i s w i l l most t y p i c a l l y c o n s i s t o f a d o c t o r a l l e v e l program ( e . g . , Ph.D. , Sc.D.1 p rov ided t h a t t h e r e s p e c t i v e i n s t i t u i o n ' s deg ree r equ i r emen t s are c o n s i s t e n t w i t h t h e o b j e c t i v e s o f t h e DSA. The advanced c l i n i c a l component is t o e n s u r e t h a t t h e c a n d i d a t e h a s t h e r e q u i s i t eadvanced c l i n i c a l knowledge and s k i l l s i n a r ecogn ized c l i n i c a l s p e c i a l t y o r o t h e r a p p r o p r i a t e d e n t a l c l i n i c a l d i s c i p l i n e . The r e s e a r c h e x p e r i e n c e component is des igned t o f a c i l i t a t e t r a n s i t i o n t o an a c t i v e r e s e a r c h career. T h i s component r e q u i r e s a r e s e a r c h program p l a n u s i n g a b a s i c s c i e n c e o r a c l i n i c a l s c i e n c e approach t o problems i n o r a l medic ine . Each c a n i d i d a t e w i l l r e q u i r e t h e c l o s e sponsor sh ip o f an i n d i v i d u a l mentor w i th r ecogn ized r e s e a r c h and t r a i n i n g background.

Complete d e t a i l s on e l i g i b i l i t y , mechanism o f award, a p p l i c a t i o n procedure and rev iew c r i te r ia may be o b t a i n e d from:

Thomas M . Valega, Ph.D. S p e c i a l A s s i s t a n t f o r

Manpower Development and T r a i n i n gExt ramura l ProgramWestwood Bu i ld ing , Room 510 Na t iona l I n s t i t u t e o f Dent:al Resarch Na t iona l I n s t i t u t e s o f Hea l th Bethesda, Maryland 20892 Telephone: ( 3 0 1 ) 496-6324t

DEVELOPMENT AND CHANGE IN-PLANNING SKILLS THROUGHOUT THE LIFE SPAN

RFA AVAILABLE: 88-HDIAG-11

P.T. 34; K.W. 0404004, 0414005

N a t i o n a l I n s t i t u t e o f Ch i ld Hea l th and Human DevelopmentN a t i o n a l I n s t i t u t e on Aging

A p p l i c a t i o n r e c e i p t d a t e : J u l y 29, 1988

The Human Learn ing and Behavior Branch, N a t i o n a l I n s t i t u t e o f Ch i ld Hea l th and Human Development ( N I C H D ) , and t h e Behav io ra l and S o c i a l Research Program o f t h e N a t i o n a l I n s t i t u t e on Aging ( N I A ) , s e e k a p p l i c a t i o n s f o r s t u d i e s on t h e development o f p l a n n i n g s k i l l s i n ch i ldhood and on subsequent changes i n p l a n n i n g s k i l l s i n adu l thood . The aim i s t o encourage t h e development o f t h e o r e t i c a l models and t h e conduct of r e s e a r c h p e r t a i n i n g t o v a r i a b l e s t h a t p l a y a r o l e i n c h i l d r e n l s and a d u l t s ' : ( a ) g o a l s e t t i n g , ( b ) t h e a b i l i t y t o make p l a n s t o r e a c h g o a l s and ( c ) goa l a t t a i n m e n t .

BACKGROUND

P lann ing can be a n t i c i p a t o r y o r o p p o r t u n i s t i c , sho r t - t e rm o r long-term, s imple o r complex. It can be i n f l u e n c e d by developmenta l , m o t i v a t i o n a l , emot iona l ,s o c i a l , c u l t u r a l and o t h e r c o n t e x t u a l v a r i a t i o n s among i n d i v i d u a l s . Because o f t h i s complexi ty , t h e s c i e n t i f i c s t u d y o f p l ann ing h a s been e l u s i v e .

P l ann ing h a s t r a d i t i o n a l l y been s t u d i e d i n t h e c o n t e x t o f r e l a t i v e l yshor t - t e rm problem-solving a c t i v i t i e s i n which t h e t a s k is p r e d e f i n e d and t h e g o a l s are de termined by t h e expe r imen te r . However, t h i s RFA encourages a b r o a d e r i n t e r p r e t a t i o n of p l ann ing t h a t a c c o r d s wi th r e c e n t a t t e m p t s t o i n t e g r a t e i n d i v i d u a l d i f f e r e n c e s , v a r i a b l e s and e x p e r i e n t i a l v a r i a b l e s i n t o t h e s t u d y o f complex a c t i v i t i e s .

P l ann ing i n v o l v e s a d i s c o v e r y o f t h e need f o r a c t i o n , a n t i c i p a t i o n o f t h e a p p r o p r i a t e a c t i o n s t o t a k e and t h e c a r r y i n g o u t o f t h e p l a n u n t i l t h e g o a l o f a c t i o n i s a t t a i n e d . Plann.ing can be s t u d i e d i n r e l a t i o n t o l i f e t a s k s ( s u c h as p l a n n i n g a b i r t h d a y p a r t y , o r p l ann ing a c t i v i t i e s and budget a f t e r r e t i r e m e n t ) o r by u s i n g l a b o r a t o r y s i m u l a t i o n s o f components o f t h e p l a n n i n g p r o c e s s . Recent i n v e s t i g a t i o n s of p l a n n i n g c a l l a t t e n t i o n t o t h e need t o f o c u s on v a r i a b l e s t h a t i n f l u e n c e p l ann ing . Such v a r i a b l e s i n c l u d e : ( a )m o t i v a t i o n t o se t and implement g o a l s ; ( b ) c r o s s c u l t u r a l v a r i a t i o n i n p e r c e i v e d need f o r , and v a l u e o f , p l ann ing ; ( c ) i n d i v i d u a l d i f f e r e n c e s i n t h e o r e t i c a l l y r e l e v a n t v a r i a b l e s ( e . g . i n t e r n a l v e r s u s e x t e r n a l l o c u s o f c o n t r o l , c o g n i t i v e m a t u r i t y , b e l i e f s about t h e importance o f p l a n n i n g ) ; ( d )effects o f s p e c i f i c domains and k i n d s o f a c t i v i t y ( e . g . s c i e n c e , e n g i n e e r i n g o r a r t ; s t r u c t u r e d and c o n s t r a i n e d t a s k s v e r s u s u n s t r u c t u r e d t a s k s ) ; ( e )i n d i v i d u a l v e r s u s c o l l a b o r a t i v e p l ann ing and f e a t u r e s of t h e s e two t y p e s o f p l ann ing ; and ( f ) s h o r t - t e r m o r long-term p l a n n i n g .

For r e s e a r c h e r s i n t e r e s t e d i n a s p e c t s o f ag ing , t h e s t u d y o f p l ann ing o f f e r s f e r t i l e ground b o t h t o t e s t t h e o r i e s o f how changes i n c o g n i t i v e p r o c e s s e s and

I t

2

4’

s t r u c t u r e a f fec t f u n c t i o n i n g i n complex t a s k s , and t o unde r s t and how e x p e r i e n c e can i n t e r a c t w i t h such changes t o compensate f o r d e c l i n e and t o p r e s e r v e o r enhance p a r t i c u l a r a b i l i t i e s and f u n c t i o n s .

RESEARCH GOALS AND SCOPE

T h i s r e q u e s t f o r a p p l i c a t i o n i s aimed a t s t i m u l a t i n g r e s e a r c h about changes i n p l a n n i n g s k i l l s a c r o s s t h e l i f e span . N I C H D and N I A a r e encouraging t h e submission o f a p p l i c a t i o n s about t h e a c q u i s i t i o n o f knowledge about p l ann ing ,t h e r e p r e s e n t a t i o n of such knowledge and i t s u s e by c h i l d r e n and a d u l t s . The i n t e r e s t i s i n theory-guided r e s e a r c h t h a t e x p l o r e s c o g n i t i v e , m o t i v a t i o n a l ,s o c i a l , emot iona l and c o n t e x t u a l c o n t r i b u t i o n s to t h e above aspec ts o f p l a n n i n g . While t h e term llplanning” refers t o ( a ) t h e r e v i s i o n o f fami l ia r p l a n s , ( b ) t h e a c q u i s i t i o n and g e n e r a t i o n o f new p l a n s , and ( c ) t h e r e t r i e v a l and u s e of o l d p l a n s , N I C H D and N I A are p a r t i c u l a r l y i n t e r e s t e d i n r e s e a r c h t h a t f o c u s e s on t h e first two t y p e s o f p l a n n i n g . A p p l i c a n t s are i n v i t e d t o employ b o t h o b s e r v a t i o n a l and expe r imen ta l r e s e a r c h methodologies and t o u s e c r o s s - s e c t i o n a l o r l o n g i t u d i n a l d e s i g n s as a p p r o p r i a t e .

I t is recogn ized t h a t no one s t u d y can f o c u s on a l l t h e above a s p e c t s o f p l a n n i n g . I n v e s t i g a t o r s are encouraged t o choose a s u b s e t o f r e s e a r c h problems t h a t are c l o s e s t t o t h e i r i n t e r e s t and t o s t u d y t h e s e i n g r e a t d e p t h .

MECHANISMS OF SUPPORT

Support f o r t h i s program w i l l be th rough t h e t r a d i t i o n a l r e s e a r c h g r a n t (Roll.P o l i c i e s t h a t govern g r a n t - i n - a i d award programs o f t h e P u b l i c Hea l th S e r v i c e w i l l p r e v a i l .

The s u p p o r t o f g r a n t s p u r s u a n t t o t h i s RFA is c o n t i n g e n t upon u l t i m a t e r e c e i p to f a p p r o p r i a t e d f u n d s f o r t h i s pu rpose . The number o f awards w i l l be i n f l u e n c e d by t h e amount o f funds a v a i l a b l e t o t h e I n s t i t u t e s , by t h e o v e r a l l merit o f a p p l i c a t i o n s , and by t h e i r r e l e v a n c e t o program g o a l s . I t is a n t i c i p a t e d t h a t up t o e i g h t m e r i t o r i o u s a p p l i c a t i o n s w i l l b e funded under t h i s program ( a maximum o f f o u r by each o f t h e two i n s t i t u t e s ) . M e r i t o r i o u s a p p l i c a n t s t h a t w i l l n o t be funded by t h i s program w i l l be encouraged t o r e v i s e and r e submi t t h e i r a p p l i c a t i o n s th rough t h e r e g u l a r mechanisms f o r s u p p o r t i n g i n v e s t i g a t o r - i n i t i a t e d a p p l i c a t i o n s .

T IMETABLE

A p p l i c a t i o n r e c e i p t d a t e

I n i t i a l review d a t e

Review by Advisory Counc i l s

A n t i c i p a t e d award d a t e

ADDITIONAL INFORMATION

P o t e n t i a l a p p l i c a n t s are encouraged a p p l i c a t i o n s by w r i t i n g t o :

Sarah L . Friedman, Ph.D Hea l th S c i e n t i s t A d m i n i s t r a t o r Human Learning and Behavior Branch N a t i o n a l I n s t i t u t e o f Ch i ld H e a l t h and Human Development

J u l y 29, 1988

October , 1988

Janua ry , 1989

A p r i l 1 , 1989

t o r e q u e s t t h e d e t a i l e d r e q u e s t f o r

9000 R o c k v i l l e P ike Execu t ive P l a z a North, Room 633 Bethesda, Maryland 20892

OR

Ronald P. Abeles , Ph.D. Deputy A s s o c i a t e D i r e c t o r Behav io ra l and S o c i a l Research ProgramN a t i o n a l I n s t i t u t e on Aging9000 R o c k v i l l e P i k e B u i l d i n g 31, Room 5C32 Bethesda, Maryland 20892

3

I R O N OVERLOAD: COOLEY’S_ANEMIA AND OTHER DISORDERS

RFA AVAILABLE: NIH-88-HL-14-B

P.T. 34; K . W . 0785070, 0750010

N a t i o n a l Heart, Lung, and Blood I n s t i t u t e

A p p l i c a t i o n Rece ip t Date: September 19, 1988

The Blood Diseases Branch o f t h e D i v i s i o n o f Blood Diseases and Resources , N a t i o n a l Heart , Lung, and Blood I n s t i t u t e , announces t h e a v a i l a b i l i t y o f a Request f o r A p p l i c a t i o n s (RFA) on t h e above s u b j e c t . Copies o f t h e RFA are c u r r e n t l y a v a i l a b l e from s ta f f o f t h e Blood Diseases Branch.

The purpose o f t h i s i n i t i a t i v e i s t o s t i m u l a t e c l i n i c a l and b a s i c r e s e a r c h on t h e development o r e v a l u a t i o n o f new o r improved t h e r a p i e s f o r t h e managemento f i r o n o v e r l o a d i n Cooley’s anemia o r o t h e r t r a n s f u s i o n - r e l a t e d i r o n l o a d i n g d i s o r d e r s . T h i s s p e c i a l RFA program is i n t e n d e d t o be f o r FIVE y e a r s o f s u p p o r t . I t i s a n t i c i p a t e d t h a t about s i x g r a n t s w i l l be awarded under t h i s program. The s p e c i f i c amount t o be funded w i l l , however, depend on t h e merit and scope o f t h e a p p l i c a t i o n s r e c e i v e d and t h e a v a i l a b i l i t y o f f u n d s .

Reques t s f o r c o p i e s o f t h e complete RFA shou ld be addres sed t o :

Alan S . Levine, Ph,D.Chie f , Blood D i s e a s e s Branch D i v i s i o n o f Blood D i s e a s e s and Resources N a t i o n a l Heart, Lung, and Blood I n s t i t u t e F e d e r a l B u i l d i n g , Room 5Al2 N a t i o n a l I n s t i t u t e s o f Hea l th Bethesda, Maryland 20892 Telephone: ( 3 0 1 ) 496-5911

N C I COMPREHENSIVE MINORITY BIOMEDICAL PROGRAM CANCER CENTERS MINORITY ENHANCEMENT AWARDS

RFA AVAILABLE: 88-CA-11

P.T. 04, FF; K . W . 0715035, 0710030, 0745020, 0745055, 0415000, 0710095 “11

N a t i o n a l Cancer I n s t i t u t e

Le t t e r o f I n t e n t Date: June 1 , 1988 A p p l i c a t i o n R e c e i p t Date: August 2 , 1988

INTRODUCTION

1 . Background

The D i v i s i o n o f Cancer P r e v e n t i o n and Con t ro l (DCPC) and t h e D i v i s i o n o f Extramural A c t i v i t i e s ( D E A ) , N a t i o n a l Cancer I n s t i t u t e , i n v i t e a p p l i c a t i o n sf o r supplemental s u p p o r t t o Cancer Cen te r g r a n t s t o expand m i n o r i t yinvolvement i n c a n c e r c o n t r o l r e s e a r c h . Cancer C e n t e r s would promote t h e p a r t i c i p a t i o n o f m i n o r i t y groups i n c a n c e r c o n t r o l r e s e a r c h by b roaden ingt h e i r o p e r a t i o n a l b a s e t o f a c i l i t a t e t h e expansion o f c a n c e r c o n t r o l r e s e a r c h e f f o r t s i n e a r l y d e t e c t i o n , p r e v e n t i o n , s c r e e n i n g , p r e - t r e a t m e n t e v a l u a t i o n , t rea tment , c o n t i n u a - t i o n care r e h a b i l i t a t i o n ; and t h e i n c r e a s e d involvement o f m i n o r i t y p o p u l a t i o n p r imary care p r o v i d e r s e a r l y i n t h e c o u r s e o f c l i n i c a l t r e a t m e n t . The program e f f o r t would a l s o promote t h e p a r t i c i p a t i o n o f m i n o r i t i e s i n t r e a t m e n t c l . i n i c a 1 r e s e a r c h t h a t u t i l i z e s i n s t i t u t i o n a l p r o t o c o l s . The e f f o r t would s e e k t o s u p p o r t programs c a r r y i n g o u t c a n c e r c o n t r o l r e s e a r c h a c t i v i t i e s r e l a t e d t o d i e t and n u t r i t i o n and would h o p e f u l l yc o o r d i n a t e t h e c o n t r i b u t i o n s o f i n v e s t i g a t o r s from v a r i o u s r e l e v a n t d i s c i p l i n e s , e . g . , b e h a v i a r a l psychology and n u t r i t i o n s c i e n c e .

The p r e s e n t RFA announcement i s f o r a s i n g l e c o m p e t i t i o n w i t h a d e a d l i n e o f August 2, 1988. A p p l i c a t i o n s shou ld be p repa red and submi t t ed i n acco rdance w i t h t h e aims and r equ i r emen t s d e s c r i b e d i n t h e complete RFA document and summarized i n t h e f o l l o w i n g s e c t i o n s .

11. Research Goals and Scope

T h i s program e f f o r t would promote t h e p a r t i c i p a t i o n o f m i n o r i t i e s i n c a n c e r c o n t r o l a c t i v i t i e s a t t h o s e cance r c e n t e r s w i t h funded Cancer Cen te r SupportG r a n t s which access l a r g e o r p redomina te ly m i n o r i t y p o p u l a t i o n s .

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A supplement t o a Cancer Center Suppor t Grant (P30 "co re g r a n t " ) would p r o v i d emonies f o r i n c r e a s e d m i n o r i t y involvement i n a v a r i e t y o f a c t i v i t i e s by t h e c e n t e r s i n c l u d i n g t h e en ro l lmen t o f i n c r e a s e d numbers o f m i n o r i t y p a t i e n t s on cance r t r e a t m e n t and cance r c o n t r o l p o t o c o l s .

111. Mechanism o f Suppor t *U' Support w i l l be p rov ided through a c o m p e t i t i v e l y awarded c o r e g r a n t supplement

a t a maximum p r o j e c t e d annual d i r e c t c o s t o f $150,000. Funds may be r e q u e s t e d t o s u p p o r t : d a t a management, s u p p l i e s , s a l a r i e s o f p r o f e s s i o n a l and/or suppor t pe r sonne l , computer t i m e , a d m i n i s t r a t i v e expenses , e t c . , i n accordance wi th PHS g r a n t p o l i c i e s f o r Cancer Center Support Gran t s . The r e q u e s t must be j u s t i f i e d i n t h e budget sect i o n o f t h e a p p l i c a t i o n .

The i n i t i a l review o f a p p l i c a t i o n s w i l l be conducted by t h e D i v i s i o n o f Extramural A c t i v i t i e s , N C I , u s i n g a S p e c i a l Review Committee. F i n a l review is provided by t h e N a t i o n a l Cancer Advisory Board. I t i s a n t i c i p a t e d t h a t f i v e awards w i l l be made s u b j e c t t o r e c e i p t of m e r i t o r i o u s a p p l i c a t i o n s and con t inued a v a i l a b i l i t y o f f u n d s ,

I V . I n q u i r i e s

A copy o f t h e comple te RFA d e s c r i b i n g t h e r e s e a r c h g o a l s and scope , t h e rev iew c r i t e r i a , and t h e method o f a p p l y i n g can be ob ta ined by c o n t a c t i n g :

D r . Lemuel A . Evans Program D i r e c t o r , Comprehensive Minor i ty

Biomedical ProgramD i v i s i o n o f Ext ramura l A c t i v i t i e s Na t iona l Cancer I n s t i t u t e B u i l d i n g 31, Room 10A-04 Bethesda, Maryland 20892 Telephone: (301) 496-7344

I n q u i r i e s conce rn ing t h i s announcement a r e encouraged and shou ld be d i r e c t e d t o D r . Lemuel A. Evans a t t h e above a d d r e s s and phone number. The programs taf f would a p p r e c i a t e t h e o p p o r t u n i t y t o c l a r i f y any i s s u e s o r q u e s t i o n s .

Qw' IMPROVEMENT OF HOLDING FACILITIES FOR HIV-INFECTED CHIMPANZEES

RFA AVAILABLE: 88-RR-04

P.T. 34; K.W. 1002002, 0715120, 1002045

D i v i s i o n o f Research Resources

A p p l i c a t i o n Rece ip t Date: June 20, 1988

BACKGROUND

The D i v i s i o n o f Research Resources (DRR) is developing a program t o improveh o l d i n g f a c i l i t i e s f o r HIV-infected chimpanzees a f t e r release from a c t i v e p r o t o c o l s . Long-term maintenance o f chimpanzees i n f e c t e d w i t h H I V a f te r release from an a c t i v e p r o t o c o l i s t h e r e s p o n s i b i l i t y o f t h e owner. It is a n t i c i p a t e d t h a t funds w i l l be o b t a i n e d by t h e owner f o r long-term suppor t of i n f e c t e d chimpanzees from t h e organizations/investigators who suppor t t h e r e s e a r c h p r o t o c o l s .

ELIGIBILITY

Domestic p u b l i c and p r i v a t e i n s t i t u t i o n s and o r g a n i z a t i o n s which have chimpanzees t h a t have been i n o c u l a t e d wi th H I V i n f ede ra l ly - funded r e s e a r c h may a p p l y . A l l an ima l s must be i d e n t i f i e d under e x i s t i n g p r o t o c o l s t h a t have been approved by t h e PHS AIDS Animal Models Committee.

MECHANISM OF SUPPORT

The FY 1988 Budget i n c l u d e s $1 .43 m i l l i o n f o r t h i s i n i t i a t i v e . It is a n t i c i p a t e d t h a t several awards w i l l be made b e f o r e September 30, 1988. Chimpanzees i n o c u l a t e d wi th H I V i n Government-supported r e s e a r c h p r o j e c t s are h e l d i n s e v e r a l d i f f e r e n t i n s t i t u t i o n s .

RECEIPT OF APPLICATION 4 ,-/

To ensu re rev iew, t h e a p p l i c a t i o n must be r e c e i v e d by June 20, 1988. A p p l i c a t i o n s r e c e i v e d a f t e r t h i s d a t e w i l l be r e t u r n e d wi thout r ev iew. T h i s

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is a one-time r e q u e s t f o r a p p l i c a t i o n s based on t h e F i s c a l Year 1988 a p p r o p r i a t i o n .

To o b t a i n in fo rma t ion about t h e a p p l i c a t i o n , o t h e r a s p e c t s of t h e program, and a copy o f t h e RFA, con tac ' t :

D r . Wil l iam I . GayAnimal Resources ProgramD i v i s i o n of Research Resources N a t i o n a l I n s t i t u t e s o f Hea l th B u i l d i n g 31, Room 5B59 Bethesda, Maryland 20892 Telephone: (301) 496-517.5

APPLICATION FORMS (PHS 398 9/86) MAY BE OBTAINED FROM:

Office o f Gran t s I n q u i r i e s D i v i s i o n of Research Gran t s N a t i o n a l I n s t i t u t e s of Hea l th Westwood Bu i ld ing , Room 449 5333 Westbard Avenue Bethesda, Maryland 20892 Telephone: (301) 496-7441

T h i s program is d e s c r i b e d i n t h e Ca ta log o f F e d e r a l Domestic Assis tance No. 13.306, Labora to ry Animal S c i e n c e s and P r ima te Research . Awards w i l l be made under t h e a u t h r o i t y of t h e P u b l i c Hea l th S e r v i c e A c t , T i t l e 111, S e c t i o n 301 ( P u b l i c Law 78-410, as amended; 42 USC 241) and a d m i n i s t e r e d under PHS g r a n t p o l i c i e s and F e d e r a l Regu la t ions 42 CFR P a r t 52 and 45 CFR P a r t 74. T h i s program is n o t s u b j e c t t o t h e in t e rgove rnmen ta l review requ i r emen t s o f Execu t ive Order 12372 o r Hea l th Systems Agency rev iew.

6 bU. S. GOVERNlrQNT PRINTING OFFICE :1988-2O1-770:60O39