C Number: C20310B

Lock Date: 04/20/2010

Cage Range: ALL

Date Range: ALL

Reasons For Removal: ALL

Removal Date Range: ALL

Treatment Groups: Include ALL

Study Gender: Male

TDMSE Version: 2.2.0

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

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VehicleANIMAL ID

00006

00012

00028

00043

00051

00052

00074

00086

00097

00138

00172

00189

00190

00208

00209

00239

00297

00307

00308

00340

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00351

00360

00382

00401 * TOTALS

ALIMENTARY SYSTEM

Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 25

Gallbladder A + + + + + + A + + + + + + + + A + + + + + + + + 22

Intestine Large, Cecum A + + + + + + A + + + + + + + + A + + + + + + + + 22

Intestine Large, Colon A + + + + + + A + + + + + + + + A + + + + + + + + 22

Intestine Large, Rectum A + + + + + + A + + + + + + + + A + + + + + + + + 22

Intestine Small, Duodenum A + + + + + + A + + + + + + + + + + + + + + + + + 23Leiomyosarcoma X 1

Intestine Small, Ileum A + + + + + + A + + + + + + + + A + + + + + + + + 22

Intestine Small, Jejunum A + + + + + + A + + + + + + + + + + + + + + + + + 23Adenocarcinoma X 1

Liver + + + + + + + + + + + + + + + + + + + + + + + + + 25Hepatocellular Adenoma X 1Lymphoma Malignant X 1

Mesentery + + + 3Leiomyosarcoma, Metastatic, Intestine Small,

DuodenumX 1

Sarcoma X 1

Pancreas A + + + + + + + + + + + + + + + + + + + + + + + + 24

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 2

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

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VehicleANIMAL ID

00006

00012

00028

00043

00051

00052

00074

00086

00097

00138

00172

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00190

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00209

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00297

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00382

00401 * TOTALS

Leiomyosarcoma, Metastatic, Intestine Small,Duodenum

X 1

Sarcoma, Metastatic, Tissue Nos X 1

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 25

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 25

Stomach, Glandular A + + + + + + + + + + + + + + + A + + + + + + + + 23

CARDIOVASCULAR SYSTEM

Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + + 25Lymphoma Malignant X 1

Heart + + + + + + + + + + + + + + + + + + + + + + + + + 25Lymphoma Malignant X 1

ENDOCRINE SYSTEM

Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 25

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 25

Islets, Pancreatic A + + + + + + + + + + + + + + + + + + + + + + + + 24

Parathyroid Gland + M + + + + + + + M + + + + + + + + + + + + + + + 23

Pituitary Gland + + + + + + + + + + + + + + M + + + + + + + + + + 24

Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 25

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 3

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0190

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VehicleANIMAL ID

00006

00012

00028

00043

00051

00052

00074

00086

00097

00138

00172

00189

00190

00208

00209

00239

00297

00307

00308

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00350

00351

00360

00382

00401 * TOTALS

GENERAL BODY SYSTEM

Tissue NOS + 1Abdominal, Sarcoma X 1

GENITAL SYSTEM

Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + 25

Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + + 25

Prostate + + + + + + + + + + + + + + + + + + + + + + + + + 25

Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + + 25

Testes + + + + + + + + + + + + + + + + + + + + + + + + + 25

HEMATOPOIETIC SYSTEM

Bone Marrow A + + + + + + A + + + + + + + + + + + + + + + + + 23

Lymph Node + + 2Mediastinal, Sarcoma, Metastatic, Tissue Nos X 1Pancreatic, Lymphoma Malignant X 1Renal, Lymphoma Malignant X 1

Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + + 25Lymphoma Malignant X 1

Lymph Node, Mesenteric + + + + + + + + + + + + + + + + A + + + + + + + + 24

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 4

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0190

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0337

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0332

0332

0339

0327

0330

0334

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0329

0334

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VehicleANIMAL ID

00006

00012

00028

00043

00051

00052

00074

00086

00097

00138

00172

00189

00190

00208

00209

00239

00297

00307

00308

00340

00350

00351

00360

00382

00401 * TOTALS

Sarcoma, Metastatic, Tissue Nos X 1

Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 25Lymphoma Malignant X 1

Thymus + + + + + + + + + + + + + + + + A + + + + + + + + 24Lymphoma Malignant X 1

INTEGUMENTARY SYSTEM

Mammary Gland M M M M M M M M M M M M M M M M M M M + M M M M M 1

Skin + + + + + + + + + + + + + + + + + + + + + + + + + 25

MUSCULOSKELETAL SYSTEM

Bone + + + 3Osteosarcoma X 1Humerus, Osteosarcoma X 1Tibia, Osteosarcoma X 1

Bone, Femur + + + + + + + + + + + + + + + + + + + + + + + + + 25

Skeletal Muscle + + + 3Leiomyosarcoma, Metastatic, Intestine Small,

DuodenumX 1

Diaphragm, Sarcoma, Metastatic, Tissue Nos X 1

NERVOUS SYSTEM

Brain, Brain Stem + + + + + + + + + + + + + + + + + + + + + + + + + 25

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 5

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0190

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0330

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0333

0335

0337

0337

0332

0332

0339

0327

0330

0334

0334

0334

0334

0329

0334

0335

VehicleANIMAL ID

00006

00012

00028

00043

00051

00052

00074

00086

00097

00138

00172

00189

00190

00208

00209

00239

00297

00307

00308

00340

00350

00351

00360

00382

00401 * TOTALS

Brain, Cerebellum + + + + + + + + + + + + + + + + + + + + + + + + + 25

Brain, Cerebrum + + + + + + + + + + + + + + + + + + + + + + + + + 25

Peripheral Nerve + 1

Spinal Cord, Cervical + 1

Spinal Cord, Lumbar + 1

Spinal Cord, Thoracic + 1

RESPIRATORY SYSTEM

Lung + + + + + + + + + + + + + + + + + + + + + + + + + 25Lymphoma Malignant X 1Osteosarcoma, Metastatic, Bone X 1

Nose + + + + + + + + + + + + + + + + + + + + + + + + + 25

Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 25

SPECIAL SENSES SYSTEM

Eye A + + + + + + A + + + + + + + + A + + + + + + + + 22

Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 25

URINARY SYSTEM

Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 25

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 6

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0190

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0333

0335

0337

0337

0332

0332

0339

0327

0330

0334

0334

0334

0334

0329

0334

0335

VehicleANIMAL ID

00006

00012

00028

00043

00051

00052

00074

00086

00097

00138

00172

00189

00190

00208

00209

00239

00297

00307

00308

00340

00350

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00360

00382

00401 * TOTALS

Lymphoma Malignant X 1

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 25

SYSTEMIC LESIONS

Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 25Lymphoma Malignant X 1

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 7

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0190

0254

0056

0334

0334

0330

0330

0299

0336

0335

0335

0333

0333

0336

0336

0278

0332

0182

0341

0358

0333

0334

0330

0333

0332

AZT 60ANIMAL ID

00010

00016

00026

00033

00034

00059

00060

00088

00102

00103

00104

00153

00154

00184

00188

00198

00206

00221

00237

00296

00303

00329

00344

00345

00363 * TOTALS

ALIMENTARY SYSTEM

Esophagus + + A + + + + + + + + + + + + + + + + + + + + + + 24

Gallbladder + + A + + + + A + M + + + + + + + + + A + + + + + 21

Intestine Large, Cecum + + A + + + + A + + + + + + + + + + + A + + + + + 22Lymphoma Malignant X 1

Intestine Large, Colon + + A + + + + A + + + + + + + + + + + A + + + + + 22

Intestine Large, Rectum + + A + + + + A + + + + + + + + + + + A + + + + + 22Lymphoma Malignant X 1

Intestine Small, Duodenum + + A + + + + A + + + + + + + + + + + A + + + + + 22

Intestine Small, Ileum + + A + + + + A + + + + + + + + + + + A + + + + + 22

Intestine Small, Jejunum + + A + + + + A + + + + + + + + + + + A + + + + + 22

Liver + + A + + + + + + + + + + + + + + + + + + + + + + 24Hepatocellular Adenoma X X X X 4Hepatocellular Adenoma, Multiple X X X X 4Hepatocellular Carcinoma X 1Lymphoma Malignant X X 2

Pancreas + + A + + + + + + + + + + + + + + + + A + + + + + 23

Salivary Glands + + A + + + + + + + + + + + + + + + + A + + + + + 23

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 8

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0190

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0278

0332

0182

0341

0358

0333

0334

0330

0333

0332

AZT 60ANIMAL ID

00010

00016

00026

00033

00034

00059

00060

00088

00102

00103

00104

00153

00154

00184

00188

00198

00206

00221

00237

00296

00303

00329

00344

00345

00363 * TOTALS

Stomach, Forestomach + + A + + + + + + + + + + + + + + + + A + + + + + 23

Stomach, Glandular + + A + + + + A + + + + + + + + + + + A + + + + + 22

CARDIOVASCULAR SYSTEM

Blood Vessel + + A + + + + + + + + + + + + + + + + + + + + + + 24Lymphoma Malignant X X 2

Heart + + + + + + + + + + + + + + + + + + + + + + + + + 25Lymphoma Malignant X X 2

ENDOCRINE SYSTEM

Adrenal Cortex + + A + + + + + + + + + + + + + + + + + + + + + + 24

Adrenal Medulla + + A + + + + + + + + + + + + + + + + A + + + + + 23

Islets, Pancreatic + + A + + + + + + + + + + + + + + + + + + + + + + 24

Parathyroid Gland + + A + + + M + M + + + + + + + + + + + + M + + + 21

Pituitary Gland + + M + + + + + + + + + + + + M + M + + + + + + + 22

Thyroid Gland + + A + + + + + + + + + + + + + + + + A + + + + + 23

GENERAL BODY SYSTEM

NONE

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 9

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0190

0254

0056

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0330

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0336

0335

0335

0333

0333

0336

0336

0278

0332

0182

0341

0358

0333

0334

0330

0333

0332

AZT 60ANIMAL ID

00010

00016

00026

00033

00034

00059

00060

00088

00102

00103

00104

00153

00154

00184

00188

00198

00206

00221

00237

00296

00303

00329

00344

00345

00363 * TOTALS

GENITAL SYSTEM

Epididymis + + A + + + + + + + + + + + + + + + + A + + + + + 23

Preputial Gland + + + + + + + + + + + + + + + + + + + A + + + + + 24

Prostate + + A + + + + + + + + + + + + + + + + A + + + + + 23

Seminal Vesicle + + A + + + + + + + + + + + + + + + + A + + + + + 23

Testes + + + + + + + + + + + + + + + + + + + A + + + + + 24

HEMATOPOIETIC SYSTEM

Bone Marrow + + + + + + + + + + + + + + + + + + + A + + + + + 24Lymphoma Malignant X 1

Lymph Node + + 2Axillary, Lymphoma Malignant X 1Inguinal, Lymphoma Malignant X 1Mediastinal, Lymphoma Malignant X 1Pancreatic, Lymphoma Malignant X 1Renal, Lymphoma Malignant X X 2

Lymph Node, Mandibular + + M + + + + + + + + + + + + + + + + A + + + + + 23Lymphoma Malignant X X 2

Lymph Node, Mesenteric + + A + + + + + + + + + + + + + + + + A + + + + + 23Lymphoma Malignant X 1

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 10

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0190

0254

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0330

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0333

0333

0336

0336

0278

0332

0182

0341

0358

0333

0334

0330

0333

0332

AZT 60ANIMAL ID

00010

00016

00026

00033

00034

00059

00060

00088

00102

00103

00104

00153

00154

00184

00188

00198

00206

00221

00237

00296

00303

00329

00344

00345

00363 * TOTALS

Spleen + + + + + + + A + + + + + + + + + + + A + + + + + 23Lymphoma Malignant X X 2

Thymus + + A + + + + M + + + + + + + + + + + A + + + + + 22Lymphoma Malignant X X 2

INTEGUMENTARY SYSTEM

Mammary Gland M M M M M M M M M M M M M M M M M M M M M M M M M 0

Skin + + + + + + + + + + + + + + + + + + + + + + + + + 25

MUSCULOSKELETAL SYSTEM

Bone + 1Pelvis, Osteosarcoma X 1

Bone, Femur + + + + + + + + + + + + + + + + + + + + + + + + + 25

Skeletal Muscle + + 2Lymphoma Malignant X 1Rhabdomyosarcoma X 1

NERVOUS SYSTEM

Brain, Brain Stem + + A + + + + + + + + + + + + + + + + + + + + + + 24Lymphoma Malignant X 1

Brain, Cerebellum + + A + + + + + + + + + + + + + + + + + + + + + + 24

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 11

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0190

0254

0056

0334

0334

0330

0330

0299

0336

0335

0335

0333

0333

0336

0336

0278

0332

0182

0341

0358

0333

0334

0330

0333

0332

AZT 60ANIMAL ID

00010

00016

00026

00033

00034

00059

00060

00088

00102

00103

00104

00153

00154

00184

00188

00198

00206

00221

00237

00296

00303

00329

00344

00345

00363 * TOTALS

Brain, Cerebrum + + A + + + + + + + + + + + + + + + + + + + + + + 24Lymphoma Malignant X 1

RESPIRATORY SYSTEM

Lung + + + + + + + + + + + + + + + + + + + A + + + + + 24Alveolar/Bronchiolar Carcinoma X 1Lymphoma Malignant X X X 3

Nose + + + + + + + + + + + + + + + + + + + + + + + + + 25Osteosarcoma X 1

Trachea + + A + + + + + + + + + + + + + + + + A + + + + + 23

SPECIAL SENSES SYSTEM

Eye + + A + + + + A + + + + + + + + + + + A + + + + + 22

Harderian Gland + + A + + + + A + + + + + + + + + + + A + + + + + 22

URINARY SYSTEM

Kidney + + A + + + + + + + + + + + + + + + + + + + + + + 24Lymphoma Malignant X 1

Urinary Bladder + + A + + + + + + + + + + + + + + + + + + + + + + 24

SYSTEMIC LESIONS

Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 25

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 12

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0190

0254

0056

0334

0334

0330

0330

0299

0336

0335

0335

0333

0333

0336

0336

0278

0332

0182

0341

0358

0333

0334

0330

0333

0332

AZT 60ANIMAL ID

00010

00016

00026

00033

00034

00059

00060

00088

00102

00103

00104

00153

00154

00184

00188

00198

00206

00221

00237

00296

00303

00329

00344

00345

00363 * TOTALS

Lymphoma Malignant X X X 3

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 13

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0196

0334

0337

0336

0334

0334

0334

0334

0333

0333

0334

0334

0333

0333

0332

0332

0334

0335

0333

0333

0264

0332

0334

0332

0332

3TC 37.5ANIMAL ID

00008

00024

00071

00090

00091

00092

00162

00163

00199

00200

00259

00260

00261

00262

00274

00275

00332

00333

00334

00335

00355

00377

00395

00396

00406 * TOTALS

ALIMENTARY SYSTEM

Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 25

Gallbladder + + + + + + + + + + + + + + + + + + + + + + + + + 25

Intestine Large, Cecum A + + + + + + + + + + + + + + + + + + + + + + + + 24

Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 25

Intestine Large, Rectum A + + + + + + + + + + + + + + + + + + + A + + + + 23

Intestine Small, Duodenum A + + + + + + + + + + + + + + + + + + + A + + + + 23

Intestine Small, Ileum A + + + + + + + + + + + + + + + + + + + + + + + + 24

Intestine Small, Jejunum A + + + + + + + + + + + + + + + + + + + A + + + + 23

Liver + + + + + + + + + + + + + + + + + + + + + + + + + 25Hepatocellular Adenoma X X 2Hepatocellular Adenoma, Multiple X 1Sarcoma, Metastatic, Uncertain Primary Site X 1Capsule, Alveolar/Bronchiolar Carcinoma,

Metastatic, LungX 1

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 25Alveolar/Bronchiolar Carcinoma, Metastatic,

LungX 1

Sarcoma, Metastatic, Uncertain Primary Site X 1

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 14

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0196

0334

0337

0336

0334

0334

0334

0334

0333

0333

0334

0334

0333

0333

0332

0332

0334

0335

0333

0333

0264

0332

0334

0332

0332

3TC 37.5ANIMAL ID

00008

00024

00071

00090

00091

00092

00162

00163

00199

00200

00259

00260

00261

00262

00274

00275

00332

00333

00334

00335

00355

00377

00395

00396

00406 * TOTALS

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 25

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 25

Stomach, Glandular + + + + + + + + + + + + + + + + + + + + A + + + + 24

CARDIOVASCULAR SYSTEM

Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + + 25Alveolar/Bronchiolar Carcinoma, Metastatic,

LungX 1

Heart + + + + + + + + + + + + + + + + + + + + + + + + + 25Alveolar/Bronchiolar Carcinoma, Metastatic,

LungX 1

ENDOCRINE SYSTEM

Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 25

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 25

Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 25

Parathyroid Gland + + + + + M + + + + + + + + + + + + + + + + + + + 24

Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 25

Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 25

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 15

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0196

0334

0337

0336

0334

0334

0334

0334

0333

0333

0334

0334

0333

0333

0332

0332

0334

0335

0333

0333

0264

0332

0334

0332

0332

3TC 37.5ANIMAL ID

00008

00024

00071

00090

00091

00092

00162

00163

00199

00200

00259

00260

00261

00262

00274

00275

00332

00333

00334

00335

00355

00377

00395

00396

00406 * TOTALS

GENERAL BODY SYSTEM

Tissue NOS + 1Abdominal, Sarcoma X 1

GENITAL SYSTEM

Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + 25Sarcoma, Metastatic, Uncertain Primary Site X 1

Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + + 25

Prostate + + + + + + + + + + + + + + + + + + + + + + + + + 25

Seminal Vesicle A + + + + + + + + + + + + + + + + + + + + + + + + 24Sarcoma, Metastatic, Uncertain Primary Site X 1

Testes + + + + + + + + + + + + + + + + + + + + A + + + + 24

HEMATOPOIETIC SYSTEM

Bone Marrow A + + + + + + + + + + + + + + + + + + + + + + + + 24

Lymph Node + 1Sarcoma, Metastatic, Uncertain Primary Site X 1Mediastinal, Sarcoma, Metastatic, Uncertain

Primary SiteX 1

Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + + 25

Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + 25

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 16

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0196

0334

0337

0336

0334

0334

0334

0334

0333

0333

0334

0334

0333

0333

0332

0332

0334

0335

0333

0333

0264

0332

0334

0332

0332

3TC 37.5ANIMAL ID

00008

00024

00071

00090

00091

00092

00162

00163

00199

00200

00259

00260

00261

00262

00274

00275

00332

00333

00334

00335

00355

00377

00395

00396

00406 * TOTALS

Sarcoma, Metastatic, Uncertain Primary Site X 1

Spleen A + + + + + + + + + + + + + + + + + + + + + + + + 24

Thymus + + + + + + + + + + + + + + + + + + + + A + + + + 24Sarcoma, Metastatic, Uncertain Primary Site X 1

INTEGUMENTARY SYSTEM

Mammary Gland M M M M M M M M M M M M M M M M M M M M M M M M M 0

Skin + + + + + + + + + + + + + + + + + + + + + + + + + 25

MUSCULOSKELETAL SYSTEM

Bone + 1Cranium, Osteosarcoma X 1

Bone, Femur + + + + + + + + + + + + + + + + + + + + + + + + + 25Osteosarcoma X 1

Skeletal Muscle + 1Diaphragm, Sarcoma, Metastatic, Uncertain

Primary SiteX 1

NERVOUS SYSTEM

Brain, Brain Stem + + + + + + + + + + + + + + + + + + + + + + + + + 25

Brain, Cerebellum + + + + + + + + + + + + + + + + + + + + + + + + + 25

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 17

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0196

0334

0337

0336

0334

0334

0334

0334

0333

0333

0334

0334

0333

0333

0332

0332

0334

0335

0333

0333

0264

0332

0334

0332

0332

3TC 37.5ANIMAL ID

00008

00024

00071

00090

00091

00092

00162

00163

00199

00200

00259

00260

00261

00262

00274

00275

00332

00333

00334

00335

00355

00377

00395

00396

00406 * TOTALS

Brain, Cerebrum + + + + + + + + + + + + + + + + + + + + + + + + + 25

RESPIRATORY SYSTEM

Lung + + + + + + + + + + + + + + + + + + + + + + + + + 25Alveolar/Bronchiolar Adenoma X 1Alveolar/Bronchiolar Carcinoma X 1

Nose + + + + + + + + + + + + + + + + + + + + + + + + + 25

Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 25

SPECIAL SENSES SYSTEM

Eye A + + + + + + + + + + + + + + + + + + + A + + + + 23

Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 25Adenoma X 1Carcinoma X 1

URINARY SYSTEM

Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 25Capsule, Alveolar/Bronchiolar Carcinoma,

Metastatic, LungX 1

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 25

SYSTEMIC LESIONS

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 18

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0196

0334

0337

0336

0334

0334

0334

0334

0333

0333

0334

0334

0333

0333

0332

0332

0334

0335

0333

0333

0264

0332

0334

0332

0332

3TC 37.5ANIMAL ID

00008

00024

00071

00090

00091

00092

00162

00163

00199

00200

00259

00260

00261

00262

00274

00275

00332

00333

00334

00335

00355

00377

00395

00396

00406 * TOTALS

Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 25

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 19

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0053

0229

0257

0191

0334

0334

0334

0336

0336

0336

0335

0334

0351

0333

0333

0334

0334

0334

0333

0333

0334

0333

0334

0334

0334

NVP 10.5ANIMAL ID

00002

00015

00019

00021

00036

00063

00064

00080

00107

00108

00109

00142

00157

00173

00174

00212

00213

00263

00276

00277

00309

00310

00370

00371

00387

males(cont...)

ALIMENTARY SYSTEM

Esophagus + + A + + + + + + + + + + + + + + + + + + + + + +

Gallbladder A A A A + + + + + + + + + + + + + + + + + + + + +

Intestine Large, Cecum A A A A + + + + + + + + + + + + + + + + + + + + +Adenoma

Intestine Large, Colon A A A + + + + + + + + + + + + + + + + + + + + + +

Intestine Large, Rectum A A A A + + + + + + + + + + + + + + + + + + + + +

Intestine Small, Duodenum A A A A + + + + + + + + + + + + + + + + + + + + +

Intestine Small, Ileum A A A A + + + + + + + + + + + + + + + + + + + + +

Intestine Small, Jejunum A A A A + + + + + + + + + + + + + + + + + + + + +

Liver + + A + + + + + + + + + + + + + + + + + + + + + +Hepatocellular Adenoma X X

Mesentery +Sarcoma X

Pancreas + + A + + + + + + + + + + + + + + + + + + + + + +

Salivary Glands + + A + + + + + + + + + + + + + + + + + + + + + +

Stomach, Forestomach A + A A + + + + + + + + + + + + + + + + + + + + +

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 20

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0053

0229

0257

0191

0334

0334

0334

0336

0336

0336

0335

0334

0351

0333

0333

0334

0334

0334

0333

0333

0334

0333

0334

0334

0334

NVP 10.5ANIMAL ID

00002

00015

00019

00021

00036

00063

00064

00080

00107

00108

00109

00142

00157

00173

00174

00212

00213

00263

00276

00277

00309

00310

00370

00371

00387

males(cont...)

Stomach, Glandular A A A A + + + + + + + + + + + + + + + + + + + + +

CARDIOVASCULAR SYSTEM

Blood Vessel + + A + + + + + + + + + + + + + + + + + + + + + +

Heart + + A + + + + + + + + + + + + + + + + + + + + + +Histiocytic Sarcoma X

ENDOCRINE SYSTEM

Adrenal Cortex + + A + + + + + + + + + + + + + + + + + + + + + +

Adrenal Medulla + M A + + + + + + + + + + + M + + + + + + + + + +

Islets, Pancreatic + + A + + + + + + + + + + + + + + + + + + + + + +

Parathyroid Gland M M M + M M M + + + + + + + M + M + + + + + + + +

Pituitary Gland + + A + + + + + + + + + + + + + + + + + + + + + +

Thyroid Gland + + M + M + + + + + + + + + M + + + + + + + + + +

GENERAL BODY SYSTEM

Tissue NOS + + +Abdominal, Sarcoma XThoracic, Histiocytic Sarcoma X

GENITAL SYSTEM

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 21

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0053

0229

0257

0191

0334

0334

0334

0336

0336

0336

0335

0334

0351

0333

0333

0334

0334

0334

0333

0333

0334

0333

0334

0334

0334

NVP 10.5ANIMAL ID

00002

00015

00019

00021

00036

00063

00064

00080

00107

00108

00109

00142

00157

00173

00174

00212

00213

00263

00276

00277

00309

00310

00370

00371

00387

males(cont...)

Epididymis + + A + + + + + + + + + + + + + + + + + + + + + +

Preputial Gland + + A + + + + + + + + + + + + + + + + + + + + + +

Prostate + + A + + + + + + + + + + + + + + + + + + + + + +

Seminal Vesicle + + A + + + + + + + + + + + + + + + + + + + + + +

Testes + + A + + + + + + + + + + + + + + + + + + + + + +

HEMATOPOIETIC SYSTEM

Bone Marrow + + A + + + + + + + + + + + + + + + + + + + + + +

Lymph Node A +

Lymph Node, Mandibular + + A + + + + + + + + + + + + + + + + + + + + + +

Lymph Node, Mesenteric + + A + + + + + + + + + + + + + + + + + + + + + +

Spleen + + A + + + + + + + + + + + + + + + + + + + + + +

Thymus A + A M + + + + + + + + + + + + + + + + + + + + +

INTEGUMENTARY SYSTEM

Mammary Gland M M A M M M M M M M M M M M M M M M M M M + M M M

Skin + + A + + + + + + + + + + + + + + + + + + + + + +

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 22

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0053

0229

0257

0191

0334

0334

0334

0336

0336

0336

0335

0334

0351

0333

0333

0334

0334

0334

0333

0333

0334

0333

0334

0334

0334

NVP 10.5ANIMAL ID

00002

00015

00019

00021

00036

00063

00064

00080

00107

00108

00109

00142

00157

00173

00174

00212

00213

00263

00276

00277

00309

00310

00370

00371

00387

males(cont...)

MUSCULOSKELETAL SYSTEM

Bone +Pelvis, Osteosarcoma X

Bone, Femur + + A + + + + + + + + + + + + + + + + + + + + + +

NERVOUS SYSTEM

Brain, Brain Stem + + A + + + + + + + + + + + + + + + + + + + + + +

Brain, Cerebellum + + A + + + + + + + + + + + + + + + + + + + + + +

Brain, Cerebrum + + A + + + + + + + + + + + + + + + + + + + + + +

RESPIRATORY SYSTEM

Lung + + A + + + + + + + + + + + + + + + + + + + + + +Alveolar/Bronchiolar Adenoma XHistiocytic Sarcoma X

Nose + + A + + + + + + + + + + + + + + + + + + + + + +

Trachea + + A + + + + + + + + + + + + + + + + + + + + + +

SPECIAL SENSES SYSTEM

Eye + A A A + + + + + + + + + + + + + + + + + + + + +

Harderian Gland + + A + + + + + + + + + + + + + + + + + + + + + +

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 23

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0053

0229

0257

0191

0334

0334

0334

0336

0336

0336

0335

0334

0351

0333

0333

0334

0334

0334

0333

0333

0334

0333

0334

0334

0334

NVP 10.5ANIMAL ID

00002

00015

00019

00021

00036

00063

00064

00080

00107

00108

00109

00142

00157

00173

00174

00212

00213

00263

00276

00277

00309

00310

00370

00371

00387

males(cont...)

Adenoma X

URINARY SYSTEM

Kidney + + A + + + + + + + + + + + + + + + + + + + + + +

Urinary Bladder + + A + + + + + + + + + + + + + + + + + + + + + +Sarcoma X

SYSTEMIC LESIONS

Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + +Histiocytic Sarcoma X

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 24

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0334

NVP 10.5ANIMAL ID

00388 * TOTALS

ALIMENTARY SYSTEM

Esophagus + 25

Gallbladder + 22

Intestine Large, Cecum + 22Adenoma X 1

Intestine Large, Colon + 23

Intestine Large, Rectum + 22

Intestine Small, Duodenum + 22

Intestine Small, Ileum + 22

Intestine Small, Jejunum + 22

Liver + 25Hepatocellular Adenoma 2

Mesentery 1Sarcoma 1

Pancreas + 25

Salivary Glands + 25

Stomach, Forestomach + 23

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 25

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0334

NVP 10.5ANIMAL ID

00388 * TOTALS

Stomach, Glandular + 22

CARDIOVASCULAR SYSTEM

Blood Vessel + 25

Heart + 25Histiocytic Sarcoma 1

ENDOCRINE SYSTEM

Adrenal Cortex + 25

Adrenal Medulla + 23

Islets, Pancreatic + 25

Parathyroid Gland + 18

Pituitary Gland + 25

Thyroid Gland + 23

GENERAL BODY SYSTEM

Tissue NOS 3Abdominal, Sarcoma 1Thoracic, Histiocytic Sarcoma 1

GENITAL SYSTEM

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 26

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0334

NVP 10.5ANIMAL ID

00388 * TOTALS

Epididymis + 25

Preputial Gland + 25

Prostate + 25

Seminal Vesicle + 25

Testes + 25

HEMATOPOIETIC SYSTEM

Bone Marrow + 25

Lymph Node 1

Lymph Node, Mandibular + 25

Lymph Node, Mesenteric + 25

Spleen + 25

Thymus + 23

INTEGUMENTARY SYSTEM

Mammary Gland M 1

Skin + 25

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 27

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0334

NVP 10.5ANIMAL ID

00388 * TOTALS

MUSCULOSKELETAL SYSTEM

Bone 1Pelvis, Osteosarcoma 1

Bone, Femur + 25

NERVOUS SYSTEM

Brain, Brain Stem + 25

Brain, Cerebellum + 25

Brain, Cerebrum + 25

RESPIRATORY SYSTEM

Lung + 25Alveolar/Bronchiolar Adenoma 1Histiocytic Sarcoma 1

Nose + 25

Trachea + 25

SPECIAL SENSES SYSTEM

Eye + 23

Harderian Gland + 25

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 28

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0334

NVP 10.5ANIMAL ID

00388 * TOTALS

Adenoma 1

URINARY SYSTEM

Kidney + 25

Urinary Bladder + 25Sarcoma 1

SYSTEMIC LESIONS

Multiple Organ + 26Histiocytic Sarcoma 1

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 29

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0113

0334

0334

0334

0217

0170

0335

0335

0335

0335

0331

0331

0334

0334

0330

0330

0332

0335

0335

0333

0332

0335

0334

0321

0331

AZT 60 3TC 37.5ANIMAL ID

00011

00041

00042

00068

00069

00085

00134

00135

00149

00150

00151

00152

00177

00178

00265

00266

00271

00280

00281

00282

00318

00354

00379

00380

00397 * TOTALS

ALIMENTARY SYSTEM

Esophagus + + + + + + + + + + + + + + + + + + + + + + + A + 24

Gallbladder + + + + + + + + + + + + + + + + + + + + + + + A + 24

Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + A + 24

Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + A + 24

Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + A + 24

Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + A + 24

Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + A + 24

Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + A + 24

Liver + + + + + + + + + + + + + + + + + + + + + + + + + 25Hemangiosarcoma X 1Hepatocellular Adenoma X X X X X X X 7Hepatocellular Adenoma, Multiple X X 2Hepatocellular Carcinoma, Multiple X 1Histiocytic Sarcoma X 1Lymphoma Malignant X X 2

Mesentery + + 2Fibrosarcoma X 1

Pancreas + + + + + + + + + + + + + + + + + + + + + + + A + 24

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 30

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0113

0334

0334

0334

0217

0170

0335

0335

0335

0335

0331

0331

0334

0334

0330

0330

0332

0335

0335

0333

0332

0335

0334

0321

0331

AZT 60 3TC 37.5ANIMAL ID

00011

00041

00042

00068

00069

00085

00134

00135

00149

00150

00151

00152

00177

00178

00265

00266

00271

00280

00281

00282

00318

00354

00379

00380

00397 * TOTALS

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + A + 24

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + A + 24

Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + A + 24

CARDIOVASCULAR SYSTEM

Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + A + 24Lymphoma Malignant X X 2

Heart + + + + + + + + + + + + + + + + + + + + + + + A + 24Lymphoma Malignant X X 2

ENDOCRINE SYSTEM

Adrenal Cortex + M + + + + + + + + + + + + + + + + + + + + + A + 23

Adrenal Medulla + M + + + + + + + + + + + + + + + M + + + M + A + 21

Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + A + 24

Parathyroid Gland + + + + + + M M M + + + + M + + M + + + + + + A + 19

Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + A + 24Lymphoma Malignant X 1

Thyroid Gland + + + + + + M + + + + + + + + + + + + + + + + A + 23

GENERAL BODY SYSTEM

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 31

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0113

0334

0334

0334

0217

0170

0335

0335

0335

0335

0331

0331

0334

0334

0330

0330

0332

0335

0335

0333

0332

0335

0334

0321

0331

AZT 60 3TC 37.5ANIMAL ID

00011

00041

00042

00068

00069

00085

00134

00135

00149

00150

00151

00152

00177

00178

00265

00266

00271

00280

00281

00282

00318

00354

00379

00380

00397 * TOTALS

NONE

GENITAL SYSTEM

Epididymis + + + + + + + + + + + + + + + + + + + + + + + A + 24

Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + A + 24

Prostate + + + + + + + + + + + + + + + + + + + + + + + A + 24

Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + A + 24

Testes + + + + + + + + + + + + + + + + + + + + + + + A + 24

HEMATOPOIETIC SYSTEM

Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + A + 24Lymphoma Malignant X X 2

Lymph Node + + 2Axillary, Lymphoma Malignant X X 2Cervical, Lymphoma Malignant X 1Lumbar, Lymphoma Malignant X X 2

Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + A + 24Lymphoma Malignant X X 2

Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + A + 24Lymphoma Malignant X X 2

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 32

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0113

0334

0334

0334

0217

0170

0335

0335

0335

0335

0331

0331

0334

0334

0330

0330

0332

0335

0335

0333

0332

0335

0334

0321

0331

AZT 60 3TC 37.5ANIMAL ID

00011

00041

00042

00068

00069

00085

00134

00135

00149

00150

00151

00152

00177

00178

00265

00266

00271

00280

00281

00282

00318

00354

00379

00380

00397 * TOTALS

Spleen + + + + + + + + + + + + + + + + + + + + + + + A + 24Hemangiosarcoma X 1Lymphoma Malignant X X 2

Thymus M + + + + + + + + + + + + + + + + + + + M + + A + 22Lymphoma Malignant X X 2

INTEGUMENTARY SYSTEM

Mammary Gland M M M M M M M M M M M M + M M M M M M M M M M M M 1

Skin + + + + + + + + + + + + + + + + + + + + + + + A + 24

MUSCULOSKELETAL SYSTEM

Bone, Femur + + + + + + + + + + + + + + + + + + + + + + + + + 25

NERVOUS SYSTEM

Brain, Brain Stem + + + + + + + + + + + + + + + + + + + + + + + A + 24Lymphoma Malignant X 1

Brain, Cerebellum + + + + + + + + + + + + + + + + + + + + + + + A + 24Lymphoma Malignant X 1

Brain, Cerebrum + + + + + + + + + + + + + + + + + + + + + + + A + 24Lymphoma Malignant X 1

RESPIRATORY SYSTEM

Lung + + + + + + + + + + + + + + + + + + + + + + + A + 24

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 33

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0113

0334

0334

0334

0217

0170

0335

0335

0335

0335

0331

0331

0334

0334

0330

0330

0332

0335

0335

0333

0332

0335

0334

0321

0331

AZT 60 3TC 37.5ANIMAL ID

00011

00041

00042

00068

00069

00085

00134

00135

00149

00150

00151

00152

00177

00178

00265

00266

00271

00280

00281

00282

00318

00354

00379

00380

00397 * TOTALS

Lymphoma Malignant X X X 3

Nose + + + + + + + + + + + + + + + + + + + + + + + + + 25Lymphoma Malignant X 1

Trachea + + + + + + + + + + + + + + + + + + + + + + + A + 24

SPECIAL SENSES SYSTEM

Eye + + + + + + + + + + + + + + + + + + + + + + + A + 24

Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + A + 24

URINARY SYSTEM

Kidney + + + + + + + + + + + + + + + + + + + + + + + A + 24Lymphoma Malignant X X 2

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + A + 24

SYSTEMIC LESIONS

Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 25Histiocytic Sarcoma X 1Lymphoma Malignant X X X 3

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 34

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0333

0333

0311

0331

0335

0335

0335

0335

0334

0339

0339

0332

0332

0331

0338

0333

0332

0332

0331

0329

0335

0331

0334

0334

0332

A20,3T12.5,NV3.5ANIMAL ID

00030

00031

00050

00057

00077

00078

00098

00099

00139

00191

00192

00215

00216

00222

00247

00311

00312

00313

00336

00337

00353

00374

00375

00376

00391 * TOTALS

ALIMENTARY SYSTEM

Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 25

Gallbladder M + + + + + + + + + + + + + + + + + + + + + + + + 24

Intestine Large, Cecum + + A + + + + + + + + + + + + + + + + + + + + + + 24

Intestine Large, Colon + + A + + + + + + + + + + + + + + + + + + + + + + 24

Intestine Large, Rectum + + A + + + + + + + + + + + + + + + + + + + + + + 24

Intestine Small, Duodenum + + A + + + + + + + + + + + + + + + + + + + + + + 24

Intestine Small, Ileum + + A + + + + + + + + + + + + + + + + + + + + + + 24

Intestine Small, Jejunum + + A + + + + + + + + + + + + + + + + + + + + + + 24

Liver + + + + + + + + + + + + + + + + + + + + + + + + + 25Hepatocellular Adenoma X X X X 4Hepatocellular Adenoma, Multiple X X X 3Hepatocellular Carcinoma X X 2Leukemia Granulocytic X 1

Mesentery + 1Hemangiosarcoma X 1

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 25

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 25

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 35

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0333

0333

0311

0331

0335

0335

0335

0335

0334

0339

0339

0332

0332

0331

0338

0333

0332

0332

0331

0329

0335

0331

0334

0334

0332

A20,3T12.5,NV3.5ANIMAL ID

00030

00031

00050

00057

00077

00078

00098

00099

00139

00191

00192

00215

00216

00222

00247

00311

00312

00313

00336

00337

00353

00374

00375

00376

00391 * TOTALS

Leukemia Granulocytic X 1

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 25

Stomach, Glandular + + A + + + + + + + + + + + + + + + + + + + + + + 24

CARDIOVASCULAR SYSTEM

Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + + 25

Heart + + + + + + + + + + + + + + + + + + + + + + + + + 25

ENDOCRINE SYSTEM

Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 25

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 25

Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 25

Parathyroid Gland + + + + + + + + + + + + + M + + + + + + + + M + + 23

Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 25

Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 25

GENERAL BODY SYSTEM

NONE

GENITAL SYSTEM

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 36

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0333

0333

0311

0331

0335

0335

0335

0335

0334

0339

0339

0332

0332

0331

0338

0333

0332

0332

0331

0329

0335

0331

0334

0334

0332

A20,3T12.5,NV3.5ANIMAL ID

00030

00031

00050

00057

00077

00078

00098

00099

00139

00191

00192

00215

00216

00222

00247

00311

00312

00313

00336

00337

00353

00374

00375

00376

00391 * TOTALS

Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + 25

Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + + 25

Prostate + + + + + + + + + + + + + + + + + + + + + + + + + 25

Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + + 25

Testes + + + + + + + + + + + + + + + + + + + + + + + + + 25

HEMATOPOIETIC SYSTEM

Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 25Leukemia Granulocytic X 1

Lymph Node + + + 3Lumbar, Leukemia Granulocytic X 1Popliteal, Leukemia Granulocytic X 1

Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + + 25Leukemia Granulocytic X 1

Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + 25Leukemia Granulocytic X 1

Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 25Leukemia Granulocytic X 1

Thymus + + + + + + + + + + + + + + + + + + + + + + + + + 25Leukemia Granulocytic X 1

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 37

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0333

0333

0311

0331

0335

0335

0335

0335

0334

0339

0339

0332

0332

0331

0338

0333

0332

0332

0331

0329

0335

0331

0334

0334

0332

A20,3T12.5,NV3.5ANIMAL ID

00030

00031

00050

00057

00077

00078

00098

00099

00139

00191

00192

00215

00216

00222

00247

00311

00312

00313

00336

00337

00353

00374

00375

00376

00391 * TOTALS

INTEGUMENTARY SYSTEM

Mammary Gland M M M M M M M M M M + M M M M M M M M M M M M M M 1

Skin + + + + + + + + + + + + + + + + + + + + + + + + + 25

MUSCULOSKELETAL SYSTEM

Bone, Femur + + + + + + + + + + + + + + + + + + + + + + + + + 25

NERVOUS SYSTEM

Brain, Brain Stem + + A + + + + + + + + + + + + + + + + + + + + + + 24

Brain, Cerebellum + + A + + + + + + + + + + + + + + + + + + + + + + 24

Brain, Cerebrum + + + + + + + + + + + + + + + + + + + + + + + + + 25Leukemia Granulocytic X 1

RESPIRATORY SYSTEM

Lung + + + + + + + + + + + + + + + + + + + + + + + + + 25

Nose + + + + + + + + + + + + + + + + + + + + + + + + + 25

Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 25

SPECIAL SENSES SYSTEM

Eye + + A + + + + + + + + + + + + + + + + + + + + + + 24

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 38

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0333

0333

0311

0331

0335

0335

0335

0335

0334

0339

0339

0332

0332

0331

0338

0333

0332

0332

0331

0329

0335

0331

0334

0334

0332

A20,3T12.5,NV3.5ANIMAL ID

00030

00031

00050

00057

00077

00078

00098

00099

00139

00191

00192

00215

00216

00222

00247

00311

00312

00313

00336

00337

00353

00374

00375

00376

00391 * TOTALS

Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 25Adenoma X 1

URINARY SYSTEM

Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 25Leukemia Granulocytic X 1

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 25

SYSTEMIC LESIONS

Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 25Leukemia Granulocytic X 1

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 39

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0334

0334

0335

0335

0335

0335

0334

0334

0333

0339

0339

0332

0332

0333

0333

0337

0334

0334

0332

0332

0363

0363

0330

0333

0332

AZT40,3TC25,NVP7ANIMAL ID

00083

00084

00126

00127

00128

00129

00130

00131

00146

00193

00194

00205

00218

00233

00234

00249

00287

00288

00300

00320

00323

00324

00347

00385

00386 * TOTALS

ALIMENTARY SYSTEM

Esophagus + + + + + + + + + + + + + + + + + + + + + + + 23

Gallbladder + + + + + + + + + + + + + + + + + + + + + + + 23

Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + 23Lymphoma Malignant X 1

Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + 23Lymphoma Malignant X 1

Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + 23

Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + 23

Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + 23

Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + 23

Liver + + + + + + + + + + + + + + + + + + + + + + + 23Hepatocellular Adenoma X X X X X 5Hepatocellular Adenoma, Multiple X X 2Hepatocellular Carcinoma X X 2Lymphoma Malignant X 1

Mesentery + + 2

Pancreas + + + + + + + + + + + + + + + + + + + + + + + 23

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 40

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0334

0334

0335

0335

0335

0335

0334

0334

0333

0339

0339

0332

0332

0333

0333

0337

0334

0334

0332

0332

0363

0363

0330

0333

0332

AZT40,3TC25,NVP7ANIMAL ID

00083

00084

00126

00127

00128

00129

00130

00131

00146

00193

00194

00205

00218

00233

00234

00249

00287

00288

00300

00320

00323

00324

00347

00385

00386 * TOTALS

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + 23

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + 23

Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + 23Lymphoma Malignant X 1

CARDIOVASCULAR SYSTEM

Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + 23Lymphoma Malignant X 1

Heart + + + + + + + + + + + + + + + + + + + + + + + 23

ENDOCRINE SYSTEM

Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + 23

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + 23Lymphoma Malignant X 1Pheochromocytoma Benign X 1

Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + 23

Parathyroid Gland + + + + + + + + + + + + + + + + + + + + + + + 23

Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + 23

Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + 23

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 41

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0334

0334

0335

0335

0335

0335

0334

0334

0333

0339

0339

0332

0332

0333

0333

0337

0334

0334

0332

0332

0363

0363

0330

0333

0332

AZT40,3TC25,NVP7ANIMAL ID

00083

00084

00126

00127

00128

00129

00130

00131

00146

00193

00194

00205

00218

00233

00234

00249

00287

00288

00300

00320

00323

00324

00347

00385

00386 * TOTALS

GENERAL BODY SYSTEM

NONE

GENITAL SYSTEM

Epididymis + + + + + + + + + + + + + + + + + + + + + + + 23

Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + 23Squamous Cell Carcinoma X 1

Prostate + + + + + + + + + + + + + + + + + + + + + + + 23

Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + 23

Testes + + + + + + + + + + + + + + + + + + + + + + + 23

HEMATOPOIETIC SYSTEM

Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + 23

Lymph Node + 1Axillary, Lymphoma Malignant X 1Inguinal, Lymphoma Malignant X 1Lumbar, Lymphoma Malignant X 1Popliteal, Lymphoma Malignant X 1Renal, Lymphoma Malignant X 1

Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + 23Lymphoma Malignant X 1

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 42

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0334

0334

0335

0335

0335

0335

0334

0334

0333

0339

0339

0332

0332

0333

0333

0337

0334

0334

0332

0332

0363

0363

0330

0333

0332

AZT40,3TC25,NVP7ANIMAL ID

00083

00084

00126

00127

00128

00129

00130

00131

00146

00193

00194

00205

00218

00233

00234

00249

00287

00288

00300

00320

00323

00324

00347

00385

00386 * TOTALS

Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + 23Lymphoma Malignant X 1

Spleen + + + + + + + + + + + + + + + + + + + + + + + 23Lymphoma Malignant X 1

Thymus + + + + + + M + + + + M + + + + M + + + + + + 20Lymphoma Malignant X 1

INTEGUMENTARY SYSTEM

Mammary Gland M M M M M M M M M M M M M M M M M M M M M M M 0

Skin + + + + + + + + + + + + + + + + + + + + + + + 23Squamous Cell Papilloma X 1

MUSCULOSKELETAL SYSTEM

Bone + 1Cranium, Neuroblastoma, Metastatic, Nose X 1

Bone, Femur + + + + + + + + + + + + + + + + + + + + + + + 23

NERVOUS SYSTEM

Brain, Brain Stem + + + + + + + + + + + + + + + + + + + + + + + 23

Brain, Cerebellum + + + + + + + + + + + + + + + + + + + + + + + 23

Brain, Cerebrum + + + + + + + + + + + + + + + + + + + + + + + 23

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 43

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0334

0334

0335

0335

0335

0335

0334

0334

0333

0339

0339

0332

0332

0333

0333

0337

0334

0334

0332

0332

0363

0363

0330

0333

0332

AZT40,3TC25,NVP7ANIMAL ID

00083

00084

00126

00127

00128

00129

00130

00131

00146

00193

00194

00205

00218

00233

00234

00249

00287

00288

00300

00320

00323

00324

00347

00385

00386 * TOTALS

Olfactory Lobe, Neuroblastoma, Metastatic,Nose

X 1

RESPIRATORY SYSTEM

Lung + + + + + + + + + + + + + + + + + + + + + + + 23Alveolar/Bronchiolar Adenoma X X 2Lymphoma Malignant X 1

Nose + + + + + + + + + + + + + + + + + + + + + + + 23Neuroblastoma X 1

Trachea + + + + + + + + + + + + + + + + + + + + + + + 23

SPECIAL SENSES SYSTEM

Eye + + + + + + + + + + + + + + + + + + + + + + + 23

Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + 23Neuroblastoma, Metastatic, Nose X 1

URINARY SYSTEM

Kidney + + + + + + + + + + + + + + + + + + + + + + + 23Lymphoma Malignant X 1

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + 23

SYSTEMIC LESIONS

Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + 23

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 44

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0334

0334

0335

0335

0335

0335

0334

0334

0333

0339

0339

0332

0332

0333

0333

0337

0334

0334

0332

0332

0363

0363

0330

0333

0332

AZT40,3TC25,NVP7ANIMAL ID

00083

00084

00126

00127

00128

00129

00130

00131

00146

00193

00194

00205

00218

00233

00234

00249

00287

00288

00300

00320

00323

00324

00347

00385

00386 * TOTALS

Lymphoma Malignant X 1

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 45

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0102

0331

0334

0335

0335

0333

0334

0334

0339

0339

0321

0334

0334

0334

0341

0341

0341

0339

0339

0330

0376

0334

0334

0334

0332

A60,3T37.5,N10.5ANIMAL ID

00004

00066

00114

00115

00116

00144

00167

00168

00186

00187

00220

00223

00231

00232

00242

00243

00244

00245

00246

00319

00322

00346

00367

00405

00407 * TOTALS

ALIMENTARY SYSTEM

Esophagus + + + + + + + + + + + + + + + + + + + + + + + + 24

Gallbladder A + + + + + + + + + + + + + + + + + + + + + + + 23

Intestine Large, Cecum A + + + + + + + + + + + + + + + + + + + + + + + 23

Intestine Large, Colon A + + + + + + + + + + + + + + + + + + + + + + + 23Lymphoma Malignant X 1

Intestine Large, Rectum A + + + + + + + + + + + + + + + + + + + + + + + 23

Intestine Small, Duodenum A + + + + + + + + + + + + + + + + + + + + + + + 23Lymphoma Malignant X 1

Intestine Small, Ileum A + + + + + + + + + + + + + + + + + + + + + + + 23

Intestine Small, Jejunum A + + + + + + + + + + + + + + + + + + + + + + + 23

Liver A + + + + + + + + + + + + + + + + + + + + + + + 23Hepatocellular Adenoma X X X X X X X 7Hepatocellular Adenoma, Multiple X X 2Hepatocellular Carcinoma, Multiple X 1Lymphoma Malignant X 1

Pancreas A + + + + + + + + + + + + + + + + + + + + + + + 23Lymphoma Malignant X 1

Salivary Glands A + + + + + + + + + + + + + + + + + + + + + + + 23

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 46

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0102

0331

0334

0335

0335

0333

0334

0334

0339

0339

0321

0334

0334

0334

0341

0341

0341

0339

0339

0330

0376

0334

0334

0334

0332

A60,3T37.5,N10.5ANIMAL ID

00004

00066

00114

00115

00116

00144

00167

00168

00186

00187

00220

00223

00231

00232

00242

00243

00244

00245

00246

00319

00322

00346

00367

00405

00407 * TOTALS

Stomach, Forestomach A + + + + + + + + + + + + + + + + + + + + + + + 23

Stomach, Glandular A + + + + + + + + + + + + + + + + + + + + + + + 23

CARDIOVASCULAR SYSTEM

Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + 24

Heart + + + + + + + + + + + + + + + + + + + + + + + + 24

ENDOCRINE SYSTEM

Adrenal Cortex A + + + + + + + + + + + + + + + + + + + + + + + 23

Adrenal Medulla A + + + + + + + + + + + M + + + + + + + + + + + 22

Islets, Pancreatic A + + + + + + + + + + + + + + + + + + + + + + + 23

Parathyroid Gland A + + + + + + + + + + + + + + + + + + + + + + + 23

Pituitary Gland A + + + + + + + + + + + + + + + + + + + + + + + 23

Thyroid Gland A + + + + + + + + + + + + + + + + + + + + + + + 23

GENERAL BODY SYSTEM

NONE

GENITAL SYSTEM

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 47

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0102

0331

0334

0335

0335

0333

0334

0334

0339

0339

0321

0334

0334

0334

0341

0341

0341

0339

0339

0330

0376

0334

0334

0334

0332

A60,3T37.5,N10.5ANIMAL ID

00004

00066

00114

00115

00116

00144

00167

00168

00186

00187

00220

00223

00231

00232

00242

00243

00244

00245

00246

00319

00322

00346

00367

00405

00407 * TOTALS

Epididymis A + + + + + + + + + + + + + + + + + + + + + + + 23

Preputial Gland A + + + + + + + + + + + + + + + + + + + + + + + 23Squamous Cell Papilloma X 1

Prostate A + + + + + + + + + + + + + + + + + + + + + + + 23

Seminal Vesicle A + + + + + + + + + + + + + + + + + + + + + + + 23

Testes A + + + + + + + + + + + + + + + + + + + + + + + 23

HEMATOPOIETIC SYSTEM

Bone Marrow A + + + + + + + + + + + + + + + + + + + + + + + 23Lymphoma Malignant X 1

Lymph Node + 1Mediastinal, Lymphoma Malignant X 1Renal, Lymphoma Malignant X 1

Lymph Node, Mandibular A + + + + + + + + + + + + + + + + + + + + + + + 23Lymphoma Malignant X 1

Lymph Node, Mesenteric A + + + + + + + + + + + + + + + + + + + + + + + 23Lymphoma Malignant X 1

Spleen A + + + + + + + + + + + + + + + + + + + + + + + 23Lymphoma Malignant X X 2

Thymus A + + + + + + + + + M + M + + + M + + + + + + + 20

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 48

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0102

0331

0334

0335

0335

0333

0334

0334

0339

0339

0321

0334

0334

0334

0341

0341

0341

0339

0339

0330

0376

0334

0334

0334

0332

A60,3T37.5,N10.5ANIMAL ID

00004

00066

00114

00115

00116

00144

00167

00168

00186

00187

00220

00223

00231

00232

00242

00243

00244

00245

00246

00319

00322

00346

00367

00405

00407 * TOTALS

Lymphoma Malignant X 1

INTEGUMENTARY SYSTEM

Mammary Gland M M M M M M M M M M M M M M M M M M M M M M M M 0

Skin + + + + + + + + + + + + + + + + + + + + + + + + 24Lymphoma Malignant X 1Osteosarcoma, Metastatic, Bone X 1

MUSCULOSKELETAL SYSTEM

Bone + 1Rib, Osteosarcoma X 1

Bone, Femur + + + + + + + + + + + + + + + + + + + + + + + + 24

NERVOUS SYSTEM

Brain, Brain Stem A + + + + + + + + + + + + + + + + + + + + + + + 23

Brain, Cerebellum A + + + + + + + + + + + + + + + + + + + + + + + 23

Brain, Cerebrum A + + + + + + + + + + + + + + + + + + + + + + + 23

RESPIRATORY SYSTEM

Lung A + + + + + + + + + + + + + + + + + + + + + + + 23Lymphoma Malignant X 1

Nose + + + + + + + + + + + + + + + + + + + + + + + + 24

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 49

DAY ON TEST

C3B6F1-+/TRP53(TM1BRD) NCTRMICE MALE

0102

0331

0334

0335

0335

0333

0334

0334

0339

0339

0321

0334

0334

0334

0341

0341

0341

0339

0339

0330

0376

0334

0334

0334

0332

A60,3T37.5,N10.5ANIMAL ID

00004

00066

00114

00115

00116

00144

00167

00168

00186

00187

00220

00223

00231

00232

00242

00243

00244

00245

00246

00319

00322

00346

00367

00405

00407 * TOTALS

Trachea A + + + + + + + + + + + + + + + + + + + + + + + 23

SPECIAL SENSES SYSTEM

Eye A + + + + + + + + + + + + + + + + + + + + + + + 23

Harderian Gland A + + + + + + + + + + + + + + + + + + + + + + + 23

URINARY SYSTEM

Kidney A + + + + + + + + + + + + + + + + + + + + + + + 23

Urinary Bladder A + + + + + + + + + + + + + + + + + + + + + + + 23

SYSTEMIC LESIONS

Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + 24Lymphoma Malignant X X 2

*** END OF REPORT ***

TDMS No. 20310 - 03 P04: NEOPLASMS BY INDIVIDUAL ANIMAL Date Report Requested: 05/04/2010Test Type: 26-39 WEEKS AZT+3TC combination Time Report Requested: 12:30:53

Route: GAVAGE CAS Number: AZT3TCCOMBO First Dose M/F: 12/22/06 / NASpecies/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue

Page 50