ntr450 b12, veganism, pregnancy
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Types of Vegetarians
0 Vegan: no animal foods OF ANY KIND
0 Lacto-vegetarian: vegan diet, adding milk products
0 Lacto-ovo vegetarian: vegan diet, adding milk and egg products
0 Vegetarian: no meat
0 Pescetarian: vegetarian diet, adding fish
Reasons for being a Vegetarian
0 Lowers disease risk
0Environmental benefits
0Health condition necessitates it
0Religion
0 Limited access to meat, or quality meat products
0 Family members who are vegetarian
Recommendations
0 Per day:
0 6-11 servings of Grains
0 5-7 servings of legumes, nuts, seeds, dairy
0 4 servings of vegetables
0 2 servings of fruit
0 2+ servings of fats, oils, and sweets
0 Prenatal supplement
Important Considerations
0 It is very possible to have a healthy pregnancy while on a vegetarian/vegan diet
0 Pay attention to complementary proteins
0 Fortified foods can be an easy way to meet nutrient content
Most Common Deficiencies
0Vitamin B12
0Vitamin D
0 Calcium
0 Iron
0 Zinc
0Omega 3s: EPA, DHA
0What are some vegetarian options high in these nutrients?
Vitamin B12
0 Found only in animal sources
0Derived from bacteria
0 Found in plant sources ONLY if they are contaminated by bacteria (usually only external contamination)
(Herbert 1988)
Vitamin B12 Analogues
0Methylcobalamin
0 Active
0Adenosylcobalamin
0 Active
0Hydroxycobalamin
0 Inactive
0 Cyanocobalamin
0 Inactive
(Pawlak et al 2013)
Vitamin B12 Assessment
0 Urinary MMA0 Deficiency
0 Accurate
0 Holo-Transcobalamin II0 Carrier of active form in
blood
0 Depletion
0 Accurate
0 Total plasma B120 Unreliable
0 Standard in medical field
(Pawlak et al 2013)
Vitamin B12 Metabolism
Folate and B12
0B12 is necessary to metabolize dietary folate (not supplemental folate)
0B12 deficiency is often assessed by measuring intermediates (homocysteine)
0High amounts of folate can mask symptoms of B12 deficiency (anemia)
(Wadsworth Cengage Learning 2009)
B12 and Homocysteine (tHcy)
0 Low B12 High tHcy
0 Infant consequences:
0 low birth weight
0 premature delivery
0 neural tube defects
0Maternal consequences:
0 preeclampsia
(Vollset et al 2000)
B12 and Homocysteine (tHcy)
0B12 supplementation during pregnancy at 34 weeks
0 Decreased child’s tHcyat 2 years
0High tHcy can also be caused by folate deficiency
(Vollset et al 2000) (Lubree et al 2012)
B12 and Breastfeeding
0Vegetarian mothers who did not supplement
0 tHcy was higher at two years in those breastfeeding than in non-breastfed at two years
0 Infant B12 deficiency
0 intellectual delay
0 psychomotor delay
(Chalouchi 2008) (Lubree et al 2012)
B12 and Folate Recommendations
0 Pregnant Women0 B12: 2.6 μg/day
0 Folate (total): 600 μg/day
0 Lactating Women0 B12: 2.8 μg/day
0 Infants (0-6 mos)0 B12: 0.4 μg/day
0 Infants (6-12 mos)0 B12: 0.5 μg/day
(Wadsworth Cengage Learning 2009)
Vitamin B12 Supplements
(Carmel 2008)
Supplements
(usp.org)
Case Study #1
0 9 m/o female infant0 Almost exclusively
breastfed
0 Past 2 days0Vomiting, diarrhea,
decreased urine output
0 Past 3 months0Lethargy, reduced tone
0Mother of Southeast-Asian origin0 Strict, lifelong vegan
0 Pre-natal supplements
Case Study #1
0Megaloblastic erythrocytes
0B12: <37 pmol/L
0 Ideal (adults): 133-635 pmol
0 Folate: 14 nmol/L
0 Ideal: 7-36 pmol
0Bone marrow alterations
(Welch 2010)
Case Study #10Deficiency due to mother’s dietary habits
0Anemia managed with transfusion
0 Intramuscular B12 injections were administered over the course of one month
0Mother began taking oral vitamin B12 supplements
(Welch 2010)
Case Study #2
0 7 m/o male infant
0Exclusively breastfed0 Past 2 weeks
0Lethargy, loss of milestones
0 Past 2 months0Diarrhea, unwell
0 Treated by family doc with antibiotics
0Mother has no dietary restrictions
(Welch 2010)
Case Study #2
0 Loss of tone
0 Large red blood cells
0Alterations in bone marrow
0B12: <37 pmol/L
0 Folate: 30 nmol/L
0 Incomplete myelination
0No metabolic issues
0Mother found to have intrinsic factor antibodies
(Welch 2010)
Case Study #2
0Deficiency due to mother’s diagnosis of pernicious anemia
0 Consumption of solid food increased
0Both baby and mother received intramuscular injections
(Welch 2010)