occupational health update: extended care...

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Occupational Health Update: Extended Care Facilities James J. Hill III, MD MPH FACOEM Medical Director, Occupational Health University of North Carolina at Chapel Hill Associate Professor, Department of Physical Medicine & Rehabilitation University of North Carolina School of Medicine Diplomate, American Board of Physical Medicine & Rehabilitation Diplomate, American Board of Preventive Medicine/Occupational Medicine Goals Understand pre-exposure evaluation and vaccine-preventable disease for healthcare personnel Understand TB surveillance for health care providers Understand how to manage exposure to blood or potentially infectious material Managing COVID-19 in the workplace

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Page 1: Occupational Health Update: Extended Care Facilitiesspice.unc.edu/wp-content/uploads/2020/09/11-2020_SPICE_LTC_Fall … · 11/09/2020  · Centers for Disease Control and Prevention

Occupational Health Update:Extended Care Facilities

James J. Hill III, MD MPH FACOEM

Medical Director, Occupational Health

University of North Carolina at Chapel Hill

Associate Professor, Department of Physical Medicine & Rehabilitation

University of North Carolina School of Medicine

Diplomate, American Board of Physical Medicine & Rehabilitation

Diplomate, American Board of Preventive Medicine/Occupational Medicine

Goals

• Understand pre-exposure evaluation and vaccine-preventable disease for healthcare personnel

• Understand TB surveillance for health care providers

• Understand how to manage exposure to blood or potentially infectious material

• Managing COVID-19 in the workplace

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• No financial relationships to disclose

• No off-label or investigational use of medications and/or devices

• The information and views set out in this presentation are those of the author and do not necessarily reflect the official opinion of the University of North Carolina at Chapel Hill or UNC Hospitals

Disclosures

ACIP June 2019 update

• Human Papillomavirus (HPV) Vaccine» Catch-up vaccination for persons through age

26 years who are not adequately vaccinated

» Catch-up vaccinations for persons aged 27 through 45 years who are not adequately vaccinated. HPV vaccines are not licensed for use in adults older than age 45 years

• Pneumococcal Vaccines» Adults 65 years or older who do not have an

immunocompromising condition and who have not previously received PCV13.

» All adults 65 years or older should receive a dose of PPSV23.

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ACIP June 2019 update

• Serogroup B Meningococcal (MenB) Vaccines» Persons aged ≥10 years with complement

deficiency, complement inhibitor use, asplenia, or who are microbiologists:

» MenB booster dose 1 year following completion of a MenB primary series followed by MenB booster doses every 2-3 years thereafter, for as long as increased risk remains

ACIP October 2019 update

• Td or Tdap can be used for the decennial Td booster. » There was no previous recommendation for a

routine second Tdap. There is still insufficient evidence to preferentially recommend that Tdap replace Td.

» Persons aged >= 19 years who have never received a dose of Tdap should receive one dose of Tdap.

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• Persons aged 11–18 years» Single dose of Tdap, preferably at a preventive care visit at

age 11–12 years, then one booster dose of either Td or Tdap every 10 years throughout life.

• Persons aged ≥19 years» Regardless of the interval since their last tetanus or diphtheria

toxoid–containing vaccine, persons aged ≥19 years who have never received a dose of Tdap should receive 1 dose of Tdap, then one booster dose of either Td or Tdap every 10 years throughout life.

• Pregnant women» Pregnant women should receive 1 dose of Tdap during each

pregnancy, irrespective of their history of receiving the vaccine. Tdap should be administered at 27–36 weeks’ gestation, preferably during the earlier part of this period, although it may be administered at any time during pregnancy

Tetanus Prophylaxis for Wound Management Recommendations

» A tetanus toxoid–containing vaccine is indicated for wound management when > 5 years have passed since the last tetanus toxoid–containing vaccine dose.

» If a tetanus toxoid–containing vaccine is indicated for persons aged ≥ 11 years, Tdap is preferred for persons who have not previously received Tdap or whose Tdap history is unknown.

» If a tetanus toxoid–containing vaccine is indicated for a pregnant woman, Tdap should be used.

» For nonpregnant persons with documentation of previous Tdap vaccination, either Td or Tdap may be used if a tetanus toxoid–containing vaccine is indicated.

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Pre-exposure prophylaxis

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Vaccines for HCP

• There are minimal difference between the adult and HCP schedules, all of which go away when you include recommended childhood vaccinations.

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Why do I have to get vaccinated? • Vaccine-preventable diseases haven’t gone away.

• Vaccination can mean the difference between life and death.» In the US, vaccine-preventable infections kill

more individuals annually than HIV/AIDS, breast cancer, or traffic accidents. Approximately 50,000 adults die each year from vaccine-preventable diseases in the US.

• Vaccines are safe and effective.

• When you get sick, your children, grandchildren, and parents are at risk, too.

I’ve heard that vaccines don’t work

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So, do I have to get vaccinated?• 10A NCAC 13D .2209 INFECTION CONTROL

» (a) A facility shall establish and maintain an infection control program for the purpose of providing a safe, clean and comfortable environment and preventing the transmission of diseases and infection.

I can’t get vaccinated, I’m …….• Pregnant

» Live-attenuated vaccines contraindicated (with some exceptions)

• Immunocompromised» Case-dependent, concern is vaccine efficacy as

well as patient safety• Allergic to eggs

» Vaccine-dependent (may have egg-free formulations available)

• On blood thinners» “Let me see your arm”

• Afraid of needles» “Quick, look over there”

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I can’t get vaccinated, I’m …….

“Not willing to get vaccinated, despite all the things you have just told me ”

Disease Herd Immunity Threshold

Diphtheria 85%

Measles 83-94%

Mumps 75-86%

Pertussis 92-94%

Polio 80-86%

Rubella 80-85%

Smallpox 83-85%

”Pick battles that are small enough to win, big enough to be important”

Specific Vaccines

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Hepatitis B• Indications

» Universal; HCP with potential blood exposure (OSHA required OR signed refusal)

• Administration» Prior to administration do not routinely perform

serologic screening for HB unless cost effective

» After last dose in the series, test for immunity (>10 mIU/mL); if inadequate provide one more series and test again for immunity; if inadequate test consider as “non-responder”

» If non-immune after two series, test for HBsAg

Hepatitis B

• HEPLISAV-B approved in late 2017

• Adults > 18 years of age

• Two doses one month apart

• Not studied in hemodialysis patients

https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM584762.pdf

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Hepatitis B

Centers for Disease Control and Prevention. Epidemiology and Prevention of Vaccine-Preventable Diseases. Hamborsky J,

Kroger A, Wolfe S, eds. 13th ed. Washington D.C. Public Health Foundation, 2015.

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Influenza vaccines for 2020-2021

Influenza vaccines• ACIP recommendations

» One annual dose for all persons > 6 months of age

» Required to be offered to residents and HCP in ECFs in NC (1 N.C. Gen. Stat. Ann. § 131E-113(a))

» Required in SC LTC (S.C. Code Ann. Regs. 61-17)

» Immunize as soon as vaccine becomes available for the current season

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Measles, Mumps, Rubella (MMR)• Measles

» Born before 1957: Consider immune (except during outbreak): Born after 1957: 2 doses

» Immunity = Appropriate immunizations or positive serology

• Mumps

» Born before 1957: Consider immune (except during outbreak): Born after 1957: 2 doses.

» 3rd dose considered in outbreak settings.

» Immunity = Appropriate immunizations or positive serology

• Rubella

» 1 dose of MMR to susceptible women of childbearing potential

» Immunity = Appropriate immunizations or positive serology

Varicella

• Special consideration should be given to those who have close contact with» Persons at high risk for severe disease (e.g.,

immunocompromised persons)

» Persons are at high risk for exposure or transmission (e.g., teachers of young children, college students, military recruits, international travelers)

• Immunity» Birth before 1980 (not HCP or pregnant

women), history of varicella or zoster by a HCP, positive serology, or laboratory evidence of infection

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Zoster VaccineZostavax®(ZVL)  Shingrix®(RZV) 

Approved 2006  Approved 2017 

Live, attenuated virus  Recombinant, inactivated varicella antigen 

Adults > 50 years and older  Adults > 50 years and older 

One dose  Two doses, 2‐ 6 months apart 

51% reduction  in risk of zoster in subjects > 60 years old (41% in 70‐79yrs, 18% in > 80 yrs) 

90% effective, 85% for at least four years after vaccination 

Reduced efficacy if given with PNEUMOVAX 23 (wait 4 weeks) 

Should be given even if patient has had shingles, had Zostavax, 

unsure  if they had chickenpox 

Adults over 60 may be given RZV or ZVL (RZV is preferred) 

Wait 8 weeks after Zostavax administration. Can give with 

inactivated flu vaccine  

Tetanus-diphtheria-acellularpertussis (/Tdap)

• Substitute 1 dose Tdap for all adults when Td booster due if no history of Tdap. » May be used to provide tetanus PEP

» Provide to all adults with exposure to young children (no delay after Td)

» Recommended for pregnant women (preferably 27-36 weeks gestational age)

» Only one dose of Tdap is required, employees who are 10 years out from Tdap can be boosted with Td or Tdap.

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Meningococcal Vaccine

• Recommended for adults had high risk of disease (persistent complement deficiency, functional or anatomic asplenia, or HIV infection (adolescents)). Two vaccines series are needed: MenACWY and Serogroup B (MenB)

• MenACWY» Immunosuppressed – 2 doses of MenACWY

and boosters every 5 years, 2 or 3-dose MenB

» Microbiologists – 1 dose, booster every 5 years (MenACWY), 2 or 3-dose MenB

» Anatomic/functional asplenia patients should be vaccinated against MenACWY/MenB

TB surveillance

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TB transmission in health care settings

• 1994 – CDC publishes guidance for health-care facilities (i.e., hospitals and specific areas in those hospitals), focusing on active TB case management and infection control

• 2005 – updated guidance expanding the locations where screening was recommended – entire facility, laboratories, outpatient facilities, correctional facilities, homeless facilities

• January 2017 – everything about occupational health TB programs changed

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Serial screening and testing for health care personnel without LTBI. In the absence of known exposure or evidence of ongoing TB transmission, U.S. health care personnel (as identified in the 2005 guidelines) without LTBI should not undergo routine serial TB screening or testing at any interval after baseline (e.g., annually).

Baseline (preplacement) screening and testing. All U.S. health care personnel should have baseline TB screening, including an individual risk assessment, which is necessary for interpreting any test result.

Health care personnel with LTBI and no prior treatment should be offered, and strongly encouraged to completetreatment with a recommended regimen, including short-course treatments, unless a contraindication exists

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NC TB Control Manual

• Patients in long term care facilities» 10A NCAC 41A .0205; 10A NCAC 13D .2202

&.2209

» Testing upon admission (two-step TST or IGRA). Annual screening which can be accomplished by a verbal elicitation of symptoms.

• Long term care facility employees» 10A NCAC 41A .0205; 10A NCAC 13D .2202

& .2209; OSHA

» Testing upon employment (two-step for TST or IGRA). Annual screening which can be accomplished by a verbal elicitation of symptoms.

Bloodborne Pathogens

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• Approximately 385,000 needle sticks and other sharps-related injuries to hospital-based healthcare personnel each year.

• 88% (50/57) of the documented cases of occupational HIV transmission from 1985-2004 involved a percutaneous exposure. Of those, 45/57 involved a hollow-borne needle.

• 41% of sharp injuries occur during use; 40% after use/before disposal; 15% during/after disposal

Bloodborne pathogens

• Employers must establish a written exposure control plan and provide annual training

• Mandates use of universal precautions (all body fluids assumed contaminated except sweat)

• Employers must utilize engineering and work practice controls to minimize/eliminate exposure» Needleless devices, single-hand recapping,

handwashing stations, sharps containers, laundry, disposal of contaminated material

OSHA BloodbornePathogens Standard

(29 CFR 1910.1013)

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• Requires offering hepatitis B vaccine to persons with the potential for exposure

• Testing of exposed employees for Hepatitis B and HIV

• Post-exposure prophylaxis must be immediately available as per CDC guidelines

OSHA BloodbornePathogens Standard

(29 CFR 1910.1013)

OSHA BloodbornePathogens Standard

• All work-related needle stick injuries and cuts from sharp objects that are contaminated with another person's blood or other potentially infectious material are OSHA-reportable regardless of the source patient disease status.

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Bloodborne Pathogens• Risk (percutaneous exposure)

» HBV• 22.0 – 30.0% (HBeAG+)• 1.0 – 6.0% (HBeAG-)

» HCV• 1.8%

» HIV• 0.3% (1 in 300)

• Risk (mucous membrane)» HBV

• Yes (rate unknown)» HCV

• Yes (rate unknown but very small)» HIV

• 0.1% (1 in 1000)• < 0.1% (non-intact skin)

CDC, 2003

RISK

Post-exposure pathway

• Test source for hepatitis B (HBsAg), hepatitis C (HCV PCR), HIV (4th gen, HIV antibodies and p24 antigen)

• Provide hepatitis B prophylaxis, if indicated

• Provide follow-up for hepatitis C, if indicated

• If source HIV+ or at “high risk” for HIV, offer employee HIV prophylaxis per CDC protocol

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Post-exposure pathway

• 10A NCAC 41A .0202

• CONTROL MEASURES – HIV » When the source case is known, the attending

physician or occupational health provider responsible for the exposed person shall notify the healthcare provider of the source case that an exposure has occurred.

» This healthcare provider shall arrange HIV testing of the source person (unless known to be HIV+) and notify the OHS provider of the test results.

» Source patient consent is not required

Current HIV PEP

• Three-drug regiment» Tenofovir-emtricitabine (Truvada) + raltegravir

(Isentress) for 4 weeks

» Other regiments are available for known HIV-source patients with specific drug resistance but these cases are rare.

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Hepatitis B

• Universal; HCP with potential blood exposure (OSHA required or HCP may decline)» No need to routinely obtain Hep B titers if an

employee has documented vaccine series and a positive titer

» In practice, we usually titer and give a booster if titer is < 10 mIU/mL

» For known non-responders, they should get Hepatitis B Immune Globulin (HBIG) within 24 hours (up to 7 days after exposure)

Hepatitis C

• No post-exposure prophylaxis

Source patients should be tested by Hep C PCR

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Follow-up testing

• Hepatitis B» Not required if employee has immunity

• HIV» Dependent on source patient and available

testing

• Hepatitis C» Dependent on source patient, test for HCV

antibodies and HCV RNA

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• Background» UNCMC has had a 24/7 COVID-19 hotline

since March 2019 and staffing that has allowed us to do full case investigations of all positive COVID-19 patients and HCP since March 2020

» Access to 24-hr turn-around time testing since March

» Full support of UNCH and UNC SOM leadership to support COVID-related absences for Medium and High-risk exposures per CDC criteria

» Early universal masking of HCP and patients

» Symptom-screening of patients, visitors and HCP

Managing COVID-19 in the workplace

Managing COVID-19 in the workplace

• PPE works» Emphasis on universal pandemic precautions

(i.e. wrap-around eye protection and surgical mask for ALL HCP in all clinical areas)

• Positive COVID rates are low in asymptomatic people » Prioritize symptomatic HCP access to < 24-

hour TAT accurate COVID-19 testing

• Social distancing» Eating with other HCP continues to be one of

our largest sources of occupational COVID-19 exposures. Start paying attention to indoor eating spaces as the weather gets colder. Verify if any household contacts work in a healthcare setting.

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• HCP are exhausted» Need strategies that do not require the HCP to

remember to do the right thing. Make it easy, make it obvious, PPE needs to fit and be comfortable for continuous use.

• Testing is not a substitute for prevention» Emphasis on masking, symptom-screening, not

working while sick, social distancing. A negative test does not mean you do not follow proper precautions.

• Watch your testing vendor closely» Day 1: collect samples; Day 2: get samples to

the lab; Day 3: lab runs the samples; Day 4: vendor uploads results; Day 5: health department notifies HCP. Five-day turn-around time is too late to prevent transmission.

Managing COVID-19 in the workplace

Take your son to work day

Thanks!

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Contact Information

[email protected]