novel approaches to lipid management: modulating the pcsk9/ldl receptor balance
DESCRIPTION
Novel Approaches to Lipid Management: Modulating the PCSK9/LDL Receptor Balance. MENDEL: AMG 145 Monotherapy for Hypercholesterolemia. LAPLACE-TIMI 57: AMG 145 Combined With Statin for Hypercholesterolemia . GAUSS: AMG 145 in Statin Intolerance. Dosing and Administration. GLAGOV Trial . - PowerPoint PPT PresentationTRANSCRIPT
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Novel Approaches to Lipid Management: Modulating the PCSK9/LDL Receptor Balance
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MENDEL: AMG 145 Monotherapy for Hypercholesterolemia
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LAPLACE-TIMI 57: AMG 145 Combined With Statin for Hypercholesterolemia
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GAUSS: AMG 145 in Statin Intolerance
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Dosing and Administration
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GLAGOV Trial
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JUPITER: Attaining an LDL-C Level < 50 mg/dL
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Phase 3 Trials
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Novel Approaches to Lipid Management: Modulating the PCSK9/LDL Receptor Balance
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Genetic defects identified in FH
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ENHANCESimvastatin/Ezetimibe in FH
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OSLER Study: Long-term AMG 145 Therapy
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Safety of AMG 145
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How low is too low?
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Novel Approaches to Lipid Management: Modulating the PCSK9/LDL Receptor Balance
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Genetics: PCSK9
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Loss-of-Function PCSK9 Mutation:Distribution of LDL-C Levels
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Diagnosis of FH
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Determinants of PCSK9 Efficacy
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Novel Approaches to Lipid Management: Modulating the PCSK9/LDL Receptor Balance
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Timelines of Lipid-Lowering Agents
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Dallas Heart Study: Lipid Characteristics of African American
Individuals With Nonsense Mutations in PCSK9
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Diagnosis and Treatment of FH
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Diagnosis and Treatment of FH
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Novel Approaches to Lipid Management: Modulating the PCSK9/LDL Receptor Balance
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ENHANCE: Heterozygous FH
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PCSK9 mAb vs Placebo on LDL-C Levels
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Statin Therapy: Muscular Adverse Effects
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Safety of Long-term AMG 145
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Lipid-Lowering Therapy Initiation
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Abbreviations
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Abbreviations (cont)
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References
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References (cont)
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References (cont)
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References (cont)
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References (cont)