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Nizhny Novgorod-Maryland Biotechnology Partnership September 10-11, 2013

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Maryland-Russia Collaborations

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Baltimores deepwater port Rail: AmTrak corridor Air: BWI, Washington-Dulles & Reagan International UNSURPASSED BUSINESS ACCESS: 100 mi. 200 mi. 400 mi. 300 mi. 500 mi. 600 mi. Same day or overnight access to 1/3 of U.S. industry, markets, and population Same day or overnight access to 1/3 of U.S. industry, markets, and population Just two hour access to 80% of the U.S. pharmaceutical industry and more than 2,000 biotechnology companies CONNECTED GLOBALLY and REGIONALLY MARYLAND Road: Multi interstate 95

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Judy Britz, Ph.D., Executive Director BioMaryland Center From Research to Reality to Revenues The Government as a Catalyst of Innovation and Growth: the Case for BioMaryland 2020

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Governor OMalley committed to $1.3 Billion Investment/10 Years BioMaryland 2020

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Maryland Biotechnology Industry Biomanufacturing Agriculture/Food Bioinformatics Genomics Therapeutics Proteomics Diagnostics BioDefense Environment Devices

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Dmitri Mendeleev Chemist Periodic Chart 1st Vodka Standards Founded 1 st Oil Refinery

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Increase access to capital Connect entrepreneurs with resources Grow jobs in the BIO industry Assist translation of research to products Other Provide Business Plan Feedback Identify Partners, Collaborators and Clients Match Training and Workforce

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> 500 BioCompanies -Focus: 50% Biotherapeutics -25% Medical Devices/Diagnostics -25% CROs/Research Tools > 34,000 Employees - Average Salary: $91,100 > $10 Billion in Revenues

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JCVI USAMRIID USAMRMC NIBC, NBACC, NCI UMCP VMRCVM ECBC UMB-SOM, IHV GTU GWU USUHS WRAIR JHU FDA CVM USDA NIH MDA MD DBED UMD NIST BARC FDA CFSAN UMBC UMCES UMD- ACES FDA JHU APL

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National Institutes of Health (NIH) Food and Drug Administration (FDA) Center for Medicare and Medicaid Services (CMS) Center for Excellence in Regulatory Science (CERSI) Food Safety and Inspection Service (FSIS) Federal Labs: BioDefense and Human Health Johns Hopkins University University of Maryland System Marylands Unique Assets

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Maryland Center for Excellence in Regulatory Science and Innovation

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$1.1 B Acquisition

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UniversitiesCompanies MD STEM Cell Research Fund MD Innovation Initiative (MII) Phase II Phase IIIPhase I Basic Research Translational Research Product Development Technology Validation Program Patent Assistance Program Tech. Commercialization Fund Angel Affinity Funds Maryland Industrial Partnerships (MIPS) Translational Research AwardBiotechnology Commercialization Award Biotechnology Tax Credit MD Venture Fund Cybersecurity Tax Credit Research and Development Tax Credit TEDCO USM MBC DBED KEY:

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BioMaryland Award Programs: $7M Maryland Innovation Initiative: 10.8M Biotechnology Tax Credits: $48M InvestMaryland: $84M next 3yrs Stem Cell Funding: ~$100M R&D Tax Credit: >$30M Cumulative Investment

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BioMaryland Centers Biotechnology Development Awards Program Applicants have tripled from since inception Two main Categories: Translational Research and Commercialization Awards >$7.0M Awarded to >30 Companies and 3 University projects

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Maryland Innovation Initiative Purpose: Commercialization of University Research/IP Participating: Hopkins, University of Maryland (UMBC, UMB, UMCP),Morgan State 2012: $5.8M First Year Funding 2013: $5M Followon Companies who have licensed University Research eligible Administered by TEDCO

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BioMaryland LIFE Prize Collaborative Prize with Johns Hopkins and University of Maryland Annual Alliance Meeting 100+ Angels, VCs, Pharma, Entrepreneurs Two $50,000 Competitive Awards Abell Foundation added $100,000 to pool

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DBEDs Biotechnology Investor Tax Credit Model Program for Nation for Angel Investors 2013: Increase from $8M to $10M $48M in credits deployed to >60 companies >$90 leveraged in investment Goal: $24M by 2020

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DBEDs Invest Maryland VC Program 2011- InvestMaryland Legislation passed 2012 - $84 M Raised in Tax Credit Auction $28M+ Maryland Venture Fund $56M Private Venture Capital First Bioinvestments BrainscopeAdLyfe TheranosticsPlasmonix PathSensors

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InvestMaryland Challenge Statewide Business Plan Competition $425K in Prizes Over 200 Applications received Life Science Maryland Only (55 Companies) Cyber/IT Maryland Only General Outside Maryland

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Leveraged financing from the private sector Direct financing (Loans, Contract Financing) Loan Guarantees & Credit Enhancement Tax Exempt and Taxable-Revenue Bonds Tax Credits (Job Creation, Enterprise Zone) Export Assistance Other State Resources: TEDCO, MIPs (University) Federal Sources: SBIR/STTR Other Sources of Capital

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FREE Access to Market Research Resources BioMed Tracker Frost & Sullivan Deloitte Recap MedTrack

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San Diego June 23-26, 2014

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www.Bio.Maryland.gov

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From Research to Reality to Revenues !