Nutrigenomics

KNH 413

Nutrigenomics and Disease

CancerUse of omega-3 & EPA for rare typesPredicting benefit difficult in other types

Responders and non-responders

Colon cancerFolate intake and alcoholFruits and vegetables

Breast cancerAntioxidants

Nutrigenomics and Disease

ObesitySusceptibility with conducive environmentPolygenic traitPromising research

Perilipin Serotonin receptor gene promoter

Nutrigenomics and Disease

Thrifty Gene hypothesisMetabolic status and fetal adaptation predict disease

in adulthoodProneness to metabolic syndrome, obesity, diabetes,

CVD

Nutrigenomics and Disease

DiabetesFocus on type 2Metabolic syndrome, insulin resistanceGLUT 2PPARyAPOE

Nutrigenomics and Disease

Cardiovascular DiseaseDyslipidemiasFamilial hypercholesterolemiaPUFAs on HDLOmega-3s and TGOmega-6s and inflammation

Dietetics and Genetics

Understanding nutrient interactions and genes

Future of diet counseling

Beware of home testing kits“DNA diet”ScionaCostly

EGAPP ProjectTo establish a coordinated process Evaluation of genomic applications and

practice/preventionq