ok computer - what lies beyond 3d printing and how it will save your life
TRANSCRIPT
3D-Printed heart saves the life
of baby John
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John Doe Jr JOHN Doe Sr* *JOHN Doe Sr is a fictitious person with a fictitious disease and a fictitious clinical outcome, any resemblance to a real person, living or dead, is purely coincidental
*Clinical images from Prof Dr Peter de Jaegere, EMC, Rotterdam
Which device size would be the best for JOHN?
26 mm 29 mm
JOHN had a severe complication …
* Kodali et al., 2012, N Engl J Med
Months after implantation
Death
s (
%)
Low leakage
High leakage
chance of dying 100% higher
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Virtual heart saves the life of John Doe Sr
Bigger size decreases leakage with 70%
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Validation
The model can predict the valve morphology
In silico In vivo
0
5
10
15
20
25
Sellers 0, 1 Sellers > 2
Clinically observed leakage
29 pts included, further enrolling
p < 0.05
Pre
dic
ted leakage
The model can predict the valve function
Integration
What have we learned today? ‘
“
’ - P. Huysentruyt
SIZE matters